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Volumn 73, Issue 20, 2013, Pages 6243-6253

Erlotinib resistance in lung cancer cells mediated by integrin β1/Src/Akt-driven bypass signaling

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA2 INTEGRIN; ALPHA5 INTEGRIN; BETA1 INTEGRIN; COMPLEMENTARY DNA; DASATINIB; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; GEFITINIB; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; PROTEIN TYROSINE KINASE; SMALL INTERFERING RNA;

EID: 84886002801     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-12-4502     Document Type: Article
Times cited : (129)

References (41)
  • 2
    • 35548962203 scopus 로고    scopus 로고
    • Mutations of the epidermal growth factor receptor gene and related genes as determinants of epidermal growth factor receptor tyrosine kinase inhibitors sensitivity in lung cancer
    • Mitsudomi T, Yatabe Y. Mutations of the epidermal growth factor receptor gene and related genes as determinants of epidermal growth factor receptor tyrosine kinase inhibitors sensitivity in lung cancer. Cancer Sci 2007; 98:1817-24.
    • (2007) Cancer Sci , vol.98 , pp. 1817-1824
    • Mitsudomi, T.1    Yatabe, Y.2
  • 3
    • 33746789922 scopus 로고    scopus 로고
    • Prospective phase II study of gefitinib for chemotherapy-naive patients with advanced non-small-cell lung cancer with epidermal growth factor receptor gene mutations
    • Inoue A, Suzuki T, Fukuhara T., Maemondo M, Kimura Y, Morikawa N., et al Prospective phase II study of gefitinib for chemotherapy-naive patients with advanced non-small-cell lung cancer with epidermal growth factor receptor gene mutations. J Clin Oncol 2006; 24:3340-6.
    • (2006) J Clin Oncol , vol.24 , pp. 3340-3346
    • Inoue, A.1    Suzuki, T.2    Fukuhara, T.3    Maemondo, M.4    Kimura, Y.5    Morikawa, N.6
  • 4
    • 80051965827 scopus 로고    scopus 로고
    • Relative abundance of EGFR mutations predicts benefit from gefitinib treatment for advanced non-small-cell lung cancer
    • Zhou Q, Zhang XC, Chen Z.H., Yin XL, Yang JJ, Xu CR, et al Relative abundance of EGFR mutations predicts benefit from gefitinib treatment for advanced non-small-cell lung cancer. J Clin Oncol 2011; 29:3316-21.
    • (2011) J Clin Oncol , vol.29 , pp. 3316-3321
    • Zhou, Q.1    Zhang, X.C.2    Chen, Z.H.3    Yin, X.L.4    Yang, J.J.5    Xu, C.R.6
  • 5
    • 84857502654 scopus 로고    scopus 로고
    • Erlotinib versus standard chemotherapy as first-line treatment for european patients with advanced EGFR mutation-positive non-smallcell lung cancer (EURTAC): A multicentre, open-label, randomised phase 3 trial
    • Rosell R, Carcereny E, Gervais R., Vergnenegre A, Massuti B, Felip E., et al Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-smallcell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial. Lancet Oncol 2012; 13:239-46.
    • (2012) Lancet Oncol , vol.13 , pp. 239-246
    • Rosell, R.1    Carcereny, E.2    Gervais, R.3    Vergnenegre, A.4    Massuti, B.5    Felip, E.6
  • 6
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch TJ, Bell DW, Sordella R, Gurubhagavatula S., Okimoto RA, Brannigan BW, et al Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 2004; 350:2129-39.
    • (2004) N Engl J Med , vol.350 , pp. 2129-2139
    • Lynch, T.J.1    Bell, D.W.2    Sordella, R.3    Gurubhagavatula, S.4    Okimoto, R.A.5    Brannigan, B.W.6
  • 7
    • 84863652136 scopus 로고    scopus 로고
    • Circumventing cancer drug resistance in the era of personalized medicine
    • Garraway LA, Janne PA Circumventing cancer drug resistance in the era of personalized medicine. Cancer Discov 2012; 2:214-216.
    • (2012) Cancer Discov , vol.2 , pp. 214-216
    • Garraway, L.A.1    Janne, P.A.2
  • 9
    • 18244371651 scopus 로고    scopus 로고
    • Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
    • Pao W, Miller VA, Politi K.A., Riely GJ, Somwar R, Zakowski MF, et al Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med 2005; 2:e73.
    • (2005) PLoS Med , vol.2
    • Pao, W.1    Miller, V.A.2    Politi, K.A.3    Riely, G.J.4    Somwar, R.5    Zakowski, M.F.6
  • 10
    • 34249075147 scopus 로고    scopus 로고
    • MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
    • Engelman JA, Zejnullahu K, Mitsudomi T., Song Y, Hyland C, Park J.O., et al MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science 2007; 316:1039-43.
    • (2007) Science , vol.316 , pp. 1039-1043
    • Engelman, J.A.1    Zejnullahu, K.2    Mitsudomi, T.3    Song, Y.4    Hyland, C.5    Park, J.O.6
  • 11
    • 73349105243 scopus 로고    scopus 로고
    • Resistance to targeted therapies: Refining anticancer therapy in the era of molecular oncology
    • Ellis LM, Hicklin DJ Resistance to targeted therapies: refining anticancer therapy in the era of molecular oncology. Clin Cancer Res 2009; 15:7471-78.
    • (2009) Clin Cancer Res , vol.15 , pp. 7471-7478
    • Ellis, L.M.1    Hicklin, D.J.2
  • 12
    • 84870020040 scopus 로고    scopus 로고
    • MED12 controls the response to multiple cancer drugs through regulation of TGF-β receptor signaling
    • Huang S, Hoölzel M, Knijnenburg T., Schlicker A, Roepman P, McDermott U., et al MED12 controls the response to multiple cancer drugs through regulation of TGF-β receptor signaling. Cell 2012; 151:937-50.
    • (2012) Cell , vol.151 , pp. 937-950
    • Huang, S.1    Hoölzel, M.2    Knijnenburg, T.3    Schlicker, A.4    Roepman, P.5    McDermott, U.6
  • 13
    • 33846202907 scopus 로고    scopus 로고
    • Molecular mechanisms of epidermal growth factor receptor (EGFR) activation and response to gefitinib and other EGFRtargeting drugs
    • Ono M, Kuwano M. Molecular mechanisms of epidermal growth factor receptor (EGFR) activation and response to gefitinib and other EGFRtargeting drugs. Clin Cancer Res 2006; 12:7242-51.
    • (2006) Clin Cancer Res , vol.12 , pp. 7242-7251
    • Ono, M.1    Kuwano, M.2
  • 14
    • 78449283888 scopus 로고    scopus 로고
    • Loss of PTEN expression by blocking nuclear translocation of EGR1 in gefitinib-resistant lung cancer cells harboring epidermal growth factor receptor-activating mutations
    • Yamamoto C, Basaki Y, Kawahara A., Nakashima K, Kage M, Izumi H., et al Loss of PTEN expression by blocking nuclear translocation of EGR1 in gefitinib-resistant lung cancer cells harboring epidermal growth factor receptor-activating mutations. Cancer Res 2010; 70: 8715-25.
    • (2010) Cancer Res , vol.70 , pp. 8715-8725
    • Yamamoto, C.1    Basaki, Y.2    Kawahara, A.3    Nakashima, K.4    Kage, M.5    Izumi, H.6
  • 15
    • 84855543629 scopus 로고    scopus 로고
    • EGFR and MET receptor tyrosine kinase-altered microRNA expression induces tumorigenesis and gefitinib resistance in lung cancers
    • Garofalo M, Romano G, Di Leva G, Nuovo G, Jeon Y.J., Ngankeu A., et al EGFR and MET receptor tyrosine kinase-altered microRNA expression induces tumorigenesis and gefitinib resistance in lung cancers. Nat Med 2011; 18:74-82.
    • (2011) Nat Med , vol.18 , pp. 74-82
    • Garofalo, M.1    Romano, G.2    Di Leva, G.3    Nuovo, G.4    Jeon, Y.J.5    Ngankeu, A.6
  • 16
    • 84855677127 scopus 로고    scopus 로고
    • Overcoming erlotinib resistance in EGFR mutation-positive non-small cell lung cancer cells by targeting survivin
    • Okamoto K, Okamoto I, Hatashita E., Kuwata K, Yamaguchi H, Kita A., et al Overcoming erlotinib resistance in EGFR mutation-positive non-small cell lung cancer cells by targeting survivin. Mol Cancer Ther 2012; 11:204-13.
    • (2012) Mol Cancer Ther , vol.11 , pp. 204-213
    • Okamoto, K.1    Okamoto, I.2    Hatashita, E.3    Kuwata, K.4    Yamaguchi, H.5    Kita, A.6
  • 17
    • 84864015211 scopus 로고    scopus 로고
    • Loss of activating EGFR mutation gene contributes to acquired resistance to EGFR tyrosine kinase inhibitors in lung cancer cells
    • Tabara K, Kanda R, Sonoda K., Kubo T, Murakami Y, Kawahara A., et al Loss of activating EGFR mutation gene contributes to acquired resistance to EGFR tyrosine kinase inhibitors in lung cancer cells. PLoS ONE 2012; 7:e41017
    • (2012) PLoS ONE , vol.7
    • Tabara, K.1    Kanda, R.2    Sonoda, K.3    Kubo, T.4    Murakami, Y.5    Kawahara, A.6
  • 18
    • 2642570481 scopus 로고    scopus 로고
    • Sensitivity to gefitinib (Iressa, ZD1839) in non-small cell lung cancer cell lines correlates with dependence on the epidermal growth factor (EGF) receptor/extracellular signal-regulated kinase 1/2 and EGF receptor/ akt pathway for proliferation
    • Ono M, Hirata A, Kometani T., Miyagawa M, Ueda S, Kinoshita H., et al Sensitivity to gefitinib (Iressa, ZD1839) in non-small cell lung cancer cell lines correlates with dependence on the epidermal growth factor (EGF) receptor/extracellular signal-regulated kinase 1/2 and EGF receptor/ Akt pathway for proliferation. Mol Cancer Ther 2004; 3:465-72.
    • (2004) Mol Cancer Ther , vol.3 , pp. 465-472
    • Ono, M.1    Hirata, A.2    Kometani, T.3    Miyagawa, M.4    Ueda, S.5    Kinoshita, H.6
  • 19
    • 0031468814 scopus 로고    scopus 로고
    • A canalicular multispecific organic anion transporter (cMOAT) antisense cDNA enhances drug sensitivity in human hepatic cancer cells
    • Koike K, Kawabe T, Tanaka T., Toh S, Uchiumi T, Wada M., et al A canalicular multispecific organic anion transporter (cMOAT) antisense cDNA enhances drug sensitivity in human hepatic cancer cells. Cancer Res 1997; 57:5475-9.
    • (1997) Cancer Res , vol.57 , pp. 5475-5479
    • Koike, K.1    Kawabe, T.2    Tanaka, T.3    Toh, S.4    Uchiumi, T.5    Wada, M.6
  • 20
    • 33750952261 scopus 로고    scopus 로고
    • HMG-coa reductase inhibitor simvastatin mitigates VEGF-induced "inside-out" signaling to extracellular matrix by preventing RhoA activation
    • Xu H, Zeng L, Peng H., Chen S, Jones J, Chew T.L., et al HMG-CoA reductase inhibitor simvastatin mitigates VEGF-induced "inside-out" signaling to extracellular matrix by preventing RhoA activation. Am J Physiol Renal Physiol 2006; 291:F995-1004.
    • (2006) Am J Physiol Renal Physiol , vol.291
    • Xu, H.1    Zeng, L.2    Peng, H.3    Chen, S.4    Jones, J.5    Chew, T.L.6
  • 21
    • 79953687627 scopus 로고    scopus 로고
    • Expression of selected gene for acquired drug resistance to EGFR-TKI in lung adenocarcinoma
    • Uramoto H, Shimokawa H, Hanagiri T., Kuwano M, Ono M. Expression of selected gene for acquired drug resistance to EGFR-TKI in lung adenocarcinoma. Lung Cancer 2011; 73:361-5.
    • (2011) Lung Cancer , vol.73 , pp. 361-365
    • Uramoto, H.1    Shimokawa, H.2    Hanagiri, T.3    Kuwano, M.4    Ono, M.5
  • 22
    • 77950460014 scopus 로고    scopus 로고
    • Acquired resistance to gefitinib: The contribution of mechanisms other than the T790M, MET, and HGF status
    • Onitsuka T, Uramoto H, Nose N., Takenoyama M, Hanagiri T, Sugio K., et al Acquired resistance to gefitinib: the contribution of mechanisms other than the T790M, MET, and HGF status. Lung Cancer 2010; 68:198-203.
    • (2010) Lung Cancer , vol.68 , pp. 198-203
    • Onitsuka, T.1    Uramoto, H.2    Nose, N.3    Takenoyama, M.4    Hanagiri, T.5    Sugio, K.6
  • 23
    • 77953720122 scopus 로고    scopus 로고
    • Molecular diagnosis of activating EGFR mutations in nonsmall cell lung cancer using mutation-specific antibodies for immunohistochemical analysis
    • Kawahara A, Yamamoto C, Nakashima K., Azuma K, Hattori S, Kashihara M., et al Molecular diagnosis of activating EGFR mutations in nonsmall cell lung cancer using mutation-specific antibodies for immunohistochemical analysis. Clin Cancer Res 2010; 16:3163-70.
    • (2010) Clin Cancer Res , vol.16 , pp. 3163-3170
    • Kawahara, A.1    Yamamoto, C.2    Nakashima, K.3    Azuma, K.4    Hattori, S.5    Kashihara, M.6
  • 25
    • 84862924585 scopus 로고    scopus 로고
    • Reconstitution of integrin activation
    • Ye F, Kim C, Ginsberg H. Reconstitution of integrin activation. Blood 2012; 119:26-33.
    • (2012) Blood , vol.119 , pp. 26-33
    • Ye, F.1    Kim, C.2    Ginsberg, H.3
  • 26
    • 0031439247 scopus 로고    scopus 로고
    • Cellular functions regulated by src family kinases
    • Thomas SM, Brugge JS Cellular functions regulated by Src family kinases. Annu Rev Cell Dev Biol 1997; 13:513-609.
    • (1997) Annu Rev Cell Dev Biol , vol.13 , pp. 513-609
    • Thomas, S.M.1    Brugge, J.S.2
  • 27
    • 78649762711 scopus 로고    scopus 로고
    • Integrin beta1 over-expression associates with resistance to tyrosine kinase inhibitor gefitinib in non-small cell lung cancer
    • Ju L, Zhou C, Li W., Yan L. Integrin beta1 over-expression associates with resistance to tyrosine kinase inhibitor gefitinib in non-small cell lung cancer. J Cell Biochem 2010; 111:1565-74.
    • (2010) J Cell Biochem , vol.111 , pp. 1565-1574
    • Ju, L.1    Zhou, C.2    Li, W.3    Yan, L.4
  • 28
    • 36849038378 scopus 로고    scopus 로고
    • Extracellular matrix regulation of drug resistance in small-cell lung cancer
    • Rintoul RC, Sethi T. Extracellular matrix regulation of drug resistance in small-cell lung cancer. Int J Radiat Biol 2007; 83:733-41.
    • (2007) Int J Radiat Biol , vol.83 , pp. 733-741
    • Rintoul, R.C.1    Sethi, T.2
  • 30
    • 70549084933 scopus 로고    scopus 로고
    • Integrated genomics of chemotherapy resistant ovarian cancer: A role for extracellular matrix, TGFbeta and regulating microRNAs
    • Helleman J, Jansen MP, Burger C, van der Burg ME, Berns EM. Integrated genomics of chemotherapy resistant ovarian cancer: a role for extracellular matrix, TGFbeta and regulating microRNAs. Int J Biochem Cell Biol 2010; 42:25-30.
    • (2010) Int J Biochem Cell Biol , vol.42 , pp. 25-30
    • Helleman, J.1    Jansen, M.P.2    Burger, C.3    Van Der Burg, M.E.4    Berns, E.M.5
  • 31
    • 84859598676 scopus 로고    scopus 로고
    • β1 integrin/FAK/cortactin signaling is essential for human head and neck cancer resistance to radiotherapy
    • Eke I, Deuse Y, Hehlgans S., Gurtner K, Krause M, Baumann M., et al β1 integrin/FAK/cortactin signaling is essential for human head and neck cancer resistance to radiotherapy. J Clin Invest 2012; 122:1529-40.
    • (2012) J Clin Invest , vol.122 , pp. 1529-1540
    • Eke, I.1    Deuse, Y.2    Hehlgans, S.3    Gurtner, K.4    Krause, M.5    Baumann, M.6
  • 32
    • 0027157861 scopus 로고
    • Integrin expression in cutaneous Malignant melanoma: Association of the alpha 3/beta 1 heterodimer with tumor progression
    • Natali PG, Nicotra MR, Bartolazzi A, Cavaliere R., Bigotti A. Integrin expression in cutaneous malignant melanoma: association of the alpha 3/beta 1 heterodimer with tumor progression. Int J Cancer 1993; 54:68-72.
    • (1993) Int J Cancer , vol.54 , pp. 68-72
    • Natali, P.G.1    Nicotra, M.R.2    Bartolazzi, A.3    Cavaliere, R.4    Bigotti, A.5
  • 33
    • 0028978457 scopus 로고
    • Re-expression of the alpha 2 beta 1 integrin abrogates the Malignant phenotype of breast carcinoma cells
    • Zutter MM, Santoro SA, Staatz W.D., Tsung YL Re-expression of the alpha 2 beta 1 integrin abrogates the malignant phenotype of breast carcinoma cells. Proc Natl Acad Sci U S A 1995; 92:7411-5.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 7411-7415
    • Zutter, M.M.1    Santoro, S.A.2    Staatz, W.D.3    Tsung, Y.L.4
  • 34
    • 79953220086 scopus 로고    scopus 로고
    • Ligandindependent activation of c-met by fibronectin and α5β1-integrin regulates ovarian cancer invasion and metastasis
    • Mitra AK, Sawada K, Tiwari P., Mui K, Gwin K, Lengyel E. Ligandindependent activation of c-Met by fibronectin and α5β1- integrin regulates ovarian cancer invasion and metastasis. Oncogene 2011; 30: 1566-76.
    • (2011) Oncogene , vol.30 , pp. 1566-1576
    • Mitra, A.K.1    Sawada, K.2    Tiwari, P.3    Mui, K.4    Gwin, K.5    Lengyel, E.6
  • 35
    • 84863384604 scopus 로고    scopus 로고
    • NKX2-1/TITF1/TTF1-induced ROR1 is required to sustain EGFR signaling in lung adenocarcinoma
    • Yamaguchi T, Yanagisawa K, Sugiyama R., Hosono Y, Shimada Y, Arima C., et al NKX2-1/TITF1/TTF1-induced ROR1 is required to sustain EGFR signaling in lung adenocarcinoma. Cancer Cell 2012; 21:348-61.
    • (2012) Cancer Cell , vol.21 , pp. 348-361
    • Yamaguchi, T.1    Yanagisawa, K.2    Sugiyama, R.3    Hosono, Y.4    Shimada, Y.5    Arima, C.6
  • 36
    • 33745243692 scopus 로고    scopus 로고
    • Dasatinib (BMS354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival
    • Song L, Morris M, Bagui T., Lee FY, Jove R, Haura EB Dasatinib (BMS354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival. Cancer Res 2010; 66:5542-8.
    • (2010) Cancer Res , vol.66 , pp. 5542-5548
    • Song, L.1    Morris, M.2    Bagui, T.3    Lee, F.Y.4    Jove, R.5    Haura, E.B.6
  • 37
    • 71849120012 scopus 로고    scopus 로고
    • Effects of src inhibitors on cell growth and epidermal growth factor receptor and MET signaling in gefitinib-resistant non-small cell lung cancer cells with acquired MET amplification
    • Yoshida T, Okamoto I, Okamoto W., Hatashita E, Yamada Y, Kuwata K., et al Effects of Src inhibitors on cell growth and epidermal growth factor receptor and MET signaling in gefitinib-resistant non-small cell lung cancer cells with acquired MET amplification. Cancer Sci 2010; 101:167-72.
    • (2010) Cancer Sci , vol.101 , pp. 167-172
    • Yoshida, T.1    Okamoto, I.2    Okamoto, W.3    Hatashita, E.4    Yamada, Y.5    Kuwata, K.6
  • 38
    • 85027940454 scopus 로고    scopus 로고
    • Phosphoproteomic mass spectrometry profiling links src family kinases to escape from HER2 tyrosine kinase inhibition
    • Rexer BN, Ham AJ, Rinehart C, Hill S., Granja-Ingram N de M, Gonzalez Angulo AM, et al. Phosphoproteomic mass spectrometry profiling links Src family kinases to escape from HER2 tyrosine kinase inhibition. Oncogene 2011; 30:4163-74.
    • (2011) Oncogene , vol.30 , pp. 4163-4174
    • Rexer, B.N.1    Ham, A.J.2    Rinehart, C.3    Hill, S.4    Granja-Ingram, N.D.M.5    Gonzalez Angulo, A.M.6
  • 39
    • 77950491674 scopus 로고    scopus 로고
    • Phase I/II study of the src inhibitor dasatinib in combination with erlotinib in advanced non-small-cell lung cancer
    • Haura EB, Tanvetyanon T, Chiappori A., Williams C, Simon G, Antonia S., et al Phase I/II study of the Src inhibitor dasatinib in combination with erlotinib in advanced non-small-cell lung cancer. J Clin Oncol 2010; 28:1387-94.
    • (2010) J Clin Oncol , vol.28 , pp. 1387-1394
    • Haura, E.B.1    Tanvetyanon, T.2    Chiappori, A.3    Williams, C.4    Simon, G.5    Antonia, S.6
  • 41
    • 84871568127 scopus 로고    scopus 로고
    • Phase ib safety and pharmacokinetic study of volociximab, an antiα5β1 integrin antibody, in combination with carboplatin and paclitaxel in advanced non-small-cell lung cancer
    • Besse B, Tsao LC, Chao D.T., Fang Y., Soria JC, Almokadem S, et al Phase Ib safety and pharmacokinetic study of volociximab, an antiα5β1 integrin antibody, in combination with carboplatin and paclitaxel in advanced non-small-cell lung cancer. Ann Oncol 2013; 24:90-6.
    • (2013) Ann Oncol , vol.24 , pp. 90-96
    • Besse, B.1    Tsao, L.C.2    Chao, D.T.3    Fang, Y.4    Soria, J.C.5    Almokadem, S.6


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