Identification of a nuclear localization signal in suppressor of cytokine signaling 1

FASEB Journal

Volumn 22, Issue 12, 2008, Pages 4296-4305

  Baetz, Andrea ^a   Koelsche, Christian ^a   Strebovsky, Julia ^a   Heeg, Klaus ^a   Dalpke, Alexander H ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Cell activation; Cytokine receptors; Inflammation; Signal transduction

Indexed keywords

GAMMA INTERFERON; INTERCELLULAR ADHESION MOLECULE 1; PROTEIN SH2; STAT1 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 1;

ANIMAL CELL; ARTICLE; CELL STIMULATION; CONTROLLED STUDY; GENE DELETION; GENE MUTATION; HUMAN; HUMAN CELL; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SEQUENCE ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CELL NUCLEUS; HELA CELLS; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; INTERFERONS; MICE; MOLECULAR SEQUENCE DATA; MUTATION; NIH 3T3 CELLS; NUCLEAR LOCALIZATION SIGNALS; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS;

EID: 57349102472     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.08-116079     Document Type: Article

References (39)

1. Naka, T., Fujimoto, M., Tsutsui, H., and Yoshimura, A. (2005) Negative regulation of cytokine and TLR signalings by SOCS and others. Adv. Immunol. 87, 61-122
2. Alexander, W. S., and Hilton, D. J. (2003) The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response. Annu. Rev. Immunol. 22, 503-529
3. Hilton, D. J., Richardson, R. T., Alexander, W. S., Viney, E. M., Willson, T. A., Sprigg, N. S., Starr, R., Nicholson, S. E., Metcalf, D., and Nicola, N. A. (1998) Twenty proteins containing a C-terminal SOCS box form five structural classes. Proc. Natl. Acad. Sci. U. S. A. 95, 114-119
4. Yasukawa, H., Misawa, H., Sakamoto, H., Masuhara, M., Sasaki, A., Wakioka, T., Ohtsuka, S., Imaizumi, T., Matsuda, T., Ihle, J. N., and Yoshimura, A. (1999) The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop. EMBO J. 18, 1309-1320
5. Schmitz, J., Weissenbach, M., Haan, S., Heinrich, P. C., and Schaper, F. (2000) SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130. J. Biol. Chem. 275, 12848-12856
6. Nicholson, S. E., De Souza, D., Fabri, L. J., Corbin, J., Willson, T. A., Zhang, J. G., Silva, A., Asimakis, M., Farley, A., Nash, A. D., Metcalf, D., Hilton, D. J., Nicola, N. A., and Baca, M. (2000) Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130. Proc. Natl. Acad. Sci. U. S. A. 97, 6493-6498
7. Kamura, T., Maenaka, K., Kotoshiba, S., Matsumoto, M., Kohda, D., Conaway, R. C., Conaway, J. W., and Nakayama, K. I. (2004) VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases. Genes Dev. 18, 3055-3065
8. Kamura, T., Sato, S., Haque, D., Liu, L., Kaelin, W. G. J., Conaway, R. C., and Conaway, J. W. (1998) The elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families. Genes Dev. 12, 3872-3881
9. Bullock, A. N., Debreczeni, J. E., Edwards, A. M., Sundstrom, M., and Knapp, S. (2006) Crystal structure of the SOCS2-elongin C-elongin B complex defines a prototypical SOCS box ubiquitin ligase. Proc. Natl. Acad. Sci. U. S. A. 103, 7637-7642
10. Zhang, J. G., Farley, A., Nicholson, S. E., Willson, T. A., Zugaro, L. M., Simpson, R. J., Moritz, R. L., Cary, D., Richardson, R., Hausmann, G., Kile, B. J., Kent, S. B., Alexander, W. S., Metcalf, D., Hilton, D. J., Nicola, N. A., and Baca, M. (1999) The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation. Proc. Natl. Acad. Sci. U. S. A. 96, 2071-2076
11. Maine, G. N., Mao, X., Komarck, C. M., and Burstein, E. (2007) COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligase. EMBO J. 26, 436-447
12. Ryo, A., Suizu, F., Yoshida, Y., Perrem, K., Liou, Y. C., Wulf, G., Rottapel, R., Yamaoka, S., and Lu, K. P. (2003) Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA. Mol. Cell. 12, 1413-1426
13. Saccani, S., Marazzi, I., Beg, A. A., and Natoli, G. (2004) Degradation of promoter-bound p65/RelA is essential for the prompt termination of the nuclear factor κB response. J. Exp. Med. 200, 107-113
14. Kamio, M., Yoshida, T., Ogata, H., Douchi, T., Nagata, Y., Inoue, M., Hasegawa, M., Yonemitsu, Y., and Yoshimura, A. (2004) SOCS1 [corrected] inhibits HPV-E7-mediated transformation by inducing degradation of E7 protein. Oncogene 23, 3107-3115
15. Marine, J. C., Topham, D. J., McKay, C., Wang, D., Parganas, E., Stravopodis, D., Yoshimura, A., and Ihle, J. N. (1999) SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality. Cell 98, 609-616
16. Alexander, W. S., Starr, R., Fenner, J. E., Scott, C. L., Handman, E., Sprigg, N. S., Corbin, J. E., Cornish, A. L., Darwiche, R., Owczarek, C. M., Kay, T. W., Nicola, N. A., Hertzog, P. J., Metcalf, D., and Hilton, D. J. (1999) SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine. Cell 98, 597-608
17. Eyles, J. L., Metcalf, D., Grusby, M. J., Hilton, D. J., and Starr, R. (2002) Negative regulation of interleukin-12 signaling by suppressor of cytokine signaling-1. J. Biol. Chem. 277, 43735-43740
18. Naka, T., Tsutsui, H., Fujimoto, M., Kawazoe, Y., Kohzaki, H., Morita, Y., Nakagawa, R., Narazaki, M., Adachi, K., Yoshimoto, T., Nakanishi, K., and Kishimoto, T. (2001) SOCS-1/SSI-1-deficient NKT cells participate in severe hepatitis through dysregulated cross-talk inhibition of IFN-gamma and IL-4 signaling in vivo. Immunity 14, 535-545
19. Metcalf, D., Mifsud, S., Di Rago, L., Nicola, N. A., Hilton, D. J., and Alexander, W. S. (2002) Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1). Proc. Natl. Acad. Sci. U. S. A. 99, 943-948
20. Zhang, J. G., Metcalf, D., Rakar, S., Asimakis, M., Greenhalgh, C. J., Willson, T. A., Starr, R., Nicholson, S. E., Carter, W., Alexander, W. S., Hilton, D. J., and Nicola, N. A. (2001) The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo. Proc. Natl. Acad. Sci. U. S. A. 98, 13261-13265
21. Cokol, M., Nair, R., and Rost, B. (2000) Finding nuclear localization signals. EMBO Rep. 1, 411-415
22. Vuong, B. Q., Arenzana, T. L., Showalter, B. M., Losman, J., Chen, X. P., Mostecki, J., Banks, A. S., Limnander, A., Fernandez, N., and Rothman, P. B. (2004) SOCS-1 Localizes to the microtubule organizing complex-associated 20S proteasome. Mol. Cell. Biol. 24, 9092-9101
23. Siewert, E., Muller-Esterl, W., Starr, R., Heinrich, P. C., and Schaper, F. (1999) Different protein turnover of interleukin-6-type cytokine signalling components. Eur. J. Biochem. 265, 251-257
24. Dalpke, A. H., Opper, S., Zimmermann, S., and Heeg, K. (2001) Suppressors of cytokine signaling (SOCS)-1 and SOCS-3 are induced by CpG-DNA and modulate cytokine responses in APCs. J. Immunol. 166, 7082-7089
25. Ben Yair, L., Slaaby, R., Herman, A., Cohen, Y., Biener, E., Moran, N., Yoshimura, A., Whittaker, J., De Meyts, P., Herman, B., and Gertler, A. (2002) Preparation and expression of biologically active prolactin and growth hormone receptors and suppressor of cytokine signaling proteins 1, 2, 3, and 6 tagged with cyan and yellow fluorescent proteins. Protein Expr. Purif. 25, 456
26. Lee, K. H., Moon, K. J., Kim, H. S., Yoo, B. C., Park, S., Lee, H., Kwon, S., Lee, E. S., and Yoon, S. (2008) Increased cytoplasmic levels of CIS, SOCS1, SOCS2, or SOCS3 are required for nuclear translocation. FEBS Lett. 582, 2319-2324
27. Emanuelli, B., Peraldi, P., Filloux, C., Sawka-Verhelle, D., Hilton, D., and Van Obberghen, E. (2000) SOCS-3 is an insulin-induced negative regulator of insulin signaling. J. Biol. Chem. 275, 15985-15991
28. Ketteler, R., Moghraby, C. S., Hsiao, J. G., Sandra, O., Lodish, H. F., and Klingmuller, U. (2003) The cytokine-inducible Scr homology domain-containing protein negatively regulates signaling by promoting apoptosis in erythroid progenitor cells. J. Biol. Chem. 278, 2654-2660
29. Boulikas, T. (1993) Nuclear localization signals (NLS). Crit. Rev. Eukaryot. Gene Expr. 3, 193-227
30. Conti, E., Uy, M., Leighton, L., Blobel, G., and Kuriyan, J. (1998) Crystallographic analysis of the recognition of a nuclear localization signal by the nuclear import factor karyopherin alpha. Cell 94, 193-204
31. Gorlich, D., Kutay, U. (1999) Transport between the cell nucleus and the cytoplasm. Annu. Rev. Cell Dev. Biol. 15, 607-660
32. Bullock, A. N., Rodriguez, M. C., Debreczeni, J. E., Songyang, Z., and Knapp, S. (2007) Structure of the SOCS4-ElonginB/C complex reveals a distinct SOCS box interface and the molecular basis for SOCS-dependent EGFR degradation. Structure 15, 1493-1504
33. Saleh, A. Z., Fang, A. T., Arch, A. E., Neupane, D., El Fiky, A., and Krolewski, J. J. (2004) Regulated proteolysis of the IFNaR2 subunit of the interferon-alpha receptor. Oncogene 23, 7076-7086
34. Subramaniam, P. S., Johnson, H. M. (2004) The IFNAR1 subunit of the type I IFN receptor complex contains a functional nuclear localization sequence. FEBS Lett. 578, 207-210
35. Ahmed, C. M. I., Johnson, H. M. (2006) IFN-γ and its receptor subunit IFNGR1 are recruited to the IFN-γ-activated sequence element at the promoter site of IFN-γ-activated genes: evidence of transactivational activity in IFNGR1. J. Immunol. 177, 315-321
36. Kim, T. K., Maniatis, T. (1996) Regulation of interferon-gamma-activated STAT1 by the ubiquitin-proteasome pathway. Science 273, 1717-1719
37. Platanias, L. C. (2005) Mechanisms of type-I- and type-II-interferon- mediated signalling. Nat. Rev. Immunol. 5, 375-386
38. Yang, C. H., Murti, A., Pfeffer, S. R., Basu, L., Kim, J. G., and Pfeffer, L. M. (2000) IFNalpha /beta promotes cell survival by activating NF-kappa B. Proc. Natl. Acad. Sci. U. S. A. 97, 13631-13636
39. Roebuck, K. A., Finnegan, A. (1999) Regulation of intercellular adhesion molecule-1 (CD54) gene expression. J. Leukoc. Biol. 66, 876-888