Peptidomimetic Targeting of Cavβ2 Overcomes Dysregulation of the L-Type Calcium Channel Density and Recovers Cardiac Function

Circulation

Volumn 134, Issue 7, 2016, Pages 534-546

  Rusconi, Francesca ^a,b   Ceriotti, Paola ^a,b   Miragoli, Michele ^a,e   Carullo, Pierluigi ^a   Salvarani, Nicolò ^a,b   Rocchetti, Marcella ^c   Di Pasquale, Elisa ^a,b   Rossi, Stefano ^d   Tessari, Maddalena ^f   Caprari, Silvia ^g   Cazade, Magali ^h   Kunderfranco, Paolo ^g   Chemin, Jean ^h   Bang, Marie Louise ^a   Polticelli, Fabio ⁱ   Zaza, Antonio ^c   Faggian, Giuseppe ^f   Condorelli, Gianluigi ^a   Catalucci, Daniele ^a,b  

^a HUMANITAS CLINICAL AND RESEARCH CENTER   (Italy)

^b Milan Unit   (Italy)

^c UNIVERSITY OF MILANO BICOCCA   (Italy)

^d Departments of Life Sciences   (Italy)

^e UNIVERSITY OF PARMA   (Italy)

^f UNIVERSITY HOSPITAL OF VERONA   (Italy)

^g ROMA TRE UNIVERSITY   (Italy)

^h UNIV MONTPELLIER   (France)

ⁱ INFN SEZIONE DI ROMA   (Italy)

Author keywords

calcium; calcium channels, L type; cardiovascular diseases; diabetic cardiomyopathies; drug therapy; peptides; protein transport

Indexed keywords

CALCIUM CHANNEL L TYPE; CALCIUM V ALPHA1; CALCIUM V BETA2; CHAPERONE; DYNAMIN; GLUTAMINE; HETEROCHROMATIN PROTEIN 1; HETEROCHROMATIN PROTEIN 1 GAMMA; PROTEIN KINASE B; RNA; UNCLASSIFIED DRUG; BIOMIMETIC MATERIAL; CACNB2 PROTEIN, MOUSE; PEPTIDOMIMETIC AGENT;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA STENOSIS; APOPTOSIS; ARTICLE; BIOTINYLATION; CALCIUM CURRENT; CARDIOMYOPATHY; CELL LYSATE; CELL MEMBRANE; CHROMATIN IMMUNOPRECIPITATION; CLINICAL ARTICLE; COMPARATIVE STUDY; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DIABETES MELLITUS; ENDOCYTOSIS; FLUORESCENCE MICROSCOPY; GENE EXPRESSION; HEART DISEASE; HEART FUNCTION; HEART MUSCLE BIOPSY; HEART MUSCLE EXCITABILITY; HUMAN; HUMAN TISSUE; IMMUNOPRECIPITATION; IN VITRO STUDY; IN VIVO STUDY; MALE; MOLECULAR MODEL; MOUSE; NEGATIVE FEEDBACK; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN INTERACTION ASSAY; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; QUANTITATIVE ANALYSIS; RETROSPECTIVE STUDY; SITE DIRECTED MUTAGENESIS; STEADY STATE; STEREOSPECIFICITY; TRANSCRIPTION INITIATION; WESTERN BLOTTING; AMINO ACID SEQUENCE; ANIMAL; C57BL MOUSE; CARDIAC MUSCLE CELL; CARDIOVASCULAR DISEASES; CELL CULTURE; CHEMISTRY; DRUG DELIVERY SYSTEM; DRUG EFFECTS; FEMALE; GENETICS; HEK293 CELL LINE; METABOLISM; PROCEDURES; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE;

AMINO ACID SEQUENCE; ANIMALS; BIOMIMETIC MATERIALS; CALCIUM CHANNELS, L-TYPE; CARDIOVASCULAR DISEASES; CELLS, CULTURED; DRUG DELIVERY SYSTEMS; FEMALE; HEK293 CELLS; HUMANS; MALE; MICE; MICE, INBRED C57BL; MYOCYTES, CARDIAC; PEPTIDOMIMETICS; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RETROSPECTIVE STUDIES;

EID: 84981244026     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.116.021347     Document Type: Article

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