Acquired EGFR C797S mutation mediates resistance to AZD9291 in non-small cell lung cancer harboring EGFR T790M

Nature Medicine

Volumn 21, Issue 6, 2015, Pages 560-562

  Thress, Kenneth S ^a   Paweletz, Cloud P ^b   Felip, Enriqueta ^c,d   Cho, Byoung Chul ^e   Stetson, Daniel ^a   Dougherty, Brian ^a   Lai, Zhongwu ^a   Markovets, Aleksandra ^a   Vivancos, Ana ^c   Kuang, Yanan ^b   Ercan, Dalia ^b   Matthews, Sarah E ^b   Cantarini, Mireille ^a   Barrett, J Carl ^a   Jänne, Pasi A ^b   Oxnard, Geoffrey R ^b  

^a ASTRAZENECA   (United Kingdom)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c VALL D HEBRON UNIVERSITY HOSPITAL   (Spain)

^d HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^e Yonsei University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; MERELETINIB; ACRYLAMIDE DERIVATIVE; ANILINE DERIVATIVE; EGFR PROTEIN, HUMAN; OSIMERTINIB;

ADULT; ANIMAL CELL; ARTICLE; CANCER CHEMOTHERAPY; CANCER RESISTANCE; CASE REPORT; CELL FREE SYSTEM; CONTROLLED STUDY; COVALENT BOND; EGFR GENE; EXON; FEMALE; GENE; GENE EXPRESSION; GENE MUTATION; HUMAN; HUMAN TISSUE; IN VITRO STUDY; LUNG BIOPSY; LUNG CANCER; MOUSE; NEXT GENERATION SEQUENCING; NON SMALL CELL LUNG CANCER; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TREATMENT RESPONSE; AGED; CARCINOMA, NON-SMALL-CELL LUNG; DRUG RESISTANCE; GENETICS; HIGH THROUGHPUT SEQUENCING; MALE; MIDDLE AGED; MUTATION; PATHOLOGY;

ACRYLAMIDES; ADULT; AGED; ANILINE COMPOUNDS; CARCINOMA, NON-SMALL-CELL LUNG; DRUG RESISTANCE, NEOPLASM; FEMALE; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; MALE; MIDDLE AGED; MUTATION; RECEPTOR, EPIDERMAL GROWTH FACTOR;

EID: 84930755018     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.3854     Document Type: Article

References (16)

1. Mok, T.S. et al. N. Engl. J. Med. 361, 947-957 (2009).
2. Rosell, R. et al. N. Engl. J. Med. 361, 958-967 (2009).
3. Arcila, M.E. et al. Clin. Cancer Res. 17, 1169-1180 (2011).
4. Sequist, L.V. et al. Sci. Transl. Med. 3, 75ra26 (2011).
5. Zhou, W. et al. Nature 462, 1070-1074 (2009).
6. Ward, R.A. et al. J. Med. Chem. 56, 7025-7048 (2013).
7. Cross, D.A.E. et al. Cancer Discov. 4, 1046-0161 (2014).
8. Jänne, P.A. et al. N. Engl. J. Med. (in the press, 2015).
9. Yu, Z. et al. Cancer Res. 67, 10417-10427 (2007).
10. Godin-Heymann, N. et al. Mol. Cancer Ther. 7, 874-879 (2008).
11. Avizienyte, E., Ward, R.A. & Garner, A.P. Biochem. J. 415, 197-206 (2008).
12. Sequist, L.V. et al. N. Engl. J. Med. (in the press, 2015).
13. Oxnard, G.R. et al. Clin. Cancer Res. 20, 1698-1705 (2014).
14. Woyach, J.A. et al. N. Engl. J. Med. 370, 2286-2294 (2014).
15. Eisenhauer, E.A. et al. Eur. J. Cancer 45, 228-247 (2009).
16. Engelman, J.A. et al. Cancer Res. 67, 11924-11932 (2007).