Centrosome Amplification Is Sufficient to Promote Spontaneous Tumorigenesis in Mammals

Developmental Cell

Volumn 40, Issue 3, 2017, Pages 313-322.e5

  Levine, Michelle S ^a   Bakker, Bjorn ^b   Boeckx, Bram ^c,d   Moyett, Julia ^a   Lu, James ^a   Vitre, Benjamin ^e   Spierings, Diana C ^b   Lansdorp, Peter M ^b   Cleveland, Don W ^f,g   Lambrechts, Diether ^c,d   Foijer, Floris ^b   Holland, Andrew J ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^c DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^d KU Leuven and University Hospitals Leuven and Leuven Cancer Institute   (Belgium)

^e Centre National de la Recherche Scientifique   (France)

^f LUDWIG INSTITUTE FOR CANCER RESEARCH   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

aneuploidy; centriole; centrosome amplification; genomic instability; mitosis; Plk4; tumorigenesis

Indexed keywords

POLO LIKE KINASE 4; PLK4 PROTEIN, MOUSE; PROTEIN SERINE THREONINE KINASE;

ANEUPLOIDY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENESIS; CELL COUNT; CELL FUNCTION; CELL PROLIFERATION; CENTROSOME; CENTROSOME AMPLIFICATION; CHROMOSOME 15; CHROMOSOME 16; CONTROLLED STUDY; EMBRYONIC STEM CELL; FLUORESCENCE IN SITU HYBRIDIZATION; GENOMIC INSTABILITY; IN VITRO STUDY; MITOSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; WHOLE GENOME SEQUENCING; ANIMAL; ANTIBODY SPECIFICITY; C57BL MOUSE; EPIDERMIS; INTESTINE TUMOR; MAMMAL; METABOLISM; PATHOLOGY;

ANEUPLOIDY; ANIMALS; CARCINOGENESIS; CENTROSOME; EPIDERMIS; INTESTINAL NEOPLASMS; MAMMALS; MICE, INBRED C57BL; ORGAN SPECIFICITY; PROTEIN-SERINE-THREONINE KINASES;

EID: 85010877195     PISSN: 15345807     EISSN: 18781551     Source Type: Journal    
DOI: 10.1016/j.devcel.2016.12.022     Document Type: Article

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