Functional polymorphism in the suppressor of cytokine signaling 1 gene associated with adult asthma

American Journal of Respiratory Cell and Molecular Biology

Volumn 36, Issue 4, 2007, Pages 491-496

  Harada, Michishige ^b   Nakashima, Kazuko ^b   Hirota, Tomomitsu ^b   Shimizu, Makiko ^b   Doi, Satoru ^b   Fujita, Kimie ^b   Shirakawa, Taro ^b   Enomoto, Tadao ^b   Yoshikawa, Mamoru ^b   Moriyama, Hiroshi ^b   Matsumoto, Kenji ^b   Saito, Hirohisa ^b   Suzuki, Yoichi ^b   Nakamura, Yusuke ^b   Tamari, Mayumi ^a  

^a INST OF PHYS AND CHEMICAL RESEARCH   (Japan)

^b NONE

Author keywords

Association study; Bronchial asthma; Haplotype; Polymorphisms; SOCS1

Indexed keywords

INTERFERON; STAT1 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 1;

ADULT; AGED; ARTICLE; ASTHMA; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE COURSE; FEMALE; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE LINKAGE DISEQUILIBRIUM; GENE MAPPING; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC EPIDEMIOLOGY; GENETIC SCREENING; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE PHENOTYPE CORRELATION; HAPLOTYPE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; JAPANESE; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; POPULATION GENETIC PARAMETERS; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REPORTER GENE; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; SOCS1 GENE; SUPPRESSOR GENE; TRANSCRIPTION REGULATION; VIRUS INFECTION;

ADULT; AGED; ASTHMA; CHROMOSOME MAPPING; DISEASE SUSCEPTIBILITY; FEMALE; GENE FREQUENCY; GENES, REPORTER; HAPLOTYPES; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS (GENETICS); SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; TRANSFECTION;

EID: 34247265510     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2006-0090OC     Document Type: Article

References (36)

1. Kay AB. Allergy and allergic diseases: first of two parts. N Engl J Med 2001;344:30-37.
2. Kay AB. Allergy and allergic diseases: second of two parts. N Engl J Med 2001;344:109-113.
3. Renauld JC. New insights into the role of cytokines in asthma. J Clin Pathol 2001;54:577-589.
4. Alexander WS. Suppressors of cytokine signalling (SOCS) in the immune system. Nut Rev Immunol 2002;2:410-416.
5. Kubo M, Hanada T, Yoshimura A. Suppressors of cytokine signaling and immunity. Nat Immunol 2003;4:1169-1176.
6. Marine JC, Topham DJ, McKay C, Wang D, Parganas E, Stravopodis D, Yoshimura A, Ihle JN. SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality. Cell 1999;98:609-616.
7. Alexander WS, Starr R, Fenner JE, Scott CL, Handman E, Sprigg NS, Corbin JE, Cornish AL, Darwiche R, Owczarek CM, et al. SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine. Cell 1999;98:597-608.
8. Gern JE. Viral and bacterial infections in the development and progression of asthma. J Allergy Clin Immunol 2000;105:5497-5502.
9. Message SD, Johnston SL. Viruses in asthma. Br Med Bull 2002;61:29-43.
10. Fenner JE, Starr R, Cornish AL, Zhang JG, Metcalf D, Schreiber RD, Sheehan K, Hilton DJ, Alexander WS, Hertzog PJ. Suppressor of cytokine signaling 1 regulates the immune response to infection by a unique inhibition of type I interferon activity. Nat Immunol 2006;7:33-39.
11. Yasukawa H, Yajima T, Duplain H, Iwatate M, Kido M, Hoshijima M, Weitzman MD, Nakamura T, Woodard S, Xiong D, et al. The suppressor of cytokine signaling-1 (SOCS1) is a novel therapeutic target for enterovirus-induced cardiac injury. J Clin Invest 2003;111:469-478.
12. Brand S, Zitzmann K, Dambacher J, Beigel F, Olszak T, Vlotides G, Eichhorst ST, Goke B, Diepolder H, Auernhammer CJ. SOCS-1 inhibits expression of the antiviral proteins 2′,5′-OAS and MxA induced by the novel interferon-lambdas IL-28A and IL-29. Biochem Biophys Res Commun 2005;331:543-548.
13. Dai X, Sayama K, Yamasaki K, Tohyama M, Shirakata Y, Hanakawa Y, Tokumaru S, Yahata Y, Yang L, Yoshimura A, et al. SOCS1-negative feedback of STAT1 activation is a key pathway in the dsRNA-induced innate immune response of human keratinocytes. J Invest Dermatol 2006;126:1574-1581.
14. Palmer LJ, Cookson WO. Using single nucleotide polymorphisms as a means to understanding the pathophysiology of asthma. Respir Res 2001;2:102-112.
15. Cookson WO, Moffatt MF. Genetics of asthma and allergic disease. Hum Mol Genet 2000;9:2359-2364.
16. Hoffjan S, Ober C. Present status on the genetic studies of asthma. Curr Opin Immunol 2002;14:709-717.
17. Nakao F, Ihara K, Kusuhara K, Sasaki Y, Kinukawa N, Takabayashi A, Nishima S, Hara T. Association of IFN-gamma and IFN regulatory factor 1 polymorphisms with childhood atopic asthma. J Allergy Clin Immunol 2001;107:499-504.
18. Birkisson IF, Halapi E, Bjornsdottir US, Shkolny DL, Adalsteinsdottir E, Arnason T, Gislason D, Gislason T, Gulcher J, Stefansson K, et al. Genetic approaches to assessing evidence for a T helper type 1 cytokine defect in adult asthma. Am J Respir Crit Care Med 2004;169:1007-1013.
19. American Thoracic Society. Chronic bronchitis, asthma and pulmonary emphysema: a statement by the Committee on Diagnostic Standards for Nontuberculous Respiratory Diseases. Am Rev Respir Dis 1962;85:762-768.
20. Fujita K, Kasayama S, Hashimoto J, Nagasaka Y, Nakano N, Morimoto Y, Barnes PJ, Miyatake A. Inhaled corticostcroids reduce bone mineral density in early postmenopausal but not premenopausal asthmatic women. J Bone Miner Res 2001;16:782-787.
21. Matsuda A, Hirota T, Akahoshi M, Shimizu M, Tamari M, Miyatake A, Takahashi A, Nakashima K, Takahashi N, Obara K, et al. Coding SNP in tenascin-C Fn-III-D domain associates with adult asthma. Hum Mol Genet 2005;14:2779-2786.
22. Hirota T, Suzuki Y, Hasegawa K, Obara K, Matsuda A, Akahoshi M, Nakashima K, Cheng L, Takahashi N, Shimizu M, et al. Functional haplotypes of IL-12B are associated with childhood atopic asthma. J Allergy Clin Immunol 2005;116:789-795.
23. Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention. National Institutes of Health, 2002, NIH pub. No. 02-3659.
24. Pritchard JK, Rosenberg NA. Use of unlinked genetic markers to detect population stratification in association studies. Am J Hum Genet 1999;65:220-228.
25. Yoshikawa M, Nakajima T, Matsumoto K, Okada N, Tsukidate T, Iida M, Otori N, Haruna S, Moriyama H, Imai T, et al. TNF-alpha and IL-4 regulate expression of fractalkine (CX3CL1) as a membrane-anchored proadhesive protein and soluble chemotactic peptide on human fibroblasts. FEBS Lett 2004;561:105-110.
26. Gern JE, Busse WW. Relationship of viral infections to wheezing illnesses and asthma. Nat Rev Immunol 2002;2:132-138.
27. Nicholson KG, Kent J, Ireland DC. Respiratory viruses and exacerbations of asthma in adults. BMJ 1993;307:982-986.
28. Muller U, Steinhoff U, Reis LF, Hemmi S, Pavlovic J, Zinkernagel RM, Aguet M. Functional role of type I and type II interferons in antiviral defense. Science 1994;264:1918-1921.
29. Wark PA, Johnston SL, Bucchieri F, Powell R, Puddicombe S, Laza-Stanca V, Holgate ST, Davies DE. Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus. J Exp Med 2005;201:937-947.
30. Neurath MF, Finotto S, Glimcher LH. The role of Th1/Th2 polarization in mucosal immunity. Nat Med 2002;8:567-573.
31. Ebner C, Schenk S, Najafian N, Siemann U, Steiner R, Fischer GW, Hoffmann K, Szepfalusi Z, Scheiner O, Kraft D. Nonallergic individuals recognize the same T cell epitopes of Bet v 1, the major birch pollen allergen, as atopic patients. J immunol 1995;154:1932-1940.
32. Papadopoulos NG, Stanciu LA, Papi A, Holgate ST, Johnston SL. A defective type I response to rhinovirus in atopic asthma. Thorax 2002;57:328-332.
33. Eyles JL, Metcalf D, Grusby MJ, Hilton DJ, Starr R. Negative regulation of interleukin-12 signaling by suppressor of cytokine signaling-1. J Biol Chem 2002;277:43735-43740.
34. Leonard C, Tormey V, Burke C, Poulter LW. Allergen-induced cytokine production in atopic disease and its relationship to disease severity. Am J Respir Cell Mol Biol 1997;17:368-375.
35. Smart JM, Horak E, Kemp AS, Robertson CF, Tang ML. Polyclonal and allergen-induced cytokine responses in adults with asthma: resolution of asthma is associated with normalization of IFN-gamma responses. J Allergy Clin Immunol 2002;110:450-456.
36. Brooks GD, Buchta KA, Swenson CA, Gern JE, Busse WW. Rhinovirus-induced interferon-gamma and airway responsiveness in asthma. Am J Respir Crit Care Med 2003;168:1091-1094.