-
1
-
-
84923762812
-
A new initiative on precision medicine
-
Collins, F.S. & Varmus, H. A new initiative on precision medicine. N. Engl. J. Med. 372, 793-795 (2015).
-
(2015)
N. Engl. J. Med.
, vol.372
, pp. 793-795
-
-
Collins, F.S.1
Varmus, H.2
-
2
-
-
77952768072
-
Ten years on - The human genome and medicine
-
Varmus, H. Ten years on - the human genome and medicine. N. Engl. J. Med. 362, 2028-2029 (2010).
-
(2010)
N. Engl. J. Med.
, vol.362
, pp. 2028-2029
-
-
Varmus, H.1
-
3
-
-
84879469580
-
The 2011 Gordon Wilson lecture: Overcoming resistance to targeted cancer drugs
-
discussion 123-125
-
Sawyers, C.L. The 2011 Gordon Wilson lecture: overcoming resistance to targeted cancer drugs. Trans. Am. Clin. Climatol. Assoc. 123, 114-123, discussion 123-125 (2012).
-
(2012)
Trans. Am. Clin. Climatol. Assoc.
, vol.123
, pp. 114-123
-
-
Sawyers, C.L.1
-
4
-
-
70349682746
-
Lessons learned from the development of kinase inhibitors
-
Sawyers, C.L. Lessons learned from the development of kinase inhibitors. Clin. Adv. Hematol. Oncol. 7, 588-589 (2009).
-
(2009)
Clin. Adv. Hematol. Oncol.
, vol.7
, pp. 588-589
-
-
Sawyers, C.L.1
-
5
-
-
70350435633
-
Shifting paradigms: The seeds of oncogene addiction
-
Sawyers, C.L. Shifting paradigms: the seeds of oncogene addiction. Nat. Med. 15, 1158-1161 (2009).
-
(2009)
Nat. Med.
, vol.15
, pp. 1158-1161
-
-
Sawyers, C.L.1
-
6
-
-
77957364747
-
Translating cancer research into targeted therapeutics
-
de Bono, J.S. & Ashworth, A. Translating cancer research into targeted therapeutics. Nature 467, 543-549 (2010).
-
(2010)
Nature
, vol.467
, pp. 543-549
-
-
De Bono, J.S.1
Ashworth, A.2
-
7
-
-
84863652136
-
Circumventing cancer drug resistance in the era of personalized medicine
-
Garraway, L.A. & Jänne, P.A. Circumventing cancer drug resistance in the era of personalized medicine. Cancer Discov. 2, 214-226 (2012).
-
(2012)
Cancer Discov.
, vol.2
, pp. 214-226
-
-
Garraway, L.A.1
Jänne, P.A.2
-
8
-
-
84927126291
-
Overall response rate, progression-free survival, and overall survival with targeted and standard therapies in advanced non-small-cell lung cancer: US Food and Drug Administration trial-level and patient-level analyses
-
Blumenthal, G.M. et al. Overall response rate, progression-free survival, and overall survival with targeted and standard therapies in advanced non-small-cell lung cancer: US Food and Drug Administration trial-level and patient-level analyses. J. Clin. Oncol. 33, 1008-1014 (2015).
-
(2015)
J. Clin. Oncol.
, vol.33
, pp. 1008-1014
-
-
Blumenthal, G.M.1
-
9
-
-
10944258521
-
Lack of sustained regression of c-MYC-induced mammary adenocarcinomas following brief or prolonged MYC inactivation
-
Boxer, R.B., Jang, J.W., Sintasath, L. & Chodosh, L.A. Lack of sustained regression of c-MYC-induced mammary adenocarcinomas following brief or prolonged MYC inactivation. Cancer Cell 6, 577-586 (2004).
-
(2004)
Cancer Cell
, vol.6
, pp. 577-586
-
-
Boxer, R.B.1
Jang, J.W.2
Sintasath, L.3
Chodosh, L.A.4
-
10
-
-
84864402225
-
Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer
-
Zhang, Z. et al. Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer. Nat. Genet. 44, 852-860 (2012).
-
(2012)
Nat. Genet.
, vol.44
, pp. 852-860
-
-
Zhang, Z.1
-
11
-
-
84941013285
-
RAS-MAPK dependence underlies a rational polytherapy strategy in EML4-ALK-positive lung cancer
-
Hrustanovic, G. et al. RAS-MAPK dependence underlies a rational polytherapy strategy in EML4-ALK-positive lung cancer. Nat. Med. 21, 1038-1047 (2015).
-
(2015)
Nat. Med.
, vol.21
, pp. 1038-1047
-
-
Hrustanovic, G.1
-
12
-
-
84877100240
-
Analysis of tumor specimens at the time of acquired resistance to EGFR-TKI therapy in 155 patients with EGFR-mutant lung cancers
-
Yu, H.A. et al. Analysis of tumor specimens at the time of acquired resistance to EGFR-TKI therapy in 155 patients with EGFR-mutant lung cancers. Clin. Cancer Res. 19, 2240-2247 (2013).
-
(2013)
Clin. Cancer Res.
, vol.19
, pp. 2240-2247
-
-
Yu, H.A.1
-
13
-
-
84891894051
-
The genetic landscape of clinical resistance to RAF inhibition in metastatic melanoma
-
Van Allen, E.M. et al. The genetic landscape of clinical resistance to RAF inhibition in metastatic melanoma. Cancer Discov. 4, 94-109 (2014).
-
(2014)
Cancer Discov.
, vol.4
, pp. 94-109
-
-
Van Allen, E.M.1
-
14
-
-
84933040790
-
Clinical acquired resistance to RAF inhibitor combinations in BRAF-mutant colorectal cancer through MAPK pathway alterations
-
Ahronian, L.G. et al. Clinical acquired resistance to RAF inhibitor combinations in BRAF-mutant colorectal cancer through MAPK pathway alterations. Cancer Discov. 5, 358-367 (2015).
-
(2015)
Cancer Discov.
, vol.5
, pp. 358-367
-
-
Ahronian, L.G.1
-
15
-
-
77949732073
-
RAF inhibitors transactivate RAF dimers and ERK signaling in cells with wild-type BRAF
-
Poulikakos, P.I., Zhang, C., Bollag, G., Shokat, K.M. & Rosen, N. RAF inhibitors transactivate RAF dimers and ERK signaling in cells with wild-type BRAF. Nature 464, 427-430 (2010).
-
(2010)
Nature
, vol.464
, pp. 427-430
-
-
Poulikakos, P.I.1
Zhang, C.2
Bollag, G.3
Shokat, K.M.4
Rosen, N.5
-
16
-
-
84887478023
-
Tumor adaptation and resistance to RAF inhibitors
-
Lito, P., Rosen, N. & Solit, D.B. Tumor adaptation and resistance to RAF inhibitors. Nat. Med. 19, 1401-1409 (2013).
-
(2013)
Nat. Med.
, vol.19
, pp. 1401-1409
-
-
Lito, P.1
Rosen, N.2
Solit, D.B.3
-
18
-
-
84869067183
-
V600E melanomas
-
V600E melanomas. Cancer Cell 22, 668-682 (2012).
-
(2012)
Cancer Cell
, vol.22
, pp. 668-682
-
-
Lito, P.1
-
19
-
-
84863230465
-
V600E inhibition through feedback activation of EGFR
-
V600E inhibition through feedback activation of EGFR. Nature 483, 100-103 (2012).
-
(2012)
Nature
, vol.483
, pp. 100-103
-
-
Prahallad, A.1
-
20
-
-
84938799837
-
Toward understanding and exploiting tumor heterogeneity
-
Alizadeh, A.A. et al. Toward understanding and exploiting tumor heterogeneity. Nat. Med. 21, 846-853 (2015).
-
(2015)
Nat. Med.
, vol.21
, pp. 846-853
-
-
Alizadeh, A.A.1
-
21
-
-
84907855592
-
Spatial and temporal diversity in genomic instability processes defines lung cancer evolution
-
de Bruin, E.C. et al. Spatial and temporal diversity in genomic instability processes defines lung cancer evolution. Science 346, 251-256 (2014).
-
(2014)
Science
, vol.346
, pp. 251-256
-
-
De Bruin, E.C.1
-
22
-
-
84922910667
-
Deciphering intratumor heterogeneity and temporal acquisition of driver events to refine precision medicine
-
Hiley, C., de Bruin, E.C., McGranahan, N. & Swanton, C. Deciphering intratumor heterogeneity and temporal acquisition of driver events to refine precision medicine. Genome Biol. 15, 453 (2014).
-
(2014)
Genome Biol.
, vol.15
, pp. 453
-
-
Hiley, C.1
De Bruin, E.C.2
McGranahan, N.3
Swanton, C.4
-
23
-
-
84914112343
-
Tumor heterogeneity and the evolution of polyclonal drug resistance
-
Burrell, R.A. & Swanton, C. Tumor heterogeneity and the evolution of polyclonal drug resistance. Mol. Oncol. 8, 1095-1111 (2014).
-
(2014)
Mol. Oncol.
, vol.8
, pp. 1095-1111
-
-
Burrell, R.A.1
Swanton, C.2
-
24
-
-
73649102105
-
Preexistence and clonal selection of MET amplification in EGFR-mutant NSCLC
-
Turke, A.B. et al. Preexistence and clonal selection of MET amplification in EGFR-mutant NSCLC. Cancer Cell 17, 77-88 (2010).
-
(2010)
Cancer Cell
, vol.17
, pp. 77-88
-
-
Turke, A.B.1
-
25
-
-
79952264325
-
T790M mutation and BRCA1 mRNA expression in erlotinib-treated advanced non-small-cell lung cancer patients with EGFR mutations
-
T790M mutation and BRCA1 mRNA expression in erlotinib-treated advanced non-small-cell lung cancer patients with EGFR mutations. Clin. Cancer Res. 17, 1160-1168 (2011).
-
(2011)
Clin. Cancer Res.
, vol.17
, pp. 1160-1168
-
-
Rosell, R.1
-
26
-
-
84923957819
-
The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies
-
Lin, L. et al. The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies. Nat. Genet. 47, 250-256 (2015).
-
(2015)
Nat. Genet.
, vol.47
, pp. 250-256
-
-
Lin, L.1
-
27
-
-
79960927451
-
PIK3CA mutations frequently coexist with RAS and BRAF mutations in patients with advanced cancers
-
Janku, F. et al. PIK3CA mutations frequently coexist with RAS and BRAF mutations in patients with advanced cancers. PLoS One 6, e22769 (2011).
-
(2011)
PLoS One
, vol.6
-
-
Janku, F.1
-
28
-
-
84978619027
-
Tumor cells can follow distinct evolutionary paths to become resistant to epidermal growth factor receptor inhibition
-
Hata, A.N. et al. Tumor cells can follow distinct evolutionary paths to become resistant to epidermal growth factor receptor inhibition. Nat. Med. 22, 262-269 (2016).
-
(2016)
Nat. Med.
, vol.22
, pp. 262-269
-
-
Hata, A.N.1
-
29
-
-
84923345635
-
Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma
-
Müller, J. et al. Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma. Nat. Commun. 5, 5712 (2014).
-
(2014)
Nat. Commun.
, vol.5
, pp. 5712
-
-
Müller, J.1
-
30
-
-
84864285794
-
Tumor microenvironment elicits innate resistance to RAF inhibitors through HGF secretion
-
Straussman, R. et al. Tumor microenvironment elicits innate resistance to RAF inhibitors through HGF secretion. Nature 487, 500-504 (2012).
-
(2012)
Nature
, vol.487
, pp. 500-504
-
-
Straussman, R.1
-
31
-
-
84927695240
-
NF-κB-activating complex engaged in response to EGFR oncogene inhibition drives tumor cell survival and residual disease in lung cancer
-
Blakely, C.M. et al. NF-κB-activating complex engaged in response to EGFR oncogene inhibition drives tumor cell survival and residual disease in lung cancer. Cell Rep. 11, 98-110 (2015).
-
(2015)
Cell Rep.
, vol.11
, pp. 98-110
-
-
Blakely, C.M.1
-
32
-
-
77950809059
-
A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations
-
Sharma, S.V. et al. A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations. Cell 141, 69-80 (2010).
-
(2010)
Cell
, vol.141
, pp. 69-80
-
-
Sharma, S.V.1
-
33
-
-
84905726946
-
Drug resistance via feedback activation of Stat3 in oncogene-addicted cancer cells
-
Lee, H.J. et al. Drug resistance via feedback activation of Stat3 in oncogene-addicted cancer cells. Cancer Cell 26, 207-221 (2014).
-
(2014)
Cancer Cell
, vol.26
, pp. 207-221
-
-
Lee, H.J.1
-
34
-
-
84876436850
-
Oncogenic BRAF regulates oxidative metabolism via PGC-1α and MITF
-
Haq, R. et al. Oncogenic BRAF regulates oxidative metabolism via PGC-1α and MITF. Cancer Cell 23, 302-315 (2013).
-
(2013)
Cancer Cell
, vol.23
, pp. 302-315
-
-
Haq, R.1
-
35
-
-
84864286442
-
Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors
-
Wilson, T.R. et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature 487, 505-509 (2012).
-
(2012)
Nature
, vol.487
, pp. 505-509
-
-
Wilson, T.R.1
-
36
-
-
84928174677
-
Therapy-induced tumor secretomes promote resistance and tumor progression
-
Obenauf, A.C. et al. Therapy-induced tumor secretomes promote resistance and tumor progression. Nature 520, 368-372 (2015).
-
(2015)
Nature
, vol.520
, pp. 368-372
-
-
Obenauf, A.C.1
-
37
-
-
77956513286
-
Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma
-
Bollag, G. et al. Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma. Nature 467, 596-599 (2010).
-
(2010)
Nature
, vol.467
, pp. 596-599
-
-
Bollag, G.1
-
38
-
-
84898626787
-
Vemurafenib oral bioavailability: An insoluble problem
-
Szmulewitz, R.Z. & Ratain, M.J. Vemurafenib oral bioavailability: an insoluble problem. J. Clin. Pharmacol. 54, 375-377 (2014).
-
(2014)
J. Clin. Pharmacol.
, vol.54
, pp. 375-377
-
-
Szmulewitz, R.Z.1
Ratain, M.J.2
-
39
-
-
20344407085
-
Pharmacokinetic variability of anticancer agents
-
Undevia, S.D., Gomez-Abuin, G. & Ratain, M.J. Pharmacokinetic variability of anticancer agents. Nat. Rev. Cancer 5, 447-458 (2005).
-
(2005)
Nat. Rev. Cancer
, vol.5
, pp. 447-458
-
-
Undevia, S.D.1
Gomez-Abuin, G.2
Ratain, M.J.3
-
40
-
-
84941271406
-
Stromal biology and therapy in pancreatic cancer: A changing paradigm
-
Neesse, A., Algül, H., Tuveson, D.A. & Gress, T.M. Stromal biology and therapy in pancreatic cancer: a changing paradigm. Gut 64, 1476-1484 (2015).
-
(2015)
Gut
, vol.64
, pp. 1476-1484
-
-
Neesse, A.1
Algül, H.2
Tuveson, D.A.3
Gress, T.M.4
-
41
-
-
84912096468
-
Antiangiogenesis strategies revisited: From starving tumors to alleviating hypoxia
-
Jain, R.K. Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia. Cancer Cell 26, 605-622 (2014).
-
(2014)
Cancer Cell
, vol.26
, pp. 605-622
-
-
Jain, R.K.1
-
42
-
-
84894589324
-
Phase 1 safety and pharmacokinetic study of the PI3K-mTOR inhibitor SAR245409 (XL765) in combination with erlotinib in patients with advanced solid tumors
-
Jänne, P.A. et al. Phase 1 safety and pharmacokinetic study of the PI3K-mTOR inhibitor SAR245409 (XL765) in combination with erlotinib in patients with advanced solid tumors. J. Thorac. Oncol. 9, 316-323 (2014).
-
(2014)
J. Thorac. Oncol.
, vol.9
, pp. 316-323
-
-
Jänne, P.A.1
-
43
-
-
84891770347
-
Targeted therapies in brain metastases
-
Lin, N.U. Targeted therapies in brain metastases. Curr. Treat. Options Neurol. 16, 276 (2014).
-
(2014)
Curr. Treat. Options Neurol.
, vol.16
, pp. 276
-
-
Lin, N.U.1
-
44
-
-
76149121455
-
Targeting the anti-apoptotic signaling pathway
-
Thompson, C.B. Targeting the anti-apoptotic signaling pathway. Clin. Adv. Hematol. Oncol. 7, 819-822 (2009).
-
(2009)
Clin. Adv. Hematol. Oncol.
, vol.7
, pp. 819-822
-
-
Thompson, C.B.1
-
45
-
-
84896957081
-
Ceritinib in ALK-rearranged non-small-cell lung cancer
-
Shaw, A.T. et al. Ceritinib in ALK-rearranged non-small-cell lung cancer. N. Engl. J. Med. 370, 1189-1197 (2014).
-
(2014)
N. Engl. J. Med.
, vol.370
, pp. 1189-1197
-
-
Shaw, A.T.1
-
46
-
-
84928746232
-
Rociletinib in EGFR-mutated non-small-cell lung cancer
-
Sequist, L.V. et al. Rociletinib in EGFR-mutated non-small-cell lung cancer. N. Engl. J. Med. 372, 1700-1709 (2015).
-
(2015)
N. Engl. J. Med.
, vol.372
, pp. 1700-1709
-
-
Sequist, L.V.1
-
47
-
-
84928739294
-
AZD9291 in EGFR inhibitor-resistant non-small-cell lung cancer
-
Jänne, P.A. et al. AZD9291 in EGFR inhibitor-resistant non-small-cell lung cancer. N. Engl. J. Med. 372, 1689-1699 (2015).
-
(2015)
N. Engl. J. Med.
, vol.372
, pp. 1689-1699
-
-
Jänne, P.A.1
-
48
-
-
84911922237
-
V600-mutant melanoma experiencing progression with single-agent BRAF inhibitor
-
V600-mutant melanoma experiencing progression with single-agent BRAF inhibitor. J. Clin. Oncol. 32, 3697-3704 (2014).
-
(2014)
J. Clin. Oncol.
, vol.32
, pp. 3697-3704
-
-
Johnson, D.B.1
-
49
-
-
84959867957
-
Targeting MET and EGFR in NSCLC - What can we learn from the recently reported phase 3 trial of onartuzumab in combination with erlotinib in advanced non-small cell lung cancer?
-
Charakidis, M. & Boyer, M. Targeting MET and EGFR in NSCLC - what can we learn from the recently reported phase 3 trial of onartuzumab in combination with erlotinib in advanced non-small cell lung cancer? Transl. Lung Cancer Res. 3, 395-396 (2014).
-
(2014)
Transl. Lung Cancer Res.
, vol.3
, pp. 395-396
-
-
Charakidis, M.1
Boyer, M.2
-
50
-
-
34548853993
-
Prospective assessment of discontinuation and reinitiation of erlotinib or gefitinib in patients with acquired resistance to erlotinib or gefitinib followed by the addition of everolimus
-
Riely, G.J. et al. Prospective assessment of discontinuation and reinitiation of erlotinib or gefitinib in patients with acquired resistance to erlotinib or gefitinib followed by the addition of everolimus. Clin. Cancer Res. 13, 5150-5155 (2007).
-
(2007)
Clin. Cancer Res.
, vol.13
, pp. 5150-5155
-
-
Riely, G.J.1
-
51
-
-
84891899026
-
MAP kinase pathway alterations in BRAF-mutant melanoma patients with acquired resistance to combined RAF-MEK inhibition
-
Wagle, N. et al. MAP kinase pathway alterations in BRAF-mutant melanoma patients with acquired resistance to combined RAF-MEK inhibition. Cancer Discov. 4, 61-68 (2014).
-
(2014)
Cancer Discov.
, vol.4
, pp. 61-68
-
-
Wagle, N.1
-
53
-
-
84908257665
-
Combined BRAF and MEK inhibition versus BRAF inhibition alone in melanoma
-
Long, G.V. et al. Combined BRAF and MEK inhibition versus BRAF inhibition alone in melanoma. N. Engl. J. Med. 371, 1877-1888 (2014).
-
(2014)
N. Engl. J. Med.
, vol.371
, pp. 1877-1888
-
-
Long, G.V.1
-
54
-
-
84937761544
-
Studying clonal dynamics in response to cancer therapy using high-complexity barcoding
-
Bhang, H.E. et al. Studying clonal dynamics in response to cancer therapy using high-complexity barcoding. Nat. Med. 21, 440-448 (2015).
-
(2015)
Nat. Med.
, vol.21
, pp. 440-448
-
-
Bhang, H.E.1
-
55
-
-
84881483492
-
Evolutionary dynamics of cancer in response to targeted combination therapy
-
Bozic, I. et al. Evolutionary dynamics of cancer in response to targeted combination therapy. eLife 2, e00747 (2013).
-
(2013)
eLife
, vol.2
-
-
Bozic, I.1
-
56
-
-
84937990975
-
On the road to precision cancer medicine: Analysis of genomic biomarker actionability in 439 patients
-
Schwaederle, M. et al. On the road to precision cancer medicine: analysis of genomic biomarker actionability in 439 patients. Mol. Cancer Ther. 14, 1488-1494 (2015).
-
(2015)
Mol. Cancer Ther.
, vol.14
, pp. 1488-1494
-
-
Schwaederle, M.1
-
57
-
-
84919443958
-
Patient-derived models of acquired resistance can identify effective drug combinations for cancer
-
Crystal, A.S. et al. Patient-derived models of acquired resistance can identify effective drug combinations for cancer. Science 346, 1480-1486 (2014).
-
(2014)
Science
, vol.346
, pp. 1480-1486
-
-
Crystal, A.S.1
-
58
-
-
84907554319
-
Organoid cultures derived from patients with advanced prostate cancer
-
Gao, D. et al. Organoid cultures derived from patients with advanced prostate cancer. Cell 159, 176-187 (2014).
-
(2014)
Cell
, vol.159
, pp. 176-187
-
-
Gao, D.1
-
59
-
-
84944056882
-
Liquid biopsy: Will it be the 'magic tool' for monitoring response of solid tumors to anticancer therapies?
-
Gingras, I., Salgado, R. & Ignatiadis, M. Liquid biopsy: will it be the 'magic tool' for monitoring response of solid tumors to anticancer therapies? Curr. Opin. Oncol. 27, 560-567 (2015).
-
(2015)
Curr. Opin. Oncol.
, vol.27
, pp. 560-567
-
-
Gingras, I.1
Salgado, R.2
Ignatiadis, M.3
-
60
-
-
84904066077
-
Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture
-
Li, X. et al. Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture. Nat. Med. 20, 769-777 (2014).
-
(2014)
Nat. Med.
, vol.20
, pp. 769-777
-
-
Li, X.1
-
61
-
-
84907552531
-
Identification of multipotent luminal progenitor cells in human prostate organoid cultures
-
Karthaus, W.R. et al. Identification of multipotent luminal progenitor cells in human prostate organoid cultures. Cell 159, 163-175 (2014).
-
(2014)
Cell
, vol.159
, pp. 163-175
-
-
Karthaus, W.R.1
-
62
-
-
84937414146
-
T790-positive cancers with a third-generation EGFR inhibitor
-
T790-positive cancers with a third-generation EGFR inhibitor. Cancer Discov. 5, 713-722 (2015).
-
(2015)
Cancer Discov.
, vol.5
, pp. 713-722
-
-
Piotrowska, Z.1
-
63
-
-
84859820567
-
Imaging tumor-stroma interactions during chemotherapy reveals contributions of the microenvironment to resistance
-
Nakasone, E.S. et al. Imaging tumor-stroma interactions during chemotherapy reveals contributions of the microenvironment to resistance. Cancer Cell 21, 488-503 (2012).
-
(2012)
Cancer Cell
, vol.21
, pp. 488-503
-
-
Nakasone, E.S.1
-
64
-
-
0027941369
-
Intensive postremission chemotherapy in adults with acute myeloid leukemia
-
Mayer, R.J. et al. Intensive postremission chemotherapy in adults with acute myeloid leukemia. N. Engl. J. Med. 331, 896-903 (1994).
-
(1994)
N. Engl. J. Med.
, vol.331
, pp. 896-903
-
-
Mayer, R.J.1
-
67
-
-
84856990335
-
Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small-cell lung cancer
-
Doebele, R.C. et al. Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small-cell lung cancer. Clin. Cancer Res. 18, 1472-1482 (2012).
-
(2012)
Clin. Cancer Res.
, vol.18
, pp. 1472-1482
-
-
Doebele, R.C.1
-
68
-
-
84902148239
-
Whole-exome sequencing and clinical interpretation of formalin-fixed, paraffin-embedded tumor samples to guide precision cancer medicine
-
Van Allen, E.M. et al. Whole-exome sequencing and clinical interpretation of formalin-fixed, paraffin-embedded tumor samples to guide precision cancer medicine. Nat. Med. 20, 682-688 (2014).
-
(2014)
Nat. Med.
, vol.20
, pp. 682-688
-
-
Van Allen, E.M.1
-
69
-
-
84946497286
-
Molecular effects of lapatinib in the treatment of HER2-overexpressing oesophago-gastric adenocarcinoma
-
De Silva, N. et al. Molecular effects of lapatinib in the treatment of HER2-overexpressing oesophago-gastric adenocarcinoma. Br. J. Cancer 113, 1305-1312 (2015).
-
(2015)
Br. J. Cancer
, vol.113
, pp. 1305-1312
-
-
De Silva, N.1
-
71
-
-
84936748494
-
Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients
-
Siravegna, G. et al. Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients. Nat. Med. 21, 795-801 (2015).
-
(2015)
Nat. Med.
, vol.21
, pp. 795-801
-
-
Siravegna, G.1
-
72
-
-
84877579861
-
Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA
-
Murtaza, M. et al. Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA. Nature 497, 108-112 (2013).
-
(2013)
Nature
, vol.497
, pp. 108-112
-
-
Murtaza, M.1
-
73
-
-
84941754980
-
Mass cytometric functional profiling of acute myeloid leukemia defines cell-cycle and immunophenotypic properties that correlate with known responses to therapy
-
Behbehani, G.K. et al. Mass cytometric functional profiling of acute myeloid leukemia defines cell-cycle and immunophenotypic properties that correlate with known responses to therapy. Cancer Discov. 5, 988-1003 (2015).
-
(2015)
Cancer Discov.
, vol.5
, pp. 988-1003
-
-
Behbehani, G.K.1
-
74
-
-
84929684999
-
Highly parallel genome-wide expression profiling of individual cells using nanoliter droplets
-
Macosko, E.Z. et al. Highly parallel genome-wide expression profiling of individual cells using nanoliter droplets. Cell 161, 1202-1214 (2015).
-
(2015)
Cell
, vol.161
, pp. 1202-1214
-
-
Macosko, E.Z.1
-
75
-
-
84936147067
-
Combined nivolumab and ipilimumab, or monotherapy, in untreated melanoma
-
Larkin, J. et al. Combined nivolumab and ipilimumab, or monotherapy, in untreated melanoma. N. Engl. J. Med. 373, 23-34 (2015).
-
(2015)
N. Engl. J. Med.
, vol.373
, pp. 23-34
-
-
Larkin, J.1
-
76
-
-
80051974548
-
Randomized phase 2 study of erlotinib plus tivantinib versus erlotinib plus placebo in previously treated non-small-cell lung cancer
-
Sequist, L.V. et al. Randomized phase 2 study of erlotinib plus tivantinib versus erlotinib plus placebo in previously treated non-small-cell lung cancer. J. Clin. Oncol. 29, 3307-3315 (2011).
-
(2011)
J. Clin. Oncol.
, vol.29
, pp. 3307-3315
-
-
Sequist, L.V.1
-
77
-
-
84866881753
-
Final efficacy results from OAM4558g, a randomized phase 2 study evaluating MetMAb or placebo in combination with erlotinib in advanced NSCLC
-
7505 American Society of Clinical Oncology, Alexandria, Virginia, USA
-
Spigel, D.R. et al. Final efficacy results from OAM4558g, a randomized phase 2 study evaluating MetMAb or placebo in combination with erlotinib in advanced NSCLC (ASCO Annual Meeting) 7505 (American Society of Clinical Oncology, Alexandria, Virginia, USA, 2011).
-
(2011)
ASCO Annual Meeting
-
-
Spigel, D.R.1
-
78
-
-
77958161544
-
Phase 2 trial of gefitinib and everolimus in advanced non-small-cell lung cancer
-
Price, K.A. et al. Phase 2 trial of gefitinib and everolimus in advanced non-small-cell lung cancer. J. Thorac. Oncol. 5, 1623-1629 (2010).
-
(2010)
J. Thorac. Oncol.
, vol.5
, pp. 1623-1629
-
-
Price, K.A.1
-
79
-
-
84864004796
-
Randomized phase 2 trial of erlotinib with and without entinostat in patients with advanced non-small-cell lung cancer who progressed on prior chemotherapy
-
Witta, S.E. et al. Randomized phase 2 trial of erlotinib with and without entinostat in patients with advanced non-small-cell lung cancer who progressed on prior chemotherapy. J. Clin. Oncol. 30, 2248-2255 (2012).
-
(2012)
J. Clin. Oncol.
, vol.30
, pp. 2248-2255
-
-
Witta, S.E.1
-
80
-
-
84933509294
-
Phase 1/2 study of HSP90 inhibitor AUY922 and erlotinib for EGFR-mutant lung cancer with acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors
-
Johnson, M.L. et al. Phase 1/2 study of HSP90 inhibitor AUY922 and erlotinib for EGFR-mutant lung cancer with acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors. J. Clin. Oncol. 33, 1666-1673 (2015).
-
(2015)
J. Clin. Oncol.
, vol.33
, pp. 1666-1673
-
-
Johnson, M.L.1
-
81
-
-
84966443786
-
V600E mutated (mut) metastatic non-small-cell lung cancer (NSCLC)
-
8006 American Society of Clinical Oncology, Alexandria, Virginia, USA
-
V600E mutated (mut) metastatic non-small-cell lung cancer (NSCLC) (ASCO Annual Meeting) 8006 (American Society of Clinical Oncology, Alexandria, Virginia, USA, 2011).
-
(2011)
ASCO Annual Meeting
-
-
Planchard, D.1
-
82
-
-
84927604543
-
Pilot trial of combined BRAF and EGFR inhibition in BRAF-mutant metastatic colorectal cancer patients
-
Yaeger, R. et al. Pilot trial of combined BRAF and EGFR inhibition in BRAF-mutant metastatic colorectal cancer patients. Clin. Cancer Res. 21, 1313-1320 (2015).
-
(2015)
Clin. Cancer Res.
, vol.21
, pp. 1313-1320
-
-
Yaeger, R.1
-
83
-
-
84937523280
-
Combination of everolimus with trastuzumab plus paclitaxel as first-line treatment for patients with HER2-positive advanced breast cancer (BOLERO-1): A phase 3, randomized, double-blind, multicenter trial
-
Hurvitz, S.A. et al. Combination of everolimus with trastuzumab plus paclitaxel as first-line treatment for patients with HER2-positive advanced breast cancer (BOLERO-1): a phase 3, randomized, double-blind, multicenter trial. Lancet Oncol. 16, 816-829 (2015).
-
(2015)
Lancet Oncol.
, vol.16
, pp. 816-829
-
-
Hurvitz, S.A.1
-
84
-
-
84923052492
-
Pertuzumab, trastuzumab, and docetaxel in HER2-positive metastatic breast cancer
-
Swain, S.M. et al. Pertuzumab, trastuzumab, and docetaxel in HER2-positive metastatic breast cancer. N. Engl. J. Med. 372, 724-734 (2015).
-
(2015)
N. Engl. J. Med.
, vol.372
, pp. 724-734
-
-
Swain, S.M.1
|