MDA5 and TLR3 initiate pro-inflammatory signaling pathways leading to rhinovirus-induced airways inflammation and hyperresponsiveness

PLoS Pathogens

Volumn 7, Issue 5, 2011, Pages

  Wang, Qiong ^a   Miller, David J ^a   Bowman, Emily R ^a   Nagarkar, Deepti R ^a   Schneider, Dina ^a   Zhao, Ying ^a   Linn, Marisa J ^a   Goldsmith, Adam M ^a   Bentley, J Kelley ^a   Sajjan, Umadevi S ^a   Hershenson, Marc B ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; ALPHA2 INTERFERON; BETA INTERFERON; CXCL1 CHEMOKINE; CXCL2 CHEMOKINE; DOUBLE STRANDED RNA; EOTAXIN; GAMMA INTERFERON; MELANOMA DIFFERENTIATION ASSOCIATED GENE 5 PROTEIN; MONOCYTE CHEMOTACTIC PROTEIN 1; OVALBUMIN; PROTEIN; TOLL LIKE RECEPTOR 3; UNCLASSIFIED DRUG; VIRUS RNA; DEAD BOX PROTEIN; IFIH1PROTEIN, MOUSE; INTERFERON; TLR3 PROTEIN, MOUSE;

AIRWAY RESISTANCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATTENUATION; CONTROLLED STUDY; COPY NUMBER VARIATION; CYTOKINE PRODUCTION; FEMALE; IMMUNE RESPONSE; IN VIVO STUDY; MOUSE; NONHUMAN; OUTCOME ASSESSMENT; PNEUMONIA; RHINOVIRUS; RHINOVIRUS INFECTION; SIGNAL TRANSDUCTION; ULTRAVIOLET RADIATION; VIRUS ATTENUATION; VIRUS LOAD; VIRUS REPLICATION; ANIMAL; BRONCHUS HYPERREACTIVITY; C57BL MOUSE; DISEASE MODEL; INFLAMMATION; ISOLATION AND PURIFICATION; LUNG; LUNG DISEASE; MALE; METABOLISM; MOUSE MUTANT; PATHOPHYSIOLOGY; PHYSIOLOGY; PICORNAVIRUS INFECTION; VIROLOGY;

MUS; PICORNAVIRIDAE; RHINOVIRUS;

ANIMALS; BRONCHIAL HYPERREACTIVITY; DEAD-BOX RNA HELICASES; DISEASE MODELS, ANIMAL; INFLAMMATION; INTERFERONS; LUNG; LUNG DISEASES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PICORNAVIRIDAE INFECTIONS; RHINOVIRUS; RNA, DOUBLE-STRANDED; RNA, VIRAL; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 3;

EID: 79958062793     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1002070     Document Type: Article

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