Atypical pulmonary eosinophilia is mediated by a specific amino acid sequence of the attachment (G) protein of respiratory syncytial virus

Journal of Experimental Medicine

Volumn 188, Issue 10, 1998, Pages 1967-1972

  Tebbey, Paul W ^a   Hagen, Michael ^a   Hancock, Gerald E ^a  

^a Wyeth Lederle Vaccines and Pediat ^*  (United States)

Author keywords

Eosinophilia; G protein; Peptide; Respiratory syncytial virus; T helper cell

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 5; PEPTIDE; VIRUS PROTEIN;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CYTOKINE PRODUCTION; EOSINOPHILIA; HELPER CELL; IMMUNE RESPONSE; IMMUNOPATHOLOGY; LUNG DISEASE; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; SPLEEN CELL;

AMINO ACID SEQUENCE; ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL DIVISION; CYTOKINES; HEMOCYANIN; HUMANS; LEUKOCYTES, MONONUCLEAR; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PULMONARY EOSINOPHILIA; RESPIRATORY SYNCYTIAL VIRUSES; SPLEEN; VACCINATION; VIRAL PROTEINS;

EID: 0032538913     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.188.10.1967     Document Type: Article

References (28)

1. Hancock, G.E., D.J. Speelman, K. Heers, E. Bortell, J. Smith, and C. Cosco. 1996. Generation of atypical pulmonary inflammatory responses in BALB/c mice after immunization with the native attachment (G) glycoprotein of respiratory syncytial virus. J. Virol. 70:7783-7791.
2. Hall, C.B., E.E. Walsh, C.E. Long, and K.C. Schnabel. 1991. Immunity to and frequency of reinfection with respiratory syncytial virus. J. Infect. Dis. 163:693-698.
3. Murphy, B.R., D.W. Alling, M.H. Snyder, E.E. Walsh, G.A. Prince, R.M. Chanock, V.G. Hemming, W.J. Rodriguez, H.W. Kim, B.S. Graham, and P.F. Wright. 1986. Effect of age and preexisiting antibody on serum antibody response of infants and children to the F and G glycoproteins during respiratory syncytial virus infection. J. Clin. Microbiol. 24:894-898.
4. Alwan, W., and P. Openshaw. 1993. Distinct patterns of T-and B-cell immunity to respiratory syncytial virus induced by individual viral proteins. Vaccine. 11:431-437.
5. Kim, H.W., J.G. Canchola, C.D. Brandt, R.M. Chanock, K. Jensen, and R.H. Parrott. 1969. Respiratory syncytial virus disease in infants despite prior administration of antigenic inactivated vaccine. Am. J. Epidemiol. 89:422-434.
6. Connors, M., N.A. Giese, A.B. Kulkarni, C.-Y. Firestone, H.C. Morse, and B.R. Murphy. 1994. Enhanced pulmonary histopathology induced by respiratory syncytial virus (RSV) challenge of formalin-inactivated RSV-immunized BALB/c mice is abrogated by depletion of IL-4 and IL-10. J. Virol. 68: 5321-5325.
7. Graham, B.S. 1996. Immunological determinants of disease caused by respiratory syncytial virus. Trends Microbiol. 4:290-294.
8. Waris, M.E., C. Tsou, D.D. Erdman, S.R. Zaki, and L.J. Anderson. 1996. Respiratory syncytial virus infection in BALB/c mice previously immunized with formalin-inactivated virus induces enhanced pulmonary inflammatory response with a predominant Th2-like cytokine pattern. J. Virol. 70:2852-2860.
9. Wertz, G.W., P.L. Collins, Y. Huang, C. Gruber, S. Levine, and L.A. Ball. 1985. Nucleotide sequence of the G protein gene of human respiratory syncytial virus reveals an unusual type of viral membrane protein. Proc. Natl. Acad. Sci. USA. 82:4075-4079.
10. Alwan, W.H., W.J. Kozlowska, and P.J.M. Openshaw. 1994. Distinct types of lung disease caused by functional subsets of antiviral T cells. J. Exp. Med. 179:81-89.
11. Roberts, S.R., D. Lichtenstein, L.A. Ball, and G.W. Wertz. 1994. The membrane-associated and secreted forms of the respiratory syncytial virus attachment glycoprotein G are synthesized from alternative initiation codons. J. Virol. 68:4538-4546.
12. Johnson, T.R., J.E. Johnson, S.R. Roberts, G.W. Wertz, R.A. Parker, and B.S. Graham. 1998. Priming with secreted glycoprotein G of respiratory syncytial virus (RSV) augments Interleukin-5 production and tissue eosinophilia after RSV challenge. J. Virol. 72:2871-2880.
13. Partis, M.D., D.G. Griffifths, G.C. Roberts, and R.B. Beechey. 1983. Cross-linking of protein by ω-maleimido alkanoyl N-hydroxysuccinimido esters. J. Prot. Chem. 2:263-277.
14. Tsao, J., X. Lin, H. Lackland, G. Tous, Y. Wu, and S. Stein. 1991. Internally standardized amino acid analysis for determining peptide/carrier protein coupling ratio. Anal. Biochem. 197:137-142.
15. Curry, R.C., P.A. Kiener, and G.L. Spitalny. 1987. A sensitive immunochemical assay for biologically active murine IFN-γ. J. Immunol. Methods. 104:137-142.
16. Familletti, P.C., S. Rubinstein, and S. Pestka. 1981. A convenient and rapid cytopathic effect inhibition assay for interferon. Methods Enzymol. 78:387-394.
17. Coffman, R.L., W.P. Seymour, S. Hudak, J. Jackson, and D. Rennick. 1989. Antibody to interleukin-5 inhibits helminth-induced eosinophilia in mice. Science. 245:308-310.
18. Pfieffer, C., J. Stein, S. Southwood, H. Ketelaar, A. Sette, and K. Bottomly. 1995. Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo. J. Exp. Med. 181: 1569-1574.
19. Murray, J.S., D. Ferrandis-Edwards, C.J. Wolfe, and T. Schountz. 1994. Major histocompatibility complex regulation of T helper functions mapped to a peptide C terminus that controls ligand density. Eur. J. Immunol. 24:2337-2344.
20. Rammensee, H-G., T. Friede, and S. Stevanovic. 1995. MHC ligand and peptide motifs: first listing. Immunogenetics. 41:178-228.
21. Tebbey, P.W., and G.E. Hancock. 1997. Characterization of immune responses to the attachment (G) protein of respiratory syncytial virus in inbred mice. 10th International Conference on Negative Strand Viruses. A152 (Abstr.)
22. Sparer, T.E., S. Matthews, T. Hussell, A.J. Rae, B. Garcia-Barreno, J.A. Melero, and P.J.M. Openshaw. 1998. Eliminating a region of respiratory syncytial virus attachment protein allows induction of protective immunity without vaccine-enhanced lung eosinophilia. J. Exp. Med. 187:1921-1926.
23. Trudel, M., F. Nadon, C. Seguin, and H. Binz. 1991. Protection of BALB/c mice from respiratory syncytial virus infection by immunization with a synthetic peptide derived from the G glycoprotein. Virology. 185:749-757.
24. Mosmann, T.R., H. Cherwinski, M.W. Bond, M.A. Giedlin, and R.L. Coffman. 1986. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136:2348-2357.
25. Abbas, A.K., K.M. Murphy, and A. Sher. 1996. Functional diversity of helper T lymphocytes. Nature. 383:787-793.
26. + T lymphocytes downregulate T helper cell type 2 cytokine secretion and pulmonary eosinophilia during experimental murine respiratory syncytial virus infection. J. Exp. Med. 186:421-432.
27. + T cells control Th2-driven pathology during pulmonary respiratory syncytial virus infection. Eur. J. Immunol. 27:3341-3349.
28. Welliver, J.R., and R.C. Welliver. 1993. Bronchiolitis. Pediatr. Rev. 14:134-139.