Alternative evolutionary histories in the sequence space of an ancient protein

Nature

Volumn 549, Issue 7672, 2017, Pages 409-413

  Starr, Tyler N ^a   Picton, Lora K ^a   Thornton, Joseph W ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANCIENT DNA; TRANSCRIPTION FACTOR; DNA; DNA BINDING PROTEIN; STEROID RECEPTOR;

ANCESTRY; EPISTASIS; EVOLUTION; EVOLUTIONARY BIOLOGY; NATURAL SELECTION; PROTEIN; RECONSTRUCTION;

ALPHA HELIX; AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; DNA BINDING; DNA RESPONSIVE ELEMENT; EPISTASIS; GENETIC CODE; GENETIC DISTANCE; GENOTYPE; HYDROGEN BOND; HYDROPHOBICITY; MOLECULAR EVOLUTION; MUTATIONAL ANALYSIS; NATURAL SELECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; PURIFYING SELECTION; SACCHAROMYCES CEREVISIAE; SANGER SEQUENCING; CHEMISTRY; ENZYME SPECIFICITY; GENETIC SELECTION; GENETICS; METABOLISM; MUTATION; NUCLEOTIDE SEQUENCE; VALIDATION STUDY;

AMINO ACID SEQUENCE; BASE SEQUENCE; DNA; DNA-BINDING PROTEINS; EVOLUTION, MOLECULAR; MUTATION; RECEPTORS, STEROID; RESPONSE ELEMENTS; SELECTION, GENETIC; SUBSTRATE SPECIFICITY;

EID: 85029786145     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature23902     Document Type: Article

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