The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity

Nature Medicine

Volumn 19, Issue 2, 2013, Pages 232-237

  Collison, Adam ^a   Hatchwell, Luke ^a   Verrills, Nicole ^a   Wark, Peter A B ^a,b   De Siqueira, Ana Pereira ^a   Tooze, Melinda ^a,b   Carpenter, Helen ^a   Don, Anthony S ^c   Morris, Jonathan C ^d   Zimmermann, Nives ^e   Bartlett, Nathan W ^f   Rothenberg, Marc E ^e   Johnston, Sebastian L ^f   Foster, Paul S ^a   Mattes, Joerg ^a,g  

^a UNIVERSITY OF NEWCASTLE   (Australia)

^b JOHN HUNTER HOSPITAL   (Australia)

^c UNIVERSITY OF NEW SOUTH WALES   (Australia)

^d UNIVERSITY OF NEW SOUTH WALES   (Australia)

^e UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^f NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^g Paediatric Respiratory and Sleep Medicine Unit   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; E3 UBIQUITIN LIGASE MIDLINE 1; FINGOLIMOD; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 13; INTERLEUKIN 25; INTERLEUKIN 33; INTERLEUKIN 5; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHOPROTEIN PHOSPHATASE 2A; SMALL INTERFERING RNA; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ALLERGIC AIRWAY INFLAMMATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTHMA; BRONCHUS MUCOSA; CONTROLLED STUDY; DERMATOPHAGOIDES; DISEASE COURSE; DISEASE EXACERBATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; EOSINOPHIL; EPITHELIUM CELL; GENE SILENCING; MALE; MOUSE; MYELOID DENDRITIC CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; RHINOVIRUS; RHINOVIRUS INFECTION; T LYMPHOCYTE; UPREGULATION;

ALLERGENS; ANIMALS; ASTHMA; CELLS, CULTURED; HUMANS; MALE; MICE; MICE, INBRED BALB C; MICROTUBULE PROTEINS; NUCLEAR PROTEINS; PICORNAVIRIDAE INFECTIONS; PROTEIN PHOSPHATASE 2; PROTEINS; RHINOVIRUS; TRANSCRIPTION FACTORS; UBIQUITIN-PROTEIN LIGASES;

MUS; PYROGLYPHIDAE; RHINOVIRUS;

EID: 84873569230     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.3049     Document Type: Article

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