Towards a recombinant antigen vaccine against Onchocerca volvulus

Trends in Parasitology

Volumn 18, Issue 3, 2002, Pages 135-141

  Lustigman, Sara ^a   James, Eric R ^b   Tawe, Wilson ^a   Abraham, David ^c  

^a NEW YORK BLOOD CENTER   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AV ABC VACCINE; AV UBI VACCINE; CATALASE; CYSTATIN; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G3; MACROPHAGE MIGRATION INHIBITION FACTOR; O15 O13; OV 103; OV ALT 1; OV ASP 1; OV B20; OV B8; OV CAL 1; OV CHI 1; OV CHI 2; OV CPI 2; OV FBA 1; OV RAL 2; OV RBP 1; OV TMY 1; RECOMBINANT ANTIGEN; SERINE PROTEINASE INHIBITOR; SUPEROXIDE DISMUTASE; THIOREDOXIN PEROXIDASE; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; VACCINE;

ANTIBODY RESPONSE; DNA LIBRARY; HUMAN; IMMUNITY; IMMUNIZATION; MICROFILARIA; MOLECULAR CLONING; NONHUMAN; ONCHOCERCA VOLVULUS; ONCHOCERCIASIS; POLYMERASE CHAIN REACTION; REVIEW; SEQUENCE HOMOLOGY; TH1 CELL; TH2 CELL; VACCINATION;

ANIMALS; ANTIGENS, PROTOZOAN; BASE SEQUENCE; HUMANS; MOLECULAR SEQUENCE DATA; ONCHOCERCA VOLVULUS; ONCHOCERCIASIS; POLYMERASE CHAIN REACTION; PROTOZOAN VACCINES; VACCINATION; VACCINES, SYNTHETIC;

ANIMALIA; NEMATODA; ONCHOCERCA; ONCHOCERCA VOLVULUS;

EID: 0036498233     PISSN: 14714922     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4922(01)02211-5     Document Type: Review

References (59)

1. WHO expert Committee on Onchocerciasis Control. Onchocerciasis and its control
2. The impact of Mectizan on the transmission of onchocerciasis
3. Protective immunity linked with a distinct developmental stage of a filarial parasite
4. Parasitology and immunology of mice vaccinated with irradiated Litomosoides sigmodontis larvae
5. Acanthocheilonema viteae: Vaccination of jirds with irradiation-attenuated stage-3 larvae and with exported larval antigens
6. Immune responses to filarial infection in laboratory mice
7. Development of a recombinant antigen vaccine against infection with the filarial worm Onchocerca volvulus
8. Immunity to onchocerciasis: Identification of a putatively immune population in a hyperendemic area of Ecuador
9. Immunity to onchocerciasis: Cells from putatively immune individuals produce enhanced levels of interleukin-5, gamma interferon, and granulocyte-macrophage colony-stimulating factor in response to Onchocerca volvulus larval and male worm antigens
10. Guatemalan human onchocerciasis. II. Evidence for IgG3 involvement in acquired immunity to Onchocerca volvulus and identification of possible immune-associated antigens
11. Isotype-specific characterization of antibody responses to Onchocerca volvulus in putatively immune individuals
12. Identification of larval-stage-specific antigens on Onchocerca volvulus uniquely recognized by putative immune sera from humans and vaccination sera from animal models
13. Immunoregulation in onchocerciasis: Predominance of Th1-type responsiveness to low molecular weight antigens of Onchocerca volvulus in exposed individuals without microfilaridermia and clinical disease
14. The diverse expression of immunity in humans at distinct states of Onchocerca volvulus infection
15. Immunity to onchocerciasis: Putative immune persons produce a Th1-like response to Onchocerca volvulus
16. The contribution of different age groups to the transmission of onchocerciasis in a Cameroon forest village
17. Age-specific acquisition of immunity to infective larvae in a bancroftian filariasis endemic area of Papua New Guinea
18. Depression of antigen-specific interleukin-5 and interferon-γ responses in human lymphatic filariasis as a function of clinical status and age
19. Antibody responses to filarial infective larvae are not dominated by the IgG4 isotype
20. Induction of protective immunity against larval Onchocerca volvulus in a mouse model
21. Protective immunity against Onchocerca volvulus and Onchocerca lienalis infective larvae in mice
22. Immune responses to third-stage larvae of Onchocerca volvulus in interferon-gamma and interleukin-4 knockout mice
23. Onchocerca volvulus: Immunization of chimpanzees with X-irradiated third-stage (L3) larvae
24. Onchocerca ochengi infections in cattle as a model for human onchocerciasis: Recent developments
25. IL-4 and IL-5-dependent protective immunity to Onchocerca volvulus infective larvae in BALB/cBYJ mice
26. IL-5 is essential for vaccine-induced protection and for resolution of primary infection in murine filariasis
27. Role of B lymphocytes in host protection against the human filarial parasite, Brugia malayi
28. Onchocerca volvulus larval antigen, OvB20, induces partial protection in a rodent model of onchocerciasis
29. Recognition of schistosome glycolipids by immunoglobulin E: Possible role in immunity
30. Glycans as targets for monoclonal antibodies that protect rats against Trichinella spiralis
31. Participation of parasite surface glycoproteins in antibody-mediated protection of epithelia against Trichinella spiralis
32. Antibodies to tyvelose exhibit multiple modes of interference with the epithelial niche of Trichinella spiratis
33. Onchocerca volvulus: In vitro cytotoxic effects of human neutrophils and serum on third-stage larvae
34. Characterization of an Onchocerca volvulus L3-specific larval antigen, Ov-ALT-1
35. Identification of potential vaccine and drug target candidates by expressed sequence tag analysis and immunoscreening of an Onchocerca volvulus larval cDNA library
36. Onchocerca volvulus: Characterization of a highly immunogenic Gln-rich protein
37. Vaccination against parasites: Special problems imposed by the adaptation of parasitic organisms to the host immune response
38. Antioxidant enzyme families in parasitic nematodes
39. Chitinase genes expressed by infective larvae of the filarial nematodes, Acanthocheilonema viteae and Onchocerca volvulus
40. DNA immunisation with Onchocerca volvulus chitinase induces partial protection against challenge infection with L3 larvae in mice
41. Angiogenic activity of Onchocerca volvulus recombinant proteins similar to vespid venom antigen 5
42. Resistance to Onchocerca volvulus: Differential cellular and humoral responses to a recombinant antigen, OvMBP20/11
43. Molecular cloning of a developmentally regulated protein isolated from excretory-secretory products of larval Dirofilaria immitis
44. The abundant larval transcript-1 and -2 genes of Brugia malayi encode stage-specific candidate vaccine antigens for filariasis
45. Vaccination with alum-precipitated recombinant Ancylostoma-secreted protein 1 protects mice against challenge infections with infective hookworm (Ancylostoma caninum) larvae
46. Characterization of a secreted antigen of Onchocerca volvulus with host-protective potential
47. Identification of chitinase as the immunodominant filarial antigen recognized by sera of vaccinated rodents
48. Resistance of filarial nematode parasites to oxidative stress
49. Glutathione S-transferases of 28kDa as major vaccine candidates against schistosomiasis
50. Induction of specific cell-mediated immunity in mice by oral immunization with Salmonella expressing Onchocerca volvulus glutathione S-transferase
51. Immune evasion genes from filarial nematodes
52. Field studies and cost effectiveness analysis of vaccination with Gavac against the cattle tick Boophilus microplus
53. Protection studies with integral membrane fractions of Haemonchus contortus
54. Brugia pahangi: Feeding and nutrient uptake in vitro and in vivo
55. Immunisation of mice with fractions derived from the intestines of Dirofilaria immitis
56. OvGalBP, a filarial antigen with homology to vertebrate galactoside-binding proteins
57. Molecular and serological analysis of cDNAs encoding an intermediate-filament protein from Onchocerca volvulus
58. Onchocerca volvulus infections in chimpanzees: An assessment of requirements for vaccination trials
59. Onchocerca volvulus glycolytic enzyme fructose-1,6-biphosphate aldolase as a target for a protective immune response in humans