-
1
-
-
85016121430
-
Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention
-
Tomasetti C, Li L, Vogelstein B. 2017. Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention. Science 355: 1330–4.
-
(2017)
Science
, vol.355
, pp. 1330-1334
-
-
Tomasetti, C.1
Li, L.2
Vogelstein, B.3
-
2
-
-
70749158525
-
Whole chromosome instability caused by Bub1 insufficiency drives tumorigenesis through tumor suppressor gene loss of heterozygosity
-
Baker DJ, Jin F, Jeganathan KB, van Deursen JM. 2009. Whole chromosome instability caused by Bub1 insufficiency drives tumorigenesis through tumor suppressor gene loss of heterozygosity. Cancer Cell 16: 475–86.
-
(2009)
Cancer Cell
, vol.16
, pp. 475-486
-
-
Baker, D.J.1
Jin, F.2
Jeganathan, K.B.3
van Deursen, J.M.4
-
3
-
-
85010877195
-
Centrosome amplification is sufficient to promote spontaneous tumorigenesis in mammals
-
Levine MS, Bakker B, Boeckx B, Moyett J, et al. 2017. Centrosome amplification is sufficient to promote spontaneous tumorigenesis in mammals. Dev Cell 40: 313–22 e5.
-
(2017)
Dev Cell
, vol.40
, pp. 313-322
-
-
Levine, M.S.1
Bakker, B.2
Boeckx, B.3
Moyett, J.4
-
4
-
-
84983087695
-
BubR1 alterations that reinforce mitotic surveillance act against aneuploidy and cancer
-
Weaver RL, Limzerwala JF, Naylor RM, Jeganathan KB, et al. 2016. BubR1 alterations that reinforce mitotic surveillance act against aneuploidy and cancer. Elife 5: pii: e16620.
-
(2016)
Elife
, vol.5
-
-
Weaver, R.L.1
Limzerwala, J.F.2
Naylor, R.M.3
Jeganathan, K.B.4
-
5
-
-
0030936323
-
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
-
Li J, Yen C, Liaw D, Podsypanina K, et al. 1997. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 275: 1943–7.
-
(1997)
Science
, vol.275
, pp. 1943-1947
-
-
Li, J.1
Yen, C.2
Liaw, D.3
Podsypanina, K.4
-
6
-
-
17144436629
-
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
-
Steck PA, Pershouse MA, Jasser SA, Yung WK, et al. 1997. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet 15: 356–62.
-
(1997)
Nat Genet
, vol.15
, pp. 356-362
-
-
Steck, P.A.1
Pershouse, M.A.2
Jasser, S.A.3
Yung, W.K.4
-
7
-
-
0032577699
-
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
-
Maehama T, Dixon JE. 1998. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 273: 13375–8.
-
(1998)
J Biol Chem
, vol.273
, pp. 13375-13378
-
-
Maehama, T.1
Dixon, J.E.2
-
8
-
-
0033514509
-
Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway
-
Ramaswamy S, Nakamura N, Vazquez F, Batt DB, et al. 1999. Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway. Proc Natl Acad Sci USA 96: 2110–5.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 2110-2115
-
-
Ramaswamy, S.1
Nakamura, N.2
Vazquez, F.3
Batt, D.B.4
-
9
-
-
0033563157
-
Adenovirus-mediated gene transfer of MMAC1/PTEN to glioblastoma cells inhibits S phase entry by the recruitment of p27Kip1 into cyclin E/CDK2 complexes
-
Cheney IW, Neuteboom ST, Vaillancourt MT, Ramachandra M, et al. 1999. Adenovirus-mediated gene transfer of MMAC1/PTEN to glioblastoma cells inhibits S phase entry by the recruitment of p27Kip1 into cyclin E/CDK2 complexes. Cancer Res 59: 2318–23.
-
(1999)
Cancer Res
, vol.59
, pp. 2318-2323
-
-
Cheney, I.W.1
Neuteboom, S.T.2
Vaillancourt, M.T.3
Ramachandra, M.4
-
10
-
-
13044305289
-
PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway
-
Sun H, Lesche R, Li DM, Liliental J, et al. 1999. PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway. Proc Natl Acad Sci USA 96: 6199–204.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 6199-6204
-
-
Sun, H.1
Lesche, R.2
Li, D.M.3
Liliental, J.4
-
11
-
-
0036841293
-
Activation of Akt/protein kinase B overcomes a G(2)/m cell cycle checkpoint induced by DNA damage
-
Kandel ES, Skeen J, Majewski N, Di Cristofano A, et al. 2002. Activation of Akt/protein kinase B overcomes a G(2)/m cell cycle checkpoint induced by DNA damage. Mol Cell Biol 22: 7831–41.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 7831-7841
-
-
Kandel, E.S.1
Skeen, J.2
Majewski, N.3
Di Cristofano, A.4
-
12
-
-
13844251972
-
Lack of PTEN sequesters CHK1 and initiates genetic instability
-
Puc J, Keniry M, Li HS, Pandita TK, et al. 2005. Lack of PTEN sequesters CHK1 and initiates genetic instability. Cancer Cell 7: 193–204.
-
(2005)
Cancer Cell
, vol.7
, pp. 193-204
-
-
Puc, J.1
Keniry, M.2
Li, H.S.3
Pandita, T.K.4
-
13
-
-
0037439684
-
Increased nuclear phosphatase and tensin homologue deleted on chromosome 10 is associated with G0-G1 in MCF-7 cells
-
Ginn-Pease ME, Eng C. 2003. Increased nuclear phosphatase and tensin homologue deleted on chromosome 10 is associated with G0-G1 in MCF-7 cells. Cancer Res 63: 282–6.
-
(2003)
Cancer Res
, vol.63
, pp. 282-286
-
-
Ginn-Pease, M.E.1
Eng, C.2
-
14
-
-
20144384760
-
Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) has nuclear localization signal-like sequences for nuclear import mediated by major vault protein
-
Chung JH, Ginn-Pease ME, Eng C. 2005. Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) has nuclear localization signal-like sequences for nuclear import mediated by major vault protein. Cancer Res 65: 4108–16.
-
(2005)
Cancer Res
, vol.65
, pp. 4108-4116
-
-
Chung, J.H.1
Ginn-Pease, M.E.2
Eng, C.3
-
15
-
-
21744441932
-
Nuclear PTEN-mediated growth suppression is independent of Akt down-regulation
-
Liu JL, Sheng X, Hortobagyi ZK, Mao Z, et al. 2005. Nuclear PTEN-mediated growth suppression is independent of Akt down-regulation. Mol Cell Biol 25: 6211–24.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 6211-6224
-
-
Liu, J.L.1
Sheng, X.2
Hortobagyi, Z.K.3
Mao, Z.4
-
16
-
-
24944568790
-
Nuclear-cytoplasmic partitioning of phosphatase and tensin homologue deleted on chromosome 10 (PTEN) differentially regulates the cell cycle and apoptosis
-
Chung JH, Eng C. 2005. Nuclear-cytoplasmic partitioning of phosphatase and tensin homologue deleted on chromosome 10 (PTEN) differentially regulates the cell cycle and apoptosis. Cancer Res 65: 8096–100.
-
(2005)
Cancer Res
, vol.65
, pp. 8096-8100
-
-
Chung, J.H.1
Eng, C.2
-
17
-
-
33845999615
-
Essential role for nuclear PTEN in maintaining chromosomal integrity
-
Shen WH, Balajee AS, Wang J, H Wu, et al. 2007. Essential role for nuclear PTEN in maintaining chromosomal integrity. Cell 128: 157–70.
-
(2007)
Cell
, vol.128
, pp. 157-170
-
-
Shen, W.H.1
Balajee, A.S.2
Wang, J.3
Wu, H.4
-
18
-
-
84880710673
-
Nuclear PTEN controls DNA repair and sensitivity to genotoxic stress
-
Bassi C, Ho J, Srikumar T, Dowling RJ, et al. 2013. Nuclear PTEN controls DNA repair and sensitivity to genotoxic stress. Science 341: 395–9.
-
(2013)
Science
, vol.341
, pp. 395-399
-
-
Bassi, C.1
Ho, J.2
Srikumar, T.3
Dowling, R.J.4
-
19
-
-
84947330552
-
PTEN regulates DNA replication progression and stalled fork recovery
-
He J, Kang X, Yin Y, Chao KS, et al. 2015. PTEN regulates DNA replication progression and stalled fork recovery. Nat Commun 6: 7620.
-
(2015)
Nat Commun
, vol.6
, pp. 7620
-
-
He, J.1
Kang, X.2
Yin, Y.3
Chao, K.S.4
-
20
-
-
84947341958
-
PTEN controls the DNA replication process through MCM2 in response to replicative stress
-
Feng J, Liang J, Li J, Li Y, et al. 2015. PTEN controls the DNA replication process through MCM2 in response to replicative stress. Cell Rep 13: 1295–303.
-
(2015)
Cell Rep
, vol.13
, pp. 1295-1303
-
-
Feng, J.1
Liang, J.2
Li, J.3
Li, Y.4
-
21
-
-
84946488498
-
PTEN regulates RPA1 and protects DNA replication forks
-
Wang G, Li Y, Wang P, Liang H, et al. 2015. PTEN regulates RPA1 and protects DNA replication forks. Cell Res 25: 1189–204.
-
(2015)
Cell Res
, vol.25
, pp. 1189-1204
-
-
Wang, G.1
Li, Y.2
Wang, P.3
Liang, H.4
-
22
-
-
84973149519
-
Pten regulates spindle pole movement through Dlg1-mediated recruitment of Eg5 to centrosomes
-
van Ree JH, Nam HJ, Jeganathan KB, Kanakkanthara A, et al. 2016. Pten regulates spindle pole movement through Dlg1-mediated recruitment of Eg5 to centrosomes. Nat Cell Biol 18: 814–21.
-
(2016)
Nat Cell Biol
, vol.18
, pp. 814-821
-
-
van Ree, J.H.1
Nam, H.J.2
Jeganathan, K.B.3
Kanakkanthara, A.4
-
23
-
-
84981273822
-
PTEN regulates EG5 to control spindle architecture and chromosome congression during mitosis
-
He J, Zhang Z, Ouyang M, Yang F, et al. 2016. PTEN regulates EG5 to control spindle architecture and chromosome congression during mitosis. Nat Commun 7: 12355.
-
(2016)
Nat Commun
, vol.7
, pp. 12355
-
-
He, J.1
Zhang, Z.2
Ouyang, M.3
Yang, F.4
-
24
-
-
84980357133
-
PTEN regulates PLK1 and controls chromosomal stability during cell division
-
Zhang Z, Hou SQ, He J, Gu T, et al. 2016. PTEN regulates PLK1 and controls chromosomal stability during cell division. Cell Cycle 15: 2476–85.
-
(2016)
Cell Cycle
, vol.15
, pp. 2476-2485
-
-
Zhang, Z.1
Hou, S.Q.2
He, J.3
Gu, T.4
-
25
-
-
84895926621
-
PTEN C-terminal deletion causes genomic instability and tumor development
-
Sun Z, Huang C, He J, Lamb KL, et al. 2014. PTEN C-terminal deletion causes genomic instability and tumor development. Cell Rep 6: 844–54.
-
(2014)
Cell Rep
, vol.6
, pp. 844-854
-
-
Sun, Z.1
Huang, C.2
He, J.3
Lamb, K.L.4
-
26
-
-
84878888088
-
High cumulative risks of cancer in patients with PTEN hamartoma tumour syndrome
-
Bubien V, Bonnet F, Brouste V, Hoppe S, et al. 2013. High cumulative risks of cancer in patients with PTEN hamartoma tumour syndrome. J Med Genet 50: 255–63.
-
(2013)
J Med Genet
, vol.50
, pp. 255-263
-
-
Bubien, V.1
Bonnet, F.2
Brouste, V.3
Hoppe, S.4
-
27
-
-
84907395649
-
PTEN interacts with histone H1 and controls chromatin condensation
-
Chen ZH, Zhu M, Yang J, Liang H, et al. 2014. PTEN interacts with histone H1 and controls chromatin condensation. Cell Rep 8: 2003–14.
-
(2014)
Cell Rep
, vol.8
, pp. 2003-2014
-
-
Chen, Z.H.1
Zhu, M.2
Yang, J.3
Liang, H.4
-
28
-
-
84943782609
-
Nuclear PTEN tumor-suppressor functions through maintaining heterochromatin structure
-
Gong L, Govan JM, Evans EB, Dai H, et al. 2015. Nuclear PTEN tumor-suppressor functions through maintaining heterochromatin structure. Cell Cycle 14: 2323–32.
-
(2015)
Cell Cycle
, vol.14
, pp. 2323-2332
-
-
Gong, L.1
Govan, J.M.2
Evans, E.B.3
Dai, H.4
-
29
-
-
30144438249
-
Roles of FHIT and WWOX fragile genes in cancer
-
Iliopoulos D, Guler G, Han SY, Druck T, et al. 2006. Roles of FHIT and WWOX fragile genes in cancer. Cancer Lett 232: 27–36.
-
(2006)
Cancer Lett
, vol.232
, pp. 27-36
-
-
Iliopoulos, D.1
Guler, G.2
Han, S.Y.3
Druck, T.4
-
30
-
-
33749033347
-
The replication clamp-loading machine at work in the three domains of life
-
Indiani C, O'Donnell M. 2006. The replication clamp-loading machine at work in the three domains of life. Nat Rev Mol Cell Biol 7: 751–61.
-
(2006)
Nat Rev Mol Cell Biol
, vol.7
, pp. 751-761
-
-
Indiani, C.1
O'Donnell, M.2
-
31
-
-
84855908936
-
Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication
-
Sorensen CS, Syljuasen RG. 2012. Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication. Nucleic Acids Res 40: 477–86.
-
(2012)
Nucleic Acids Res
, vol.40
, pp. 477-486
-
-
Sorensen, C.S.1
Syljuasen, R.G.2
-
32
-
-
84991109185
-
Novel insights into RAD51 activity and regulation during homologous recombination and DNA replication
-
Godin SK, Sullivan MR, Bernstein KA. 2016. Novel insights into RAD51 activity and regulation during homologous recombination and DNA replication. Biochem Cell Biol 94: 407–18.
-
(2016)
Biochem Cell Biol
, vol.94
, pp. 407-418
-
-
Godin, S.K.1
Sullivan, M.R.2
Bernstein, K.A.3
-
33
-
-
85013306193
-
The intra-S checkpoint responses to DNA damage
-
Iyer DR, Rhind N. 2017. The intra-S checkpoint responses to DNA damage. Genes 8: 74.
-
(2017)
Genes
, vol.8
, pp. 74
-
-
Iyer, D.R.1
Rhind, N.2
-
34
-
-
18244401922
-
Unwind and slow down: checkpoint activation by helicase and polymerase uncoupling
-
Cortez D. 2005. Unwind and slow down: checkpoint activation by helicase and polymerase uncoupling. Genes Dev 19: 1007–12.
-
(2005)
Genes Dev
, vol.19
, pp. 1007-1012
-
-
Cortez, D.1
-
35
-
-
0037567268
-
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
-
Zou L, Elledge SJ. 2003. Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science 300: 1542–8.
-
(2003)
Science
, vol.300
, pp. 1542-1548
-
-
Zou, L.1
Elledge, S.J.2
-
36
-
-
18244371925
-
Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint
-
Byun TS, Pacek M, Yee MC, Walter JC, et al. 2005. Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint. Genes Dev 19: 1040–52.
-
(2005)
Genes Dev
, vol.19
, pp. 1040-1052
-
-
Byun, T.S.1
Pacek, M.2
Yee, M.C.3
Walter, J.C.4
-
37
-
-
81955162971
-
RAD51 paralogs: roles in DNA damage signalling, recombinational repair and tumorigenesis
-
Suwaki N, Klare K, Tarsounas M. 2011. RAD51 paralogs: roles in DNA damage signalling, recombinational repair and tumorigenesis. Semin Cell Dev Biol 22: 898–905.
-
(2011)
Semin Cell Dev Biol
, vol.22
, pp. 898-905
-
-
Suwaki, N.1
Klare, K.2
Tarsounas, M.3
-
38
-
-
77954358148
-
PTEN loss compromises homologous recombination repair in astrocytes: implications for glioblastoma therapy with temozolomide or poly(ADP-ribose) polymerase inhibitors
-
McEllin B, Camacho CV, Mukherjee B, Hahm B, et al. 2010. PTEN loss compromises homologous recombination repair in astrocytes: implications for glioblastoma therapy with temozolomide or poly(ADP-ribose) polymerase inhibitors. Cancer Res 70: 5457–64.
-
(2010)
Cancer Res
, vol.70
, pp. 5457-5464
-
-
McEllin, B.1
Camacho, C.V.2
Mukherjee, B.3
Hahm, B.4
-
39
-
-
84880327883
-
Attenuation of PTEN perturbs genomic stability via activation of Akt and down-regulation of Rad51 in human embryonic kidney cells
-
Mukherjee A, Karmakar P. 2013. Attenuation of PTEN perturbs genomic stability via activation of Akt and down-regulation of Rad51 in human embryonic kidney cells. Mol Carcinog 52: 611–8.
-
(2013)
Mol Carcinog
, vol.52
, pp. 611-618
-
-
Mukherjee, A.1
Karmakar, P.2
-
40
-
-
76849109722
-
Hydroxyurea-stalled replication forks become progressively inactivated and require two different RAD51-mediated pathways for restart and repair
-
Petermann E, Orta ML, Issaeva N, Schultz N, et al. 2010. Hydroxyurea-stalled replication forks become progressively inactivated and require two different RAD51-mediated pathways for restart and repair. Mol Cell 37: 492–502.
-
(2010)
Mol Cell
, vol.37
, pp. 492-502
-
-
Petermann, E.1
Orta, M.L.2
Issaeva, N.3
Schultz, N.4
-
41
-
-
85006797225
-
RPA stabilization of single-stranded DNA is critical for break-induced replication
-
Ruff P, Donnianni RA, Glancy E, Oh J, et al. 2016. RPA stabilization of single-stranded DNA is critical for break-induced replication. Cell Rep 17: 3359–68.
-
(2016)
Cell Rep
, vol.17
, pp. 3359-3368
-
-
Ruff, P.1
Donnianni, R.A.2
Glancy, E.3
Oh, J.4
-
42
-
-
84949558302
-
PTEN stabilizes TOP2A and regulates the DNA decatenation
-
Kang X, Song C, Du X, Zhang C, et al. 2015. PTEN stabilizes TOP2A and regulates the DNA decatenation. Sci Rep 5: 17873.
-
(2015)
Sci Rep
, vol.5
, pp. 17873
-
-
Kang, X.1
Song, C.2
Du, X.3
Zhang, C.4
-
43
-
-
84944910067
-
Sister chromatid decatenation: bridging the gaps in our knowledge
-
Broderick R, Niedzwiedz W. 2015. Sister chromatid decatenation: bridging the gaps in our knowledge. Cell Cycle 14: 3040–4.
-
(2015)
Cell Cycle
, vol.14
, pp. 3040-3044
-
-
Broderick, R.1
Niedzwiedz, W.2
-
45
-
-
80053893481
-
Polo-like kinase 1 facilitates loss of Pten tumor suppressor-induced prostate cancer formation
-
Liu XS, Song B, Elzey BD, Ratliff TL, et al. 2011. Polo-like kinase 1 facilitates loss of Pten tumor suppressor-induced prostate cancer formation. J Biol Chem 286: 35795–800.
-
(2011)
J Biol Chem
, vol.286
, pp. 35795-35800
-
-
Liu, X.S.1
Song, B.2
Elzey, B.D.3
Ratliff, T.L.4
-
46
-
-
84877124532
-
The PTEN-Akt pathway impacts the integrity and composition of mitotic centrosomes
-
Leonard MK, Hill NT, Bubulya PA, Kadakia MP. 2013. The PTEN-Akt pathway impacts the integrity and composition of mitotic centrosomes. Cell Cycle 12: 1406–15.
-
(2013)
Cell Cycle
, vol.12
, pp. 1406-1415
-
-
Leonard, M.K.1
Hill, N.T.2
Bubulya, P.A.3
Kadakia, M.P.4
-
47
-
-
85011931000
-
Mitotic spindle assembly in animal cells: a fine balancing act
-
Prosser SL, Pelletier L. 2017. Mitotic spindle assembly in animal cells: a fine balancing act. Nat Rev Mol Cell Biol 18: 187–201.
-
(2017)
Nat Rev Mol Cell Biol
, vol.18
, pp. 187-201
-
-
Prosser, S.L.1
Pelletier, L.2
-
48
-
-
84901024010
-
Plk1 protein phosphorylates phosphatase and tensin homolog (PTEN) and regulates its mitotic activity during the cell cycle
-
Choi BH, Pagano M, Dai W. 2014. Plk1 protein phosphorylates phosphatase and tensin homolog (PTEN) and regulates its mitotic activity during the cell cycle. J Biol Chem 289: 14066–74.
-
(2014)
J Biol Chem
, vol.289
, pp. 14066-14074
-
-
Choi, B.H.1
Pagano, M.2
Dai, W.3
-
49
-
-
84906952905
-
Plk1 phosphorylation of PTEN causes a tumor-promoting metabolic state
-
Li Z, Li J, Bi P, Lu Y, et al. 2014. Plk1 phosphorylation of PTEN causes a tumor-promoting metabolic state. Mol Cell Biol 34: 3642–61.
-
(2014)
Mol Cell Biol
, vol.34
, pp. 3642-3661
-
-
Li, Z.1
Li, J.2
Bi, P.3
Lu, Y.4
-
50
-
-
85028336871
-
Playing polo during mitosis: PLK1 takes the lead
-
in press, [Epub ahead of print]
-
Combes G, Alharbi I, Braga LG, Elowe S. 2017. Playing polo during mitosis: PLK1 takes the lead. Oncogene in press, [Epub ahead of print]. https://doi.org/10.1038/onc.2017.113
-
(2017)
Oncogene
-
-
Combes, G.1
Alharbi, I.2
Braga, L.G.3
Elowe, S.4
-
51
-
-
33847196481
-
PTEN − a new guardian of the genome
-
Kritikou E. 2007. PTEN − a new guardian of the genome. Nat Rev Mol Cell Biol 8: 179.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 179
-
-
Kritikou, E.1
|