Randomized, placebo-controlled, double-blind trial of the Na-ASP-2 Hookworm Vaccine in unexposed adults

Vaccine

Volumn 26, Issue 19, 2008, Pages 2408-2417

  Bethony, Jeffrey M ^a   Simon, Gary ^b   Diemert, David J ^a,c   Parenti, David ^b   Desrosiers, Aimee ^b   Schuck, Suzanne ^b   Fujiwara, Ricardo ^d   Santiago, Helton ^a   Hotez, Peter J ^a,c  

^a GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^b GEORGE WASHINGTON UNIVERSITY   (United States)

^c Albert B Sabin Vaccine Institute   (United States)

^d INSTITUTO OSWALDO CRUZ   (Brazil)

Author keywords

Hookworm; Nematode; Phase 1; Recombinant vaccine

Indexed keywords

ALUMINUM HYDROXIDE; IMMUNOGLOBULIN G ANTIBODY; PLACEBO; RECOMBINANT NECATOR AMERICANUS ANCYLOSTOMA SECRETED PROTEIN 2; RECOMBINANT VACCINE; SODIUM CHLORIDE;

ADULT; ANTIBODY TITER; ARTHRALGIA; ARTICLE; CELL PROLIFERATION; CELL STIMULATION; CLINICAL TRIAL; COHORT ANALYSIS; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG DOSE ESCALATION; DRUG FEVER; DRUG INDUCED HEADACHE; DRUG SAFETY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FOLLOW UP; HOOKWORM INFECTION; HUMAN; IMMUNIZATION; IMMUNOGENICITY; IN VITRO STUDY; INJECTION SITE ERYTHEMA; INJECTION SITE PAIN; INJECTION SITE PRURITUS; INJECTION SITE SWELLING; MALE; MYALGIA; NAUSEA; NORMAL HUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; STATISTICAL SIGNIFICANCE;

ADOLESCENT; ADULT; ANIMALS; ANTIBODIES, HELMINTH; CELL PROLIFERATION; CELLS, CULTURED; DOUBLE-BLIND METHOD; GENE EXPRESSION; HELMINTH PROTEINS; HOOKWORM INFECTIONS; HUMANS; IMMUNIZATION, SECONDARY; IMMUNOGLOBULIN G; INJECTIONS, INTRAMUSCULAR; LEUKOCYTES, MONONUCLEAR; NECATOR AMERICANUS; PICHIA; PLACEBOS; VACCINES, SYNTHETIC;

EID: 42649132461     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2008.02.049     Document Type: Article

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