Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability

Molecular Cell

Volumn 68, Issue 3, 2017, Pages 552-565.e8

  Shen, Kuang ^a,b,c   Choe, Abigail ^a   Sabatini, David M ^a,b,c  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c KOCH INSTITUTE FOR INTEGRATIVE CANCER RESEARCH   (United States)

Author keywords

amino acid sensing; enzymatic mechanism; mTORC1; negative cooperativity; Rag GTPases

Indexed keywords

AMINO ACID; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE; GUANOSINE TRIPHOSPHATE; HETERODIMER; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; RAG GTPASE; UNCLASSIFIED DRUG; MONOMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; PROTEIN BINDING; RRAGA PROTEIN, HUMAN; RRAGC PROTEIN, HUMAN;

ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DIMERIZATION; EMBRYO; ENZYME SUBUNIT; HEK293T CELL LINE; HUMAN; HUMAN CELL; HYDROLYSIS; MOLECULAR DYNAMICS; PROTEIN BINDING; PROTEIN CROSS LINKING; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; SIGNAL TRANSDUCTION; BINDING SITE; CHEMISTRY; ENZYME STABILITY; GENETIC TRANSFECTION; GENETICS; HEK293 CELL LINE; KINETICS; METABOLISM; MOLECULAR MODEL; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; PROTEIN SUBUNIT; STRUCTURE ACTIVITY RELATION;

AMINO ACIDS; BINDING SITES; ENZYME STABILITY; GUANOSINE TRIPHOSPHATE; HEK293 CELLS; HUMANS; HYDROLYSIS; KINETICS; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MODELS, MOLECULAR; MONOMERIC GTP-BINDING PROTEINS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; PROTEIN SUBUNITS; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION;

EID: 85031798280     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2017.09.026     Document Type: Article

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