Rhinovirus-induced lower respiratory illness is increased in asthma and related to virus load and Th1/2 cytokine and IL-10 production

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 36, 2008, Pages 13562-13567

  Message, Simon D ^a,c   Laza Stanca, Vasile ^a   Mallia, Patrick ^a,c   Parker, Hayley L ^a   Zhu, Jie ^a   Kebadze, Tatiana ^a   Contoli, Marco ^a,b,c   Sanderson, Gwen ^a   Kon, Onn M ^c   Papi, Alberto ^b   Jeffery, Peter K ^a   Stanciu, Luminita A ^a   Johnston, Sebastian L ^a,c  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b UNIVERSITY OF FERRARA   (Italy)

^c NATIONAL HEALTH SERVICE   (United Kingdom)

Author keywords

Exacerbation; Human experimental virus infection; Immunology; Respiratory viruses

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5;

ADULT; ALLERGIC ASTHMA; ARTICLE; ASTHMA; BLOOD; BRONCHUS HYPERREACTIVITY; CELLULAR IMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE EXACERBATION; EOSINOPHIL; HUMAN; HUMAN CELL; IMMUNOPATHOLOGY; LOWER RESPIRATORY TRACT INFECTION; LUNG DISEASE; NEUTROPHIL; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RESPIRATORY FUNCTION; RESPIRATORY TRACT INFLAMMATION; RHINOVIRUS; SPUTUM; TH1 CELL; TH2 CELL; TRACHEOBRONCHIAL TOILET; VIRUS LOAD; VIRUS REPLICATION; VOLUNTEER;

ASTHMA; BRONCHOALVEOLAR LAVAGE; CELLS, CULTURED; CYTOKINES; HEALTH; HUMANS; LEUKOCYTES; PICORNAVIRIDAE INFECTIONS; RHINOVIRUS; TH1 CELLS; TH2 CELLS; TISSUE CULTURE TECHNIQUES;

RHINOVIRUS;

EID: 51649109114     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0804181105     Document Type: Article

References (29)

1. Campbell MJ, Holgate ST, Johnston SL (1997) Trends in asthmamortality. Br Med J 315:1012.
2. Weiss KB, Sullivan SD (2001) The health economics of asthma and rhinitis. I. Assessing the economic impact. J Allergy Clin Immunol 107:3-8.
3. Johnston NW, et al. (2005) The September epidemic of asthma exacerbations in children: A search for etiology. J Allergy Clin Immunol 115:132-138.
4. Pauwels RA, et al. (2003) Early intervention with budesonide in mild persistent asthma: A randomized, double-blind trial. Lancet 361:1071-1076.
5. Pauwels RA, et al. (1997) Effect of inhaled formoterol and budesonide on exacerbations of asthma. Formoterol and Corticosteroids Establishing Therapy (FACET) International Study Group. N Engl J Med 337:1405-1411.
6. Doull IJ, et al. (1997) Effect of inhaled corticosteroids on episodes of wheezing associated with viral infection in school-age children: Randomized double-blind placebo controlled trial. Br Med J 315:858-862.
7. Oommen A, et al. (2003) Efficacy of a short course of parent-initiated oral prednisolone for viral wheeze in children aged 1-5 years: Randomized controlled trial. Lancet 362:1433-1438.
8. Johnston SL, et al. (1995) Community study of role of viral infections in exacerbations of asthma in 9- to 11-year-old children. Br Med J 310:1225-1229.
9. 2) and the severity of virus-induced asthma in children. Lancet 361:1939-1944.
10. Wark PA, et al. (2002) Neutrophil degranulation and cell lysis is associated with clinical severity in virus-induced asthma. Eur Respir J 19:68-75.
11. Grissell TV, et al. (2005) Interleukin-10 gene expression in acute virus-induced asthma. Am J Respir Crit Care Med 172:433-439.
12. Corne JM, et al. (2002) Frequency, severity, and duration of rhinovirus infections in asthmatic and nonasthmatic individuals: A longitudinal cohort study. Lancet 359:831-834.
13. Wark PA, et al. (2005) Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus. J Exp Med 201:937-947.
14. Contoli M, et al. (2006) Role of deficient type III interferon-λ production in asthma exacerbations. Nat Med 12: 1023-1026.
15. Pizzichini MM, et al. (1998) Asthma and natural colds. Inflammatory indices in induced sputum: A feasibility study. Am J Respir Crit Care Med 158:1178-1184.
16. Lemanske RFJ, et al. (1989) Rhinovirus upper respiratory infection increases airway hyperreactivity and late asthmatic reactions. J Clin Invest 83:1-10.
17. Calhoun WJ, et al. (1994) A common cold virus, rhinovirus 16, potentiates airway inflammation after segmental antigen bronchoprovocation in allergic subjects. J Clin Invest 94:2200-2208.
18. Bardin PG, et al. (2000) Peak expiratory flow changes during experimental rhinovirus infection. Eur Respir J 16:980-985.
19. Grunberg K, et al. (1999) Experimental rhinovirus 16 infection causes variable airway obstruction in subjects with atopic asthma. Am J Respir Crit Care Med 160:1375-1380.
20. Cheung D, et al. (1995) Rhinovirus inhalation causes long-lasting excessive airway narrowing in response to methacholine in asthmatic subjects in vivo. Am J Respir Crit Care Med 152:1490-1496.
21. Fraenkel DJ, et al. (1995) Lower airways inflammation during rhinovirus colds in normal and in asthmatic subjects. Am J Respir Crit Care Med 151:879-886.
22. Fleming HE, et al. (1999) Rhinovirus-16 colds in healthy and in asthmatic subjects: Similar changes in upper and lower airways. Am J Respir Crit Care Med 160:100-108.
23. Gern JE, et al. (2000) Relationship of upper and lower airway cytokines to outcome of experimental rhinovirus infection. Am J Respir Crit Care Med 162:2226-2231.
24. Hawrylowicz CM, O'Garra A (2005) Potential role of interleukin-10- secreting regulatory T cells in allergy and asthma. Nat Rev Immunol. 5:271-283.
25. Busse WW, Gern JE (2005) Is interleukin-10 a "10" in virus-provoked asthma? Am J Respir Crit Care Med 172:405-406.
26. Message SD, Johnston SL (2004) Host defense function of the airway epithelium in health and disease: Clinical background. J Leukocyte Biol 75:5-17.
27. Bartlett NW, et al. (2008) Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation. Nat Med 14:199-204.
28. Bardin PG, et al. (1996) Experimental rhinovirus infection in volunteers. Eur Respir J 9:2250-2255.
29. + T cell type 1 and type 2 cytokine production in atopic asthmatic and normal subjects. Clin Exp All 32:427-433.