메뉴 건너뛰기




Volumn 140, Issue 4, 2017, Pages 909-920

Viral infections in allergy and immunology: How allergic inflammation influences viral infections and illness

Author keywords

allergic inflammation; asthma; interferon; TH2; Virus

Indexed keywords

BIOLOGICAL PRODUCT; INTERFERON; MESSENGER RNA;

EID: 85031856879     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2017.07.025     Document Type: Review
Times cited : (176)

References (96)
  • 3
    • 84908374296 scopus 로고    scopus 로고
    • Rhinovirus-induced IL-25 in asthma exacerbation drives type 2 immunity and allergic pulmonary inflammation
    • Beale, J., Jayaraman, A., Jackson, D.J., Macintyre, J.D., Edwards, M.R., Walton, R.P., et al. Rhinovirus-induced IL-25 in asthma exacerbation drives type 2 immunity and allergic pulmonary inflammation. Sci Transl Med, 6, 2014, 256ra134.
    • (2014) Sci Transl Med , vol.6 , pp. 256ra134
    • Beale, J.1    Jayaraman, A.2    Jackson, D.J.3    Macintyre, J.D.4    Edwards, M.R.5    Walton, R.P.6
  • 4
    • 0036118734 scopus 로고    scopus 로고
    • Atopic phenotype in children is associated with decreased virus-induced interferon-alpha release
    • Bufe, A., Gehlhar, K., Grage-Griebenow, E., Ernst, M., Atopic phenotype in children is associated with decreased virus-induced interferon-alpha release. Int Arch Allergy Immunol 127 (2002), 82–88.
    • (2002) Int Arch Allergy Immunol , vol.127 , pp. 82-88
    • Bufe, A.1    Gehlhar, K.2    Grage-Griebenow, E.3    Ernst, M.4
  • 5
    • 17144403499 scopus 로고    scopus 로고
    • Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus
    • Wark, P.A., Johnston, S.L., Bucchieri, F., Powell, R., Puddicombe, S., Laza-Stanca, V., et al. Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus. J Exp Med 201 (2005), 937–947.
    • (2005) J Exp Med , vol.201 , pp. 937-947
    • Wark, P.A.1    Johnston, S.L.2    Bucchieri, F.3    Powell, R.4    Puddicombe, S.5    Laza-Stanca, V.6
  • 6
    • 33748446393 scopus 로고    scopus 로고
    • Role of deficient type III interferon-lambda production in asthma exacerbations
    • Contoli, M., Message, S.D., Laza-Stanca, V., Edwards, M.R., Wark, P.A., Bartlett, N.W., et al. Role of deficient type III interferon-lambda production in asthma exacerbations. Nat Med 12 (2006), 1023–1026.
    • (2006) Nat Med , vol.12 , pp. 1023-1026
    • Contoli, M.1    Message, S.D.2    Laza-Stanca, V.3    Edwards, M.R.4    Wark, P.A.5    Bartlett, N.W.6
  • 7
    • 51649109114 scopus 로고    scopus 로고
    • Rhinovirus-induced lower respiratory illness is increased in asthma and related to virus load and Th1/2 cytokine and IL-10 production
    • Message, S.D., Laza-Stanca, V., Mallia, P., Parker, H.L., Zhu, J., Kebadze, T., et al. Rhinovirus-induced lower respiratory illness is increased in asthma and related to virus load and Th1/2 cytokine and IL-10 production. Proc Natl Acad Sci U S A 105 (2008), 13562–13567.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 13562-13567
    • Message, S.D.1    Laza-Stanca, V.2    Mallia, P.3    Parker, H.L.4    Zhu, J.5    Kebadze, T.6
  • 9
    • 0028990124 scopus 로고
    • Community study of role of viral infections in exacerbations of asthma in 9-11 year old children
    • Johnston, S.L., Pattemore, P.K., Sanderson, G., Smith, S., Lampe, F., Josephs, L., et al. Community study of role of viral infections in exacerbations of asthma in 9-11 year old children. BMJ 310 (1995), 1225–1229.
    • (1995) BMJ , vol.310 , pp. 1225-1229
    • Johnston, S.L.1    Pattemore, P.K.2    Sanderson, G.3    Smith, S.4    Lampe, F.5    Josephs, L.6
  • 10
    • 10144222913 scopus 로고    scopus 로고
    • The relationship between upper respiratory infections and hospital admissions for asthma: a time-trend analysis
    • Johnston, S.L., Pattemore, P.K., Sanderson, G., Smith, S., Campbell, M.J., Josephs, L.K., et al. The relationship between upper respiratory infections and hospital admissions for asthma: a time-trend analysis. Am J Respir Crit Care Med 154 (1996), 654–660.
    • (1996) Am J Respir Crit Care Med , vol.154 , pp. 654-660
    • Johnston, S.L.1    Pattemore, P.K.2    Sanderson, G.3    Smith, S.4    Campbell, M.J.5    Josephs, L.K.6
  • 11
    • 79955674573 scopus 로고    scopus 로고
    • Association between human rhinovirus C and severity of acute asthma in children
    • Bizzintino, J., Lee, W.M., Laing, I.A., Vang, F., Pappas, T., Zhang, G., et al. Association between human rhinovirus C and severity of acute asthma in children. Eur Respir J 37 (2010), 1037–1042.
    • (2010) Eur Respir J , vol.37 , pp. 1037-1042
    • Bizzintino, J.1    Lee, W.M.2    Laing, I.A.3    Vang, F.4    Pappas, T.5    Zhang, G.6
  • 13
    • 77956594925 scopus 로고    scopus 로고
    • Newly identified respiratory viruses in children with asthma exacerbation not requiring admission to hospital
    • Arden, K.E., Chang, A.B., Lambert, S.B., Nissen, M.D., Sloots, T.P., Mackay, I.M., Newly identified respiratory viruses in children with asthma exacerbation not requiring admission to hospital. J Med Virol 82 (2010), 1458–1461.
    • (2010) J Med Virol , vol.82 , pp. 1458-1461
    • Arden, K.E.1    Chang, A.B.2    Lambert, S.B.3    Nissen, M.D.4    Sloots, T.P.5    Mackay, I.M.6
  • 14
    • 0034105129 scopus 로고    scopus 로고
    • Respiratory syncytial virus bronchiolitis in infancy is an important risk factor for asthma and allergy at age 7
    • Sigurs, N., Bjarnason, R., Sigurbergsson, F., Kjellman, B., Respiratory syncytial virus bronchiolitis in infancy is an important risk factor for asthma and allergy at age 7. Am J Respir Crit Care Med 161 (2000), 1501–1507.
    • (2000) Am J Respir Crit Care Med , vol.161 , pp. 1501-1507
    • Sigurs, N.1    Bjarnason, R.2    Sigurbergsson, F.3    Kjellman, B.4
  • 15
    • 0030831247 scopus 로고    scopus 로고
    • Respiratory syncytial virus infection in infants is associated with predominant Th-2-like response
    • Roman, M., Calhoun, W.J., Hinton, K.L., Avendano, L.F., Simon, V., Escobar, A.M., et al. Respiratory syncytial virus infection in infants is associated with predominant Th-2-like response. Am J Respir Crit Care Med 156 (1997), 190–195.
    • (1997) Am J Respir Crit Care Med , vol.156 , pp. 190-195
    • Roman, M.1    Calhoun, W.J.2    Hinton, K.L.3    Avendano, L.F.4    Simon, V.5    Escobar, A.M.6
  • 16
    • 84860666096 scopus 로고    scopus 로고
    • Viral infections and atopy in asthma pathogenesis: new rationales for asthma prevention and treatment
    • Holt, P.G., Sly, P.D., Viral infections and atopy in asthma pathogenesis: new rationales for asthma prevention and treatment. Nat Med 18 (2012), 726–735.
    • (2012) Nat Med , vol.18 , pp. 726-735
    • Holt, P.G.1    Sly, P.D.2
  • 17
    • 33748740987 scopus 로고    scopus 로고
    • Respiratory syncytial virus(RSV)-induced allergy may be controlled by IL-4 and CX3C fractalkine antagonists and CpG ODN as adjuvant: hypothesis and implications for treatment
    • Becker, Y., Respiratory syncytial virus(RSV)-induced allergy may be controlled by IL-4 and CX3C fractalkine antagonists and CpG ODN as adjuvant: hypothesis and implications for treatment. Virus Genes 33 (2006), 253–264.
    • (2006) Virus Genes , vol.33 , pp. 253-264
    • Becker, Y.1
  • 18
    • 0037243222 scopus 로고    scopus 로고
    • IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex
    • Kotenko, S.V., Gallagher, G., Baurin, V.V., Lewis-Antes, A., Shen, M., Shah, N.K., et al. IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex. Nat Immunol 4 (2003), 69–77.
    • (2003) Nat Immunol , vol.4 , pp. 69-77
    • Kotenko, S.V.1    Gallagher, G.2    Baurin, V.V.3    Lewis-Antes, A.4    Shen, M.5    Shah, N.K.6
  • 20
    • 0034977353 scopus 로고    scopus 로고
    • Functional classification of interferon-stimulated genes identified using microarrays
    • de Veer, M.J., Holko, M., Frevel, M., Walker, E., Der, S., Paranjape, J.M., et al. Functional classification of interferon-stimulated genes identified using microarrays. J Leukoc Biol 69 (2001), 912–920.
    • (2001) J Leukoc Biol , vol.69 , pp. 912-920
    • de Veer, M.J.1    Holko, M.2    Frevel, M.3    Walker, E.4    Der, S.5    Paranjape, J.M.6
  • 21
    • 33845605155 scopus 로고    scopus 로고
    • Interferons alpha and lambda inhibit hepatitis C virus replication with distinct signal transduction and gene regulation kinetics
    • Marcello, T., Grakoui, A., Barba-Spaeth, G., Machlin, E.S., Kotenko, S.V., MacDonald, M.R., et al. Interferons alpha and lambda inhibit hepatitis C virus replication with distinct signal transduction and gene regulation kinetics. Gastroenterology 131 (2006), 1887–1898.
    • (2006) Gastroenterology , vol.131 , pp. 1887-1898
    • Marcello, T.1    Grakoui, A.2    Barba-Spaeth, G.3    Machlin, E.S.4    Kotenko, S.V.5    MacDonald, M.R.6
  • 22
    • 84872375201 scopus 로고    scopus 로고
    • Defining critical roles for NF-kappaB p65 and type I interferon in innate immunity to rhinovirus
    • Bartlett, N.W., Slater, L., Glanville, N., Haas, J.J., Caramori, G., Casolari, P., et al. Defining critical roles for NF-kappaB p65 and type I interferon in innate immunity to rhinovirus. EMBO Mol Med 4 (2012), 1244–1260.
    • (2012) EMBO Mol Med , vol.4 , pp. 1244-1260
    • Bartlett, N.W.1    Slater, L.2    Glanville, N.3    Haas, J.J.4    Caramori, G.5    Casolari, P.6
  • 23
    • 79955542915 scopus 로고    scopus 로고
    • A diverse range of gene products are effectors of the type I interferon antiviral response
    • Schoggins, J.W., Wilson, S.J., Panis, M., Murphy, M.Y., Jones, C.T., Bieniasz, P., et al. A diverse range of gene products are effectors of the type I interferon antiviral response. Nature 472 (2011), 481–485.
    • (2011) Nature , vol.472 , pp. 481-485
    • Schoggins, J.W.1    Wilson, S.J.2    Panis, M.3    Murphy, M.Y.4    Jones, C.T.5    Bieniasz, P.6
  • 24
    • 79251492014 scopus 로고    scopus 로고
    • Co-ordinated role of TLR3, RIG-I and MDA5 in the innate response to rhinovirus in bronchial epithelium
    • Slater, L., Bartlett, N.W., Haas, J.J., Zhu, J., Message, S.D., Walton, R.P., et al. Co-ordinated role of TLR3, RIG-I and MDA5 in the innate response to rhinovirus in bronchial epithelium. PLoS Pathog, 6, 2010, e1001178.
    • (2010) PLoS Pathog , vol.6 , pp. e1001178
    • Slater, L.1    Bartlett, N.W.2    Haas, J.J.3    Zhu, J.4    Message, S.D.5    Walton, R.P.6
  • 25
    • 79958062793 scopus 로고    scopus 로고
    • MDA5 and TLR3 initiate pro-inflammatory signaling pathways leading to rhinovirus-induced airways inflammation and hyperresponsiveness
    • Wang, Q., Miller, D.J., Bowman, E.R., Nagarkar, D.R., Schneider, D., Zhao, Y., et al. MDA5 and TLR3 initiate pro-inflammatory signaling pathways leading to rhinovirus-induced airways inflammation and hyperresponsiveness. PLoS Pathog, 7, 2011, e1002070.
    • (2011) PLoS Pathog , vol.7 , pp. e1002070
    • Wang, Q.1    Miller, D.J.2    Bowman, E.R.3    Nagarkar, D.R.4    Schneider, D.5    Zhao, Y.6
  • 26
    • 73349104638 scopus 로고    scopus 로고
    • Role of double-stranded RNA pattern recognition receptors in rhinovirus-induced airway epithelial cell responses
    • Wang, Q., Nagarkar, D.R., Bowman, E.R., Schneider, D., Gosangi, B., Lei, J., et al. Role of double-stranded RNA pattern recognition receptors in rhinovirus-induced airway epithelial cell responses. J Immunol 183 (2009), 6989–6997.
    • (2009) J Immunol , vol.183 , pp. 6989-6997
    • Wang, Q.1    Nagarkar, D.R.2    Bowman, E.R.3    Schneider, D.4    Gosangi, B.5    Lei, J.6
  • 27
    • 0037045846 scopus 로고    scopus 로고
    • Frequency, severity, and duration of rhinovirus infections in asthmatic and non-asthmatic individuals: a longitudinal cohort study
    • Corne, J.M., Marshall, C., Smith, S., Schreiber, J., Sanderson, G., Holgate, S.T., et al. Frequency, severity, and duration of rhinovirus infections in asthmatic and non-asthmatic individuals: a longitudinal cohort study. Lancet 359 (2002), 831–834.
    • (2002) Lancet , vol.359 , pp. 831-834
    • Corne, J.M.1    Marshall, C.2    Smith, S.3    Schreiber, J.4    Sanderson, G.5    Holgate, S.T.6
  • 28
    • 77953404932 scopus 로고    scopus 로고
    • Counterregulation between the FcepsilonRI pathway and antiviral responses in human plasmacytoid dendritic cells
    • Gill, M.A., Bajwa, G., George, T.A., Dong, C.C., Dougherty, I.I., Jiang, N., et al. Counterregulation between the FcepsilonRI pathway and antiviral responses in human plasmacytoid dendritic cells. J Immunol 184 (2010), 5999–6006.
    • (2010) J Immunol , vol.184 , pp. 5999-6006
    • Gill, M.A.1    Bajwa, G.2    George, T.A.3    Dong, C.C.4    Dougherty, I.I.5    Jiang, N.6
  • 29
    • 84864419876 scopus 로고    scopus 로고
    • Innate immune responses to rhinovirus are reduced by the high-affinity IgE receptor in allergic asthmatic children
    • Durrani, S.R., Montville, D.J., Pratt, A.S., Sahu, S., Devries, M.K., Rajamanickam, V., et al. Innate immune responses to rhinovirus are reduced by the high-affinity IgE receptor in allergic asthmatic children. J Allergy Clin Immunol 130 (2012), 489–495.
    • (2012) J Allergy Clin Immunol , vol.130 , pp. 489-495
    • Durrani, S.R.1    Montville, D.J.2    Pratt, A.S.3    Sahu, S.4    Devries, M.K.5    Rajamanickam, V.6
  • 33
    • 84978128762 scopus 로고    scopus 로고
    • Impaired airway epithelial cell responses from children with asthma to rhinoviral infection
    • Kicic, A., Stevens, P.T., Sutanto, E.N., Kicic-Starcevich, E., Ling, K.M., Looi, K., et al. Impaired airway epithelial cell responses from children with asthma to rhinoviral infection. Clin Exp Allergy 46 (2016), 1441–1455.
    • (2016) Clin Exp Allergy , vol.46 , pp. 1441-1455
    • Kicic, A.1    Stevens, P.T.2    Sutanto, E.N.3    Kicic-Starcevich, E.4    Ling, K.M.5    Looi, K.6
  • 34
    • 84870291769 scopus 로고    scopus 로고
    • Deficient antiviral immune responses in childhood: distinct roles of atopy and asthma
    • Baraldo, S., Contoli, M., Bazzan, E., Turato, G., Padovani, A., Marku, B., et al. Deficient antiviral immune responses in childhood: distinct roles of atopy and asthma. J Allergy Clin Immunol 130 (2012), 1307–1314.
    • (2012) J Allergy Clin Immunol , vol.130 , pp. 1307-1314
    • Baraldo, S.1    Contoli, M.2    Bazzan, E.3    Turato, G.4    Padovani, A.5    Marku, B.6
  • 35
    • 77955300029 scopus 로고    scopus 로고
    • Double-stranded RNA induces disproportionate expression of thymic stromal lymphopoietin versus interferon-beta in bronchial epithelial cells from donors with asthma
    • Uller, L., Leino, M., Bedke, N., Sammut, D., Green, B., Lau, L., et al. Double-stranded RNA induces disproportionate expression of thymic stromal lymphopoietin versus interferon-beta in bronchial epithelial cells from donors with asthma. Thorax 65 (2010), 626–632.
    • (2010) Thorax , vol.65 , pp. 626-632
    • Uller, L.1    Leino, M.2    Bedke, N.3    Sammut, D.4    Green, B.5    Lau, L.6
  • 36
    • 84879400685 scopus 로고    scopus 로고
    • Impaired innate interferon induction in severe therapy resistant atopic asthmatic children
    • Edwards, M.R., Regamey, N., Vareille, M., Kieninger, E., Gupta, A., Shoemark, A., et al. Impaired innate interferon induction in severe therapy resistant atopic asthmatic children. Mucosal Immunol 6 (2012), 797–806.
    • (2012) Mucosal Immunol , vol.6 , pp. 797-806
    • Edwards, M.R.1    Regamey, N.2    Vareille, M.3    Kieninger, E.4    Gupta, A.5    Shoemark, A.6
  • 37
    • 84906932841 scopus 로고    scopus 로고
    • The effect of inhaled IFN-beta on worsening of asthma symptoms caused by viral infections. A randomized trial
    • Djukanovic, R., Harrison, T., Johnston, S.L., Gabbay, F., Wark, P., Thomson, N.C., et al. The effect of inhaled IFN-beta on worsening of asthma symptoms caused by viral infections. A randomized trial. Am J Respir Crit Care Med 190 (2014), 145–154.
    • (2014) Am J Respir Crit Care Med , vol.190 , pp. 145-154
    • Djukanovic, R.1    Harrison, T.2    Johnston, S.L.3    Gabbay, F.4    Wark, P.5    Thomson, N.C.6
  • 38
  • 39
    • 67649210683 scopus 로고    scopus 로고
    • In vitro susceptibility to rhinovirus infection is greater for bronchial than for nasal airway epithelial cells in human subjects
    • Lopez-Souza, N., Favoreto, S., Wong, H., Ward, T., Yagi, S., Schnurr, D., et al. In vitro susceptibility to rhinovirus infection is greater for bronchial than for nasal airway epithelial cells in human subjects. J Allergy Clin Immunol 123 (2009), 1384–1390.e2.
    • (2009) J Allergy Clin Immunol , vol.123 , pp. 1384-1390.e2
    • Lopez-Souza, N.1    Favoreto, S.2    Wong, H.3    Ward, T.4    Yagi, S.5    Schnurr, D.6
  • 40
    • 84919633225 scopus 로고    scopus 로고
    • Interferon response and respiratory virus control are preserved in bronchial epithelial cells in asthma
    • Patel, D.A., You, Y., Huang, G., Byers, D.E., Kim, H.J., Agapov, E., et al. Interferon response and respiratory virus control are preserved in bronchial epithelial cells in asthma. J Allergy Clin Immunol 134 (2014), 1402–1412.e7.
    • (2014) J Allergy Clin Immunol , vol.134 , pp. 1402-1412.e7
    • Patel, D.A.1    You, Y.2    Huang, G.3    Byers, D.E.4    Kim, H.J.5    Agapov, E.6
  • 41
    • 84991200374 scopus 로고    scopus 로고
    • Human metapneumovirus impairs apoptosis of nasal epithelial cells in asthma via HSP70
    • Baturcam, E., Snape, N., Yeo, T.H., Schagen, J., Thomas, E., Logan, J., et al. Human metapneumovirus impairs apoptosis of nasal epithelial cells in asthma via HSP70. J Innate Immun 9 (2016), 52–64.
    • (2016) J Innate Immun , vol.9 , pp. 52-64
    • Baturcam, E.1    Snape, N.2    Yeo, T.H.3    Schagen, J.4    Thomas, E.5    Logan, J.6
  • 42
    • 79955634439 scopus 로고    scopus 로고
    • Exogenous IFN-β has antiviral and anti-inflammatory properties in primary bronchial epithelial cells from asthmatic subjects exposed to rhinovirus
    • Cakebread, J.A., Xu, Y., Grainge, C., Kehagia, V., Howarth, P.H., Holgate, S.T., et al. Exogenous IFN-β has antiviral and anti-inflammatory properties in primary bronchial epithelial cells from asthmatic subjects exposed to rhinovirus. J Allergy Clin Immunol 127 (2011), 1148–1154.e9.
    • (2011) J Allergy Clin Immunol , vol.127 , pp. 1148-1154.e9
    • Cakebread, J.A.1    Xu, Y.2    Grainge, C.3    Kehagia, V.4    Howarth, P.H.5    Holgate, S.T.6
  • 43
    • 84893914123 scopus 로고    scopus 로고
    • Rhinovirus-induced interferon production is not deficient in well controlled asthma
    • Sykes, A., Macintyre, J., Edwards, M.R., Del Rosario, A., Haas, J., Gielen, V., et al. Rhinovirus-induced interferon production is not deficient in well controlled asthma. Thorax 69 (2014), 240–246.
    • (2014) Thorax , vol.69 , pp. 240-246
    • Sykes, A.1    Macintyre, J.2    Edwards, M.R.3    Del Rosario, A.4    Haas, J.5    Gielen, V.6
  • 44
    • 61349118001 scopus 로고    scopus 로고
    • Diversity in the bronchial epithelial cell response to infection with different rhinovirus strains
    • Wark, P.A., Grissell, T., Davies, B., See, H., Gibson, P.G., Diversity in the bronchial epithelial cell response to infection with different rhinovirus strains. Respirology 14 (2009), 180–186.
    • (2009) Respirology , vol.14 , pp. 180-186
    • Wark, P.A.1    Grissell, T.2    Davies, B.3    See, H.4    Gibson, P.G.5
  • 45
    • 84899774977 scopus 로고    scopus 로고
    • Viral and host factors determine innate immune responses in airway epithelial cells from children with wheeze and atopy
    • Spann, K.M., Baturcam, E., Schagen, J., Jones, C., Straub, C.P., Preston, F.M., et al. Viral and host factors determine innate immune responses in airway epithelial cells from children with wheeze and atopy. Thorax 69 (2014), 918–925.
    • (2014) Thorax , vol.69 , pp. 918-925
    • Spann, K.M.1    Baturcam, E.2    Schagen, J.3    Jones, C.4    Straub, C.P.5    Preston, F.M.6
  • 46
    • 84892981475 scopus 로고    scopus 로고
    • dsRNA-induced changes in gene expression profiles of primary nasal and bronchial epithelial cells from patients with asthma, rhinitis and controls
    • Wagener, A.H., Zwinderman, A.H., Luiten, S., Fokkens, W.J., Bel, E.H., Sterk, P.J., et al. dsRNA-induced changes in gene expression profiles of primary nasal and bronchial epithelial cells from patients with asthma, rhinitis and controls. Respir Res, 15, 2014, 9.
    • (2014) Respir Res , vol.15 , pp. 9
    • Wagener, A.H.1    Zwinderman, A.H.2    Luiten, S.3    Fokkens, W.J.4    Bel, E.H.5    Sterk, P.J.6
  • 47
    • 79958177225 scopus 로고    scopus 로고
    • Peripheral blood mononuclear cells from patients with bronchial asthma show impaired innate immune responses to rhinovirus in vitro
    • Iikura, K., Katsunuma, T., Saika, S., Saito, S., Ichinohe, S., Ida, H., et al. Peripheral blood mononuclear cells from patients with bronchial asthma show impaired innate immune responses to rhinovirus in vitro. Int Arch Allergy Immunol 155:suppl 1 (2011), 27–33.
    • (2011) Int Arch Allergy Immunol , vol.155 , pp. 27-33
    • Iikura, K.1    Katsunuma, T.2    Saika, S.3    Saito, S.4    Ichinohe, S.5    Ida, H.6
  • 48
    • 85032375457 scopus 로고    scopus 로고
    • Phenotyping immune responses in asthma and respiratory infections
    • Proceedings of the American Thoracic Society Conference San Francisco
    • Lin, L., Belgrave, D., Bakhsoliani, E., Hirsman, A., Edwards, M.R., Walton, R.P., et al. Phenotyping immune responses in asthma and respiratory infections. 2016 May 13-18, Proceedings of the American Thoracic Society Conference, San Francisco, A7870.
    • (2016) , pp. A7870
    • Lin, L.1    Belgrave, D.2    Bakhsoliani, E.3    Hirsman, A.4    Edwards, M.R.5    Walton, R.P.6
  • 49
    • 84941283549 scopus 로고    scopus 로고
    • Toll-like receptor 7 governs interferon and inflammatory responses to rhinovirus and is suppressed by IL-5-induced lung eosinophilia
    • Hatchwell, L., Collison, A., Girkin, J., Parsons, K., Li, J., Zhang, J., et al. Toll-like receptor 7 governs interferon and inflammatory responses to rhinovirus and is suppressed by IL-5-induced lung eosinophilia. Thorax 70 (2015), 854–861.
    • (2015) Thorax , vol.70 , pp. 854-861
    • Hatchwell, L.1    Collison, A.2    Girkin, J.3    Parsons, K.4    Li, J.5    Zhang, J.6
  • 50
    • 84873569230 scopus 로고    scopus 로고
    • The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity
    • Collison, A., Hatchwell, L., Verrills, N., Wark, P.A., de Siqueira, A.P., Tooze, M., et al. The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity. Nat Med 19 (2013), 232–237.
    • (2013) Nat Med , vol.19 , pp. 232-237
    • Collison, A.1    Hatchwell, L.2    Verrills, N.3    Wark, P.A.4    de Siqueira, A.P.5    Tooze, M.6
  • 51
    • 84952639005 scopus 로고    scopus 로고
    • Preseasonal treatment with either omalizumab or an inhaled corticosteroid boost to prevent fall asthma exacerbations
    • Teach, S.J., Gill, M.A., Togias, A., Sorkness, C.A., Arbes, S.J. Jr., Calatroni, A., et al. Preseasonal treatment with either omalizumab or an inhaled corticosteroid boost to prevent fall asthma exacerbations. J Allergy Clin Immunol 136 (2015), 1476–1485.
    • (2015) J Allergy Clin Immunol , vol.136 , pp. 1476-1485
    • Teach, S.J.1    Gill, M.A.2    Togias, A.3    Sorkness, C.A.4    Arbes, S.J.5    Calatroni, A.6
  • 52
    • 85006324650 scopus 로고    scopus 로고
    • Impaired virus replication and decreased innate immune responses to viral infections in nasal epithelial cells from patients with allergic rhinitis
    • Globinska, A., Pawelczyk, M., Piechota-Polanczyk, A., Olszewska-Ziaber, A., Moskwa, S., Mikolajczyk, A., et al. Impaired virus replication and decreased innate immune responses to viral infections in nasal epithelial cells from patients with allergic rhinitis. Clin Exp Immunol 187 (2016), 100–112.
    • (2016) Clin Exp Immunol , vol.187 , pp. 100-112
    • Globinska, A.1    Pawelczyk, M.2    Piechota-Polanczyk, A.3    Olszewska-Ziaber, A.4    Moskwa, S.5    Mikolajczyk, A.6
  • 53
    • 84991491374 scopus 로고    scopus 로고
    • Raised interferon-beta, type 3 interferon and interferon-stimulated genes—evidence of innate immune activation in neutrophilic asthma
    • da Silva, J., Hilzendeger, C., Moermans, C., Schleich, F., Henket, M., Kebadze, T., et al. Raised interferon-beta, type 3 interferon and interferon-stimulated genes—evidence of innate immune activation in neutrophilic asthma. Clin Exp Allergy 47 (2016), 313–323.
    • (2016) Clin Exp Allergy , vol.47 , pp. 313-323
    • da Silva, J.1    Hilzendeger, C.2    Moermans, C.3    Schleich, F.4    Henket, M.5    Kebadze, T.6
  • 55
    • 85016488815 scopus 로고    scopus 로고
    • A comprehensive evaluation of nasal and bronchial cytokines and chemokines following experimental rhinovirus infection in allergic asthma: increased interferons (IFN-γ and IFN-λ) and type 2 inflammation (IL-5 and IL-13)
    • Hansel, T.T., Tunstall, T., Trujillo-Torralbo, M.B., Shamji, B., Del-Rosario, A., Dhariwal, J., et al. A comprehensive evaluation of nasal and bronchial cytokines and chemokines following experimental rhinovirus infection in allergic asthma: increased interferons (IFN-γ and IFN-λ) and type 2 inflammation (IL-5 and IL-13). EBioMedicine 19 (2017), 128–138.
    • (2017) EBioMedicine , vol.19 , pp. 128-138
    • Hansel, T.T.1    Tunstall, T.2    Trujillo-Torralbo, M.B.3    Shamji, B.4    Del-Rosario, A.5    Dhariwal, J.6
  • 56
    • 55549094831 scopus 로고    scopus 로고
    • Gene expression profiles during in vivo human rhinovirus infection: insights into the host response
    • Proud, D., Turner, R.B., Winther, B., Wiehler, S., Tiesman, J.P., Reichling, T.D., et al. Gene expression profiles during in vivo human rhinovirus infection: insights into the host response. Am J Respir Crit Care Med 178 (2008), 962–968.
    • (2008) Am J Respir Crit Care Med , vol.178 , pp. 962-968
    • Proud, D.1    Turner, R.B.2    Winther, B.3    Wiehler, S.4    Tiesman, J.P.5    Reichling, T.D.6
  • 57
    • 35649028488 scopus 로고    scopus 로고
    • Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids
    • Woodruff, P.G., Boushey, H.A., Dolganov, G.M., Barker, C.S., Yang, Y.H., Donnelly, S., et al. Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids. Proc Natl Acad Sci U S A 104 (2007), 15858–15863.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 15858-15863
    • Woodruff, P.G.1    Boushey, H.A.2    Dolganov, G.M.3    Barker, C.S.4    Yang, Y.H.5    Donnelly, S.6
  • 58
    • 79251582522 scopus 로고    scopus 로고
    • Gene expression patterns of Th2 inflammation and intercellular communication in asthmatic airways
    • Choy, D.F., Modrek, B., Abbas, A.R., Kummerfeld, S., Clark, H.F., Wu, L.C., et al. Gene expression patterns of Th2 inflammation and intercellular communication in asthmatic airways. J Immunol 186 (2010), 1861–1869.
    • (2010) J Immunol , vol.186 , pp. 1861-1869
    • Choy, D.F.1    Modrek, B.2    Abbas, A.R.3    Kummerfeld, S.4    Clark, H.F.5    Wu, L.C.6
  • 59
    • 57149098273 scopus 로고    scopus 로고
    • Association analysis identifies TLR7 and TLR8 as novel risk genes in asthma and related disorders
    • Moller-Larsen, S., Nyegaard, M., Haagerup, A., Vestbo, J., Kruse, T.A., Borglum, A.D., Association analysis identifies TLR7 and TLR8 as novel risk genes in asthma and related disorders. Thorax 63 (2008), 1064–1069.
    • (2008) Thorax , vol.63 , pp. 1064-1069
    • Moller-Larsen, S.1    Nyegaard, M.2    Haagerup, A.3    Vestbo, J.4    Kruse, T.A.5    Borglum, A.D.6
  • 60
    • 84904035337 scopus 로고    scopus 로고
    • Fine-mapping of IgE-associated loci 1q23, 5q31, and 12q13 using 1000 Genomes Project data
    • Sharma, V., Michel, S., Gaertner, V., Franke, A., Vogelberg, C., von Berg, A., et al. Fine-mapping of IgE-associated loci 1q23, 5q31, and 12q13 using 1000 Genomes Project data. Allergy 69 (2014), 1077–1084.
    • (2014) Allergy , vol.69 , pp. 1077-1084
    • Sharma, V.1    Michel, S.2    Gaertner, V.3    Franke, A.4    Vogelberg, C.5    von Berg, A.6
  • 62
    • 84866126983 scopus 로고    scopus 로고
    • Transforming growth factor-Beta promotes rhinovirus replication in bronchial epithelial cells by suppressing the innate immune response
    • Bedke, N., Sammut, D., Green, B., Kehagia, V., Dennison, P., Jenkins, G., et al. Transforming growth factor-Beta promotes rhinovirus replication in bronchial epithelial cells by suppressing the innate immune response. PLoS One, 7, 2012, e44580.
    • (2012) PLoS One , vol.7 , pp. e44580
    • Bedke, N.1    Sammut, D.2    Green, B.3    Kehagia, V.4    Dennison, P.5    Jenkins, G.6
  • 63
    • 84949117566 scopus 로고    scopus 로고
    • Increased nuclear suppressor of cytokine signaling 1 in asthmatic bronchial epithelium suppresses rhinovirus induction of innate interferons
    • Gielen, V., Sykes, A., Zhu, J., Chan, B., Macintyre, J., Regamey, N., et al. Increased nuclear suppressor of cytokine signaling 1 in asthmatic bronchial epithelium suppresses rhinovirus induction of innate interferons. J Allergy Clin Immunol 136 (2015), 177–188.e11.
    • (2015) J Allergy Clin Immunol , vol.136 , pp. 177-188.e11
    • Gielen, V.1    Sykes, A.2    Zhu, J.3    Chan, B.4    Macintyre, J.5    Regamey, N.6
  • 64
  • 65
    • 34247265510 scopus 로고    scopus 로고
    • Functional polymorphism in the suppressor of cytokine signaling 1 gene associated with adult asthma
    • Harada, M., Nakashima, K., Hirota, T., Shimizu, M., Doi, S., Fujita, K., et al. Functional polymorphism in the suppressor of cytokine signaling 1 gene associated with adult asthma. Am J Respir Cell Mol Biol 36 (2007), 491–496.
    • (2007) Am J Respir Cell Mol Biol , vol.36 , pp. 491-496
    • Harada, M.1    Nakashima, K.2    Hirota, T.3    Shimizu, M.4    Doi, S.5    Fujita, K.6
  • 66
    • 42149119018 scopus 로고    scopus 로고
    • Cutting edge: innate immune response triggered by influenza A virus is negatively regulated by SOCS1 and SOCS3 through a RIG-I/IFNAR1-dependent pathway
    • Pothlichet, J., Chignard, M., Si-Tahar, M., Cutting edge: innate immune response triggered by influenza A virus is negatively regulated by SOCS1 and SOCS3 through a RIG-I/IFNAR1-dependent pathway. J Immunol 180 (2008), 2034–2038.
    • (2008) J Immunol , vol.180 , pp. 2034-2038
    • Pothlichet, J.1    Chignard, M.2    Si-Tahar, M.3
  • 67
    • 57349102472 scopus 로고    scopus 로고
    • Identification of a nuclear localization signal in suppressor of cytokine signaling 1
    • Baetz, A., Koelsche, C., Strebovsky, J., Heeg, K., Dalpke, A.H., Identification of a nuclear localization signal in suppressor of cytokine signaling 1. FASEB J 22 (2008), 4296–4305.
    • (2008) FASEB J , vol.22 , pp. 4296-4305
    • Baetz, A.1    Koelsche, C.2    Strebovsky, J.3    Heeg, K.4    Dalpke, A.H.5
  • 68
    • 84986223763 scopus 로고    scopus 로고
    • Reduced epithelial suppressor of cytokine signalling 1 in severe eosinophilic asthma
    • Doran, E., Choy, D.F., Shikotra, A., Butler, C.A., O'Rourke, D.M., Johnston, J.A., et al. Reduced epithelial suppressor of cytokine signalling 1 in severe eosinophilic asthma. Eur Respir J 48 (2016), 715–725.
    • (2016) Eur Respir J , vol.48 , pp. 715-725
    • Doran, E.1    Choy, D.F.2    Shikotra, A.3    Butler, C.A.4    O'Rourke, D.M.5    Johnston, J.A.6
  • 69
    • 84925546187 scopus 로고    scopus 로고
    • Type 2 inflammation in asthma—present in most, absent in many
    • Fahy, J.V., Type 2 inflammation in asthma—present in most, absent in many. Nat Rev Immunol 15 (2014), 57–65.
    • (2014) Nat Rev Immunol , vol.15 , pp. 57-65
    • Fahy, J.V.1
  • 70
    • 0037196927 scopus 로고    scopus 로고
    • Synergism between allergens and viruses and risk of hospital admission with asthma: case-control study
    • Green, R.M., Custovic, A., Sanderson, G., Hunter, J., Johnston, S.L., Woodcock, A., Synergism between allergens and viruses and risk of hospital admission with asthma: case-control study. BMJ, 324, 2002, 763.
    • (2002) BMJ , vol.324 , pp. 763
    • Green, R.M.1    Custovic, A.2    Sanderson, G.3    Hunter, J.4    Johnston, S.L.5    Woodcock, A.6
  • 71
    • 33646555487 scopus 로고    scopus 로고
    • Study of modifiable risk factors for asthma exacerbations: virus infection and allergen exposure increase the risk of asthma hospital admissions in children
    • Murray, C.S., Poletti, G., Kebadze, T., Morris, J., Woodcock, A., Johnston, S.L., et al. Study of modifiable risk factors for asthma exacerbations: virus infection and allergen exposure increase the risk of asthma hospital admissions in children. Thorax 61 (2006), 376–382.
    • (2006) Thorax , vol.61 , pp. 376-382
    • Murray, C.S.1    Poletti, G.2    Kebadze, T.3    Morris, J.4    Woodcock, A.5    Johnston, S.L.6
  • 72
    • 38949170602 scopus 로고    scopus 로고
    • Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation
    • Bartlett, N.W., Walton, R.P., Edwards, M.R., Aniscenko, J., Caramori, G., Zhu, J., et al. Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation. Nat Med 14 (2008), 199–204.
    • (2008) Nat Med , vol.14 , pp. 199-204
    • Bartlett, N.W.1    Walton, R.P.2    Edwards, M.R.3    Aniscenko, J.4    Caramori, G.5    Zhu, J.6
  • 73
    • 0032101551 scopus 로고    scopus 로고
    • Eliminating a region of respiratory syncytial virus attachment protein allows induction of protective immunity without vaccine-enhanced lung eosinophilia
    • Sparer, T.E., Matthews, S., Hussell, T., Rae, A.J., Garcia-Barreno, B., Melero, J.A., et al. Eliminating a region of respiratory syncytial virus attachment protein allows induction of protective immunity without vaccine-enhanced lung eosinophilia. J Exp Med 187 (1998), 1921–1926.
    • (1998) J Exp Med , vol.187 , pp. 1921-1926
    • Sparer, T.E.1    Matthews, S.2    Hussell, T.3    Rae, A.J.4    Garcia-Barreno, B.5    Melero, J.A.6
  • 74
    • 0032538913 scopus 로고    scopus 로고
    • Atypical pulmonary eosinophilia is mediated by a specific amino acid sequence of the attachment (G) protein of respiratory syncytial virus
    • Tebbey, P.W., Hagen, M., Hancock, G.E., Atypical pulmonary eosinophilia is mediated by a specific amino acid sequence of the attachment (G) protein of respiratory syncytial virus. J Exp Med 188 (1998), 1967–1972.
    • (1998) J Exp Med , vol.188 , pp. 1967-1972
    • Tebbey, P.W.1    Hagen, M.2    Hancock, G.E.3
  • 75
    • 0030794556 scopus 로고    scopus 로고
    • Respiratory syncytial virus infection results in airway hyperresponsiveness and enhanced airway sensitization to allergen
    • Schwarze, J., Hamelmann, E., Bradley, K.L., Takeda, K., Gelfand, E.W., Respiratory syncytial virus infection results in airway hyperresponsiveness and enhanced airway sensitization to allergen. J Clin Invest 100 (1997), 226–233.
    • (1997) J Clin Invest , vol.100 , pp. 226-233
    • Schwarze, J.1    Hamelmann, E.2    Bradley, K.L.3    Takeda, K.4    Gelfand, E.W.5
  • 76
    • 0037202790 scopus 로고    scopus 로고
    • Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial
    • Green, R.H., Brightling, C.E., McKenna, S., Hargadon, B., Parker, D., Bradding, P., et al. Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial. Lancet 360 (2002), 1715–1721.
    • (2002) Lancet , vol.360 , pp. 1715-1721
    • Green, R.H.1    Brightling, C.E.2    McKenna, S.3    Hargadon, B.4    Parker, D.5    Bradding, P.6
  • 77
    • 84862617592 scopus 로고    scopus 로고
    • Innate IFNs and plasmacytoid dendritic cells constrain Th2 cytokine responses to rhinovirus: a regulatory mechanism with relevance to asthma
    • Pritchard, A.L., Carroll, M.L., Burel, J.G., White, O.J., Phipps, S., Upham, J.W., Innate IFNs and plasmacytoid dendritic cells constrain Th2 cytokine responses to rhinovirus: a regulatory mechanism with relevance to asthma. J Immunol 188 (2012), 5898–5905.
    • (2012) J Immunol , vol.188 , pp. 5898-5905
    • Pritchard, A.L.1    Carroll, M.L.2    Burel, J.G.3    White, O.J.4    Phipps, S.5    Upham, J.W.6
  • 78
    • 77955503273 scopus 로고    scopus 로고
    • Cutting edge: type I IFN reverses human Th2 commitment and stability by suppressing GATA3
    • Huber, J.P., Ramos, H.J., Gill, M.A., Farrar, J.D., Cutting edge: type I IFN reverses human Th2 commitment and stability by suppressing GATA3. J Immunol 185 (2010), 813–817.
    • (2010) J Immunol , vol.185 , pp. 813-817
    • Huber, J.P.1    Ramos, H.J.2    Gill, M.A.3    Farrar, J.D.4
  • 79
    • 84874916817 scopus 로고    scopus 로고
    • TLR7 Stimulation of APCs results in inhibition of IL-5 through type I IFN and Notch signaling pathways in human peripheral blood mononuclear cells
    • Edwards, S., Jones, C., Leishman, A.J., Young, B.W., Matsui, H., Tomizawa, H., et al. TLR7 Stimulation of APCs results in inhibition of IL-5 through type I IFN and Notch signaling pathways in human peripheral blood mononuclear cells. J Immunol 190 (2013), 2585–2592.
    • (2013) J Immunol , vol.190 , pp. 2585-2592
    • Edwards, S.1    Jones, C.2    Leishman, A.J.3    Young, B.W.4    Matsui, H.5    Tomizawa, H.6
  • 80
    • 70149089062 scopus 로고    scopus 로고
    • Interactions between innate antiviral and atopic immunoinflammatory pathways precipitate and sustain asthma exacerbations in children
    • Subrata, L.S., Bizzintino, J., Mamessier, E., Bosco, A., McKenna, K.L., Wikstrom, M.E., et al. Interactions between innate antiviral and atopic immunoinflammatory pathways precipitate and sustain asthma exacerbations in children. J Immunol 183 (2009), 2793–2800.
    • (2009) J Immunol , vol.183 , pp. 2793-2800
    • Subrata, L.S.1    Bizzintino, J.2    Mamessier, E.3    Bosco, A.4    McKenna, K.L.5    Wikstrom, M.E.6
  • 81
    • 79957896032 scopus 로고    scopus 로고
    • IL-28A (IFN-lambda2) modulates lung DC function to promote Th1 immune skewing and suppress allergic airway disease
    • Koltsida, O., Hausding, M., Stavropoulos, A., Koch, S., Tzelepis, G., Ubel, C., et al. IL-28A (IFN-lambda2) modulates lung DC function to promote Th1 immune skewing and suppress allergic airway disease. EMBO Mol Med 3 (2011), 348–361.
    • (2011) EMBO Mol Med , vol.3 , pp. 348-361
    • Koltsida, O.1    Hausding, M.2    Stavropoulos, A.3    Koch, S.4    Tzelepis, G.5    Ubel, C.6
  • 82
    • 84951317601 scopus 로고    scopus 로고
    • Type I interferon restricts type 2 immunopathology through the regulation of group 2 innate lymphoid cells
    • Duerr, C.U., McCarthy, C.D., Mindt, B.C., Rubio, M., Meli, A.P., Pothlichet, J., et al. Type I interferon restricts type 2 immunopathology through the regulation of group 2 innate lymphoid cells. Nat Immunol 17 (2015), 65–75.
    • (2015) Nat Immunol , vol.17 , pp. 65-75
    • Duerr, C.U.1    McCarthy, C.D.2    Mindt, B.C.3    Rubio, M.4    Meli, A.P.5    Pothlichet, J.6
  • 83
    • 84973444977 scopus 로고    scopus 로고
    • Aeroallergen-induced IL-33 predisposes to respiratory virus-induced asthma by dampening antiviral immunity
    • Lynch, J.P., Werder, R.B., Simpson, J., Loh, Z., Zhang, V., Haque, A., et al. Aeroallergen-induced IL-33 predisposes to respiratory virus-induced asthma by dampening antiviral immunity. J Allergy Clin Immunol 138 (2016), 1326–1337.
    • (2016) J Allergy Clin Immunol , vol.138 , pp. 1326-1337
    • Lynch, J.P.1    Werder, R.B.2    Simpson, J.3    Loh, Z.4    Zhang, V.5    Haque, A.6
  • 84
    • 69449100311 scopus 로고    scopus 로고
    • Transforming growth factor-beta enhances rhinovirus infection by diminishing early innate responses
    • Thomas, B.J., Lindsay, M., Dagher, H., Freezer, N.J., Li, D., Ghildyal, R., et al. Transforming growth factor-beta enhances rhinovirus infection by diminishing early innate responses. Am J Respir Cell Mol Biol 41 (2009), 339–347.
    • (2009) Am J Respir Cell Mol Biol , vol.41 , pp. 339-347
    • Thomas, B.J.1    Lindsay, M.2    Dagher, H.3    Freezer, N.J.4    Li, D.5    Ghildyal, R.6
  • 85
    • 84938199992 scopus 로고    scopus 로고
    • Th2-cytokines impair innate immune responses to rhinovirus in respiratory epithelial cells
    • Contoli, M., Ito, K., Padovani, A., Poletti, D., Marku, B., Edwards, M.R., et al. Th2-cytokines impair innate immune responses to rhinovirus in respiratory epithelial cells. Allergy 70 (2015), 910–920.
    • (2015) Allergy , vol.70 , pp. 910-920
    • Contoli, M.1    Ito, K.2    Padovani, A.3    Poletti, D.4    Marku, B.5    Edwards, M.R.6
  • 89
    • 84865145614 scopus 로고    scopus 로고
    • Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial
    • Pavord, I.D., Korn, S., Howarth, P., Bleecker, E.R., Buhl, R., Keene, O.N., et al. Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial. Lancet 380 (2012), 651–659.
    • (2012) Lancet , vol.380 , pp. 651-659
    • Pavord, I.D.1    Korn, S.2    Howarth, P.3    Bleecker, E.R.4    Buhl, R.5    Keene, O.N.6
  • 90
    • 84919382915 scopus 로고    scopus 로고
    • Benralizumab, an anti-interleukin 5 receptor alpha monoclonal antibody, versus placebo for uncontrolled eosinophilic asthma: a phase 2b randomised dose-ranging study
    • Castro, M., Wenzel, S.E., Bleecker, E.R., Pizzichini, E., Kuna, P., Busse, W.W., et al. Benralizumab, an anti-interleukin 5 receptor alpha monoclonal antibody, versus placebo for uncontrolled eosinophilic asthma: a phase 2b randomised dose-ranging study. Lancet Respir Med 2 (2014), 879–890.
    • (2014) Lancet Respir Med , vol.2 , pp. 879-890
    • Castro, M.1    Wenzel, S.E.2    Bleecker, E.R.3    Pizzichini, E.4    Kuna, P.5    Busse, W.W.6
  • 91
    • 81455155725 scopus 로고    scopus 로고
    • Reslizumab for poorly controlled, eosinophilic asthma: a randomized, placebo-controlled study
    • Castro, M., Mathur, S., Hargreave, F., Boulet, L.P., Xie, F., Young, J., et al. Reslizumab for poorly controlled, eosinophilic asthma: a randomized, placebo-controlled study. Am J Respir Crit Care Med 184 (2011), 1125–1132.
    • (2011) Am J Respir Crit Care Med , vol.184 , pp. 1125-1132
    • Castro, M.1    Mathur, S.2    Hargreave, F.3    Boulet, L.P.4    Xie, F.5    Young, J.6
  • 92
    • 35348909044 scopus 로고    scopus 로고
    • Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies
    • Wenzel, S., Wilbraham, D., Fuller, R., Getz, E.B., Longphre, M., Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies. Lancet 370 (2007), 1422–1431.
    • (2007) Lancet , vol.370 , pp. 1422-1431
    • Wenzel, S.1    Wilbraham, D.2    Fuller, R.3    Getz, E.B.4    Longphre, M.5
  • 93
    • 84905864457 scopus 로고    scopus 로고
    • Heightened response of eosinophilic asthmatic patients to the CRTH2 antagonist OC000459
    • Pettipher, R., Hunter, M.G., Perkins, C.M., Collins, L.P., Lewis, T., Baillet, M., et al. Heightened response of eosinophilic asthmatic patients to the CRTH2 antagonist OC000459. Allergy 69 (2014), 1223–1232.
    • (2014) Allergy , vol.69 , pp. 1223-1232
    • Pettipher, R.1    Hunter, M.G.2    Perkins, C.M.3    Collins, L.P.4    Lewis, T.5    Baillet, M.6
  • 94
    • 84989904460 scopus 로고    scopus 로고
    • Fevipiprant, a prostaglandin D2 receptor 2 antagonist, in patients with persistent eosinophilic asthma: a single-centre, randomised, double-blind, parallel-group, placebo-controlled trial
    • Gonem, S., Berair, R., Singapuri, A., Hartley, R., Laurencin, M.F., Bacher, G., et al. Fevipiprant, a prostaglandin D2 receptor 2 antagonist, in patients with persistent eosinophilic asthma: a single-centre, randomised, double-blind, parallel-group, placebo-controlled trial. Lancet Respir Med 4 (2016), 699–707.
    • (2016) Lancet Respir Med , vol.4 , pp. 699-707
    • Gonem, S.1    Berair, R.2    Singapuri, A.3    Hartley, R.4    Laurencin, M.F.5    Bacher, G.6
  • 95
    • 84929774279 scopus 로고    scopus 로고
    • Allergen-induced asthmatic responses modified by a GATA3-specific DNAzyme
    • Krug, N., Hohlfeld, J.M., Kirsten, A.M., Kornmann, O., Beeh, K.M., Kappeler, D., et al. Allergen-induced asthmatic responses modified by a GATA3-specific DNAzyme. N Engl J Med 372 (2015), 1987–1995.
    • (2015) N Engl J Med , vol.372 , pp. 1987-1995
    • Krug, N.1    Hohlfeld, J.M.2    Kirsten, A.M.3    Kornmann, O.4    Beeh, K.M.5    Kappeler, D.6
  • 96
    • 79952795093 scopus 로고    scopus 로고
    • Randomized trial of omalizumab (anti-IgE) for asthma in inner-city children
    • Busse, W.W., Morgan, W.J., Gergen, P.J., Mitchell, H.E., Gern, J.E., Liu, A.H., et al. Randomized trial of omalizumab (anti-IgE) for asthma in inner-city children. N Engl J Med 364 (2011), 1005–1015.
    • (2011) N Engl J Med , vol.364 , pp. 1005-1015
    • Busse, W.W.1    Morgan, W.J.2    Gergen, P.J.3    Mitchell, H.E.4    Gern, J.E.5    Liu, A.H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.