Identification of CCDC6-RET fusion in the human lung adenocarcinoma cell line, LC-2/ad

Journal of Thoracic Oncology

Volumn 7, Issue 12, 2012, Pages 1872-1876

  Matsubara, Daisuke ^a,b   Kanai, Yoshihiko ^a   Ishikawa, Shumpei ^c   Ohara, Shiori ^a   Yoshimoto, Taichiro ^a   Sakatani, Takashi ^a   Oguni, Sachiko ^a   Tamura, Tomoko ^a   Kataoka, Hiroaki ^d   Endo, Shunsuke ^a   Murakami, Yoshinori ^b   Aburatani, Hiroyuki ^e   Fukayama, Masashi ^c   Niki, Toshiro ^a  

^a JICHI MEDICAL UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d UNIVERSITY OF MIYAZAKI   (Japan)

^e UNIVERSITY OF TOKYO   (Japan)

Author keywords

Cell line; Lung adenocarcinoma; RET fusion; Vandetanib

Indexed keywords

GEFITINIB; HYBRID PROTEIN; PROTEIN RET; VANDETANIB;

ACINAR CELL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG SENSITIVITY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG ADENOCARCINOMA; LUNG NON SMALL CELL CANCER; MORPHOLOGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR XENOGRAFT;

ADENOCARCINOMA; ANIMALS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BLOTTING, WESTERN; CARCINOMA, NON-SMALL-CELL LUNG; CELL PROLIFERATION; CYTOSKELETAL PROTEINS; FEMALE; HUMANS; IMMUNOENZYME TECHNIQUES; LUNG NEOPLASMS; MICE; MICE, INBRED NOD; MICE, SCID; ONCOGENE PROTEINS, FUSION; PHOSPHORYLATION; PIPERIDINES; PROTO-ONCOGENE PROTEINS C-RET; QUINAZOLINES; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

EID: 84870337408     PISSN: 15560864     EISSN: 15561380     Source Type: Journal    
DOI: 10.1097/JTO.0b013e3182721ed1     Document Type: Article

References (15)

1. Riely GJ, Politi KA, Miller VA, Pao W. Update on epidermal growth factor receptor mutations in non-small cell lung cancer. Clin Cancer Res 2006;12:7232-7241. (Pubitemid 46095394)
2. Bergethon K, Shaw AT, Ou SH, et al. ROS1 rearrangements define a unique molecular class of lung cancers. J Clin Oncol 2012;30:863-870.
3. Kohno T, Ichikawa H, Totoki Y, et al. KIF5B-RET fusions in lung adenocarcinoma. Nat Med 2012;18:375-377.
4. Takeuchi K, Soda M, Togashi Y, et al. RET, ROS1 and ALK fusions in lung cancer. Nat Med 2012;18:378-381.
5. Lipson D, Capelletti M, Yelensky R, et al. Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies. Nat Med 2012;18:382-384.
6. Sasaki H, Shimizu S, Tani Y, et al. RET expression and detection of KIF5B/RET gene rearrangements in Japanese lung cancer, Cancer Med 2012; 22:436-445.
7. Ju YS, Lee WC, Shin JY, et al. A transforming KIF5B and RET gene fusion in lung adenocarcinoma revealed from whole-genome and transcriptome sequencing. Genome Res 2012;22:436-445.
8. Li F, Feng Y, Fang R, et al. Identification of RET gene fusion by exon array analyses in "pan-negative" lung cancer from never smokers. Cell Res 2012;22:928-931.
9. Yokota K, Sasaki H, Okuda K, et al. KIF5B/RET fusion gene in surgically-treated adenocarcinoma of the lung. Oncol Rep 2012;28:1187-1192.
10. Pao W, Hutchinson KE. Chipping away at the lung cancer genome. Nat Med 2012;18:349-351.
11. Matsubara D, Ishikawa S, Sachiko O, Aburatani H, Fukayama M, Niki T. Co-activation of epidermal growth factor receptor and c-MET defines a distinct subset of lung adenocarcinomas. Am J Pathol 2010;177:2191-2204.
12. Matsubara D, Ishikawa S, Oguni S, Aburatani H, Fukayama M, Niki T. Molecular predictors of sensitivity to the MET inhibitor PHA665752 in lung carcinoma cells. J Thorac Oncol 2010;5:1317-1324.
13. Koivunen JP, Mermel C, Zejnullahu K, et al. EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer. Clin Cancer Res 2008;14:4275-4283.
14. Jossart GH, Greulich KM, Siperstein AE, Duh Q, Clark OH, Weier HU. Molecular and cytogenetic characterization of a t(1;10;21) translocation in the human papillary thyroid cancer cell line TPC-1 expressing the ret/ H4 chimeric transcript. Surgery 1995;118:1018-1023.
15. Kataoka H, Itoh H, Seguchi K, Koono M. Establishment and characterization of a human lung adenocarcinoma cell line (LC-2/ad) producing alpha 1-antitrypsin in vitro. Acta Pathol Jpn 1993;43:566-573. (Pubitemid 23303514)