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Volumn 34, Issue 1, 2018, Pages 64-79

Onchocerca volvulus: The Road from Basic Biology to a Vaccine

Author keywords

elimination; Onchocerca volvulus; vaccine; vaccine candidates

Indexed keywords

IVERMECTIN; MICROORGANISM PROTEIN; ONCHOCERCA VOLVULUS VACCINE; PARASITE ANTIGEN; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; VACCINE; ANTIPARASITIC AGENT;

EID: 85029680546     PISSN: 14714922     EISSN: 14715007     Source Type: Journal    
DOI: 10.1016/j.pt.2017.08.011     Document Type: Review
Times cited : (38)

References (92)
  • 1
    • 84994092049 scopus 로고    scopus 로고
    • Global, Regional, and National Incidence, Prevalence, and Years Lived with Disability for 310 Diseases and Injuries, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015
    • GBD 2015 Disease and Injury Incidence and Prevalence Collaborators, Global, Regional, and National Incidence, Prevalence, and Years Lived with Disability for 310 Diseases and Injuries, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet 388 (2016), 1545–1602.
    • (2016) Lancet , vol.388 , pp. 1545-1602
    • GBD 2015 Disease and Injury Incidence and Prevalence Collaborators1
  • 2
    • 84922249638 scopus 로고    scopus 로고
    • The Onchocerciasis Vaccine For Africa—TOVA​—initiative
    • Hotez, P.J., et al. The Onchocerciasis Vaccine For Africa—TOVA​—initiative. PLoS Negl. Trop. Dis., 9, 2015, e0003422.
    • (2015) PLoS Negl. Trop. Dis. , vol.9 , pp. e0003422
    • Hotez, P.J.1
  • 3
    • 85026752157 scopus 로고    scopus 로고
    • Genome-wide analysis of ivermectin response by Onchocerca volvulus reveals that genetic drift and soft selective sweeps contribute to loss of drug sensitivity
    • Doyle, S.R., et al. Genome-wide analysis of ivermectin response by Onchocerca volvulus reveals that genetic drift and soft selective sweeps contribute to loss of drug sensitivity. PLoS Negl. Trop. Dis., 11, 2017, e0005816.
    • (2017) PLoS Negl. Trop. Dis. , vol.11 , pp. e0005816
    • Doyle, S.R.1
  • 4
    • 84928911535 scopus 로고    scopus 로고
    • Control, elimination, and eradication of river blindness: scenarios, timelines, and ivermectin treatment needs in Africa
    • Kim, Y.E., et al. Control, elimination, and eradication of river blindness: scenarios, timelines, and ivermectin treatment needs in Africa. PLoS Negl. Trop. Dis., 9, 2015, e0003664.
    • (2015) PLoS Negl. Trop. Dis. , vol.9 , pp. e0003664
    • Kim, Y.E.1
  • 5
    • 0027722066 scopus 로고
    • Induction of protective immunity against larval Onchocerca volvulus in a mouse model
    • Lange, A.M., et al. Induction of protective immunity against larval Onchocerca volvulus in a mouse model. Am. J. Trop. Med. Hyg. 49 (1993), 783–788.
    • (1993) Am. J. Trop. Med. Hyg. , vol.49 , pp. 783-788
    • Lange, A.M.1
  • 6
    • 33845245864 scopus 로고    scopus 로고
    • Vaccination against filarial nematodes with irradiated larvae provides long-term protection against the third larval stage but not against subsequent life cycle stages
    • Babayan, S.A., et al. Vaccination against filarial nematodes with irradiated larvae provides long-term protection against the third larval stage but not against subsequent life cycle stages. Int. J. Parasitol. 36 (2006), 903–914.
    • (2006) Int. J. Parasitol. , vol.36 , pp. 903-914
    • Babayan, S.A.1
  • 7
    • 33645799250 scopus 로고    scopus 로고
    • In a bovine model of onchocerciasis, protective immunity exists naturally, is absent in drug-cured hosts, and is induced by vaccination
    • Tchakoute, V.L., et al. In a bovine model of onchocerciasis, protective immunity exists naturally, is absent in drug-cured hosts, and is induced by vaccination. Proc. Natl. Acad. Sci. U. S. A. 103 (2006), 5971–5976.
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 5971-5976
    • Tchakoute, V.L.1
  • 8
    • 33846930347 scopus 로고    scopus 로고
    • Successful vaccination against Onchocerca ochengi infestation in cattle using live Onchocerca volvulus infective larvae
    • Achukwi, M.D., et al. Successful vaccination against Onchocerca ochengi infestation in cattle using live Onchocerca volvulus infective larvae. Parasite Immunol. 29 (2007), 113–116.
    • (2007) Parasite Immunol. , vol.29 , pp. 113-116
    • Achukwi, M.D.1
  • 9
    • 0034110385 scopus 로고    scopus 로고
    • Parasitology and immunology of mice vaccinated with irradiated Litomosoides sigmodontis larvae
    • Le Goff, L., et al. Parasitology and immunology of mice vaccinated with irradiated Litomosoides sigmodontis larvae. Parasitology 120 (2000), 271–280.
    • (2000) Parasitology , vol.120 , pp. 271-280
    • Le Goff, L.1
  • 10
    • 84938562675 scopus 로고    scopus 로고
    • Human onchocerciasis: modelling the potential long-term consequences of a vaccination programme
    • Turner, H.C., et al. Human onchocerciasis: modelling the potential long-term consequences of a vaccination programme. PLoS Negl. Trop. Dis., 9, 2015, e0003938.
    • (2015) PLoS Negl. Trop. Dis. , vol.9 , pp. e0003938
    • Turner, H.C.1
  • 11
    • 0042827236 scopus 로고    scopus 로고
    • CD4+ dependent immunity to Onchocerca volvulus third-stage larvae in humans and the mouse vaccination model: common ground and distinctions
    • Lustigman, S., et al. CD4+ dependent immunity to Onchocerca volvulus third-stage larvae in humans and the mouse vaccination model: common ground and distinctions. Int. J. Parasitol. 33 (2003), 1161–1171.
    • (2003) Int. J. Parasitol. , vol.33 , pp. 1161-1171
    • Lustigman, S.1
  • 12
    • 0035171703 scopus 로고    scopus 로고
    • Development of a recombinant antigen vaccine against infection with the filarial worm Onchocerca volvulus
    • Abraham, D., et al. Development of a recombinant antigen vaccine against infection with the filarial worm Onchocerca volvulus. Infect. Immun. 69 (2001), 262–270.
    • (2001) Infect. Immun. , vol.69 , pp. 262-270
    • Abraham, D.1
  • 13
    • 0036498233 scopus 로고    scopus 로고
    • Towards a recombinant antigen vaccine against Onchocerca volvulus
    • Lustigman, S., et al. Towards a recombinant antigen vaccine against Onchocerca volvulus. Trends Parasitol. 18 (2002), 135–141.
    • (2002) Trends Parasitol. , vol.18 , pp. 135-141
    • Lustigman, S.1
  • 14
    • 0003093675 scopus 로고
    • Vaccination against parasites: special problems imposed by the adaptation of parasitic organisms to the host immune response
    • P.T. Englund A. Sher Alan R. Liss
    • Sher, A., Vaccination against parasites: special problems imposed by the adaptation of parasitic organisms to the host immune response. Englund, P.T., Sher, A., (eds.) The Biology of Parasitism, 1988, Alan R. Liss, 169–182.
    • (1988) The Biology of Parasitism , pp. 169-182
    • Sher, A.1
  • 15
    • 0034982339 scopus 로고    scopus 로고
    • Antioxidant enzyme families in parasitic nematodes
    • Henkle-Duhrsen, K., Kampkotter, A., Antioxidant enzyme families in parasitic nematodes. Mol. Biochem. Parasitol. 114 (2001), 129–142.
    • (2001) Mol. Biochem. Parasitol. , vol.114 , pp. 129-142
    • Henkle-Duhrsen, K.1    Kampkotter, A.2
  • 16
    • 0029981630 scopus 로고    scopus 로고
    • Chitinase genes expressed by infective larvae of the filarial nematodes, Acanthocheilonema viteae and Onchocerca volvulus
    • Wu, Y., et al. Chitinase genes expressed by infective larvae of the filarial nematodes, Acanthocheilonema viteae and Onchocerca volvulus. Mol. Biochem. Parasitol. 75 (1996), 207–219.
    • (1996) Mol. Biochem. Parasitol. , vol.75 , pp. 207-219
    • Wu, Y.1
  • 17
    • 0034115183 scopus 로고    scopus 로고
    • Identification of potential vaccine and drug target candidates by expressed sequence tag analysis and immunoscreening of Onchocerca volvulus larval cDNA libraries
    • Lizotte-Waniewski, M., et al. Identification of potential vaccine and drug target candidates by expressed sequence tag analysis and immunoscreening of Onchocerca volvulus larval cDNA libraries. Infect. Immun. 68 (2000), 3491–3501.
    • (2000) Infect. Immun. , vol.68 , pp. 3491-3501
    • Lizotte-Waniewski, M.1
  • 18
    • 0032713249 scopus 로고    scopus 로고
    • DNA immunisation with Onchocerca volvulus chitinase induces partial protection against challenge infection with L3 larvae in mice
    • Harrison, R.A., et al. DNA immunisation with Onchocerca volvulus chitinase induces partial protection against challenge infection with L3 larvae in mice. Vaccine 18 (1999), 647–655.
    • (1999) Vaccine , vol.18 , pp. 647-655
    • Harrison, R.A.1
  • 20
    • 0033848113 scopus 로고    scopus 로고
    • Angiogenic activity of Onchocerca volvulus recombinant proteins similar to vespid venom antigen 5
    • Tawe, W., et al. Angiogenic activity of Onchocerca volvulus recombinant proteins similar to vespid venom antigen 5. Mol. Biochem. Parasitol. 109 (2000), 91–99.
    • (2000) Mol. Biochem. Parasitol. , vol.109 , pp. 91-99
    • Tawe, W.1
  • 21
    • 84994495854 scopus 로고    scopus 로고
    • 25 Years of the Onchocerca ochengi model
    • Makepeace, B.L., Tanya, V.N., 25 Years of the Onchocerca ochengi model. Trends Parasitol. 32 (2016), 966–978.
    • (2016) Trends Parasitol. , vol.32 , pp. 966-978
    • Makepeace, B.L.1    Tanya, V.N.2
  • 22
    • 73449086949 scopus 로고    scopus 로고
    • Immunisation with a multivalent, subunit vaccine reduces patent infection in a natural bovine model of onchocerciasis during intense field exposure
    • Makepeace, B.L., et al. Immunisation with a multivalent, subunit vaccine reduces patent infection in a natural bovine model of onchocerciasis during intense field exposure. PLoS Negl. Trop. Dis., 3, 2009, e544.
    • (2009) PLoS Negl. Trop. Dis. , vol.3 , pp. e544
    • Makepeace, B.L.1
  • 23
    • 20444478000 scopus 로고    scopus 로고
    • Cloning, characterization and DNA immunization of an Onchocerca volvulus glyceraldehyde-3-phosphate dehydrogenase (Ov-GAPDH)
    • Erttmann, K.D., et al. Cloning, characterization and DNA immunization of an Onchocerca volvulus glyceraldehyde-3-phosphate dehydrogenase (Ov-GAPDH). Biochim. Biophys. Acta 1741 (2005), 85–94.
    • (2005) Biochim. Biophys. Acta , vol.1741 , pp. 85-94
    • Erttmann, K.D.1
  • 24
    • 0027182683 scopus 로고
    • Survival and development of larval Onchocerca volvulus in diffusion chambers implanted in primate and rodent hosts
    • Abraham, D., et al. Survival and development of larval Onchocerca volvulus in diffusion chambers implanted in primate and rodent hosts. J. Parasitol. 79 (1993), 571–582.
    • (1993) J. Parasitol. , vol.79 , pp. 571-582
    • Abraham, D.1
  • 25
    • 84879745249 scopus 로고    scopus 로고
    • A comprehensive, model-based review of vaccine and repeat infection trials for filariasis
    • Morris, C.P., et al. A comprehensive, model-based review of vaccine and repeat infection trials for filariasis. Clin. Microbiol. Rev. 26 (2013), 381–421.
    • (2013) Clin. Microbiol. Rev. , vol.26 , pp. 381-421
    • Morris, C.P.1
  • 26
    • 84905022037 scopus 로고    scopus 로고
    • Vaccines to combat river blindness: expression, selection and formulation of vaccines against infection with Onchocerca volvulus in a mouse model
    • Hess, J.A., et al. Vaccines to combat river blindness: expression, selection and formulation of vaccines against infection with Onchocerca volvulus in a mouse model. Int. J. Parasitol. 44 (2014), 637–646.
    • (2014) Int. J. Parasitol. , vol.44 , pp. 637-646
    • Hess, J.A.1
  • 27
    • 0029919018 scopus 로고    scopus 로고
    • Molecular cloning of a developmentally regulated protein isolated from excretory-secretory products of larval Dirofilaria immitis
    • Frank, G.R., et al. Molecular cloning of a developmentally regulated protein isolated from excretory-secretory products of larval Dirofilaria immitis. Mol. Biochem. Parasitol. 75 (1996), 231–240.
    • (1996) Mol. Biochem. Parasitol. , vol.75 , pp. 231-240
    • Frank, G.R.1
  • 28
    • 0033917103 scopus 로고    scopus 로고
    • The abundant larval transcript-1 and -2 genes of Brugia malayi encode stage-specific candidate vaccine antigens for filariasis
    • Gregory, W.F., et al. The abundant larval transcript-1 and -2 genes of Brugia malayi encode stage-specific candidate vaccine antigens for filariasis. Infect. Immun. 68 (2000), 4174–4179.
    • (2000) Infect. Immun. , vol.68 , pp. 4174-4179
    • Gregory, W.F.1
  • 29
    • 78149267039 scopus 로고    scopus 로고
    • Comparison of immuno prophylactic efficacy of Bm rALT2 or Bm rVAH or rALT + rVAH by single and multiple antigen vaccination mode
    • Anand, S.B., et al. Comparison of immuno prophylactic efficacy of Bm rALT2 or Bm rVAH or rALT + rVAH by single and multiple antigen vaccination mode. Am. J. Trop. Med. Hyg., 75, 2006, 295.
    • (2006) Am. J. Trop. Med. Hyg. , vol.75 , pp. 295
    • Anand, S.B.1
  • 30
    • 0036153614 scopus 로고    scopus 로고
    • Litomosoides sigmodontis cystatin acts as an immunomodulator during experimental filariasis
    • Pfaff, A.W., et al. Litomosoides sigmodontis cystatin acts as an immunomodulator during experimental filariasis. Int. J. Parasitol. 32 (2002), 171–178.
    • (2002) Int. J. Parasitol. , vol.32 , pp. 171-178
    • Pfaff, A.W.1
  • 31
    • 0026020716 scopus 로고
    • Characterization of an Onchocerca volvulus cDNA clone encoding a genus specific antigen present in infective larvae and adult worms
    • Lustigman, S., et al. Characterization of an Onchocerca volvulus cDNA clone encoding a genus specific antigen present in infective larvae and adult worms. Mol. Biochem. Parasitol. 45 (1991), 65–75.
    • (1991) Mol. Biochem. Parasitol. , vol.45 , pp. 65-75
    • Lustigman, S.1
  • 32
    • 0026804645 scopus 로고
    • Molecular cloning and characterization of onchocystatin, a cysteine proteinase inhibitor of Onchocerca volvulus
    • Lustigman, S., et al. Molecular cloning and characterization of onchocystatin, a cysteine proteinase inhibitor of Onchocerca volvulus. J. Biol. Chem. 267 (1992), 17339–17346.
    • (1992) J. Biol. Chem. , vol.267 , pp. 17339-17346
    • Lustigman, S.1
  • 33
    • 11144254366 scopus 로고    scopus 로고
    • The larval specific lymphatic filarial ALT-2: induction of protection using protein or DNA vaccination
    • Ramachandran, S., et al. The larval specific lymphatic filarial ALT-2: induction of protection using protein or DNA vaccination. Microbiol. Immunol. 48 (2004), 945–955.
    • (2004) Microbiol. Immunol. , vol.48 , pp. 945-955
    • Ramachandran, S.1
  • 34
    • 0242695887 scopus 로고    scopus 로고
    • Evaluation of recombinant chitinase and SXP1 antigens as antimicrofilarial vaccines
    • Wang, S.H., et al. Evaluation of recombinant chitinase and SXP1 antigens as antimicrofilarial vaccines. Am. J. Trop. Med. Hyg. 56 (1997), 474–481.
    • (1997) Am. J. Trop. Med. Hyg. , vol.56 , pp. 474-481
    • Wang, S.H.1
  • 35
    • 0030064137 scopus 로고    scopus 로고
    • Identification of chitinase as the immunodominant filarial antigen recognized by sera of vaccinated rodents
    • Adam, R., et al. Identification of chitinase as the immunodominant filarial antigen recognized by sera of vaccinated rodents. J. Biol. Chem. 271 (1996), 1441–1447.
    • (1996) J. Biol. Chem. , vol.271 , pp. 1441-1447
    • Adam, R.1
  • 36
    • 0028827382 scopus 로고
    • Onchocerca volvulus larval antigen, OvB20, induces partial protection in a rodent model of onchocerciasis
    • Taylor, M.J., et al. Onchocerca volvulus larval antigen, OvB20, induces partial protection in a rodent model of onchocerciasis. Infect. Immun. 63 (1995), 4417–4422.
    • (1995) Infect. Immun. , vol.63 , pp. 4417-4422
    • Taylor, M.J.1
  • 37
    • 0030049515 scopus 로고    scopus 로고
    • Characterization of a secreted antigen of Onchocerca volvulus with host-protective potential
    • Jenkins, R.E., et al. Characterization of a secreted antigen of Onchocerca volvulus with host-protective potential. Parasite Immunol. 18 (1996), 29–42.
    • (1996) Parasite Immunol. , vol.18 , pp. 29-42
    • Jenkins, R.E.1
  • 38
    • 0029826617 scopus 로고    scopus 로고
    • Vaccination with alum-precipitated recombinant Ancylostoma-secreted protein 1 protects mice against challenge infections with infective hookworm (Ancylostoma caninum) larvae
    • Ghosh, K., et al. Vaccination with alum-precipitated recombinant Ancylostoma-secreted protein 1 protects mice against challenge infections with infective hookworm (Ancylostoma caninum) larvae. J. Infect. Dis. 174 (1996), 1380–1383.
    • (1996) J. Infect. Dis. , vol.174 , pp. 1380-1383
    • Ghosh, K.1
  • 39
    • 25144446399 scopus 로고    scopus 로고
    • Expression of the Necator americanus hookworm larval antigen Na-ASP-2 in Pichia pastoris and purification of the recombinant protein for use in human clinical trials
    • Goud, G.N., et al. Expression of the Necator americanus hookworm larval antigen Na-ASP-2 in Pichia pastoris and purification of the recombinant protein for use in human clinical trials. Vaccine 23 (2005), 4754–4764.
    • (2005) Vaccine , vol.23 , pp. 4754-4764
    • Goud, G.N.1
  • 40
    • 33745405943 scopus 로고    scopus 로고
    • New technologies for the control of human hookworm infection
    • Hotez, P.J., et al. New technologies for the control of human hookworm infection. Trends Parasitol. 22 (2006), 327–331.
    • (2006) Trends Parasitol. , vol.22 , pp. 327-331
    • Hotez, P.J.1
  • 41
    • 42649132461 scopus 로고    scopus 로고
    • Randomized, placebo-controlled, double-blind trial of the Na-ASP-2 hookworm vaccine in unexposed adults
    • Bethony, J.M., et al. Randomized, placebo-controlled, double-blind trial of the Na-ASP-2 hookworm vaccine in unexposed adults. Vaccine 26 (2008), 2408–2417.
    • (2008) Vaccine , vol.26 , pp. 2408-2417
    • Bethony, J.M.1
  • 42
    • 4143121138 scopus 로고    scopus 로고
    • Ac-SAA-1, an immunodominant 16 kDa surface-associated antigen of infective larvae and adults of Ancylostoma caninum
    • Zhan, B., et al. Ac-SAA-1, an immunodominant 16 kDa surface-associated antigen of infective larvae and adults of Ancylostoma caninum. Int. J. Parasitol. 34 (2004), 1037–1045.
    • (2004) Int. J. Parasitol. , vol.34 , pp. 1037-1045
    • Zhan, B.1
  • 43
    • 0035189048 scopus 로고    scopus 로고
    • Intranasal immunization with recombinant Ascaris suum 14-kilodalton antigen coupled with cholera toxin B subunit induces protective immunity to A. suum infection in mice
    • Tsuji, N., et al. Intranasal immunization with recombinant Ascaris suum 14-kilodalton antigen coupled with cholera toxin B subunit induces protective immunity to A. suum infection in mice. Infect. Immun. 69 (2001), 7285–7792.
    • (2001) Infect. Immun. , vol.69 , pp. 7285-7792
    • Tsuji, N.1
  • 44
    • 0042324030 scopus 로고    scopus 로고
    • Mice intranasally immunized with a recombinant 16-kilodalton antigen from roundworm Ascaris parasites are protected against larval migration of Ascaris suum
    • Tsuji, N., et al. Mice intranasally immunized with a recombinant 16-kilodalton antigen from roundworm Ascaris parasites are protected against larval migration of Ascaris suum. Infect. Immun. 71 (2003), 5314–5323.
    • (2003) Infect. Immun. , vol.71 , pp. 5314-5323
    • Tsuji, N.1
  • 45
    • 8444242460 scopus 로고    scopus 로고
    • Recombinant Ascaris 16-kilodalton protein-induced protection against Ascaris suum larval migration after intranasal vaccination in pigs
    • Tsuji, N., et al. Recombinant Ascaris 16-kilodalton protein-induced protection against Ascaris suum larval migration after intranasal vaccination in pigs. J. Infect. Dis. 190 (2004), 1812–1820.
    • (2004) J. Infect. Dis. , vol.190 , pp. 1812-1820
    • Tsuji, N.1
  • 46
    • 84964838046 scopus 로고    scopus 로고
    • Vaccination of gerbils with Bm-103 and Bm-RAL-2 concurrently or as a fusion protein confers consistent and improved protection against Brugia malayi infection
    • Arumugam, S., et al. Vaccination of gerbils with Bm-103 and Bm-RAL-2 concurrently or as a fusion protein confers consistent and improved protection against Brugia malayi infection. PLoS Negl. Trop. Dis., 10, 2016, e0004586.
    • (2016) PLoS Negl. Trop. Dis. , vol.10 , pp. e0004586
    • Arumugam, S.1
  • 47
    • 0031869226 scopus 로고    scopus 로고
    • Immune responses to third stage larvae of Onchocerca volvulus in interferon-gamma and interleukin-4 knockout mice
    • Johnson, E.H., et al. Immune responses to third stage larvae of Onchocerca volvulus in interferon-gamma and interleukin-4 knockout mice. Parasite Immunol. 20 (1998), 319–324.
    • (1998) Parasite Immunol. , vol.20 , pp. 319-324
    • Johnson, E.H.1
  • 48
    • 0028321418 scopus 로고
    • IL-4- and IL-5-dependent protective immunity to Onchocerca volvulus infective larvae in BALB/cBYJ mice
    • Lange, A.M., et al. IL-4- and IL-5-dependent protective immunity to Onchocerca volvulus infective larvae in BALB/cBYJ mice. J. Immunol. 153 (1994), 205–211.
    • (1994) J. Immunol. , vol.153 , pp. 205-211
    • Lange, A.M.1
  • 49
    • 0842283890 scopus 로고    scopus 로고
    • Immunoglobulin E and eosinophil-dependent protective immunity to larval Onchocerca volvulus in mice immunized with irradiated larvae
    • Abraham, D., et al. Immunoglobulin E and eosinophil-dependent protective immunity to larval Onchocerca volvulus in mice immunized with irradiated larvae. Infect. Immun. 72 (2004), 810–817.
    • (2004) Infect. Immun. , vol.72 , pp. 810-817
    • Abraham, D.1
  • 50
    • 0035055286 scopus 로고    scopus 로고
    • Interleukin-4 is essential for the control of microfilariae in murine infection with the filaria Litomosoides sigmodontis
    • Volkmann, L., et al. Interleukin-4 is essential for the control of microfilariae in murine infection with the filaria Litomosoides sigmodontis. Infect. Immun. 69 (2001), 2950–2956.
    • (2001) Infect. Immun. , vol.69 , pp. 2950-2956
    • Volkmann, L.1
  • 51
    • 0033673515 scopus 로고    scopus 로고
    • IL-5 is essential for vaccine-induced protection and for resolution of primary infection in murine filariasis
    • Martin, C., et al. IL-5 is essential for vaccine-induced protection and for resolution of primary infection in murine filariasis. Med. Microbiol. Immunol. 189 (2000), 67–74.
    • (2000) Med. Microbiol. Immunol. , vol.189 , pp. 67-74
    • Martin, C.1
  • 52
    • 33748074819 scopus 로고    scopus 로고
    • Lack of eosinophil peroxidase or major basic protein impairs defense against murine filarial infection
    • Specht, S., et al. Lack of eosinophil peroxidase or major basic protein impairs defense against murine filarial infection. Infect. Immun. 74 (2006), 5236–5243.
    • (2006) Infect. Immun. , vol.74 , pp. 5236-5243
    • Specht, S.1
  • 53
    • 0344851665 scopus 로고    scopus 로고
    • Synergism of gamma interferon and interleukin-5 in the control of murine filariasis
    • Saeftel, M., et al. Synergism of gamma interferon and interleukin-5 in the control of murine filariasis. Infect. Immun. 71 (2003), 6978–6985.
    • (2003) Infect. Immun. , vol.71 , pp. 6978-6985
    • Saeftel, M.1
  • 54
    • 75249106184 scopus 로고    scopus 로고
    • Type 2 immune-inducing helminth vaccination maintains protective efficacy in the setting of repeated parasite exposures
    • Hubner, M.P., et al. Type 2 immune-inducing helminth vaccination maintains protective efficacy in the setting of repeated parasite exposures. Vaccine 28 (2010), 1746–1757.
    • (2010) Vaccine , vol.28 , pp. 1746-1757
    • Hubner, M.P.1
  • 55
    • 84980390542 scopus 로고    scopus 로고
    • The immunomodulatory role of adjuvants in vaccines formulated with the recombinant antigens Ov-103 and Ov-RAL-2 against Onchocerca volvulus in mice
    • Hess, J.A., et al. The immunomodulatory role of adjuvants in vaccines formulated with the recombinant antigens Ov-103 and Ov-RAL-2 against Onchocerca volvulus in mice. PLoS Negl. Trop. Dis., 10, 2016, e0004797.
    • (2016) PLoS Negl. Trop. Dis. , vol.10 , pp. e0004797
    • Hess, J.A.1
  • 56
    • 84872046086 scopus 로고    scopus 로고
    • Deletion of parasite immune modulatory sequences combined with immune activating signals enhances vaccine mediated protection against filarial nematodes
    • Babayan, S.A., et al. Deletion of parasite immune modulatory sequences combined with immune activating signals enhances vaccine mediated protection against filarial nematodes. PLoS Negl. Trop. Dis., 6, 2012, e1968.
    • (2012) PLoS Negl. Trop. Dis. , vol.6 , pp. e1968
    • Babayan, S.A.1
  • 57
    • 48949118048 scopus 로고    scopus 로고
    • Of mice, cattle, and humans: the immunology and treatment of river blindness
    • Allen, J.E., et al. Of mice, cattle, and humans: the immunology and treatment of river blindness. PLoS Negl. Trop. Dis., 2, 2008, e217.
    • (2008) PLoS Negl. Trop. Dis. , vol.2 , pp. e217
    • Allen, J.E.1
  • 58
    • 84888358764 scopus 로고    scopus 로고
    • The drug and vaccine landscape for neglected diseases (2000–11): a systematic assessment
    • Pedrique, B., et al. The drug and vaccine landscape for neglected diseases (2000–11): a systematic assessment. Lancet Glob. Health 1 (2013), e371–e379.
    • (2013) Lancet Glob. Health , vol.1 , pp. e371-e379
    • Pedrique, B.1
  • 59
    • 84875124377 scopus 로고    scopus 로고
    • Risk in vaccine research and development quantified
    • Pronker, E.S., et al. Risk in vaccine research and development quantified. PLoS One, 8, 2013, e57755.
    • (2013) PLoS One , vol.8 , pp. e57755
    • Pronker, E.S.1
  • 60
    • 84873506978 scopus 로고    scopus 로고
    • Designing tomorrow's vaccines
    • Nabel, G.J., Designing tomorrow's vaccines. N. Engl. J. Med. 368 (2013), 551–560.
    • (2013) N. Engl. J. Med. , vol.368 , pp. 551-560
    • Nabel, G.J.1
  • 61
    • 84903381095 scopus 로고    scopus 로고
    • From empiricism to rational design: a personal perspective of the evolution of vaccine development
    • De Gregorio, E., Rappuoli, R., From empiricism to rational design: a personal perspective of the evolution of vaccine development. Nat. Rev. Immunol. 14 (2014), 505–514.
    • (2014) Nat. Rev. Immunol. , vol.14 , pp. 505-514
    • De Gregorio, E.1    Rappuoli, R.2
  • 62
    • 84870816984 scopus 로고    scopus 로고
    • Vaccines: from empirical development to rational design
    • Rueckert, C., Guzman, C.A., Vaccines: from empirical development to rational design. PLoS Pathog., 8, 2012, e1003001.
    • (2012) PLoS Pathog. , vol.8 , pp. e1003001
    • Rueckert, C.1    Guzman, C.A.2
  • 63
    • 0037020455 scopus 로고    scopus 로고
    • A strategic approach to vaccine development: animal models, monitoring vaccine efficacy, formulation and delivery
    • Griffin, J.F., A strategic approach to vaccine development: animal models, monitoring vaccine efficacy, formulation and delivery. Adv. Drug Deliv. Rev. 54 (2002), 851–861.
    • (2002) Adv. Drug Deliv. Rev. , vol.54 , pp. 851-861
    • Griffin, J.F.1
  • 64
    • 85019039824 scopus 로고    scopus 로고
    • The role of ‘omics’ in the quest to eliminate human filariasis
    • Lustigman, S., et al. The role of ‘omics’ in the quest to eliminate human filariasis. PLoS Negl. Trop. Dis., 11, 2017, e0005464.
    • (2017) PLoS Negl. Trop. Dis. , vol.11 , pp. e0005464
    • Lustigman, S.1
  • 65
    • 65549088510 scopus 로고    scopus 로고
    • Brugia malayi excreted/secreted proteins at the host/parasite interface: stage- and gender-specific proteomic profiling
    • Bennuru, S., et al. Brugia malayi excreted/secreted proteins at the host/parasite interface: stage- and gender-specific proteomic profiling. PLoS Negl. Trop. Dis., 3, 2009, e410.
    • (2009) PLoS Negl. Trop. Dis. , vol.3 , pp. e410
    • Bennuru, S.1
  • 66
    • 84907958775 scopus 로고    scopus 로고
    • Comparative analysis of the secretome from a model filarial nematode (Litomosoides sigmodontis) reveals maximal diversity in gravid female parasites
    • Armstrong, S.D., et al. Comparative analysis of the secretome from a model filarial nematode (Litomosoides sigmodontis) reveals maximal diversity in gravid female parasites. Mol. Cell. Proteom. 13 (2014), 2527–2544.
    • (2014) Mol. Cell. Proteom. , vol.13 , pp. 2527-2544
    • Armstrong, S.D.1
  • 67
    • 84982815640 scopus 로고    scopus 로고
    • Stage-specific proteomes from Onchocerca ochengi, sister species of the human river blindness parasite, uncover adaptations to a nodular lifestyle
    • Armstrong, S.D., et al. Stage-specific proteomes from Onchocerca ochengi, sister species of the human river blindness parasite, uncover adaptations to a nodular lifestyle. Mol. Cell. Proteom. 15 (2016), 2554–2575.
    • (2016) Mol. Cell. Proteom. , vol.15 , pp. 2554-2575
    • Armstrong, S.D.1
  • 68
    • 84907185220 scopus 로고    scopus 로고
    • Kv1.3 channel-blocking immunomodulatory peptides from parasitic worms: implications for autoimmune diseases
    • Chhabra, S., et al. Kv1.3 channel-blocking immunomodulatory peptides from parasitic worms: implications for autoimmune diseases. FASEB J. 28 (2014), 3952–3964.
    • (2014) FASEB J. , vol.28 , pp. 3952-3964
    • Chhabra, S.1
  • 69
    • 84906053733 scopus 로고    scopus 로고
    • Vaccination with a genetically modified Brugia malayi cysteine protease inhibitor-2 reduces adult parasite numbers and affects the fertility of female worms following a subcutaneous challenge of Mongolian gerbils (Meriones unguiculatus) with B. malayi infective larvae
    • Arumugam, S., et al. Vaccination with a genetically modified Brugia malayi cysteine protease inhibitor-2 reduces adult parasite numbers and affects the fertility of female worms following a subcutaneous challenge of Mongolian gerbils (Meriones unguiculatus) with B. malayi infective larvae. Int. J. Parasitol. 44 (2014), 675–679.
    • (2014) Int. J. Parasitol. , vol.44 , pp. 675-679
    • Arumugam, S.1
  • 70
    • 84996538227 scopus 로고    scopus 로고
    • The genome of Onchocerca volvulus, agent of river blindness
    • Cotton, J.A., et al. The genome of Onchocerca volvulus, agent of river blindness. Nat. Microbiol., 2, 2016, 16216.
    • (2016) Nat. Microbiol. , vol.2 , pp. 16216
    • Cotton, J.A.1
  • 71
    • 85007550882 scopus 로고    scopus 로고
    • Stage-specific transcriptome and proteome analyses of the filarial parasite Onchocerca volvulus and its Wolbachia endosymbiont
    • e02028-16
    • Bennuru, S., et al. Stage-specific transcriptome and proteome analyses of the filarial parasite Onchocerca volvulus and its Wolbachia endosymbiont. mBio, 7, 2016 e02028-16.
    • (2016) mBio , vol.7
    • Bennuru, S.1
  • 72
    • 84969961367 scopus 로고    scopus 로고
    • A next-generation proteome array for Schistosoma mansoni
    • de Assis, R.R., et al. A next-generation proteome array for Schistosoma mansoni. Int. J. Parasitol. 46 (2016), 411–415.
    • (2016) Int. J. Parasitol. , vol.46 , pp. 411-415
    • de Assis, R.R.1
  • 73
    • 77649324484 scopus 로고    scopus 로고
    • Schistosomiasis vaccine discovery using immunomics
    • Driguez, P., et al. Schistosomiasis vaccine discovery using immunomics. Parasit. Vectors, 3, 2010, 4.
    • (2010) Parasit. Vectors , vol.3 , pp. 4
    • Driguez, P.1
  • 74
    • 55849095837 scopus 로고    scopus 로고
    • Profiling humoral immune responses to P. falciparum infection with protein microarrays
    • Doolan, D.L., et al. Profiling humoral immune responses to P. falciparum infection with protein microarrays. Proteomics 8 (2008), 4680–4694.
    • (2008) Proteomics , vol.8 , pp. 4680-4694
    • Doolan, D.L.1
  • 75
    • 84897465663 scopus 로고    scopus 로고
    • An immunomics approach to schistosome antigen discovery: antibody signatures of naturally resistant and chronically infected individuals from endemic areas
    • Gaze, S., et al. An immunomics approach to schistosome antigen discovery: antibody signatures of naturally resistant and chronically infected individuals from endemic areas. PLoS Pathog., 10, 2014, e1004033.
    • (2014) PLoS Pathog. , vol.10 , pp. e1004033
    • Gaze, S.1
  • 76
    • 84895883455 scopus 로고    scopus 로고
    • Genome of the human hookworm Necator americanus
    • Tang, Y.T., et al. Genome of the human hookworm Necator americanus. Nat. Genet. 46 (2014), 261–269.
    • (2014) Nat. Genet. , vol.46 , pp. 261-269
    • Tang, Y.T.1
  • 77
    • 0038605738 scopus 로고    scopus 로고
    • Protein microarrays: from serodiagnosis to whole proteome scale analysis of the immune response against pathogenic microorganisms
    • Bacarese-Hamilton, T., et al. Protein microarrays: from serodiagnosis to whole proteome scale analysis of the immune response against pathogenic microorganisms. Biotechniques 33:Suppl (2002), S24–S29.
    • (2002) Biotechniques , vol.33 , pp. S24-S29
    • Bacarese-Hamilton, T.1
  • 78
    • 85012916636 scopus 로고    scopus 로고
    • Identification of three immunodominant motifs with atypical isotype profile scattered over the Onchocerca volvulus proteome
    • Lagatie, O., et al. Identification of three immunodominant motifs with atypical isotype profile scattered over the Onchocerca volvulus proteome. PLoS Negl. Trop. Dis., 11, 2017, e0005330.
    • (2017) PLoS Negl. Trop. Dis. , vol.11 , pp. e0005330
    • Lagatie, O.1
  • 79
    • 0036174745 scopus 로고    scopus 로고
    • Resistance and susceptibility in human onchocerciasis – beyond Th1 vs. Th2
    • Hoerauf, A., Brattig, N., Resistance and susceptibility in human onchocerciasis – beyond Th1 vs. Th2. Trends Parasitol. 18 (2002), 25–31.
    • (2002) Trends Parasitol. , vol.18 , pp. 25-31
    • Hoerauf, A.1    Brattig, N.2
  • 80
    • 84859492580 scopus 로고    scopus 로고
    • Future prospects and challenges of vaccines against filariasis
    • Babayan, S.A., et al. Future prospects and challenges of vaccines against filariasis. Parasite Immunol. 34 (2012), 243–253.
    • (2012) Parasite Immunol. , vol.34 , pp. 243-253
    • Babayan, S.A.1
  • 81
    • 84922237580 scopus 로고    scopus 로고
    • Hyperreactive onchocerciasis is characterized by a combination of Th17-Th2 immune responses and reduced regulatory T cells
    • Katawa, G., et al. Hyperreactive onchocerciasis is characterized by a combination of Th17-Th2 immune responses and reduced regulatory T cells. PLoS Negl. Trop. Dis., 9, 2015, e3414.
    • (2015) PLoS Negl. Trop. Dis. , vol.9 , pp. e3414
    • Katawa, G.1
  • 82
    • 1642493655 scopus 로고    scopus 로고
    • Pathogenesis and host responses in human onchocerciasis: impact of Onchocerca filariae and Wolbachia endobacteria
    • Brattig, N.W., Pathogenesis and host responses in human onchocerciasis: impact of Onchocerca filariae and Wolbachia endobacteria. Microbes Infect. 6 (2004), 113–128.
    • (2004) Microbes Infect. , vol.6 , pp. 113-128
    • Brattig, N.W.1
  • 83
    • 0028067284 scopus 로고
    • HLA-D alleles associated with generalized disease, localized disease, and putative immunity in Onchocerca volvulus infection
    • Meyer, C.G., et al. HLA-D alleles associated with generalized disease, localized disease, and putative immunity in Onchocerca volvulus infection. Proc. Natl. Acad. Sci. U. S. A. 91 (1994), 7515–7519.
    • (1994) Proc. Natl. Acad. Sci. U. S. A. , vol.91 , pp. 7515-7519
    • Meyer, C.G.1
  • 84
    • 0036159209 scopus 로고    scopus 로고
    • The variant Arg110Gln of human IL-13 is associated with an immunologically hyper-reactive form of onchocerciasis (sowda)
    • Hoerauf, A., et al. The variant Arg110Gln of human IL-13 is associated with an immunologically hyper-reactive form of onchocerciasis (sowda). Microbes Infect. 4 (2002), 37–42.
    • (2002) Microbes Infect. , vol.4 , pp. 37-42
    • Hoerauf, A.1
  • 85
    • 0037086602 scopus 로고    scopus 로고
    • Bacterial endosymbionts of Onchocerca volvulus in the pathogenesis of posttreatment reactions
    • Keiser, P.B., et al. Bacterial endosymbionts of Onchocerca volvulus in the pathogenesis of posttreatment reactions. J. Infect. Dis. 185 (2002), 805–811.
    • (2002) J. Infect. Dis. , vol.185 , pp. 805-811
    • Keiser, P.B.1
  • 86
    • 0028178759 scopus 로고
    • Lymph nodes of onchocerciasis patients after treatment with ivermectin: reaction of eosinophil granulocytes and their cationic granule proteins
    • Wildenburg, G., et al. Lymph nodes of onchocerciasis patients after treatment with ivermectin: reaction of eosinophil granulocytes and their cationic granule proteins. Trop. Med. Parasitol. 45 (1994), 87–96.
    • (1994) Trop. Med. Parasitol. , vol.45 , pp. 87-96
    • Wildenburg, G.1
  • 87
    • 85015297808 scopus 로고    scopus 로고
    • Machine-learning algorithms define pathogen-specific local immune fingerprints in peritoneal dialysis patients with bacterial infections
    • Zhang, J., et al. Machine-learning algorithms define pathogen-specific local immune fingerprints in peritoneal dialysis patients with bacterial infections. Kidney Int. 92 (2017), 179–191.
    • (2017) Kidney Int. , vol.92 , pp. 179-191
    • Zhang, J.1
  • 88
    • 0003684449 scopus 로고    scopus 로고
    • The Elements of Statistical Learning: Data Mining, Inference, and Prediction
    • 10th edn. Springer
    • Hastie, T., et al. The Elements of Statistical Learning: Data Mining, Inference, and Prediction. 10th edn., 2009, Springer.
    • (2009)
    • Hastie, T.1
  • 89
    • 85001720558 scopus 로고    scopus 로고
    • Standardized whole-blood transcriptional profiling enables the deconvolution of complex induced immune responses
    • Urrutia, A., et al. Standardized whole-blood transcriptional profiling enables the deconvolution of complex induced immune responses. Cell Rep. 16 (2016), 2777–2791.
    • (2016) Cell Rep. , vol.16 , pp. 2777-2791
    • Urrutia, A.1
  • 90
    • 84966713314 scopus 로고    scopus 로고
    • Human anthelminthic vaccines: rationale and challenges
    • Hotez, P.J., et al. Human anthelminthic vaccines: rationale and challenges. Vaccine 34 (2016), 3549–3555.
    • (2016) Vaccine , vol.34 , pp. 3549-3555
    • Hotez, P.J.1
  • 91
    • 85020409609 scopus 로고    scopus 로고
    • Safety and immunogenicity of the Na-GST-1 hookworm vaccine in Brazilian and American adults
    • Diemert, D.J., et al. Safety and immunogenicity of the Na-GST-1 hookworm vaccine in Brazilian and American adults. PLoS Negl. Trop. Dis., 11, 2017, e0005574.
    • (2017) PLoS Negl. Trop. Dis. , vol.11 , pp. e0005574
    • Diemert, D.J.1
  • 92
    • 84963585223 scopus 로고    scopus 로고
    • Advancing a vaccine to prevent human schistosomiasis
    • Merrifield, M., et al. Advancing a vaccine to prevent human schistosomiasis. Vaccine 34 (2016), 2988–2991.
    • (2016) Vaccine , vol.34 , pp. 2988-2991
    • Merrifield, M.1


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