-
1
-
-
34948817275
-
New molecularly targeted therapies for lung cancer
-
DOI 10.1172/JCI31809
-
Sun S, Schiller JH, Spinola M, et al: New molecularly targeted therapies for lung cancer. J Clin Invest 117:2740-2750, 2007 (Pubitemid 47529602)
-
(2007)
Journal of Clinical Investigation
, vol.117
, Issue.10
, pp. 2740-2750
-
-
Sun, S.1
Schiller, J.H.2
Spinola, M.3
Minna, J.D.4
-
2
-
-
69949186250
-
Screening for epidermal growth factor receptor mutations in lung cancer
-
Rosell R, Moran T, Queralt C, et al: Screening for epidermal growth factor receptor mutations in lung cancer. N Engl J Med 361:958-967, 2007
-
(2007)
N Engl J Med
, vol.361
, pp. 958-967
-
-
Rosell, R.1
Moran, T.2
Queralt, C.3
-
3
-
-
70349342712
-
EML4-ALK: Honing in on a new target in non-small-cell lung cancer
-
Horn L, Pao W: EML4-ALK: Honing in on a new target in non-small-cell lung cancer. J Clin Oncol 27:4232-4235, 2009
-
(2009)
J Clin Oncol
, vol.27
, pp. 4232-4235
-
-
Horn, L.1
Pao, W.2
-
4
-
-
78049426513
-
EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors
-
Choi YL, Soda M, Yamashita Y, et al: EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors. N Engl J Med 363:1734-1739, 2010
-
(2010)
N Engl J Med
, vol.363
, pp. 1734-1739
-
-
Choi, Y.L.1
Soda, M.2
Yamashita, Y.3
-
5
-
-
79251490374
-
New driver mutations in non-small-cell lung cancer
-
Pao W, Girard N: New driver mutations in non-small-cell lung cancer. Lancet Oncol 12:175-180, 2011
-
(2011)
Lancet Oncol
, vol.12
, pp. 175-180
-
-
Pao, W.1
Girard, N.2
-
6
-
-
76349090221
-
Clinicopathological predictors of EGFR/KRAS mutational status in primary lung adenocarcinomas
-
Dacic S, Shuai Y, Yousem S, et al: Clinicopathological predictors of EGFR/KRAS mutational status in primary lung adenocarcinomas. Mod Pathol 23:159-168, 2010
-
(2010)
Mod Pathol
, vol.23
, pp. 159-168
-
-
Dacic, S.1
Shuai, Y.2
Yousem, S.3
-
7
-
-
42949143536
-
Frequent mutations in the neurotrophic tyrosine receptor kinase gene family in large cell neuroendocrine carcinoma of the lung
-
DOI 10.1002/humu.20707
-
Marchetti A, Felicioni L, Pelosi G, et al: Frequent mutations in the neurotrophic tyrosine receptor kinase gene family in large cell neuroendocrine carcinoma of the lung. Hum Mutat 29:609-616, 2008 (Pubitemid 351614584)
-
(2008)
Human Mutation
, vol.29
, Issue.5
, pp. 609-616
-
-
Marchetti, A.1
Felicioni, L.2
Pelosi, G.3
Del, G.M.4
Fumagalli, C.5
Sciarrotta, M.6
Malatesta, S.7
Chella, A.8
Barassi, F.9
Mucilli, F.10
Camplese, P.11
D'Antuono, T.12
Sacco, R.13
Buttitta, F.14
-
8
-
-
20044364940
-
Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers
-
DOI 10.1093/jnci/dji055
-
Shigematsu H, Lin L, Takahashi T, et al: Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers. J Natl Cancer Inst 97:339-346, 2005 (Pubitemid 40425952)
-
(2005)
Journal of the National Cancer Institute
, vol.97
, Issue.5
, pp. 339-346
-
-
Shigematsu, H.1
Lin, L.2
Takahashi, T.3
Nomura, M.4
Suzuki, M.5
Wistuba, I.I.6
Fong, K.M.7
Lee, H.8
Toyooka, S.9
Shimizu, N.10
Fujisawa, T.11
Feng, Z.12
Roth, J.A.13
Herz, J.14
Minna, J.D.15
Gazdar, A.F.16
-
9
-
-
20044364933
-
EGFR mutations in non-small-cell lung cancer: Analysis of a large series of cases and development of a rapid and sensitive method for diagnostic screening with potential implications on pharmacologic treatment
-
DOI 10.1200/JCO.2005.08.043
-
Marchetti A, Martella C, Felicioni L, et al: EGFR mutations in non-small-cell lung cancer: Analysis of a large series of cases and development of a rapid and sensitive method for diagnostic screening with potential implications on pharmacologic treatment. J Clin Oncol 23:857-865, 2005 (Pubitemid 46224186)
-
(2005)
Journal of Clinical Oncology
, vol.23
, Issue.4
, pp. 857-865
-
-
Marchetti, A.1
Martella, C.2
Felicioni, L.3
Barassi, F.4
Salvatore, S.5
Chella, A.6
Camplese, P.P.7
Iarussi, T.8
Mucilli, F.9
Mezzetti, A.10
Cuccurullo, F.11
Sacco, R.12
Buttitta, F.13
-
10
-
-
20144386787
-
Somatic mutations of the HER2 kinase domain in lung adenocarcinomas
-
DOI 10.1158/0008-5472.CAN-04-4235
-
Shigematsu H, Takahashi T, Nomura M, et al: Somatic mutations of the HER2 kinase domain in lung adenocarcinomas. Cancer Res 65:1642-1646, 2005 (Pubitemid 40478587)
-
(2005)
Cancer Research
, vol.65
, Issue.5
, pp. 1642-1646
-
-
Shigematsu, H.1
Takahashi, T.2
Nomura, M.3
Majmudar, K.4
Suzuki, M.5
Lee, H.6
Wistuba, I.I.7
Fong, K.M.8
Toyooka, S.9
Shimizu, N.10
Fujisawa, T.11
Minna, J.D.12
Gazdar, A.F.13
-
11
-
-
33750627353
-
Mutational analysis of the HER2 gene in lung tumors from Caucasian patients: Mutations are mainly present in adenocarcinomas with bronchioloalveolar features
-
DOI 10.1002/ijc.22143
-
Buttitta F, Barassi F, Fresu G, et al: Mutational analysis of the HER2 gene in lung tumors from Caucasian patients: Mutations are mainly present in adenocarcinomas with bronchioloalveolar features. Int J Cancer 119:2586-2591, 2006 (Pubitemid 44691311)
-
(2006)
International Journal of Cancer
, vol.119
, Issue.11
, pp. 2586-2591
-
-
Buttitta, F.1
Barassi, F.2
Fresu, G.3
Felicioni, L.4
Chella, A.5
Paolizzi, D.6
Lattanzio, G.7
Salvatore, S.8
Camplese, P.P.9
Rosini, S.10
Iarussi, T.11
Mucilli, F.12
Mezzetti, A.13
Sacco, R.14
Marcheti, A.15
-
12
-
-
9444260917
-
Bronchioloalveolar lung carcinomas: K-ras mutations are constant events in the mucinous subtype
-
DOI 10.1002/(SICI)1096-9896(199607)179:3<254::AID-PATH589>3.0.CO;2- J
-
Marchetti A, Buttitta F, Pellegrini S, et al: Bronchioloalveolar lung carcinomas: K-ras mutations are constant events in the mucinous subtype. J Pathol 179:254-259, 1996 (Pubitemid 26266402)
-
(1996)
Journal of Pathology
, vol.179
, Issue.3
, pp. 254-259
-
-
Marchetti, A.1
Buttitta, F.2
Pellegrini, S.3
Chella, A.4
Bertacca, G.5
Filardo, A.6
Tognoni, V.7
Ferreli, F.8
Signorini, E.9
Angeletti, C.A.10
Bevilacqua, G.11
-
13
-
-
28844501639
-
Somatic mutations of epidermal growth factor receptor signaling pathway in lung cancers
-
DOI 10.1002/ijc.21496
-
Shigematsu H, Gazdar AF: Somatic mutations of epidermal growth factor receptor signaling pathway in lung cancers. Int J Cancer 118:257-262, 2006 (Pubitemid 41779062)
-
(2006)
International Journal of Cancer
, vol.118
, Issue.2
, pp. 257-262
-
-
Shigematsu, H.1
Gazdar, A.F.2
-
14
-
-
36048996580
-
Adenocarcinoma, a molecular perspective
-
suppl 9
-
Stahel RA: Adenocarcinoma, a molecular perspective. Ann Oncol 18:ix147-ix149, 2007 (suppl 9)
-
(2007)
Ann Oncol
, vol.18
-
-
Stahel, R.A.1
-
15
-
-
79551563284
-
International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society international multidisciplinary classification of lung adenocarcinoma
-
Travis WD, Brambilla E, Noguchi M, et al: International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society international multidisciplinary classification of lung adenocarcinoma. J Thorac Oncol 6:244-285, 2011
-
(2011)
J Thorac Oncol
, vol.6
, pp. 244-285
-
-
Travis, W.D.1
Brambilla, E.2
Noguchi, M.3
-
16
-
-
5444227865
-
Guilty as charged: B-RAF is a human oncogene
-
DOI 10.1016/j.ccr.2004.09.022, PII S153561080400279X
-
Garnett MJ, Marais R: Guilty as charged: B-RAF is a human oncogene. Cancer Cell 6:313-319, 2004 (Pubitemid 39361432)
-
(2004)
Cancer Cell
, vol.6
, Issue.4
, pp. 313-319
-
-
Garnett, M.J.1
Marais, R.2
-
17
-
-
18444374405
-
Mutations of the BRAF gene in human cancer
-
DOI 10.1038/nature00766
-
Davies H, Bignell GR, Cox C, et al: Mutations of the BRAF gene in human cancer. Nature 417:949-954, 2002 (Pubitemid 34716871)
-
(2002)
Nature
, vol.417
, Issue.6892
, pp. 949-954
-
-
Davies, H.1
Bignell, G.R.2
Cox, C.3
Stephens, P.4
Edkins, S.5
Clegg, S.6
Teague, J.7
Woffendin, H.8
Garnett, M.J.9
Bottomley, W.10
Davis, N.11
Dicks, E.12
Ewing, R.13
Floyd, Y.14
Gray, K.15
Hall, S.16
Hawes, R.17
Hughes, J.18
Kosmidou, V.19
Menzies, A.20
Mould, C.21
Parker, A.22
Stevens, C.23
Watt, S.24
Hooper, S.25
Wilson, R.26
Jayatilake, H.27
Gusterson, B.A.28
Cooper, C.29
Shipley, J.30
Hargrave, D.31
Pritchard-Jones, K.32
Maitland, N.33
Chenevix-Trench, G.34
Riggins, G.J.35
Bigner, D.D.36
Palmleri, G.37
Cossu, A.38
Flanagan, A.39
Nicholson, A.40
Ho, J.W.C.41
Leung, S.Y.42
Yuen, S.T.43
Weber, B.L.44
Seigler, H.F.45
Darrow, T.L.46
Paterson, H.47
Marais, R.48
Marshall, C.J.49
Wooster, R.50
Stratton, M.R.51
Futreal, P.A.52
more..
-
18
-
-
27844567142
-
Distinct sets of genetic alterations in melanoma
-
DOI 10.1056/NEJMoa050092
-
Curtin JA, Fridlyand J, Kageshita T, et al: Distinct sets of genetic alterations in melanoma. N Engl J Med 353:2135-2147, 2005 (Pubitemid 41653105)
-
(2005)
New England Journal of Medicine
, vol.353
, Issue.20
, pp. 2135-2147
-
-
Curtin, J.A.1
Fridlyand, J.2
Kageshita, T.3
Patel, H.N.4
Busam, K.J.5
Kutzner, H.6
Cho, K.-H.7
Aiba, S.8
Brocker, E.-B.9
LeBoit, P.E.10
Pinkel, D.11
Bastian, B.C.12
-
19
-
-
0037379904
-
High prevalence of BRAF mutations in thyroid cancer: Genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma
-
Kimura ET, Nikiforova MN, Zhu Z, et al: High prevalence of BRAF mutations in thyroid cancer: Genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma. Cancer Res 63:1454-1457, 2003 (Pubitemid 36373628)
-
(2003)
Cancer Research
, vol.63
, Issue.7
, pp. 1454-1457
-
-
Kimura, E.T.1
Nikiforova, M.N.2
Zhu, Z.3
Knauf, J.A.4
Nikiforov, Y.E.5
Fagin, J.A.6
-
20
-
-
22244472992
-
Poor survival associated with the BRAF V600E mutation in microsatellite-stable colon cancers
-
Samowitz WS, Sweeney C, Herrick J, et al: Poor survival associated with the BRAF V600E mutation in microsatellite-stable colon cancers. Cancer Res 65:6063-6069, 2005
-
(2005)
Cancer Res
, vol.65
, pp. 6063-6069
-
-
Samowitz, W.S.1
Sweeney, C.2
Herrick, J.3
-
21
-
-
0037454224
-
Mutations in BRAF and KRAS characterize the development of low-grade ovarian serous carcinoma
-
Singer G, Oldt R 3rd, Cohen Y, et al: Mutations in BRAF and KRAS characterize the development of low-grade ovarian serous carcinoma. J Natl Cancer Inst 95:484-486, 2003 (Pubitemid 36432423)
-
(2003)
Journal of the National Cancer Institute
, vol.95
, Issue.6
, pp. 484-486
-
-
Singer, G.1
Oldt III, R.2
Cohen, Y.3
Wang, B.G.4
Sidransky, D.5
Kurman, R.J.6
Shih, I.-M.7
-
22
-
-
0036894746
-
BRAF and RAS mutations in human lung cancer and melanoma
-
Brose MS, Volpe P, Feldman M, et al: BRAF and RAS mutations in human lung cancer and melanoma. Cancer Res 62:6997-7000, 2002 (Pubitemid 35424092)
-
(2002)
Cancer Research
, vol.62
, Issue.23
, pp. 6997-7000
-
-
Brose, M.S.1
Volpe, P.2
Feldman, M.3
Kumar, M.4
Rishi, I.5
Gerrero, R.6
Einhorn, E.7
Herlyn, M.8
Minna, J.9
Nicholson, A.10
Roth, J.A.11
Albelda, S.M.12
Davies, H.13
Cox, C.14
Brignell, G.15
Stephens, P.16
Andrew, F.P.17
Wooster, R.18
Stratton, M.R.19
Weber, B.L.20
more..
-
23
-
-
0036895599
-
Missense mutations of the BRAF gene in human lung adenocarcinoma
-
Naoki K, Chen TH, Richards WG, et al: Missense mutations of the BRAF gene in human lung adenocarcinoma. Cancer Res 62:7001-7003, 2002 (Pubitemid 35424093)
-
(2002)
Cancer Research
, vol.62
, Issue.23
, pp. 7001-7003
-
-
Naoki, K.1
Chen, T.-H.2
Richards, W.G.3
Sugarbaker, D.J.4
Meyerson, M.5
-
24
-
-
77956030786
-
Inhibition of mutated, activated BRAF in metastatic melanoma
-
Flaherty KT, Puzanov I, Kim KB, et al: Inhibition of mutated, activated BRAF in metastatic melanoma. N Engl J Med 363:809-819, 2010
-
(2010)
N Engl J Med
, vol.363
, pp. 809-819
-
-
Flaherty, K.T.1
Puzanov, I.2
Kim, K.B.3
-
26
-
-
70149110218
-
Clinical implications of KRAS mutations in lung cancer patients treated with tyrosine kinase inhibitors: An important role for mutations in minor clones
-
Marchetti A, Milella M, Felicioni L, et al: Clinical implications of KRAS mutations in lung cancer patients treated with tyrosine kinase inhibitors: An important role for mutations in minor clones. Neoplasia 11:1084-1092, 2009
-
(2009)
Neoplasia
, vol.11
, pp. 1084-1092
-
-
Marchetti, A.1
Milella, M.2
Felicioni, L.3
-
27
-
-
55949097252
-
Genetic predictors of MEK dependence in non-small cell lung cancer
-
Pratilas CA, Hanrahan AJ, Halilovic E, et al: Genetic predictors of MEK dependence in non-small cell lung cancer. Cancer Res 68:9375-9383, 2008
-
(2008)
Cancer Res
, vol.68
, pp. 9375-9383
-
-
Pratilas, C.A.1
Hanrahan, A.J.2
Halilovic, E.3
-
28
-
-
33646791858
-
Uncommon V599E BRAF mutations in Japanese patients with lung cancer
-
Sasaki H, Kawano O, Endo K, et al: Uncommon V599E BRAF mutations in Japanese patients with lung cancer. J Surg Res 133:203-206, 2006
-
(2006)
J Surg Res
, vol.133
, pp. 203-206
-
-
Sasaki, H.1
Kawano, O.2
Endo, K.3
-
29
-
-
52149114884
-
The histopathology of BRAF-V600E-mutated lung adenocarcinoma
-
Yousem SA, Nikiforova M, Nikiforov Y: The histopathology of BRAF-V600E-mutated lung adenocarcinoma. Am J Surg Pathol 32:1317-1321, 2008
-
(2008)
Am J Surg Pathol
, vol.32
, pp. 1317-1321
-
-
Yousem, S.A.1
Nikiforova, M.2
Nikiforov, Y.3
-
30
-
-
59249107192
-
Impact of EGFR mutation analysis in non-small cell lung cancer
-
Yamamoto H, Toyooka S, Mitsudomi T: Impact of EGFR mutation analysis in non-small cell lung cancer. Lung Cancer 63:315-321, 2009
-
(2009)
Lung Cancer
, vol.63
, pp. 315-321
-
-
Yamamoto, H.1
Toyooka, S.2
Mitsudomi, T.3
-
31
-
-
69949088331
-
Immunohistochemical expression of estrogen and progesterone receptors identifies a subset of NSCLCs and correlates with EGFR mutation
-
Raso MG, Behrens C, Herynk MH, et al: Immunohistochemical expression of estrogen and progesterone receptors identifies a subset of NSCLCs and correlates with EGFR mutation. Clin Cancer Res 15:5359-5368, 2009
-
(2009)
Clin Cancer Res
, vol.15
, pp. 5359-5368
-
-
Raso, M.G.1
Behrens, C.2
Herynk, M.H.3
-
32
-
-
79851513555
-
Expression of estrogen receptor beta predicts a clinical response and longer progression-free survival after treatment with EGFR-TKI for adenocarcinoma of the lung
-
Nose N, Uramoto H, Iwata T, et al: Expression of estrogen receptor beta predicts a clinical response and longer progression-free survival after treatment with EGFR-TKI for adenocarcinoma of the lung. Lung Cancer 71:350-355, 2011
-
(2011)
Lung Cancer
, vol.71
, pp. 350-355
-
-
Nose, N.1
Uramoto, H.2
Iwata, T.3
-
33
-
-
75749102647
-
Prognostic role of KRAS and BRAF in stage II and III resected colon cancer: Results of the translational study on the PETACC-3, EORTC 40993, SAKK 60-00 trial
-
Roth AD, Tejpar S, Delorenzi M, et al: Prognostic role of KRAS and BRAF in stage II and III resected colon cancer: Results of the translational study on the PETACC-3, EORTC 40993, SAKK 60-00 trial. J Clin Oncol 28:466-474, 2010
-
(2010)
J Clin Oncol
, vol.28
, pp. 466-474
-
-
Roth, A.D.1
Tejpar, S.2
Delorenzi, M.3
-
34
-
-
79956316170
-
Clinical characteristics of patients with lung adenocarcinomas harboring BRAF mutations
-
Paik PK, Arcila ME, Fara M, et al: Clinical characteristics of patients with lung adenocarcinomas harboring BRAF mutations. J Clin Oncol 29:2046-2051, 2011
-
(2011)
J Clin Oncol
, vol.29
, pp. 2046-2051
-
-
Paik, P.K.1
Arcila, M.E.2
Fara, M.3
-
35
-
-
79952282994
-
BRAF mutation is a powerful prognostic factor in advanced and recurrent colorectal cancer
-
Yokota T, Ura T, Shibata N, et al: BRAF mutation is a powerful prognostic factor in advanced and recurrent colorectal cancer. Br J Cancer 104:856-862, 2011
-
(2011)
Br J Cancer
, vol.104
, pp. 856-862
-
-
Yokota, T.1
Ura, T.2
Shibata, N.3
-
36
-
-
73349114941
-
KRAS and BRAF mutations in advanced colorectal cancer are associated with poor prognosis but do not preclude benefit from oxaliplatin or irinotecan: Results from the MRC FOCUS trial
-
Richman SD, Seymour MT, Chambers P, et al: KRAS and BRAF mutations in advanced colorectal cancer are associated with poor prognosis but do not preclude benefit from oxaliplatin or irinotecan: Results from the MRC FOCUS trial. J Clin Oncol 27:5931-5937, 2009
-
(2009)
J Clin Oncol
, vol.27
, pp. 5931-5937
-
-
Richman, S.D.1
Seymour, M.T.2
Chambers, P.3
|