Development of a recombinant antigen vaccine against infection with the filarial worm Onchocerca volvulus

Infection and Immunity

Volumn 69, Issue 1, 2001, Pages 262-270

  Abraham, D ^a   Leon, O ^a   Leon, S ^a   Lustigman, S ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALUMINUM POTASSIUM SULFATE; COMPLEMENTARY DNA; FREUND ADJUVANT; RECOMBINANT ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; IMMUNITY; IMMUNIZATION; INFECTION CONTROL; INFECTION PREVENTION; MALE; MOUSE; NONHUMAN; ONCHOCERCA VOLVULUS; ONCHOCERCIASIS; PARASITE SURVIVAL; PRIORITY JOURNAL;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIBODIES, HELMINTH; ANTIGENS, HELMINTH; HUMANS; IMMUNIZATION; MALE; MICE; MICE, INBRED BALB C; ONCHOCERCA VOLVULUS; ONCHOCERCIASIS; PAN TROGLODYTES; RABBITS; RECOMBINANT PROTEINS; VACCINES, SYNTHETIC;

EID: 0035171703     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.69.1.262-270.2001     Document Type: Article

References (55)

1. Genetic control of murine immune responses to larval Dirofilaria immitis
2. Passive transfer of protective immunity to larval Dirofilaria immitis from dogs to BALB/c mice
3. Immunity to larval Brugia malayi in BALB/c mice: Protective immunity and inhibition of larval development
4. Dirofilaria immitis: Surface properties of third- and fourth-stage larvae
5. Active and passive immunization of mice against larval Dirofilaria immitis
6. Survival and development of larval Onchocerca volvulus in diffusion chambers implanted in primate and rodent hosts
7. Strongyloides stercoralis: Protective immunity to third-stage larvae in BALB/cByJ mice
8. Protective immune responses of the jird to larval Dipetalonema viteae
9. Expression in yeast of a Plasmodium vivax antigen of potential use in a human malaria vaccine
10. Differences in cytokine responses to Onchocerca volvulus extract and recombinant Ov33 and OvL3-1 proteins in exposed subjects with various parasitologic and clinical states
11. Strongyloides stercoralis host-adapted third-stage larvae are the target of eosinophil-associated immune-mediated killing in mice
12. Chronicity in Strongyloides stercoralis infections: Dichotomy of the protective immune response to infective and autoinfective larvae in a mouse model
13. Large scale production of the vertebrate infective stage (L3) of Onchocerca volvulus (Filarioidea: Onchocercidae)
14. The contributions of different age groups to the transmission of onchocerciasis in a Cameroon forest village
15. Protective immunity. Linked with a distinct developmental stage of a filarial parasite
16. Immunity to onchocerciasis: Identification of a putatively immune population in a hyperendemic area of Ecuador
17. Induction of TH1 and TH2 immunity in neonatal mice
18. Purification and characterization of throe larval excretory-secretory proteins of Dirofilaria immitis
19. Molecular cloning of a developmentally regulated protein isolated from excretory-secretory products of larval Dirofilaria immitis
20. Cell-mediated immune responses in human infection with Onchocerca volvulus
21. Modern medicine versus an ancient scourge: Progress toward control of onchocerciasis
22. Differentially expressed, abundant trans-spliced cDNAs from larval Brugia malayi
23. Induction of protective immunity in dogs to infection with Dirofilaria immitis using chemically-abbreviated infections
24. A filarial cysteine protease inhibitor down-regulates T cell proliferation and enhances interleukin-10 production
25. Identification and characterization of an Onchocerca volvulus cDNA clone encoding a highly immunogenic calponin-like protein
26. Characterization of a secreted antigen of Onchocerca volvulus with host-protective potential
27. Onchocerca volvulus: In vitro cytotoxic effects of human neutrophils and serum on third-stage larvae
28. Immune responses to third stage larvae of Onchocerca volvulus in interferon-gamma and interleukin-4 knockout mice
29. Characterization of an Onchocerca volvulus L3-specific larval antigen, Ov-ALT-1
30. Onchocera volvulus: Characterization of a highly immunogenic Gln-rich protein
31. Influence of adjuvants on the quantity, affinity, isotype and epitope specificity of murine antibodies
32. Regulation of the immune response in lymphatic filariasis and onchocerciasis
33. Induction of protective immunity against larval Onchocerca volvulus in a mouse model
34. IL-4- and IL-5-dependent protective immunity to Onchocerca volvulus infective larvae in BALB/cBYJ mice
35. Vaccination with recombinant filarial paramyosin induces partial immunity to Brugia malayi infection in jirds
36. Immunoregulation in onchocerciasis: Predominance of Th1-type responsiveness to low molecular weight antigens of Onchocerca volvulus in exposed individuals without microfilaridermia and clinical disease
37. Characterization of an Onchocerca volvulus eDNA clone encoding a genus specific antigen present in infective larvae and adult worms
38. Molecular cloning and characterization of onchocystatin, a cysteine proteinase inhibitor of Onchocerca volvulus
39. Onchocerca volvulus: Biochemical and morphological characteristics of the surface of third- and fourth-stage larvae
40. Cloning of a cysteine protease required for the molting of Onchocerca volvulus third stage larvae
41. Successful vaccination of cats against Brugia pahangi with larvae attenuated by irradiation with 10 krad cobalt 60
42. Immune responsiveness and the pathogenesis of human onchocerciasis
43. Acanthocheilonema viteae: Characterization of a molt-associated excretory/secretory 18kDa protein
44. Onchocerca volvulus: Immunization of chimpanzees with X-irradiated third-stage (L3) larvae
45. Vaccination against the nematode Trichinella spiralis in high- and low-responder mice. Effects of different adjuvants upon protective immunity and immune responsiveness
46. Acanthocheilonema viteae: Vaccination with irradiated L3 induces resistance in three species of rodents (Meriones unguiculatus, Mastomys coucha, Mesocricetus auratus)
47. The diverse expression of immunity in humans at distinct states of Onchocerca volvulus infection
48. Regulation of IL-5 in onchocerciasis. A critical role for IL-2
49. Onchocerca volvulus larval antigen, OvB20, induces partial protection in a rodent model of onchocerciasis
50. Characterization of a recombinant Onchocerca volvulus antigen (Ov33) produced in yeast
51. Immunity to onchocerciasis: Cells from putatively immune individuals produce enhanced levels of interleukin-5, gamma interferon, and granulocyte-macrophage colony-stimulating factor in response to Onchocerca volvulus larval and male worm antigens
52. Onchocerciasis and immunity in humans: Enhanced T cell responsiveness to parasite antigen in putatively immune individuals
53. Litomosoides carinii in jirds (Meriones unguiculatus): Ability to retard development of challenge larvae can be transferred with cells and serum
54. Dirofilaria immitis: Fate and immunogenicity of irradiated infective stage larvae in beagles
55. Adjuvant-guided type-1 and type-2 immunity: Infectious/noninfectious dichotomy defines the class of response