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Volumn 18, Issue 7, 2016, Pages 814-821

Pten regulates spindle pole movement through Dlg1-mediated recruitment of Eg5 to centrosomes

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; KINESIN; PDZ PROTEIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN DLG1; PROTEIN EG5; PROTEIN KINASE B; UNCLASSIFIED DRUG; DLG1 PROTEIN, HUMAN; EG5 PROTEIN, MOUSE; KIF11 PROTEIN, HUMAN; MEMBRANE PROTEIN; NERVE PROTEIN; PTEN PROTEIN, HUMAN; PTEN PROTEIN, MOUSE; SAPAP PROTEINS; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

EID: 84973149519     PISSN: 14657392     EISSN: 14764679     Source Type: Journal    
DOI: 10.1038/ncb3369     Document Type: Article
Times cited : (51)

References (40)
  • 1
    • 66149141021 scopus 로고    scopus 로고
    • PTEN and the PI3-kinase pathway in cancer
    • Chalhoub N, & Baker S. J. PTEN and the PI3-kinase pathway in cancer. Annu. Rev. Pathol. 4, 127-150 (2008).
    • (2008) Annu. Rev. Pathol , vol.4 , pp. 127-150
    • Chalhoub, N.1    Baker, S.J.2
  • 2
    • 84860217431 scopus 로고    scopus 로고
    • The functions and regulation of the PTEN tumour suppressor
    • Song M. S, Salmena L, & Pandolfi P. P. The functions and regulation of the PTEN tumour suppressor. Nat. Rev. Mol. Cell Biol. 13, 283-296 (2012).
    • (2012) Nat. Rev. Mol. Cell Biol , vol.13 , pp. 283-296
    • Song, M.S.1    Salmena, L.2    Pandolfi, P.P.3
  • 3
    • 35648982452 scopus 로고    scopus 로고
    • NHERFs, NEP, MAGUKs, and more: Interactions that regulate PTEN
    • Bonifant C. L, Kim J. S, & Waldman T. NHERFs, NEP, MAGUKs, and more: interactions that regulate PTEN. J. Cell Biochem. 102, 878-885 (2007).
    • (2007) J. Cell Biochem , vol.102 , pp. 878-885
    • Bonifant, C.L.1    Kim, J.S.2    Waldman, T.3
  • 4
    • 0029417238 scopus 로고
    • Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo
    • Blangy A, et al. Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo. Cell 83, 1159-1169 (1995).
    • (1995) Cell , vol.83 , pp. 1159-1169
    • Blangy, A.1
  • 5
    • 70749158525 scopus 로고    scopus 로고
    • Whole chromosome instability caused by Bub1 insufficiency drives tumorigenesis through tumor suppressor gene loss of heterozygosity
    • Baker D. J, Jin F, Jeganathan K. B, & van Deursen J. M. Whole chromosome instability caused by Bub1 insufficiency drives tumorigenesis through tumor suppressor gene loss of heterozygosity. Cancer Cell 16, 475-486 (2009).
    • (2009) Cancer Cell , vol.16 , pp. 475-486
    • Baker, D.J.1    Jin, F.2    Jeganathan, K.B.3    Van Deursen, J.M.4
  • 6
    • 79951970806 scopus 로고    scopus 로고
    • Stalled fork rescue via dormant replication origins in unchallenged S phase promotes proper chromosome segregation and tumor suppression
    • Kawabata T, et al. Stalled fork rescue via dormant replication origins in unchallenged S phase promotes proper chromosome segregation and tumor suppression. Mol. Cell 41, 543-553 (2011).
    • (2011) Mol. Cell , vol.41 , pp. 543-553
    • Kawabata, T.1
  • 7
    • 0033514509 scopus 로고    scopus 로고
    • Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway
    • Ramaswamy S, et al. Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway. Proc. Natl Acad. Sci. USA 96, 2110-2115 (1999).
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 2110-2115
    • Ramaswamy, S.1
  • 8
    • 0029810181 scopus 로고    scopus 로고
    • Akt, a pleckstrin homology domain containing kinase, is activated primarily by phosphorylation
    • Kohn A. D, Takeuchi F, & Roth R. A. Akt, a pleckstrin homology domain containing kinase, is activated primarily by phosphorylation. J. Biol. Chem. 271, 21920-21926 (1996).
    • (1996) J. Biol. Chem , vol.271 , pp. 21920-21926
    • Kohn, A.D.1    Takeuchi, F.2    Roth, R.A.3
  • 9
    • 84959140220 scopus 로고    scopus 로고
    • PTEN recruitment controls synaptic and cognitive function in Alzheimers models
    • Knafo S, et al. PTEN recruitment controls synaptic and cognitive function in Alzheimers models. Nat. Neurosci. 19, 443-453 (2016).
    • (2016) Nat. Neurosci , vol.19 , pp. 443-453
    • Knafo, S.1
  • 10
    • 84880710673 scopus 로고    scopus 로고
    • Nuclear PTEN controls DNA repair and sensitivity to genotoxic stress
    • Bassi C, et al. Nuclear PTEN controls DNA repair and sensitivity to genotoxic stress. Science 341, 395-399 (2013).
    • (2013) Science , vol.341 , pp. 395-399
    • Bassi, C.1
  • 11
    • 33845999615 scopus 로고    scopus 로고
    • Essential role for nuclear PTEN in maintaining chromosomal integrity
    • Shen W. H, et al. Essential role for nuclear PTEN in maintaining chromosomal integrity. Cell 128, 157-170 (2007).
    • (2007) Cell , vol.128 , pp. 157-170
    • Shen, W.H.1
  • 12
    • 84901766653 scopus 로고    scopus 로고
    • Cyclin B2 and p53 control proper timing of centrosome separation
    • Nam H. J, & van Deursen J. M. Cyclin B2 and p53 control proper timing of centrosome separation. Nat. Cell Biol. 16, 538-549 (2014).
    • (2014) Nat. Cell Biol , vol.16 , pp. 538-549
    • Nam, H.J.1    Van Deursen, J.M.2
  • 13
    • 84856426337 scopus 로고    scopus 로고
    • Timing of centrosome separation is important for accurate chromosome segregation
    • Silkworth W. T, Nardi I. K, Paul R, Mogilner A, & Cimini D. Timing of centrosome separation is important for accurate chromosome segregation. Mol. Biol. Cell 23, 401-411 (2012).
    • (2012) Mol. Biol. Cell , vol.23 , pp. 401-411
    • Silkworth, W.T.1    Nardi, I.K.2    Paul, R.3    Mogilner, A.4    Cimini, D.5
  • 14
    • 84907087403 scopus 로고    scopus 로고
    • Dlg1 controls planar spindle orientation in the neuroepithelium through direct interaction with LGN
    • Saadaoui M, et al. Dlg1 controls planar spindle orientation in the neuroepithelium through direct interaction with LGN. J. Cell Biol. 206, 707-717 (2014).
    • (2014) J. Cell Biol , vol.206 , pp. 707-717
    • Saadaoui, M.1
  • 15
    • 84896990026 scopus 로고    scopus 로고
    • Prime movers: The mechanochemistry of mitotic kinesins
    • Cross R. A, & McAinsh A. Prime movers: the mechanochemistry of mitotic kinesins. Nat. Rev. Mol. Cell Biol. 15, 257-271 (2014).
    • (2014) Nat. Rev. Mol. Cell Biol , vol.15 , pp. 257-271
    • Cross, R.A.1    McAinsh, A.2
  • 16
    • 0033615357 scopus 로고    scopus 로고
    • Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen
    • Mayer T. U, et al. Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen. Science 286, 971-974 (1999).
    • (1999) Science , vol.286 , pp. 971-974
    • Mayer, T.U.1
  • 17
    • 84877124532 scopus 로고    scopus 로고
    • The PTEN-Akt pathway impacts the integrity and composition of mitotic centrosomes
    • Leonard M. K, Hill N. T, Bubulya P. A, & Kadakia M. P. The PTEN-Akt pathway impacts the integrity and composition of mitotic centrosomes. Cell Cycle 12, 1406-1415 (2013).
    • (2013) Cell Cycle , vol.12 , pp. 1406-1415
    • Leonard, M.K.1    Hill, N.T.2    Bubulya, P.A.3    Kadakia, M.P.4
  • 18
    • 84901024010 scopus 로고    scopus 로고
    • Plk1 protein phosphorylates phosphatase and tensin homolog (PTEN) and regulates its mitotic activity during the cell cycle
    • Choi B. H, Pagano M, & Dai W. Plk1 protein phosphorylates phosphatase and tensin homolog (PTEN) and regulates its mitotic activity during the cell cycle. J. Biol. Chem 289, 14066-14074 (2014).
    • (2014) J. Biol. Chem , vol.289 , pp. 14066-14074
    • Choi, B.H.1    Pagano, M.2    Dai, W.3
  • 19
    • 84903464777 scopus 로고    scopus 로고
    • Cdh1, a substrate-recruiting component of anaphase-promoting complex/cyclosome (APC/C) ubiquitin E3 ligase, specifically interacts with phosphatase and tensin homolog (PTEN) and promotes its removal from chromatin
    • Choi B. H, Pagano M, Huang C, & Dai W. Cdh1, a substrate-recruiting component of anaphase-promoting complex/cyclosome (APC/C) ubiquitin E3 ligase, specifically interacts with phosphatase and tensin homolog (PTEN) and promotes its removal from chromatin. J. Biol. Chem 289, 17951-17959 (2014).
    • (2014) J. Biol. Chem , vol.289 , pp. 17951-17959
    • Choi, B.H.1    Pagano, M.2    Huang, C.3    Dai, W.4
  • 20
    • 78651482046 scopus 로고    scopus 로고
    • Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner
    • Song M. S, et al. Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner. Cell 144, 187-199 (2011).
    • (2011) Cell , vol.144 , pp. 187-199
    • Song, M.S.1
  • 21
    • 84860272984 scopus 로고    scopus 로고
    • Breaking the ties that bind: New advances in centrosome biology
    • Mardin B. R, & Schiebel E. Breaking the ties that bind: new advances in centrosome biology. J. Cell Biol. 197, 11-18 (2012).
    • (2012) J. Cell Biol , vol.197 , pp. 11-18
    • Mardin, B.R.1    Schiebel, E.2
  • 22
    • 84870061337 scopus 로고    scopus 로고
    • Switching Polo-like kinase-1 on and off in time and space
    • Bruinsma W, Raaijmakers J. A, & Medema R. H. Switching Polo-like kinase-1 on and off in time and space. Trends Biochem. Sci. 37, 534-542 (2012).
    • (2012) Trends Biochem. Sci , vol.37 , pp. 534-542
    • Bruinsma, W.1    Raaijmakers, J.A.2    Medema, R.H.3
  • 23
    • 0033946740 scopus 로고    scopus 로고
    • Phosphorylation of the PTEN tail regulates protein stability and function
    • Vazquez F, Ramaswamy S, Nakamura N, & Sellers W. R. Phosphorylation of the PTEN tail regulates protein stability and function. Mol. Cell Biol. 20, 5010-5018 (2000).
    • (2000) Mol. Cell Biol , vol.20 , pp. 5010-5018
    • Vazquez, F.1    Ramaswamy, S.2    Nakamura, N.3    Sellers, W.R.4
  • 24
    • 79957900656 scopus 로고    scopus 로고
    • Differential control of Eg5-dependent centrosome separation by Plk1 and Cdk1
    • Smith E, et al. Differential control of Eg5-dependent centrosome separation by Plk1 and Cdk1. EMBO J. 30, 2233-2245 (2011).
    • (2011) EMBO J. , vol.30 , pp. 2233-2245
    • Smith, E.1
  • 25
    • 79960056092 scopus 로고    scopus 로고
    • Nek9 is a Plk1-Activated kinase that controls early centrosome separation through Nek6/7 and Eg5
    • Bertran M. T, et al. Nek9 is a Plk1-Activated kinase that controls early centrosome separation through Nek6/7 and Eg5. EMBO J. 30, 2634-2647 (2011).
    • (2011) EMBO J. , vol.30 , pp. 2634-2647
    • Bertran, M.T.1
  • 26
    • 0023854161 scopus 로고
    • The e mu-myc transgenic mouse A model for high-incidence spontaneous lymphoma and leukemia of early B cells
    • Harris A. W, et al. The E mu-myc transgenic mouse. A model for high-incidence spontaneous lymphoma and leukemia of early B cells. J. Exp. Med. 167, 353-371 (1988).
    • (1988) J. Exp. Med , vol.167 , pp. 353-371
    • Harris, A.W.1
  • 27
    • 0035953550 scopus 로고    scopus 로고
    • Somatic activation of the K-ras oncogene causes early onset lung cancer in mice
    • Johnson L, et al. Somatic activation of the K-ras oncogene causes early onset lung cancer in mice. Nature 410, 1111-1116 (2001).
    • (2001) Nature , vol.410 , pp. 1111-1116
    • Johnson, L.1
  • 28
    • 0031870959 scopus 로고    scopus 로고
    • Pten is essential for embryonic development and tumour suppression
    • Di Cristofano A, Pesce B, Cordon-Cardo C, & Pandolfi P. P. Pten is essential for embryonic development and tumour suppression. Nat. Genet. 19, 348-355 (1998).
    • (1998) Nat. Genet , vol.19 , pp. 348-355
    • Di Cristofano, A.1    Pesce, B.2    Cordon-Cardo, C.3    Pandolfi, P.P.4
  • 29
    • 0032574718 scopus 로고    scopus 로고
    • Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression
    • Whang Y. E, et al. Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression. Proc. Natl Acad. Sci. USA 95, 5246-5250 (1998).
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 5246-5250
    • Whang, Y.E.1
  • 30
    • 84897406995 scopus 로고    scopus 로고
    • Cancer-Associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein function
    • Papa A, et al. Cancer-Associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein function. Cell 157, 595-610 (2014).
    • (2014) Cell , vol.157 , pp. 595-610
    • Papa, A.1
  • 31
    • 84895926621 scopus 로고    scopus 로고
    • PTEN C-terminal deletion causes genomic instability and tumor development
    • Sun Z, et al. PTEN C-terminal deletion causes genomic instability and tumor development. Cell Rep. 6, 844-854 (2014).
    • (2014) Cell Rep , vol.6 , pp. 844-854
    • Sun, Z.1
  • 32
    • 84861853732 scopus 로고    scopus 로고
    • Losing balance: The origin and impact of aneuploidy in cancer
    • Holland A. J, & Cleveland D. W. Losing balance: the origin and impact of aneuploidy in cancer. EMBO Rep. 13, 501-514 (2012).
    • (2012) EMBO Rep , vol.13 , pp. 501-514
    • Holland, A.J.1    Cleveland, D.W.2
  • 33
    • 0036202934 scopus 로고    scopus 로고
    • A Cre/loxP-deleter transgenic line in mouse strain 129S1/SvImJ
    • Tang S. H, Silva F. J, Tsark W. M, & Mann J. R. A Cre/loxP-deleter transgenic line in mouse strain 129S1/SvImJ. Genesis 32 199-202 (2002).
    • (2002) Genesis , vol.32 , pp. 199-202
    • Tang, S.H.1    Silva, F.J.2    Tsark, W.M.3    Mann, J.R.4
  • 34
    • 35548957419 scopus 로고    scopus 로고
    • Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis
    • Jeganathan K, Malureanu L, Baker D. J, Abraham S. C, & van Deursen J. M. Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. J. Cell Biol. 179, 255-267 (2007).
    • (2007) J. Cell Biol , vol.179 , pp. 255-267
    • Jeganathan, K.1    Malureanu, L.2    Baker, D.J.3    Abraham, S.C.4    Van Deursen, J.M.5
  • 35
    • 84871717211 scopus 로고    scopus 로고
    • Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan
    • Baker D. J, et al. Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan. Nat. Cell Biol. 15, 96-102 (2013).
    • (2013) Nat. Cell Biol , vol.15 , pp. 96-102
    • Baker, D.J.1
  • 36
    • 13044250465 scopus 로고    scopus 로고
    • Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems
    • Podsypanina K, et al. Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems. Proc. Natl Acad. Sci. USA 96, 1563-1568 (1999).
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 1563-1568
    • Podsypanina, K.1
  • 37
    • 55249105043 scopus 로고    scopus 로고
    • GluR1 controls dendrite growth through its binding partner, SAP97
    • Zhou W, et al. GluR1 controls dendrite growth through its binding partner, SAP97. J. Neurosci. 28, 10220-10233 (2008).
    • (2008) J. Neurosci , vol.28 , pp. 10220-10233
    • Zhou, W.1
  • 38
    • 84872043569 scopus 로고    scopus 로고
    • Bub1 kinase activity drives error correction and mitotic checkpoint control but not tumor suppression
    • Ricke R. M, Jeganathan K. B, Malureanu L, Harrison A. M, & van Deursen J. M. Bub1 kinase activity drives error correction and mitotic checkpoint control but not tumor suppression. J. Cell Biol. 199, 931-949 (2012).
    • (2012) J. Cell Biol , vol.199 , pp. 931-949
    • Ricke, R.M.1    Jeganathan, K.B.2    Malureanu, L.3    Harrison, A.M.4    Van Deursen, J.M.5
  • 39
    • 77951952612 scopus 로고    scopus 로고
    • Aurora B phosphorylates spatially distinct targets to differentially regulate the kinetochore-microtubule interface
    • Welburn J. P, et al. Aurora B phosphorylates spatially distinct targets to differentially regulate the kinetochore-microtubule interface. Mol. Cell 38, 383-392 (2010).
    • (2010) Mol. Cell , vol.38 , pp. 383-392
    • Welburn, J.P.1
  • 40
    • 0029167042 scopus 로고
    • Conditional binding to and cell cycle-regulated inhibition of cyclin-dependent kinase complexes by p27Kip1
    • Eblen S. T, Fautsch M. P, Anders R. A, & Leof E. B. Conditional binding to and cell cycle-regulated inhibition of cyclin-dependent kinase complexes by p27Kip1. Cell Growth Differ. 6, 915-925 (1995).
    • (1995) Cell Growth Differ , vol.6 , pp. 915-925
    • Eblen, S.T.1    Fautsch, M.P.2    Anders, R.A.3    Leof, E.B.4


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