Kv1.3 channel-blocking immunomodulatory peptides from parasitic worms: Implications for autoimmune diseases

FASEB Journal

Volumn 28, Issue 9, 2014, Pages 3952-3964

  Chhabra, Sandeep ^a   Chang, Shih Chieh ^a   Nguyen, Hai M ^b,c   Huq, Redwan ^d   Tanner, Mark R ^d   Londono, Luz M ^e   Estrada, Rosendo ^f   Dhawan, Vikas ^f   Chauhan, Satendra ^f   Upadhyay, Sanjeev K ^b   Gindin, Mariel ^g,h   Hotez, Peter J ^d   Valenzuela, Jesus G ^h   Mohanty, Biswaranjan ^a   Swarbrick, James D ^a   Wulff, Heike ^c   Iadonato, Shawn P ^e   Gutman, George A ^b   Beeton, Christine ^d   Pennington, Michael W ^f   Norton, Raymond S ^a   Chandy, K George ^b   more..

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

^e Kineta Inc   (United States)

^f Peptides International   (United States)

^g GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^h NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

Hookworm; Ion channel modulator; Probiotic worm therapy; ShK; T lymphocytes

Indexed keywords

ANCYLOSTOMA CANINUM K1; BRUGIA MALAYI K1; BRUGIA MALAYI K2; GAMMA INTERFERON; HELMINTH PROTEIN; IMMUNOMODULATING AGENT; INTERLEUKIN 14; INTERLEUKIN 2; INTERLEUKIN 4; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL KV1.3; POTASSIUM CHANNEL KV1.3 BLOCKING IMMUNOMODULATING PEPTIDE; PROTEIN KINASE C; UNCLASSIFIED DRUG; CCR7 PROTEIN, HUMAN; CHEMOKINE RECEPTOR CCR7; COELENTERATE VENOM; CYTOKINE; PEPTIDE FRAGMENT; SHK NEUROTOXIN;

ANCYLOSTOMA CANINUM; ANCYLOSTOMA CEYLANICUM; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; AUTOIMMUNE DISEASE; BRUGIA MALAYI; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DELAYED HYPERSENSITIVITY; FEMALE; FIBROBLAST; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PEPTIDE SYNTHESIS; PHYLOGENETIC TREE; PROTEIN EXPRESSION; PROTEIN STRUCTURE; STICHODACTYLA HELIANTHUS; THERAPY WITH HELMINTHS; UPREGULATION; AMINO ACID SEQUENCE; ANIMAL; ANTAGONISTS AND INHIBITORS; AUTOIMMUNE DISEASES; CELL CULTURE; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; ELECTROPHYSIOLOGY; HELMINTH; HYPERSENSITIVITY, DELAYED; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; LEWIS RAT; MALE; METABOLISM; MOLECULAR GENETICS; PHYLOGENY; PROTEIN CONFORMATION; RAT; SEQUENCE HOMOLOGY; STRUCTURE ACTIVITY RELATION; T LYMPHOCYTE;

AMINO ACID SEQUENCE; ANIMALS; AUTOIMMUNE DISEASES; CELL PROLIFERATION; CELLS, CULTURED; CNIDARIAN VENOMS; CYTOKINES; ELECTROPHYSIOLOGY; FEMALE; FIBROBLASTS; HELMINTHS; HUMANS; HYPERSENSITIVITY, DELAYED; IMMUNOLOGIC MEMORY; KV1.3 POTASSIUM CHANNEL; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PHYLOGENY; POTASSIUM CHANNEL BLOCKERS; PROTEIN CONFORMATION; RATS; RATS, INBRED LEW; RECEPTORS, CCR7; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP; T-LYMPHOCYTES;

EID: 84907185220     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.14-251967     Document Type: Article

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