Vaccination with a genetically modified brugia malayi cysteine protease inhibitor-2 reduces adult parasite numbers and affects the fertility of female worms following a subcutaneous challenge of Mongolian gerbils (meriones unguiculatus) with b. malayi infective larvae

International Journal for Parasitology

Volumn 44, Issue 10, 2014, Pages 675-679

  Arumugam, Sridhar ^a   Wei, Junfei ^b   Ward, Danielle ^a   Abraham, David ^c   Lustigman, Sara ^d   Zhan, Bin ^b   Klei, Thomas R ^a  

^a LOUISIANA STATE UNIVERSITY   (United States)

^b TEXAS CHILDREN S HOSPITAL   (United States)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

^d NEW YORK BLOOD CENTER   (United States)

Author keywords

Antibody dependent cell mediated cytotoxicity (ADCC); Brugia malayi cysteine protease inhibitor 2 (Bm CPI 2); Fecundity; Filariasis; Vaccination

Indexed keywords

CYSTEINE PROTEINASE INHIBITOR; CYSTEINE PROTEINASE INHIBITOR 2; IMMUNOGLOBULIN G ANTIBODY; UNCLASSIFIED DRUG; VACCINE;

ANTIBODY; FECUNDITY; FILARIASIS; INHIBITOR; TOXICITY; VACCINATION;

ADULT; AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANTIBODY BLOOD LEVEL; ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; ANTIBODY RESPONSE; ARTICLE; BRUGIA MALAYI; BRUGIAN FILARIASIS; CONTROLLED STUDY; DNA MODIFICATION; FEMALE; FERTILITY; IMMUNOMODULATION; IN VITRO STUDY; MALE; MERIONES UNGUICULATUS; MICROFILARIA (NEMATODE LARVA); NONHUMAN; NUCLEOTIDE SEQUENCE; PARASITE LOCALIZATION; PERITONEAL EXUDATE CELL; ANIMAL; FILARIASIS; GENE EXPRESSION REGULATION; GENETICS; GERBIL; IMMUNOLOGY; LARVA; METABOLISM; PARASITOLOGY;

BRUGIA MALAYI; GERBILLINAE; MERIONES UNGUICULATUS;

AMINO ACID SUBSTITUTION; ANIMALS; BRUGIA MALAYI; CYSTEINE PROTEINASE INHIBITORS; FEMALE; FILARIASIS; GENE EXPRESSION REGULATION; GERBILLINAE; LARVA; VACCINES;

EID: 84906053733     PISSN: 00207519     EISSN: 18790135     Source Type: Journal    
DOI: 10.1016/j.ijpara.2014.05.003     Document Type: Article

References (21)

1. Abraham D., Leon O., Leon S., Lustigman S. Development of a recombinant antigen vaccine against infection with the filarial worm Onchocerca volvulus. Infect. Immun. 2001, 69:262-270.
2. Arumugam S., Zhan B., Abraham D., Ward D., Lustigman S., Klei T.R. Vaccination with recombinant Brugia malayi cystatin proteins alters worm migration, homing and final niche selection following a subcutaneous challenge of Mongolian gerbils (Meriones unguiculatus) with B. malayi infective larvae. Parasit. Vectors 2014, 7:43.
3. Babayan S.A., Luo H., Gray N., Taylor D.W., Allen J.E. Deletion of parasite immune modulatory sequences combined with immune activating signals enhances vaccine mediated protection against filarial nematodes. PLoS Negl. Trop. Dis. 2012, 6:e1968.
4. Chandrasekhar R., Rao U.R., Subramanyam D. Serum dependent cell mediated reactions to Brugia pahangi infective larvae. Parasite Immunol. 1985, 7:633-642.
5. Dakshinamoorthy G., Kalyanasundaram R. Evaluating the efficacy of rBmHATαc as a multivalent vaccine against lymphatic filariasis in experimental animals and optimizing the adjuvant formulation. Vaccine 2013, 32:19-25.
6. de Macedo Soares M.F., de Macedo M.S. Modulation of anaphylaxis by helminth-derived products in animal models. Curr. Allergy Asthma Rep. 2007, 7:56-61.
7. Gregory W.F., Maizels R.M. Cystatins from filarial parasites: evolution, adaptation and function in the host-parasite relationship. Int. J. Biochem. Cell Biol. 2008, 40:1389-1398.
8. Hashmi S., Zhang J., Oksov Y., Ji Q., Lustigman S. The Caenorhabditis elegans CPI-2a cystatin-like inhibitor has an essential regulatory role during oogenesis and fertilization. J. Biol. Chem. 2006, 281:28415-28429.
9. Klei T.R., McVay C.S., Dennis V.A., Coleman S.U., Enright F.M., Casey H.W. Brugia pahangi: effects of duration of infection and parasite burden on lymphatic lesion severity, granulomatous hypersensitivity, and immune responses in jirds (Meriones unguiculatus). Exp. Parasitol. 1990, 71:393-405.
10. Lustigman S., Brotman B., Huima T., Prince A.M., McKerrow J.H. Molecular cloning and characterization of onchocystatin, a cysteine proteinase inhibitor of Onchocerca volvulus. J. Biol. Chem. 1992, 267:17339-17346.
11. Lustigman S., James E.R., Tawe W., Abraham D. Towards a recombinant antigen vaccine against Onchocerca volvulus. Trends Parasitol. 2002, 18:135-141.
12. Lustigman, S., 2012. Current approaches to the development of a vaccine against filarial nematodes. In: Lamb, T.J (Ed.), Immunity to Parasitic Infection. John Wiley & Sons Ltd., Chichester, UK, pp. 459-470.
13. Manoury B., Gregory W.F., Maizels R.M., Watts C. Bm-CPI-2, a cystatin homolog secreted by the filarial parasite Brugia malayi, inhibits class II MHC-restricted antigen processing. Curr. Biol. 2001, 11:447-451.
14. Murray J., Manoury B., Balic A., Watts C., Maizels R.M. Bm-CPI-2, a cystatin from Brugia malayi nematode parasites, differs from Caenorhabditis elegans cystatins in a specific site mediating inhibition of the antigen-processing enzyme AEP. Mol. Biochem. Parasitol. 2005, 139:197-203.
15. Osei-Atweneboana M.Y., Awadzi K., Attah S.K., Boakye D.A., Gyapong J.O., Prichard R.K. Phenotypic evidence of emerging ivermectin resistance in Onchocerca volvulus. PLoS Negl. Trop. Dis. 2011, 5:e998.
16. Pfaff A.W., Schulz-Key H., Soboslay P.T., Taylor D.W., MacLennan K., Hoffmann W.H. Litomosoides sigmodontis cystatin acts as an immunomodulator during experimental filariasis. Int. J. Parasitol. 2002, 32:171-178.
17. Prichard R.K., Basáñez M.G., Boatin B.A., McCarthy J.S., García H.H., Yang G.J., Sripa B., Lustigman S. A research agenda for helminth diseases of humans: intervention for control and elimination. PLoS Negl. Trop. Dis. 2012, 6:e1549.
18. WHO Global programme to eliminate lymphatic filariasis: progress report in 2011. Wkly. Epidemiol. Rec. 2012, 87:346-356.
19. Zhan B., Hotez J.P., Wang Y., Hawdon M.J. A developmentally regulated metalloprotease secreted by host-stimulated Ancylostoma caninum third-stage infective larvae is a member of the astacin family of protease. Mol. Biochem. Parasitol. 2002, 120:291-296.
20. Zipperer G.R., Arumugam S., Chirgwin S.R., Coleman S.U., Shakya K.P., Klei T.R. Brugia pahangi: Immunization with early L3 ES alters parasite migration, fecundity and lymphatic lesion formation in gerbils (Meriones unguiculatus). Exp. Parasitol. 2013, 135:446-455.
21. Ziewer, S., Hübner, M.P., Dubben, B., Hoffmann, W.H., Bain, O., Martin, C., Hoerauf, A., Specht, S., 2012. Immunization with L. sigmodontis microfilariae reduces peripheral microfilaraemia after challenge infection by inhibition of filarial embryogenesis. PLoS. Negl. Trop. Dis. 6, e1558.