Histone methyltransferase G9a is required for cardiomyocyte homeostasis and hypertrophy

Circulation

Volumn 136, Issue 13, 2017, Pages 1233-1246

  Papait, Roberto ^a,b   Serio, Simone ^a   Pagiatakis, Christina ^a   Rusconi, Francesca ^a,b   Carullo, Pierluigi ^a,b   Mazzola, Marta ^d   Salvarani, Nicolò ^a,b   Miragoli, Michele ^a,e   Condorelli, Gianluigi ^a,b,c  

^a HUMANITAS CLINICAL AND RESEARCH CENTER   (Italy)

^b Milan Unit   (Italy)

^c HUMANITAS UNIVERSITY   (Italy)

^d UNIVERSITY OF VERONA   (Italy)

^e UNIVERSITY OF PARMA   (Italy)

Author keywords

EHMT2 protein; Epigenomics; Heart failure; Heterochromatin; Histone methylation; Hypertrophy; MEF2C protein; Mouse

Indexed keywords

ATRIAL NATRIURETIC FACTOR ALPHA; CALCINEURIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; HISTONE METHYLTRANSFERASE; LYSINE; POLYCOMB REPRESSIVE COMPLEX 2; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR EZH2; TRANSCRIPTOME; ENZYME INHIBITOR; G9A PROTEIN, MOUSE; HETEROCHROMATIN; HISTONE; HISTONE LYSINE METHYLTRANSFERASE; MEF2C PROTEIN, MOUSE; MYOCYTE ENHANCER FACTOR 2; POLYCOMB GROUP PROTEIN; RNA;

ADULT; ARTICLE; CALCIUM SIGNALING; CARDIAC MUSCLE CELL; CELL FUNCTION; CHROMATIN; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DEFENSE MECHANISM; DEVELOPMENTAL GENE; DOWN REGULATION; ENZYME ACTIVE SITE; EPIGENETICS; GENE EXPRESSION; HEART FUNCTION; HEART VENTRICLE HYPERTROPHY; HETEROCHROMATIN; HOMEOSTASIS; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN INTERACTION; REGULATOR GENE; RNA SEQUENCE; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CARDIOMEGALY; CELL CULTURE; CHEMISTRY; CYTOLOGY; DIAGNOSTIC IMAGING; DRUG EFFECTS; GENETIC EPIGENESIS; GENETIC TRANSCRIPTION; GENETICS; HEART; HEART STROKE VOLUME; ISOLATION AND PURIFICATION; KNOCKOUT MOUSE; MALE; METABOLISM; PATHOLOGY; PHYSIOLOGY; SEQUENCE ANALYSIS; UPREGULATION;

ANIMALS; CARDIOMEGALY; CELLS, CULTURED; ENZYME INHIBITORS; EPIGENESIS, GENETIC; HEART; HETEROCHROMATIN; HISTONE-LYSINE N-METHYLTRANSFERASE; HISTONES; MALE; MEF2 TRANSCRIPTION FACTORS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYOCYTES, CARDIAC; POLYCOMB-GROUP PROTEINS; RNA; SEQUENCE ANALYSIS, RNA; STROKE VOLUME; TRANSCRIPTION, GENETIC; UP-REGULATION;

EID: 85030754703     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.117.028561     Document Type: Article

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