IFN-α/IFN-λ responses to respiratory viruses in paediatric asthma

European Respiratory Journal

Volumn 49, Issue 2, 2017, Pages

  Bergauer, Annika ^a   Sopel, Nina ^a   Kroß, Bettina ^a   Vuorinen, Tytti ^b   Xepapadaki, Paraskevi ^c   Weiss, Scott T ^d   Blau, Ashley ^d   Sharma, Himanshu ^d   Kraus, Cornelia ^a   Springel, Rebekka ^a   Rauh, Manfred ^a   Mittler, Susanne ^a   Graser, Anna ^a   Zimmermann, Theodor ^a   Melichar, Volker O ^a   Kiefer, Alexander ^a   Kowalski, Marek L ^e   Sobanska, Anna ^e   Jartti, Tuomas ^f   Lukkarinen, Heikki ^f,g   Papadopoulos, Nikolaos G ^c,h   Finotto, Susetta ^a   more..

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b UNIVERSITY OF TURKU   (Finland)

^c UNIVERSITY OF ATHENS   (Greece)

^d PARTNERS HEALTHCARE   (United States)

^e MEDICAL UNIVERSITY OF LODZ   (Poland)

^f TURKU UNIVERSITY HOSPITAL   (Finland)

^g UNIVERSITY OF TURKU   (Finland)

^h UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; C REACTIVE PROTEIN; INTERFERON; INTERFERON REGULATORY FACTOR 1; INTERFERON REGULATORY FACTOR 9; LAMBDA INTERFERON; MYELOID DIFFERENTIATION FACTOR 88; STAT1 PROTEIN; STAT2 PROTEIN; UNCLASSIFIED DRUG; IRF1 PROTEIN, HUMAN; MESSENGER RNA; MYD88 PROTEIN, HUMAN; STAT1 PROTEIN, HUMAN; STAT2 PROTEIN, HUMAN;

ARTICLE; ASTHMA; CHILD; CHILDHOOD DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE EXACERBATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IRF1 GENE; IRF9 GENE; MALE; MYD88 GENE; NONHUMAN; REAL TIME POLYMERASE CHAIN REACTION; RHINOVIRUS; RHINOVIRUS INFECTION; STAT1 GENE; STAT2 GENE; UPREGULATION; BLOOD; CELL CULTURE; CLINICAL TRIAL; EUROPE; GENETICS; IMMUNOLOGY; MONONUCLEAR CELL; MULTICENTER STUDY; NASOPHARYNX; PICORNAVIRUS INFECTION; PRESCHOOL CHILD; PROSPECTIVE STUDY; SIGNAL TRANSDUCTION; VIROLOGY;

ASTHMA; C-REACTIVE PROTEIN; CELLS, CULTURED; CHILD, PRESCHOOL; DISEASE PROGRESSION; EUROPE; FEMALE; HUMANS; INTERFERON REGULATORY FACTOR-1; INTERFERONS; LEUKOCYTES, MONONUCLEAR; MALE; MYELOID DIFFERENTIATION FACTOR 88; NASOPHARYNX; PICORNAVIRIDAE INFECTIONS; PROSPECTIVE STUDIES; RHINOVIRUS; RNA, MESSENGER; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; STAT2 TRANSCRIPTION FACTOR;

EID: 85013481353     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/13993003.00969-2016     Document Type: Article

References (31)

1. Leigh R, Proud D. Virus-induced modulation of lower airway diseases: pathogenesis and pharmacologic approaches to treatment. Pharmacol Ther 2015; 148: 185-198.
2. Proud D. Role of rhinovirus infections in asthma. Asian Pac J Allergy Immunol 2011; 29: 201-208.
3. Papadopoulos NG, Christodoulou I, Rohde G, et al. Viruses and bacteria in acute asthma exacerbations -A GA2LENDARE systematic review. Allergy 2011; 66: 458-468.
4. Xepapadaki P, Papadopoulos NG. Childhood asthma and infection: virus-induced exacerbations as determinants and modifiers. Eur Respir J 2010; 36: 438-445.
5. Jackson DJ, Johnston SL. The role of viruses in acute exacerbations of asthma. J Allergy Clin Immunol 2010; 125: 1178-1187.
6. Sykes A, Edwards MR, Macintyre J, et al. Rhinovirus 16-induced IFN-Alpha and IFN-beta are deficient in bronchoalveolar lavage cells in asthmatic patients. J Allergy Clin Immunol 2012; 129: 1506-1514.
7. Donnelly RP, Kotenko SV. Interferon-lambda: A new addition to an old family. J Interferon Cytokine Res 2010; 30: 555-564.
8. Ruuskanen O, Waris M, Kainulainen L. Treatment of persistent rhinovirus infection with pegylated interferon alpha2a and ribavirin in patients with hypogammaglobulinemia. Clin Infect Dis 2014; 58: 1784-1786.
9. Contoli M, Message SD, Laza-Stanca V, et al. Role of deficient type III interferon-lambda production in asthma exacerbations. Nat Med 2006; 12: 1023-1026.
10. Durbin RK, Kotenko SV, Durbin JE. Interferon induction and function at the mucosal surface. Immunol Rev 2013; 255: 25-39.
11. Platanias LC. Mechanisms of type-I-And type-II-interferon-mediated signalling. Nat Rev Immunol 2005; 5: 375-386.
12. Koch S, Finotto S. Role of interferon-lambda in allergic asthma. J Innate Immun 2015; 7: 224-230.
13. Ivashkiv LB, Donlin LT. Regulation of type I interferon responses. Nat Rev Immunol 2014; 14: 36-49.
14. Fenner JE, Starr R, Cornish AL, et al. Suppressor of cytokine signaling 1 regulates the immune response to infection by a unique inhibition of type I interferon activity. Nat Immunol 2006; 7: 33-39.
15. Szefler SJ, Chmiel JF, Fitzpatrick AM, et al. Asthma across the ages: knowledge gaps in childhood asthma. J Allergy Clin Immunol 2014; 133: 3-13.
16. Koch S, Graser A, Mirzakhani H, et al. Increased expression of nuclear factor of activated T cells 1 drives IL-9-mediated allergic asthma. J Allergy Clin Immunol 2016; 137: 1898-1902.
17. Graser A, Ekici AB, Sopel N, et al. Rhinovirus inhibits IL-17A and the downstream immune responses in allergic asthma. Mucosal Immunol 2016; 9: 1183-1192.
18. Koch S, Mousset S, Graser A, et al. IL-6 activated integrated BATF/IRF4 functions in lymphocytes are T-bet-independent and reversed by subcutaneous immunotherapy. Sci Rep 2013; 3.
19. Ubel C, Sopel N, Graser A, et al. The activating protein 1 transcription factor basic leucine zipper transcription factor, ATF-like (BATF), regulates lymphocyte-And mast cell-driven immune responses in the setting of allergic asthma. J Allergy Clin Immunol 2014; 133: 198-206 e199.
20. Najjar I, Schischmanoff PO, Baran-Marszak F, et al. Novel function of STAT1beta in B cells: induction of cell death by a mechanism different from that of STAT1alpha. J Leukoc Biol 2008; 84: 1604-1612.
21. Pepys MB, Hirschfield GM. C-reactive protein: A critical update. J Clin Invest 2003; 111: 1805-1812.
22. Wark PA, Johnston SL, Bucchieri F, et al. Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus. J Exp Med 2005; 201: 937-947.
23. Khaitov MR, Laza-Stanca V, Edwards MR, et al. Respiratory virus induction of alpha-, beta-And lambda-interferons in bronchial epithelial cells and peripheral blood mononuclear cells. Allergy 2009; 64: 375-386.
24. McClain MT, Henao R, Williams J, et al. Differential evolution of peripheral cytokine levels in symptomatic and asymptomatic responses to experimental influenza virus challenge. Clin Exp Immunol 2016; 183: 441-451.
25. Hansbro NG, Horvat JC, Wark PA, et al. Understanding the mechanisms of viral induced asthma: new therapeutic directions. Pharmacol Ther 2008; 117: 313-353.
26. Gern JE. How rhinovirus infections cause exacerbations of asthma. Clin Exp Allergy 2015; 45: 32-42.
27. Jartti T, Nieminen R, Vuorinen T, et al. Short-And long-Term efficacy of prednisolone for first acute rhinovirus-induced wheezing episode. J Allergy Clin Immunol 2015; 135: 691-698.
28. Lehtinen P, Ruohola A, Vanto T, et al. Prednisolone reduces recurrent wheezing after a first wheezing episode associated with rhinovirus infection or eczema. J Allergy Clin Immunol 2007; 119: 570-575.
29. Finney LJ, Ritchie A, Pollard E, et al. Lower airway colonization and inflammatory response in COPD: A focus on Haemophilus influenzae. Int J Chron Obstruct Pulmon Dis 2014; 9: 1119-1132.
30. Papadopoulos NG, Bates PJ, Bardin PG, et al. Rhinoviruses infect the lower airways. J Infect Dis 2000; 181: 1875-1884.
31. Corne JM, Marshall C, Smith S, et al. Frequency, severity, and duration of rhinovirus infections in asthmatic and non-Asthmatic individuals: A longitudinal cohort study. Lancet 2002; 359: 831-834.