Deletion of Parasite Immune Modulatory Sequences Combined with Immune Activating Signals Enhances Vaccine Mediated Protection against Filarial Nematodes

PLoS Neglected Tropical Diseases

Volumn 6, Issue 12, 2012, Pages

  Babayan, Simon A ^a   Luo, HongLin ^a   Gray, Nick ^a   Taylor, David W ^a,b   Allen, Judith E ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE PROTEINASE INHIBITOR 2; DNA VACCINE; FLT3 LIGAND; GAMMA INTERFERON; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; LARVAL TRANSCRIPT 1; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; PROTOZOAL PROTEIN; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DNA IMMUNIZATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FILARIA; HELPER CELL; IMMUNE RESPONSE; IMMUNOMODULATION; LEUKOCYTE ACTIVATION; LITOMOSOIDES SIGMODONTIS; MOUSE; NEMATODE; NONHUMAN; PARASITE SURVIVAL; PROTEIN EXPRESSION;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIBODIES, HELMINTH; ANTIGENS, HELMINTH; CYTOKINES; DISEASE MODELS, ANIMAL; DNA, HELMINTH; FEMALE; FILARIASIS; FILARIOIDEA; LYMPHOCYTES; MICE; MICE, INBRED BALB C; SEQUENCE DELETION; VACCINES, DNA; VACCINES, SUBUNIT;

EID: 84872046086     PISSN: 19352727     EISSN: 19352735     Source Type: Journal    
DOI: 10.1371/journal.pntd.0001968     Document Type: Article

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