Overcoming EMT-associated resistance to anti-cancer drugs via Src/FAK pathway inhibition

Oncotarget

Volumn 5, Issue 17, 2014, Pages 7328-7341

  Wilson, Catherine ^a   Nicholes, Katrina ^a   Bustos, Daisy ^a   Lin, Eva ^a   Song, Qinghua ^a   Stephan, Jean Philippe ^a   Kirkpatrick, Donald S ^a   Settleman, Jeff ^a  

^a GENENTECH INC   (United States)

Author keywords

Cancer; Dasatinib; Drug resistance; EMT; Src

Indexed keywords

ABELSON KINASE; DASATINIB; EPHRIN B1; ERLOTINIB; FOCAL ADHESION KINASE; PROTEIN TYROSINE KINASE; ANTINEOPLASTIC AGENT; EGFR PROTEIN, HUMAN; EPIDERMAL GROWTH FACTOR RECEPTOR; FOCAL ADHESION KINASE 1; PTK2 PROTEIN, HUMAN; PYRIMIDINE DERIVATIVE; QUINAZOLINE DERIVATIVE; THIAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CANCER RESISTANCE; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; EMBRYO; ENZYME PHOSPHORYLATION; EPITHELIAL MESENCHYMAL TRANSITION; HUMAN; HUMAN CELL; LUNG CANCER CELL LINE; MESENCHYME CELL; MOUSE; NONHUMAN; RNA INTERFERENCE; SIGNAL TRANSDUCTION; ANIMAL; CELL SURVIVAL; DRUG EFFECTS; DRUG RESISTANCE; DRUG SCREENING; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; IMMUNOBLOTTING; LUNG TUMOR; METABOLISM; MUTATION; NON SMALL CELL LUNG CANCER; NUDE MOUSE; PHYSIOLOGY; PROTO ONCOGENE; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CELL SURVIVAL; DRUG RESISTANCE, NEOPLASM; EPITHELIAL-MESENCHYMAL TRANSITION; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; FOCAL ADHESION KINASE 1; GENES, ERBB-1; HUMANS; IMMUNOBLOTTING; LUNG NEOPLASMS; MICE; MICE, NUDE; MUTATION; PYRIMIDINES; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES; THIAZOLES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84907495324     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.2397     Document Type: Article

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