Plk1 protein phosphorylates phosphatase and tensin homolog (PTEN) and regulates its mitotic activity during the cell cycle

Journal of Biological Chemistry

Volumn 289, Issue 20, 2014, Pages 14066-14074

  Choi, Byeong Hyeok ^a   Pagano, Michele ^a   Da, Wei ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMOSOMES;

BIOCHEMICAL STUDIES; CONCENTRATION-DEPENDENT MANNERS; GENETIC ANALYSIS; MITOTIC ACTIVITY; MUTATIONAL ANALYSIS; SIGNALING PATHWAYS; SPECIFIC INHIBITORS; TUMOR SUPPRESSORS;

PHOSPHORYLATION;

BI2635; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; POLO LIKE KINASE 1; PROTEIN SERINE THREONINE KINASE INHIBITOR; SERINE; THREONINE; UNCLASSIFIED DRUG; CELL CYCLE PROTEIN; CHROMATIN; ONCOPROTEIN; POLO-LIKE KINASE 1; PROTEIN SERINE THREONINE KINASE;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL CYCLE REGULATION; CHROMATIN; CONCENTRATION RESPONSE; ENZYME REGULATION; GENE DELETION; GENE EXPRESSION; GENETIC ANALYSIS; HUMAN; HUMAN CELL; IN VITRO STUDY; MITOSIS; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; WILD TYPE; ANIMAL; CHEMISTRY; HEK293 CELL LINE; HELA CELL LINE; METABOLISM; MOUSE; PHOSPHORYLATION;

ANIMALS; CELL CYCLE PROTEINS; CHROMATIN; HEK293 CELLS; HELA CELLS; HUMANS; MICE; MITOSIS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PTEN PHOSPHOHYDROLASE; SERINE;

EID: 84901024010     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.558155     Document Type: Article

References (42)

1. Di Cristofano, A., and Pandolfi, P. P. (2000) The multiple roles of PTEN in tumor suppression. Cell 100, 387-390
2. Salmena, L., Carracedo, A., and Pandolfi, P. P. (2008) Tenets of PTEN tumor suppression. Cell 133, 403-414
3. Trimboli, A. J., Cantemir-Stone, C. Z., Li, F., Wallace, J. A., Merchant, A., Creasap, N., Thompson, J. C., Caserta, E., Wang, H., Chong, J. L., Naidu, S., Wei, G., Sharma, S. M., Stephens, J. A., Fernandez, S. A., Gurcan, M. N., Weinstein, M. B., Barsky, S. H., Yee, L., Rosol, T. J., Stromberg, P. C., Robinson, M. L., Pepin, F., Hallett, M., Park, M., Ostrowski, M. C., and Leone, G. (2009) PTEN in stromal fibroblasts suppresses mammary epithelial tumours. Nature 461, 1084-1091
4. Yin, Y., and Shen, W. H. (2008) PTEN: a new guardian of the genome. Oncogene 27, 5443-5453
5. Carracedo, A., and Pandolfi, P. P. (2008) The PTEN-PI3K pathway: of feedbacks and cross-talks. Oncogene 27, 5527-5541
6. Berger, A. H., and Pandolfi, P. P. (2011) Haplo-insufficiency: a driving force in cancer. J. Pathol. 223, 137-146
7. Wang, X., and Jiang, X. (2008) PTEN: a default gate-keeping tumor suppressor with a versatile tail. Cell Res. 18, 807-816
8. Al-Khouri, A. M., Ma, Y., Togo, S. H., Williams, S., and Mustelin, T. (2005) Cooperative phosphorylation of the tumor suppressor phosphatase and tensin homologue (PTEN) by casein kinases and glycogen synthase kinase 3β. J. Biol. Chem. 280, 35195-35202
9. Torres, J., and Pulido, R. (2001) The tumor suppressorPTENis phosphorylated by the protein kinase CK2 at its C terminus: implications for PTEN stability to proteasome-mediated degradation. J. Biol. Chem. 276, 993-998
10. Xu, D., Yao, Y., Jiang, X., Lu, L., and Dai, W. (2010) Regulation of PTEN stability and activity by Plk3. J. Biol. Chem. 285, 39935-39942
11. Yim, E. K., Peng, G., Dai, H., Hu, R., Li, K., Lu, Y., Mills, G. B., Meric-Bernstam, F., Hennessy, B. T., Craven, R. J., and Lin, S. Y. (2009) Rak functions as a tumor suppressor by regulating PTEN protein stability and function. Cancer Cell 15, 304-314
12. Barr, F. A., Silljé, H. H., and Nigg, E. A. (2004) Polo-like kinases and the orchestration of cell division. Nat. Rev. Mol. Cell Biol. 5, 429-440
13. Strebhardt, K., and Ullrich, A. (2006) Targeting polo-like kinase 1 for cancer therapy. Nat. Rev. Cancer 6, 321-330
14. Strebhardt, K. (2010) Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy. Nat. Rev. Drug Discov. 9, 643-660
15. Liu, X., and Erikson, R. L. (2003) Polo-like kinase (Plk)1 depletion induces apoptosis in cancer cells. Proc. Natl. Acad. Sci. U.S.A. 100, 5789-5794
16. Smits, V. A., Klompmaker, R., Arnaud, L., Rijksen, G., Nigg, E. A., and Medema, R. H. (2000) Polo-like kinase-1 is a target of the DNA damage checkpoint. Nat. Cell Biol. 2, 672-676
17. Liu, X. S., Li, H., Song, B., and Liu, X. (2010) Polo-like kinase 1 phosphorylation of G2 and S-phase-expressed 1 protein is essential for p53 inactivation during G2 checkpoint recovery. EMBO Rep. 11, 626-632
18. Bassermann, F., Frescas, D., Guardavaccaro, D., Busino, L., Peschiaroli, A., and Pagano, M. (2008) The Cdc14B-Cdh1-Plk1 axis controls theG2 DNAdamage-response checkpoint. Cell 134, 256-267
19. van Vugt, M. A., Brás, A., and Medema, R. H. (2004) Polo-like kinase-1 controls recovery from a G2 DNA damage-induced arrest in mammalian cells. Mol. Cell 15, 799-811
20. Fairley, J. A., Mitchell, L. E., Berg, T., Kenneth, N. S., von Schubert, C., Silljé, H. H., Medema, R. H., Nigg, E. A., and White, R. J. (2012) Direct regulation of tRNA and 5S rRNA gene transcription by polo-like kinase 1. Mol. Cell 45, 541-552
21. Liu, X., and Erikson, R. L. (2002) Activation of Cdc2/cyclin B and inhibition of centrosome amplification in cells depleted of Plk1 by siRNA. Proc.Natl. Acad. Sci. U.S.A. 99, 8672-8676
22. Petronczki, M., Lénárt, P., and Peters, J. M. (2008) Polo on the rise: from mitotic entry to cytokinesis with Plk1. Dev. Cell 14, 646-659
23. Eldridge, A. G., Loktev, A. V., Hansen, D. V., Verschuren, E. W., Reimann, J. D., and Jackson, P. K. (2006) The evi5 oncogene regulates cyclin accumulation by stabilizing the anaphase-promoting complex inhibitor emi1. Cell 124, 367-380
24. Jackman, M., Lindon, C., Nigg, E. A., and Pines, J. (2003) Active cyclin B1-Cdk1 first appears on centrosomes in prophase. Nat. Cell Biol. 5, 143-148
25. Wang, X., Yang, Y., Duan, Q., Jiang, N., Huang, Y., Darzynkiewicz, Z., and Dai, W. (2008) sSgo1, a major splice variant of Sgo1, functions in centriole cohesion where it is regulated by Plk1. Dev. Cell 14, 331-341
26. Johmura, Y., Soung, N. K., Park, J. E., Yu, L. R., Zhou, M., Bang, J. K., Kim, B. Y., Veenstra, T. D., Erikson, R. L., and Lee, K. S. (2011) Regulation of microtubule-based microtubule nucleation by mammalian polo-like kinase 1. Proc. Natl. Acad. Sci. U.S.A. 108, 11446-11451
27. Soung, N. K., Park, J. E., Yu, L. R., Lee, K. H., Lee, J. M., Bang, J. K., Veenstra, T. D., Rhee, K., and Lee, K. S. (2009) Plk1-dependent and-independent roles of an ODF2 splice variant, hCenexin1, at the centrosome of somatic cells. Dev. Cell 16, 539-550
28. Soung, N. K., Kang, Y. H., Kim, K., Kamijo, K., Yoon, H., Seong, Y. S., Kuo, Y. L., Miki, T., Kim, S. R., Kuriyama, R., Giam, C. Z., Ahn, C. H., and Lee, K. S. (2006) Requirement of hCenexin for proper mitotic functions of polo-like kinase 1 at the centrosomes. Mol. Cell. Biol. 26, 8316-8335
29. Loncarek, J., Hergert, P., and Khodjakov, A. (2010) Centriole reduplication during prolonged interphase requires procentriole maturation governed by Plk1. Curr. Biol. 20, 1277-1282
30. Tsou, M. F., Wang, W. J., George, K. A., Uryu, K., Stearns, T., and Jallepalli, P. V. (2009) Polo kinase and separase regulate the mitotic licensing of centriole duplication in human cells. Dev. Cell 17, 344-354
31. Simizu, S., and Osada, H. (2000) Mutations in the Plk gene lead to instability of Plk protein in human tumour cell lines. Nat. Cell Biol. 2, 852-854
32. Lu, L. Y., Wood, J. L., Minter-Dykhouse, K., Ye, L., Saunders, T. L., Yu, X., and Chen, J. (2008) Polo-like kinase 1 is essential for early embryonic development and tumor suppression. Mol. Cell. Biol. 28, 6870-6876
33. Yang, Y., Bai, J., Shen, R., Brown, S. A., Komissarova, E., Huang, Y., Jiang, N., Alberts, G. F., Costa, M., Lu, L., Winkles, J. A., and Dai, W. (2008) Polo-like kinase 3 functions as a tumor suppressor and is a negative regulator of hypoxia-inducible factor-1α under hypoxic conditions. Cancer Res. 68, 4077-4085
34. Ko, M. A., Rosario, C. O., Hudson, J. W., Kulkarni, S., Pollett, A., Dennis, J. W., and Swallow, C. J. (2005) Plk4 haploinsufficiency causes mitotic infidelity and carcinogenesis. Nat. Genet. 37, 883-888
35. Baker, S. J. (2007) PTEN enters the nuclear age. Cell 128, 25-28
36. Song, M. S., Carracedo, A., Salmena, L., Song, S. J., Egia, A., Malumbres, M., and Pandolfi, P. P. (2011) Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner. Cell 144, 187-199
37. Lu, P. D., Jousse, C., Marciniak, S. J., Zhang, Y., Novoa, I., Scheuner, D., Kaufman, R. J., Ron, D., and Harding, H. P. (2004) Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2. EMBO J. 23, 169-179
38. Miller, S. J., Lou, D. Y., Seldin, D. C., Lane, W. S., and Neel, B. G. (2002) Direct identification of PTEN phosphorylation sites. FEBS Lett. 528, 145-153
39. Steegmaier, M., Hoffmann, M., Baum, A., Lénárt, P., Petronczki, M., Krssák, M., Gürtler, U., Garin-Chesa, P., Lieb, S., Quant, J., Grauert, M., Adolf, G. R., Kraut, N., Peters, J. M., and Rettig, W. J. (2007) BI 2536, a potent and selective inhibitor of polo-like kinase 1, inhibits tumor growth in vivo. Curr. Biol. 17, 316-322
40. Odriozola, L., Singh, G., Hoang, T., and Chan, A. M. (2007) Regulation of PTEN activity by its carboxyl-terminal autoinhibitory domain. J. Biol. Chem. 282, 23306-23315
41. Shen, W. H., Balajee, A. S., Wang, J., Wu, H., Eng, C., Pandolfi, P. P., and Yin, Y. (2007) Essential role for nuclear PTEN in maintaining chromosomal integrity. Cell 128, 157-170
42. Choi, B. H., Chen, Y., and Dai, W. (2013) Chromatin PTEN is involved in DNAdamage response partly through regulating Rad52 sumoylation. Cell Cycle 12, 3442-3447