-
1
-
-
0028811653
-
Protein kinase C: structure, function, and regulation
-
Newton, A.C., Protein kinase C: structure, function, and regulation. J. Biol. Chem. 270:48 (1995), 28495–28498.
-
(1995)
J. Biol. Chem.
, vol.270
, Issue.48
, pp. 28495-28498
-
-
Newton, A.C.1
-
2
-
-
0023555557
-
Protein kinase C contains a pseudosubstrate prototope in its regulatory domain
-
House, C., Kemp, B.E., Protein kinase C contains a pseudosubstrate prototope in its regulatory domain. Science 238:4834 (1987), 1726–1728.
-
(1987)
Science
, vol.238
, Issue.4834
, pp. 1726-1728
-
-
House, C.1
Kemp, B.E.2
-
3
-
-
12344323484
-
Type 2 diabetes-a matter of beta-cell life and death?
-
Rhodes, C.J., Type 2 diabetes-a matter of beta-cell life and death?. Science 307:5708 (2005), 380–384.
-
(2005)
Science
, vol.307
, Issue.5708
, pp. 380-384
-
-
Rhodes, C.J.1
-
4
-
-
84883546693
-
Role of pancreatic beta-cell death and inflammation in diabetes
-
Quan, W., Jo, E.K., Lee, M.S., Role of pancreatic beta-cell death and inflammation in diabetes. Diabetes Obes. Metab. 15:Suppl. 3 (2013), 141–151.
-
(2013)
Diabetes Obes. Metab.
, vol.15
, pp. 141-151
-
-
Quan, W.1
Jo, E.K.2
Lee, M.S.3
-
5
-
-
84942525569
-
Inflammation in acute and chronic pancreatitis
-
Habtezion, A., Inflammation in acute and chronic pancreatitis. Curr. Opin. Gastroenterol. 31:5 (2015), 395–399.
-
(2015)
Curr. Opin. Gastroenterol.
, vol.31
, Issue.5
, pp. 395-399
-
-
Habtezion, A.1
-
6
-
-
85014571316
-
Acinar cell plasticity and development of pancreatic ductal adenocarcinoma
-
Storz, P., Acinar cell plasticity and development of pancreatic ductal adenocarcinoma. Nat. Rev. Gastroenterol. Hepatol. 14:5 (2017), 296–304.
-
(2017)
Nat. Rev. Gastroenterol. Hepatol.
, vol.14
, Issue.5
, pp. 296-304
-
-
Storz, P.1
-
7
-
-
0037362895
-
Expression patterns of protein kinase C isoenzymes are characteristically modulated in chronic pancreatitis and pancreatic cancer
-
Evans, J.D., Cornford, P.A., Dodson, A., Neoptolemos, J.P., Foster, C.S., Expression patterns of protein kinase C isoenzymes are characteristically modulated in chronic pancreatitis and pancreatic cancer. Am. J. Clin. Pathol. 119:3 (2003), 392–402.
-
(2003)
Am. J. Clin. Pathol.
, vol.119
, Issue.3
, pp. 392-402
-
-
Evans, J.D.1
Cornford, P.A.2
Dodson, A.3
Neoptolemos, J.P.4
Foster, C.S.5
-
8
-
-
77949268993
-
Enhancement of glucagon secretion in mouse and human pancreatic alpha cells by protein kinase C (PKC) involves intracellular trafficking of PKCalpha and PKCdelta
-
De Marinis, Y.Z., Zhang, E., Amisten, S., Taneera, J., Renstrom, E., Rorsman, P., Eliasson, L., Enhancement of glucagon secretion in mouse and human pancreatic alpha cells by protein kinase C (PKC) involves intracellular trafficking of PKCalpha and PKCdelta. Diabetologia 53:4 (2010), 717–729.
-
(2010)
Diabetologia
, vol.53
, Issue.4
, pp. 717-729
-
-
De Marinis, Y.Z.1
Zhang, E.2
Amisten, S.3
Taneera, J.4
Renstrom, E.5
Rorsman, P.6
Eliasson, L.7
-
9
-
-
0022541880
-
Enhancement of glucagon secretion from isolated rat islets of Langerhans by phorbol 12-myristate 13-acetate
-
Hii, C.S., Stutchfield, J., Howell, S.L., Enhancement of glucagon secretion from isolated rat islets of Langerhans by phorbol 12-myristate 13-acetate. Biochem. J. 233:1 (1986), 287–289.
-
(1986)
Biochem. J.
, vol.233
, Issue.1
, pp. 287-289
-
-
Hii, C.S.1
Stutchfield, J.2
Howell, S.L.3
-
10
-
-
0029979956
-
Protein kinase C in beta-cells: expression of multiple isoforms and involvement in cholinergic stimulation of insulin secretion
-
Tian, Y.M., Urquidi, V., Ashcroft, S.J., Protein kinase C in beta-cells: expression of multiple isoforms and involvement in cholinergic stimulation of insulin secretion. Mol. Cell. Endocrinol. 119:2 (1996), 185–193.
-
(1996)
Mol. Cell. Endocrinol.
, vol.119
, Issue.2
, pp. 185-193
-
-
Tian, Y.M.1
Urquidi, V.2
Ashcroft, S.J.3
-
11
-
-
0030599453
-
Atypical isoforms of pKc and insulin secretion from pancreatic beta-cells: evidence using Go 6976 and Ro 31-8220 as Pkc inhibitors
-
Harris, T.E., Persaud, S.J., Jones, P.M., Atypical isoforms of pKc and insulin secretion from pancreatic beta-cells: evidence using Go 6976 and Ro 31-8220 as Pkc inhibitors. Biochem. Biophys. Res. Commun. 227:3 (1996), 672–676.
-
(1996)
Biochem. Biophys. Res. Commun.
, vol.227
, Issue.3
, pp. 672-676
-
-
Harris, T.E.1
Persaud, S.J.2
Jones, P.M.3
-
12
-
-
0036868797
-
Glucose-stimulated signaling pathways in biphasic insulin secretion
-
Straub, S.G., Sharp, G.W., Glucose-stimulated signaling pathways in biphasic insulin secretion. Diabetes Metab. Res. Rev. 18:6 (2002), 451–463.
-
(2002)
Diabetes Metab. Res. Rev.
, vol.18
, Issue.6
, pp. 451-463
-
-
Straub, S.G.1
Sharp, G.W.2
-
13
-
-
0037400679
-
Protein kinase A- and C-induced insulin release from Ca2 + -insensitive pools
-
Lee, I.S., Hur, E.M., Suh, B.C., Kim, M.H., Koh, D.S., Rhee, I.J., Ha, H., Kim, K.T., Protein kinase A- and C-induced insulin release from Ca2 + -insensitive pools. Cell. Signal. 15:5 (2003), 529–537.
-
(2003)
Cell. Signal.
, vol.15
, Issue.5
, pp. 529-537
-
-
Lee, I.S.1
Hur, E.M.2
Suh, B.C.3
Kim, M.H.4
Koh, D.S.5
Rhee, I.J.6
Ha, H.7
Kim, K.T.8
-
14
-
-
84948843973
-
GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation
-
Shigeto, M., Ramracheya, R., Tarasov, A.I., Cha, C.Y., Chibalina, M.V., Hastoy, B., Philippaert, K., Reinbothe, T., Rorsman, N., Salehi, A., Sones, W.R., Vergari, E., Weston, C., Gorelik, J., Katsura, M., Nikolaev, V.O., Vennekens, R., Zaccolo, M., Galione, A., Johnson, P.R., Kaku, K., Ladds, G., Rorsman, P., GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation. J. Clin. Invest. 125:12 (2015), 4714–4728.
-
(2015)
J. Clin. Invest.
, vol.125
, Issue.12
, pp. 4714-4728
-
-
Shigeto, M.1
Ramracheya, R.2
Tarasov, A.I.3
Cha, C.Y.4
Chibalina, M.V.5
Hastoy, B.6
Philippaert, K.7
Reinbothe, T.8
Rorsman, N.9
Salehi, A.10
Sones, W.R.11
Vergari, E.12
Weston, C.13
Gorelik, J.14
Katsura, M.15
Nikolaev, V.O.16
Vennekens, R.17
Zaccolo, M.18
Galione, A.19
Johnson, P.R.20
Kaku, K.21
Ladds, G.22
Rorsman, P.23
more..
-
15
-
-
85004147176
-
EX4 stabilizes and activates Nrf2 via PKCdelta, contributing to the prevention of oxidative stress-induced pancreatic beta cell damage
-
Kim, M.H., Kim, E.H., Jung, H.S., Yang, D., Park, E.Y., Jun, H.S., EX4 stabilizes and activates Nrf2 via PKCdelta, contributing to the prevention of oxidative stress-induced pancreatic beta cell damage. Toxicol. Appl. Pharmacol. 315 (2017), 60–69.
-
(2017)
Toxicol. Appl. Pharmacol.
, vol.315
, pp. 60-69
-
-
Kim, M.H.1
Kim, E.H.2
Jung, H.S.3
Yang, D.4
Park, E.Y.5
Jun, H.S.6
-
16
-
-
40749122612
-
Protein kinase C in the pancreatic acinar cell
-
Gorelick, F., Pandol, S., Thrower, E., Protein kinase C in the pancreatic acinar cell. J. Gastroenterol. Hepatol. 23:Suppl. 1 (2008), S37–41.
-
(2008)
J. Gastroenterol. Hepatol.
, vol.23
, pp. S37-41
-
-
Gorelick, F.1
Pandol, S.2
Thrower, E.3
-
17
-
-
0027960617
-
Effects of cholecystokinin (CCK) and other secretagogues on isoforms of protein kinase C (PKC) in pancreatic acini
-
Pollo, D.A., Baldassare, J.J., Honda, T., Henderson, P.A., Talkad, V.D., Gardner, J.D., Effects of cholecystokinin (CCK) and other secretagogues on isoforms of protein kinase C (PKC) in pancreatic acini. Biochim. Biophys. Acta 1224:1 (1994), 127–138.
-
(1994)
Biochim. Biophys. Acta
, vol.1224
, Issue.1
, pp. 127-138
-
-
Pollo, D.A.1
Baldassare, J.J.2
Honda, T.3
Henderson, P.A.4
Talkad, V.D.5
Gardner, J.D.6
-
18
-
-
0028889361
-
Cellular distribution of isoforms of protein kinase C (PKC) in pancreatic acini
-
Bastani, B., Yang, L., Baldassare, J.J., Pollo, D.A., Gardner, J.D., Cellular distribution of isoforms of protein kinase C (PKC) in pancreatic acini. Biochim. Biophys. Acta 1269:3 (1995), 307–315.
-
(1995)
Biochim. Biophys. Acta
, vol.1269
, Issue.3
, pp. 307-315
-
-
Bastani, B.1
Yang, L.2
Baldassare, J.J.3
Pollo, D.A.4
Gardner, J.D.5
-
19
-
-
4644292587
-
Regulation of CCK-induced amylase release by PKC-delta in rat pancreatic acinar cells
-
Li, C., Chen, X., Williams, J.A., Regulation of CCK-induced amylase release by PKC-delta in rat pancreatic acinar cells. Am. J. Physiol. Gastrointest. Liver Physiol. 287:4 (2004), G764–71.
-
(2004)
Am. J. Physiol. Gastrointest. Liver Physiol.
, vol.287
, Issue.4
, pp. G764-71
-
-
Li, C.1
Chen, X.2
Williams, J.A.3
-
20
-
-
70350630307
-
Protein kinase C delta-mediated processes in cholecystokinin-8-stimulated pancreatic acini
-
Thrower, E.C., Wang, J., Cheriyan, S., Lugea, A., Kolodecik, T.R., Yuan, J., Reeve, J.R. Jr., Gorelick, F.S., Pandol, S.J., Protein kinase C delta-mediated processes in cholecystokinin-8-stimulated pancreatic acini. Pancreas 38:8 (2009), 930–935.
-
(2009)
Pancreas
, vol.38
, Issue.8
, pp. 930-935
-
-
Thrower, E.C.1
Wang, J.2
Cheriyan, S.3
Lugea, A.4
Kolodecik, T.R.5
Yuan, J.6
Reeve, J.R.7
Gorelick, F.S.8
Pandol, S.J.9
-
21
-
-
0028113896
-
Multiple affinity states of different cholecystokinin receptors
-
Huang, S.C., Fortune, K.P., Wank, S.A., Kopin, A.S., Gardner, J.D., Multiple affinity states of different cholecystokinin receptors. J. Biol. Chem. 269:42 (1994), 26121–26126.
-
(1994)
J. Biol. Chem.
, vol.269
, Issue.42
, pp. 26121-26126
-
-
Huang, S.C.1
Fortune, K.P.2
Wank, S.A.3
Kopin, A.S.4
Gardner, J.D.5
-
22
-
-
0028143113
-
Characterization of the three different states of the cholecystokinin (CCK) receptor in pancreatic acini
-
Talkad, V.D., Patto, R.J., Metz, D.C., Turner, R.J., Fortune, K.P., Bhat, S.T., Gardner, J.D., Characterization of the three different states of the cholecystokinin (CCK) receptor in pancreatic acini. Biochim. Biophys. Acta 1224:1 (1994), 103–116.
-
(1994)
Biochim. Biophys. Acta
, vol.1224
, Issue.1
, pp. 103-116
-
-
Talkad, V.D.1
Patto, R.J.2
Metz, D.C.3
Turner, R.J.4
Fortune, K.P.5
Bhat, S.T.6
Gardner, J.D.7
-
23
-
-
0037121531
-
Cholecystokinin-stimulated tyrosine phosphorylation of PKC-delta in pancreatic acinar cells is regulated bidirectionally by PKC activation
-
Tapia, J.A., Bragado, M.J., Garcia-Marin, L.J., Jensen, R.T., Cholecystokinin-stimulated tyrosine phosphorylation of PKC-delta in pancreatic acinar cells is regulated bidirectionally by PKC activation. Biochim. Biophys. Acta 1593:1 (2002), 99–113.
-
(2002)
Biochim. Biophys. Acta
, vol.1593
, Issue.1
, pp. 99-113
-
-
Tapia, J.A.1
Bragado, M.J.2
Garcia-Marin, L.J.3
Jensen, R.T.4
-
24
-
-
33947305951
-
CCK causes PKD1 activation in pancreatic acini by signaling through PKC-delta and PKC-independent pathways
-
Berna, M.J., Hoffmann, K.M., Tapia, J.A., Thill, M., Pace, A., Mantey, S.A., Jensen, R.T., CCK causes PKD1 activation in pancreatic acini by signaling through PKC-delta and PKC-independent pathways. Biochim. Biophys. Acta 1773:4 (2007), 483–501.
-
(2007)
Biochim. Biophys. Acta
, vol.1773
, Issue.4
, pp. 483-501
-
-
Berna, M.J.1
Hoffmann, K.M.2
Tapia, J.A.3
Thill, M.4
Pace, A.5
Mantey, S.A.6
Jensen, R.T.7
-
25
-
-
0035851112
-
Rottlerin is a mitochondrial uncoupler that decreases cellular ATP levels and indirectly blocks protein kinase Cdelta tyrosine phosphorylation
-
Soltoff, S.P., Rottlerin is a mitochondrial uncoupler that decreases cellular ATP levels and indirectly blocks protein kinase Cdelta tyrosine phosphorylation. J. Biol. Chem. 276:41 (2001), 37986–37992.
-
(2001)
J. Biol. Chem.
, vol.276
, Issue.41
, pp. 37986-37992
-
-
Soltoff, S.P.1
-
26
-
-
32144454027
-
Rottlerin inhibits stimulated enzymatic secretion and several intracellular signaling transduction pathways in pancreatic acinar cells by a non-PKC-delta-dependent mechanism
-
Tapia, J.A., Jensen, R.T., Garcia-Marin, L.J., Rottlerin inhibits stimulated enzymatic secretion and several intracellular signaling transduction pathways in pancreatic acinar cells by a non-PKC-delta-dependent mechanism. Biochim. Biophys. Acta 1763:1 (2006), 25–38.
-
(2006)
Biochim. Biophys. Acta
, vol.1763
, Issue.1
, pp. 25-38
-
-
Tapia, J.A.1
Jensen, R.T.2
Garcia-Marin, L.J.3
-
27
-
-
84979520528
-
Involvement of myristoylated alanine-rich C kinase substrate phosphorylation and translocation in cholecystokinin-induced amylase release in rat pancreatic acini
-
Satoh, K., Narita, T., Katsumata-Kato, O., Sugiya, H., Seo, Y., Involvement of myristoylated alanine-rich C kinase substrate phosphorylation and translocation in cholecystokinin-induced amylase release in rat pancreatic acini. Am. J. Physiol. Gastrointest. Liver Physiol. 310:6 (2016), G399–409.
-
(2016)
Am. J. Physiol. Gastrointest. Liver Physiol.
, vol.310
, Issue.6
, pp. G399-409
-
-
Satoh, K.1
Narita, T.2
Katsumata-Kato, O.3
Sugiya, H.4
Seo, Y.5
-
28
-
-
0037731790
-
Molecular cloning, characterization, and expression of a cDNA encoding the “80- to 87-kDa” myristoylated alanine-rich C kinase substrate: a major cellular substrate for protein kinase C
-
Stumpo, D.J., Graff, J.M., Albert, K.A., Greengard, P., Blackshear, P.J., Molecular cloning, characterization, and expression of a cDNA encoding the “80- to 87-kDa” myristoylated alanine-rich C kinase substrate: a major cellular substrate for protein kinase C. Proc. Natl. Acad. Sci. U. S. A. 86:11 (1989), 4012–4016.
-
(1989)
Proc. Natl. Acad. Sci. U. S. A.
, vol.86
, Issue.11
, pp. 4012-4016
-
-
Stumpo, D.J.1
Graff, J.M.2
Albert, K.A.3
Greengard, P.4
Blackshear, P.J.5
-
29
-
-
34250182406
-
Identification of SNAREs that mediate zymogen granule exocytosis
-
Pickett, J.A., Campos-Toimil, M., Thomas, P., Edwardson, J.M., Identification of SNAREs that mediate zymogen granule exocytosis. Biochem. Biophys. Res. Commun. 359:3 (2007), 599–603.
-
(2007)
Biochem. Biophys. Res. Commun.
, vol.359
, Issue.3
, pp. 599-603
-
-
Pickett, J.A.1
Campos-Toimil, M.2
Thomas, P.3
Edwardson, J.M.4
-
30
-
-
82555167074
-
PKCtheta activation in pancreatic acinar cells by gastrointestinal hormones/neurotransmitters and growth factors is needed for stimulation of numerous important cellular signaling cascades
-
Sancho, V., Berna, M.J., Thill, M., Jensen, R.T., PKCtheta activation in pancreatic acinar cells by gastrointestinal hormones/neurotransmitters and growth factors is needed for stimulation of numerous important cellular signaling cascades. Biochim. Biophys. Acta 1813:12 (2011), 2145–2156.
-
(2011)
Biochim. Biophys. Acta
, vol.1813
, Issue.12
, pp. 2145-2156
-
-
Sancho, V.1
Berna, M.J.2
Thill, M.3
Jensen, R.T.4
-
31
-
-
0142246600
-
Role of the kinase activation loop on protein kinase C theta activity and intracellular localisation
-
Sparatore, B., Passalacqua, M., Pedrazzi, M., Ledda, S., Patrone, M., Gaggero, D., Pontremoli, S., Melloni, E., Role of the kinase activation loop on protein kinase C theta activity and intracellular localisation. FEBS Lett. 554:1–2 (2003), 35–40.
-
(2003)
FEBS Lett.
, vol.554
, Issue.1-2
, pp. 35-40
-
-
Sparatore, B.1
Passalacqua, M.2
Pedrazzi, M.3
Ledda, S.4
Patrone, M.5
Gaggero, D.6
Pontremoli, S.7
Melloni, E.8
-
32
-
-
0026752739
-
Structure, function, and regulation of cellular tight junctions
-
Schneeberger, E.E., Lynch, R.D., Structure, function, and regulation of cellular tight junctions. Am. J. Phys. 262:6 Pt 1 (1992), L647–61.
-
(1992)
Am. J. Phys.
, vol.262
, Issue.6
, pp. L647-61
-
-
Schneeberger, E.E.1
Lynch, R.D.2
-
33
-
-
77957255799
-
Transcriptional control of tight junction proteins via a protein kinase C signal pathway in human telomerase reverse transcriptase-transfected human pancreatic duct epithelial cells
-
Yamaguchi, H., Kojima, T., Ito, T., Kimura, Y., Imamura, M., Son, S., Koizumi, J., Murata, M., Nagayama, M., Nobuoka, T., Tanaka, S., Hirata, K., Sawada, N., Transcriptional control of tight junction proteins via a protein kinase C signal pathway in human telomerase reverse transcriptase-transfected human pancreatic duct epithelial cells. Am. J. Pathol. 177:2 (2010), 698–712.
-
(2010)
Am. J. Pathol.
, vol.177
, Issue.2
, pp. 698-712
-
-
Yamaguchi, H.1
Kojima, T.2
Ito, T.3
Kimura, Y.4
Imamura, M.5
Son, S.6
Koizumi, J.7
Murata, M.8
Nagayama, M.9
Nobuoka, T.10
Tanaka, S.11
Hirata, K.12
Sawada, N.13
-
34
-
-
80051519812
-
Transcriptional regulation of claudin-18 via specific protein kinase C signaling pathways and modification of DNA methylation in human pancreatic cancer cells
-
Ito, T., Kojima, T., Yamaguchi, H., Kyuno, D., Kimura, Y., Imamura, M., Takasawa, A., Murata, M., Tanaka, S., Hirata, K., Sawada, N., Transcriptional regulation of claudin-18 via specific protein kinase C signaling pathways and modification of DNA methylation in human pancreatic cancer cells. J. Cell. Biochem. 112:7 (2011), 1761–1772.
-
(2011)
J. Cell. Biochem.
, vol.112
, Issue.7
, pp. 1761-1772
-
-
Ito, T.1
Kojima, T.2
Yamaguchi, H.3
Kyuno, D.4
Kimura, Y.5
Imamura, M.6
Takasawa, A.7
Murata, M.8
Tanaka, S.9
Hirata, K.10
Sawada, N.11
-
35
-
-
0029907455
-
Interactions between secretin and acetylcholine in the regulation of fluid secretion by isolated rat pancreatic ducts
-
Evans, R.L., Ashton, N., Elliott, A.C., Green, R., Argent, B.E., Interactions between secretin and acetylcholine in the regulation of fluid secretion by isolated rat pancreatic ducts. J. Physiol. 496:Pt 1 (1996), 265–273.
-
(1996)
J. Physiol.
, vol.496
, pp. 265-273
-
-
Evans, R.L.1
Ashton, N.2
Elliott, A.C.3
Green, R.4
Argent, B.E.5
-
36
-
-
17644382324
-
Protein kinase C mediates the inhibitory effect of substance P on HCO3- secretion from guinea pig pancreatic ducts
-
Hegyi, P., Rakonczay, Z. Jr., Tiszlavicz, L., Varro, A., Toth, A., Racz, G., Varga, G., Gray, M.A., Argent, B.E., Protein kinase C mediates the inhibitory effect of substance P on HCO3- secretion from guinea pig pancreatic ducts. Am. J. Physiol. Cell Physiol. 288:5 (2005), C1030–41.
-
(2005)
Am. J. Physiol. Cell Physiol.
, vol.288
, Issue.5
, pp. C1030-41
-
-
Hegyi, P.1
Rakonczay, Z.2
Tiszlavicz, L.3
Varro, A.4
Toth, A.5
Racz, G.6
Varga, G.7
Gray, M.A.8
Argent, B.E.9
-
37
-
-
23044434059
-
Metabolon disruption: a mechanism that regulates bicarbonate transport
-
Alvarez, B.V., Vilas, G.L., Casey, J.R., Metabolon disruption: a mechanism that regulates bicarbonate transport. EMBO J. 24:14 (2005), 2499–2511.
-
(2005)
EMBO J.
, vol.24
, Issue.14
, pp. 2499-2511
-
-
Alvarez, B.V.1
Vilas, G.L.2
Casey, J.R.3
-
38
-
-
53549108010
-
Insulitis in type 2 diabetes
-
Boni-Schnetzler, M., Ehses, J.A., Faulenbach, M., Donath, M.Y., Insulitis in type 2 diabetes. Diabetes Obes. Metab. 10:Suppl. 4 (2008), 201–204.
-
(2008)
Diabetes Obes. Metab.
, vol.10
, pp. 201-204
-
-
Boni-Schnetzler, M.1
Ehses, J.A.2
Faulenbach, M.3
Donath, M.Y.4
-
39
-
-
73949126369
-
Islet inflammation impairs the pancreatic beta-cell in type 2 diabetes
-
Donath, M.Y., Boni-Schnetzler, M., Ellingsgaard, H., Ehses, J.A., Islet inflammation impairs the pancreatic beta-cell in type 2 diabetes. Physiology (Bethesda) 24 (2009), 325–331.
-
(2009)
Physiology (Bethesda)
, vol.24
, pp. 325-331
-
-
Donath, M.Y.1
Boni-Schnetzler, M.2
Ellingsgaard, H.3
Ehses, J.A.4
-
40
-
-
84934343239
-
Mechanisms linking inflammation to insulin resistance
-
Chen, L., Chen, R., Wang, H., Liang, F., Mechanisms linking inflammation to insulin resistance. Int. J. Endocrinol., 2015, 2015, 508409.
-
(2015)
Int. J. Endocrinol.
, vol.2015
, pp. 508409
-
-
Chen, L.1
Chen, R.2
Wang, H.3
Liang, F.4
-
41
-
-
80355133234
-
Macrophagse-mediated inflammation in metabolic disease
-
Chawla, A., Nguyen, K.D., Goh, Y.P., Macrophagse-mediated inflammation in metabolic disease. Nat. Rev. Immunol. 11:11 (2011), 738–749.
-
(2011)
Nat. Rev. Immunol.
, vol.11
, Issue.11
, pp. 738-749
-
-
Chawla, A.1
Nguyen, K.D.2
Goh, Y.P.3
-
42
-
-
80053395566
-
Activation of protein kinase C-zeta in pancreatic beta-cells in vivo improves glucose tolerance and induces beta-cell expansion via mTOR activation
-
Velazquez-Garcia, S., Valle, S., Rosa, T.C., Takane, K.K., Demirci, C., Alvarez-Perez, J.C., Mellado-Gil, J.M., Ernst, S., Scott, D.K., Vasavada, R.C., Alonso, L.C., Garcia-Ocana, A., Activation of protein kinase C-zeta in pancreatic beta-cells in vivo improves glucose tolerance and induces beta-cell expansion via mTOR activation. Diabetes 60:10 (2011), 2546–2559.
-
(2011)
Diabetes
, vol.60
, Issue.10
, pp. 2546-2559
-
-
Velazquez-Garcia, S.1
Valle, S.2
Rosa, T.C.3
Takane, K.K.4
Demirci, C.5
Alvarez-Perez, J.C.6
Mellado-Gil, J.M.7
Ernst, S.8
Scott, D.K.9
Vasavada, R.C.10
Alonso, L.C.11
Garcia-Ocana, A.12
-
43
-
-
84964692752
-
PKCzeta is essential for pancreatic beta-cell replication during insulin resistance by regulating mTOR and Cyclin-D2
-
Lakshmipathi, J., Alvarez-Perez, J.C., Rosselot, C., Casinelli, G.P., Stamateris, R.E., Rausell-Palamos, F., O'Donnell, C.P., Vasavada, R.C., Scott, D.K., Alonso, L.C., Garcia-Ocana, A., PKCzeta is essential for pancreatic beta-cell replication during insulin resistance by regulating mTOR and Cyclin-D2. Diabetes 65:5 (2016), 1283–1296.
-
(2016)
Diabetes
, vol.65
, Issue.5
, pp. 1283-1296
-
-
Lakshmipathi, J.1
Alvarez-Perez, J.C.2
Rosselot, C.3
Casinelli, G.P.4
Stamateris, R.E.5
Rausell-Palamos, F.6
O'Donnell, C.P.7
Vasavada, R.C.8
Scott, D.K.9
Alonso, L.C.10
Garcia-Ocana, A.11
-
44
-
-
65549130128
-
mTORC1 activation regulates beta-cell mass and proliferation by modulation of cyclin D2 synthesis and stability
-
Balcazar, N., Sathyamurthy, A., Elghazi, L., Gould, A., Weiss, A., Shiojima, I., Walsh, K., Bernal-Mizrachi, E., mTORC1 activation regulates beta-cell mass and proliferation by modulation of cyclin D2 synthesis and stability. J. Biol. Chem. 284:12 (2009), 7832–7842.
-
(2009)
J. Biol. Chem.
, vol.284
, Issue.12
, pp. 7832-7842
-
-
Balcazar, N.1
Sathyamurthy, A.2
Elghazi, L.3
Gould, A.4
Weiss, A.5
Shiojima, I.6
Walsh, K.7
Bernal-Mizrachi, E.8
-
45
-
-
78951485569
-
Deletion of protein kinase Cdelta in mice modulates stability of inflammatory genes and protects against cytokine-stimulated beta cell death in vitro and in vivo
-
Cantley, J., Boslem, E., Laybutt, D.R., Cordery, D.V., Pearson, G., Carpenter, L., Leitges, M., Biden, T.J., Deletion of protein kinase Cdelta in mice modulates stability of inflammatory genes and protects against cytokine-stimulated beta cell death in vitro and in vivo. Diabetologia 54:2 (2011), 380–389.
-
(2011)
Diabetologia
, vol.54
, Issue.2
, pp. 380-389
-
-
Cantley, J.1
Boslem, E.2
Laybutt, D.R.3
Cordery, D.V.4
Pearson, G.5
Carpenter, L.6
Leitges, M.7
Biden, T.J.8
-
46
-
-
34548036686
-
Toll-like receptor 2 senses beta-cell death and contributes to the initiation of autoimmune diabetes
-
Kim, H.S., Han, M.S., Chung, K.W., Kim, S., Kim, E., Kim, M.J., Jang, E., Lee, H.A., Youn, J., Akira, S., Lee, M.S., Toll-like receptor 2 senses beta-cell death and contributes to the initiation of autoimmune diabetes. Immunity 27:2 (2007), 321–333.
-
(2007)
Immunity
, vol.27
, Issue.2
, pp. 321-333
-
-
Kim, H.S.1
Han, M.S.2
Chung, K.W.3
Kim, S.4
Kim, E.5
Kim, M.J.6
Jang, E.7
Lee, H.A.8
Youn, J.9
Akira, S.10
Lee, M.S.11
-
47
-
-
77955492173
-
Toll-like receptor 2-deficient mice are protected from insulin resistance and beta cell dysfunction induced by a high-fat diet
-
Ehses, J.A., Meier, D.T., Wueest, S., Rytka, J., Boller, S., Wielinga, P.Y., Schraenen, A., Lemaire, K., Debray, S., Van Lommel, L., Pospisilik, J.A., Tschopp, O., Schultze, S.M., Malipiero, U., Esterbauer, H., Ellingsgaard, H., Rutti, S., Schuit, F.C., Lutz, T.A., Boni-Schnetzler, M., Konrad, D., Donath, M.Y., Toll-like receptor 2-deficient mice are protected from insulin resistance and beta cell dysfunction induced by a high-fat diet. Diabetologia 53:8 (2010), 1795–1806.
-
(2010)
Diabetologia
, vol.53
, Issue.8
, pp. 1795-1806
-
-
Ehses, J.A.1
Meier, D.T.2
Wueest, S.3
Rytka, J.4
Boller, S.5
Wielinga, P.Y.6
Schraenen, A.7
Lemaire, K.8
Debray, S.9
Van Lommel, L.10
Pospisilik, J.A.11
Tschopp, O.12
Schultze, S.M.13
Malipiero, U.14
Esterbauer, H.15
Ellingsgaard, H.16
Rutti, S.17
Schuit, F.C.18
Lutz, T.A.19
Boni-Schnetzler, M.20
Konrad, D.21
Donath, M.Y.22
more..
-
48
-
-
0035895998
-
Protein kinase Cdelta activation by interleukin-1beta stabilizes inducible nitric-oxide synthase mRNA in pancreatic beta-cells
-
Carpenter, L., Cordery, D., Biden, T.J., Protein kinase Cdelta activation by interleukin-1beta stabilizes inducible nitric-oxide synthase mRNA in pancreatic beta-cells. J. Biol. Chem. 276:7 (2001), 5368–5374.
-
(2001)
J. Biol. Chem.
, vol.276
, Issue.7
, pp. 5368-5374
-
-
Carpenter, L.1
Cordery, D.2
Biden, T.J.3
-
49
-
-
0030005411
-
The harmony of the spheres: inducible nitric oxide synthase and related genes in pancreatic beta cells
-
Eizirik, D.L., Flodstrom, M., Karlsen, A.E., Welsh, N., The harmony of the spheres: inducible nitric oxide synthase and related genes in pancreatic beta cells. Diabetologia 39:8 (1996), 875–890.
-
(1996)
Diabetologia
, vol.39
, Issue.8
, pp. 875-890
-
-
Eizirik, D.L.1
Flodstrom, M.2
Karlsen, A.E.3
Welsh, N.4
-
50
-
-
34548846648
-
Inhibition of PKCepsilon improves glucose-stimulated insulin secretion and reduces insulin clearance
-
Schmitz-Peiffer, C., Laybutt, D.R., Burchfield, J.G., Gurisik, E., Narasimhan, S., Mitchell, C.J., Pedersen, D.J., Braun, U., Cooney, G.J., Leitges, M., Biden, T.J., Inhibition of PKCepsilon improves glucose-stimulated insulin secretion and reduces insulin clearance. Cell Metab. 6:4 (2007), 320–328.
-
(2007)
Cell Metab.
, vol.6
, Issue.4
, pp. 320-328
-
-
Schmitz-Peiffer, C.1
Laybutt, D.R.2
Burchfield, J.G.3
Gurisik, E.4
Narasimhan, S.5
Mitchell, C.J.6
Pedersen, D.J.7
Braun, U.8
Cooney, G.J.9
Leitges, M.10
Biden, T.J.11
-
51
-
-
0028268936
-
Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle
-
Zhou, Y.P., Grill, V.E., Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle. J. Clin. Invest. 93:2 (1994), 870–876.
-
(1994)
J. Clin. Invest.
, vol.93
, Issue.2
, pp. 870-876
-
-
Zhou, Y.P.1
Grill, V.E.2
-
52
-
-
84907305877
-
Genetic inhibition of protein kinase Cepsilon attenuates necrosis in experimental pancreatitis
-
Liu, Y., Yuan, J., Tan, T., Jia, W., Lugea, A., Mareninova, O., Waldron, R.T., Pandol, S.J., Genetic inhibition of protein kinase Cepsilon attenuates necrosis in experimental pancreatitis. Am. J. Physiol. Gastrointest. Liver Physiol. 307:5 (2014), G550–63.
-
(2014)
Am. J. Physiol. Gastrointest. Liver Physiol.
, vol.307
, Issue.5
, pp. G550-63
-
-
Liu, Y.1
Yuan, J.2
Tan, T.3
Jia, W.4
Lugea, A.5
Mareninova, O.6
Waldron, R.T.7
Pandol, S.J.8
-
53
-
-
0031767880
-
Zymogen proteolysis within the pancreatic acinar cell is associated with cellular injury
-
Grady, T., Mah'Moud, M., Otani, T., Rhee, S., Lerch, M.M., Gorelick, F.S., Zymogen proteolysis within the pancreatic acinar cell is associated with cellular injury. Am. J. Phys. 275:5 Pt 1 (1998), G1010–7.
-
(1998)
Am. J. Phys.
, vol.275
, Issue.5
, pp. G1010-7
-
-
Grady, T.1
Mah'Moud, M.2
Otani, T.3
Rhee, S.4
Lerch, M.M.5
Gorelick, F.S.6
-
54
-
-
12344302086
-
Effects of increased intracellular cAMP on carbachol-stimulated zymogen activation, secretion, and injury in the pancreatic acinar cell
-
Chaudhuri, A., Kolodecik, T.R., Gorelick, F.S., Effects of increased intracellular cAMP on carbachol-stimulated zymogen activation, secretion, and injury in the pancreatic acinar cell. Am. J. Physiol. Gastrointest. Liver Physiol. 288:2 (2005), G235–43.
-
(2005)
Am. J. Physiol. Gastrointest. Liver Physiol.
, vol.288
, Issue.2
, pp. G235-43
-
-
Chaudhuri, A.1
Kolodecik, T.R.2
Gorelick, F.S.3
-
55
-
-
81855228093
-
Intra-acinar trypsinogen activation mediates early stages of pancreatic injury but not inflammation in mice with acute pancreatitis
-
(e2)
-
Dawra, R., Sah, R.P., Dudeja, V., Rishi, L., Talukdar, R., Garg, P., Saluja, A.K., Intra-acinar trypsinogen activation mediates early stages of pancreatic injury but not inflammation in mice with acute pancreatitis. Gastroenterology 141:6 (2011), 2210–2217 (e2).
-
(2011)
Gastroenterology
, vol.141
, Issue.6
, pp. 2210-2217
-
-
Dawra, R.1
Sah, R.P.2
Dudeja, V.3
Rishi, L.4
Talukdar, R.5
Garg, P.6
Saluja, A.K.7
-
56
-
-
48249155835
-
The novel protein kinase C isoforms -delta and -epsilon modulate caerulein-induced zymogen activation in pancreatic acinar cells
-
Thrower, E.C., Osgood, S., Shugrue, C.A., Kolodecik, T.R., Chaudhuri, A.M., Reeve, J.R. Jr., Pandol, S.J., Gorelick, F.S., The novel protein kinase C isoforms -delta and -epsilon modulate caerulein-induced zymogen activation in pancreatic acinar cells. Am. J. Physiol. Gastrointest. Liver Physiol. 294:6 (2008), G1344–53.
-
(2008)
Am. J. Physiol. Gastrointest. Liver Physiol.
, vol.294
, Issue.6
, pp. G1344-53
-
-
Thrower, E.C.1
Osgood, S.2
Shugrue, C.A.3
Kolodecik, T.R.4
Chaudhuri, A.M.5
Reeve, J.R.6
Pandol, S.J.7
Gorelick, F.S.8
-
57
-
-
0023080603
-
Exocytosis occurs at the lateral plasma membrane of the pancreatic acinar cell during supramaximal secretagogue stimulation
-
Scheele, G., Adler, G., Kern, H., Exocytosis occurs at the lateral plasma membrane of the pancreatic acinar cell during supramaximal secretagogue stimulation. Gastroenterology 92:2 (1987), 345–353.
-
(1987)
Gastroenterology
, vol.92
, Issue.2
, pp. 345-353
-
-
Scheele, G.1
Adler, G.2
Kern, H.3
-
58
-
-
0035206785
-
Supramaximal cholecystokinin displaces Munc18c from the pancreatic acinar basal surface, redirecting apical exocytosis to the basal membrane
-
Gaisano, H.Y., Lutz, M.P., Leser, J., Sheu, L., Lynch, G., Tang, L., Tamori, Y., Trimble, W.S., Salapatek, A.M., Supramaximal cholecystokinin displaces Munc18c from the pancreatic acinar basal surface, redirecting apical exocytosis to the basal membrane. J. Clin. Invest. 108:11 (2001), 1597–1611.
-
(2001)
J. Clin. Invest.
, vol.108
, Issue.11
, pp. 1597-1611
-
-
Gaisano, H.Y.1
Lutz, M.P.2
Leser, J.3
Sheu, L.4
Lynch, G.5
Tang, L.6
Tamori, Y.7
Trimble, W.S.8
Salapatek, A.M.9
-
59
-
-
34247265426
-
Alcohol-induced protein kinase Calpha phosphorylation of Munc18c in carbachol-stimulated acini causes basolateral exocytosis
-
Cosen-Binker, L.I., Lam, P.P., Binker, M.G., Gaisano, H.Y., Alcohol-induced protein kinase Calpha phosphorylation of Munc18c in carbachol-stimulated acini causes basolateral exocytosis. Gastroenterology 132:4 (2007), 1527–1545.
-
(2007)
Gastroenterology
, vol.132
, Issue.4
, pp. 1527-1545
-
-
Cosen-Binker, L.I.1
Lam, P.P.2
Binker, M.G.3
Gaisano, H.Y.4
-
60
-
-
34250368480
-
Alcohol/cholecystokinin-evoked pancreatic acinar basolateral exocytosis is mediated by protein kinase C alpha phosphorylation of Munc18c
-
Cosen-Binker, L.I., Lam, P.P., Binker, M.G., Reeve, J., Pandol, S., Gaisano, H.Y., Alcohol/cholecystokinin-evoked pancreatic acinar basolateral exocytosis is mediated by protein kinase C alpha phosphorylation of Munc18c. J. Biol. Chem. 282:17 (2007), 13047–13058.
-
(2007)
J. Biol. Chem.
, vol.282
, Issue.17
, pp. 13047-13058
-
-
Cosen-Binker, L.I.1
Lam, P.P.2
Binker, M.G.3
Reeve, J.4
Pandol, S.5
Gaisano, H.Y.6
-
61
-
-
0036007501
-
NF-kappaB activation in pancreas induces pancreatic and systemic inflammatory response
-
Chen, X., Ji, B., Han, B., Ernst, S.A., Simeone, D., Logsdon, C.D., NF-kappaB activation in pancreas induces pancreatic and systemic inflammatory response. Gastroenterology 122:2 (2002), 448–457.
-
(2002)
Gastroenterology
, vol.122
, Issue.2
, pp. 448-457
-
-
Chen, X.1
Ji, B.2
Han, B.3
Ernst, S.A.4
Simeone, D.5
Logsdon, C.D.6
-
62
-
-
4444260453
-
PKC-delta and -epsilon regulate NF-kappaB activation induced by cholecystokinin and TNF-alpha in pancreatic acinar cells
-
Satoh, A., Gukovskaya, A.S., Nieto, J.M., Cheng, J.H., Gukovsky, I., Reeve, J.R. Jr., Shimosegawa, T., Pandol, S.J., PKC-delta and -epsilon regulate NF-kappaB activation induced by cholecystokinin and TNF-alpha in pancreatic acinar cells. Am. J. Physiol. Gastrointest. Liver Physiol. 287:3 (2004), G582–91.
-
(2004)
Am. J. Physiol. Gastrointest. Liver Physiol.
, vol.287
, Issue.3
, pp. G582-91
-
-
Satoh, A.1
Gukovskaya, A.S.2
Nieto, J.M.3
Cheng, J.H.4
Gukovsky, I.5
Reeve, J.R.6
Shimosegawa, T.7
Pandol, S.J.8
-
63
-
-
78149414074
-
PKC delta mediates pro-inflammatory responses in a mouse model of caerulein-induced acute pancreatitis
-
(Berl)
-
Ramnath, R.D., Sun, J., Bhatia, M., PKC delta mediates pro-inflammatory responses in a mouse model of caerulein-induced acute pancreatitis. J. Mol. Med. 88:10 (2010), 1055–1063 (Berl).
-
(2010)
J. Mol. Med.
, vol.88
, Issue.10
, pp. 1055-1063
-
-
Ramnath, R.D.1
Sun, J.2
Bhatia, M.3
-
64
-
-
74049146296
-
PKC Delta (PKCdelta) promotes tumoral progression of human ductal pancreatic cancer
-
Mauro, L.V., Grossoni, V.C., Urtreger, A.J., Yang, C., Colombo, L.L., Morandi, A., Pallotta, M.G., Kazanietz, M.G., Bal de Kier Joffe, E.D., Puricelli, L.L., PKC Delta (PKCdelta) promotes tumoral progression of human ductal pancreatic cancer. Pancreas 39:1 (2010), e31–41.
-
(2010)
Pancreas
, vol.39
, Issue.1
, pp. e31-41
-
-
Mauro, L.V.1
Grossoni, V.C.2
Urtreger, A.J.3
Yang, C.4
Colombo, L.L.5
Morandi, A.6
Pallotta, M.G.7
Kazanietz, M.G.8
Bal de Kier Joffe, E.D.9
Puricelli, L.L.10
-
65
-
-
0036327373
-
Enhancement of anchorage-independent growth of human pancreatic carcinoma MIA PaCa-2 cells by signaling from protein kinase C to mitogen-activated protein kinase
-
Ishino, K., Fukazawa, H., Shikano, M., Ohba, M., Kuroki, T., Uehara, Y., Enhancement of anchorage-independent growth of human pancreatic carcinoma MIA PaCa-2 cells by signaling from protein kinase C to mitogen-activated protein kinase. Mol. Carcinog. 34:4 (2002), 180–186.
-
(2002)
Mol. Carcinog.
, vol.34
, Issue.4
, pp. 180-186
-
-
Ishino, K.1
Fukazawa, H.2
Shikano, M.3
Ohba, M.4
Kuroki, T.5
Uehara, Y.6
-
66
-
-
77950250455
-
Protein kinase Ciota is required for pancreatic cancer cell transformed growth and tumorigenesis
-
Scotti, M.L., Bamlet, W.R., Smyrk, T.C., Fields, A.P., Murray, N.R., Protein kinase Ciota is required for pancreatic cancer cell transformed growth and tumorigenesis. Cancer Res. 70:5 (2010), 2064–2074.
-
(2010)
Cancer Res.
, vol.70
, Issue.5
, pp. 2064-2074
-
-
Scotti, M.L.1
Bamlet, W.R.2
Smyrk, T.C.3
Fields, A.P.4
Murray, N.R.5
-
67
-
-
0033828604
-
Activation of protein kinase Calpha inhibits growth of pancreatic cancer cells via p21(cip)-mediated G(1) arrest
-
Detjen, K.M., Brembeck, F.H., Welzel, M., Kaiser, A., Haller, H., Wiedenmann, B., Rosewicz, S., Activation of protein kinase Calpha inhibits growth of pancreatic cancer cells via p21(cip)-mediated G(1) arrest. J. Cell Sci. 113:Pt 17 (2000), 3025–3035.
-
(2000)
J. Cell Sci.
, vol.113
, pp. 3025-3035
-
-
Detjen, K.M.1
Brembeck, F.H.2
Welzel, M.3
Kaiser, A.4
Haller, H.5
Wiedenmann, B.6
Rosewicz, S.7
-
68
-
-
0038308404
-
Activation of conventional PKC isoforms increases expression of the pro-apoptotic protein bad and TRAIL receptors
-
Farrow, B., Thomas, R.P., Wang, X.F., Evers, B.M., Activation of conventional PKC isoforms increases expression of the pro-apoptotic protein bad and TRAIL receptors. Int. J. Gastrointest. Cancer 32:2–3 (2002), 63–72.
-
(2002)
Int. J. Gastrointest. Cancer
, vol.32
, Issue.2-3
, pp. 63-72
-
-
Farrow, B.1
Thomas, R.P.2
Wang, X.F.3
Evers, B.M.4
-
69
-
-
14444284330
-
Tumor-suppressive pathways in pancreatic carcinoma
-
Rozenblum, E., Schutte, M., Goggins, M., Hahn, S.A., Panzer, S., Zahurak, M., Goodman, S.N., Sohn, T.A., Hruban, R.H., Yeo, C.J., Kern, S.E., Tumor-suppressive pathways in pancreatic carcinoma. Cancer Res. 57:9 (1997), 1731–1734.
-
(1997)
Cancer Res.
, vol.57
, Issue.9
, pp. 1731-1734
-
-
Rozenblum, E.1
Schutte, M.2
Goggins, M.3
Hahn, S.A.4
Panzer, S.5
Zahurak, M.6
Goodman, S.N.7
Sohn, T.A.8
Hruban, R.H.9
Yeo, C.J.10
Kern, S.E.11
-
70
-
-
84862777152
-
Presence of somatic mutations in most early-stage pancreatic intraepithelial neoplasia
-
(e9)
-
Kanda, M., Matthaei, H., Wu, J., Hong, S.M., Yu, J., Borges, M., Hruban, R.H., Maitra, A., Kinzler, K., Vogelstein, B., Goggins, M., Presence of somatic mutations in most early-stage pancreatic intraepithelial neoplasia. Gastroenterology 142:4 (2012), 730–733 (e9).
-
(2012)
Gastroenterology
, vol.142
, Issue.4
, pp. 730-733
-
-
Kanda, M.1
Matthaei, H.2
Wu, J.3
Hong, S.M.4
Yu, J.5
Borges, M.6
Hruban, R.H.7
Maitra, A.8
Kinzler, K.9
Vogelstein, B.10
Goggins, M.11
-
71
-
-
84906938439
-
Oncogenic KRAS signalling in pancreatic cancer
-
Eser, S., Schnieke, A., Schneider, G., Saur, D., Oncogenic KRAS signalling in pancreatic cancer. Br. J. Cancer 111:5 (2014), 817–822.
-
(2014)
Br. J. Cancer
, vol.111
, Issue.5
, pp. 817-822
-
-
Eser, S.1
Schnieke, A.2
Schneider, G.3
Saur, D.4
-
72
-
-
84863408964
-
Protein kinase C iota regulates pancreatic acinar-to-ductal metaplasia
-
Scotti, M.L., Smith, K.E., Butler, A.M., Calcagno, S.R., Crawford, H.C., Leitges, M., Fields, A.P., Murray, N.R., Protein kinase C iota regulates pancreatic acinar-to-ductal metaplasia. PLoS One, 7(2), 2012, e30509.
-
(2012)
PLoS One
, vol.7
, Issue.2
-
-
Scotti, M.L.1
Smith, K.E.2
Butler, A.M.3
Calcagno, S.R.4
Crawford, H.C.5
Leitges, M.6
Fields, A.P.7
Murray, N.R.8
-
73
-
-
37649023286
-
Matrix metalloproteinase 7 controls pancreatic acinar cell transdifferentiation by activating the Notch signaling pathway
-
Sawey, E.T., Johnson, J.A., Crawford, H.C., Matrix metalloproteinase 7 controls pancreatic acinar cell transdifferentiation by activating the Notch signaling pathway. Proc. Natl. Acad. Sci. U. S. A. 104:49 (2007), 19327–19332.
-
(2007)
Proc. Natl. Acad. Sci. U. S. A.
, vol.104
, Issue.49
, pp. 19327-19332
-
-
Sawey, E.T.1
Johnson, J.A.2
Crawford, H.C.3
-
74
-
-
84923323788
-
Protein kinase D1 drives pancreatic acinar cell reprogramming and progression to intraepithelial neoplasia
-
Liou, G.Y., Doppler, H., Braun, U.B., Panayiotou, R., Scotti Buzhardt, M., Radisky, D.C., Crawford, H.C., Fields, A.P., Murray, N.R., Wang, Q.J., Leitges, M., Storz, P., Protein kinase D1 drives pancreatic acinar cell reprogramming and progression to intraepithelial neoplasia. Nat. Commun., 6, 2015, 6200.
-
(2015)
Nat. Commun.
, vol.6
, pp. 6200
-
-
Liou, G.Y.1
Doppler, H.2
Braun, U.B.3
Panayiotou, R.4
Scotti Buzhardt, M.5
Radisky, D.C.6
Crawford, H.C.7
Fields, A.P.8
Murray, N.R.9
Wang, Q.J.10
Leitges, M.11
Storz, P.12
-
75
-
-
84947713840
-
K-Ras promotes Tumorigenicity through suppression of non-canonical Wnt signaling
-
Wang, M.T., Holderfield, M., Galeas, J., Delrosario, R., M.D. To, Balmain, A., McCormick, F., K-Ras promotes Tumorigenicity through suppression of non-canonical Wnt signaling. Cell 163:5 (2015), 1237–1251.
-
(2015)
Cell
, vol.163
, Issue.5
, pp. 1237-1251
-
-
Wang, M.T.1
Holderfield, M.2
Galeas, J.3
Delrosario, R.4
To, M.D.5
Balmain, A.6
McCormick, F.7
-
76
-
-
84867580010
-
Activation of protein kinase Cdelta leads to increased pancreatic acinar cell dedifferentiation in the absence of MIST1
-
Johnson, C.L., Peat, J.M., Volante, S.N., Wang, R., McLean, C.A., Pin, C.L., Activation of protein kinase Cdelta leads to increased pancreatic acinar cell dedifferentiation in the absence of MIST1. J. Pathol. 228:3 (2012), 351–365.
-
(2012)
J. Pathol.
, vol.228
, Issue.3
, pp. 351-365
-
-
Johnson, C.L.1
Peat, J.M.2
Volante, S.N.3
Wang, R.4
McLean, C.A.5
Pin, C.L.6
-
77
-
-
0027326410
-
Protein kinase C alpha activates RAF-1 by direct phosphorylation
-
Kolch, W., Heidecker, G., Kochs, G., Hummel, R., Vahidi, H., Mischak, H., Finkenzeller, G., Marme, D., Rapp, U.R., Protein kinase C alpha activates RAF-1 by direct phosphorylation. Nature 364:6434 (1993), 249–252.
-
(1993)
Nature
, vol.364
, Issue.6434
, pp. 249-252
-
-
Kolch, W.1
Heidecker, G.2
Kochs, G.3
Hummel, R.4
Vahidi, H.5
Mischak, H.6
Finkenzeller, G.7
Marme, D.8
Rapp, U.R.9
-
78
-
-
0031455541
-
Protein kinase C-epsilon associates with the Raf-1 kinase and induces the production of growth factors that stimulate Raf-1 activity
-
Ueffing, M., Lovric, J., Philipp, A., Mischak, H., Kolch, W., Protein kinase C-epsilon associates with the Raf-1 kinase and induces the production of growth factors that stimulate Raf-1 activity. Oncogene 15:24 (1997), 2921–2927.
-
(1997)
Oncogene
, vol.15
, Issue.24
, pp. 2921-2927
-
-
Ueffing, M.1
Lovric, J.2
Philipp, A.3
Mischak, H.4
Kolch, W.5
-
79
-
-
0037631323
-
Activation of Raf-1 signaling by protein kinase C through a mechanism involving Raf kinase inhibitory protein
-
Corbit, K.C., Trakul, N., Eves, E.M., Diaz, B., Marshall, M., Rosner, M.R., Activation of Raf-1 signaling by protein kinase C through a mechanism involving Raf kinase inhibitory protein. J. Biol. Chem. 278:15 (2003), 13061–13068.
-
(2003)
J. Biol. Chem.
, vol.278
, Issue.15
, pp. 13061-13068
-
-
Corbit, K.C.1
Trakul, N.2
Eves, E.M.3
Diaz, B.4
Marshall, M.5
Rosner, M.R.6
-
80
-
-
0038520185
-
Neurotensin stimulates protein kinase C-dependent mitogenic signaling in human pancreatic carcinoma cell line PANC-1
-
Guha, S., Lunn, J.A., Santiskulvong, C., Rozengurt, E., Neurotensin stimulates protein kinase C-dependent mitogenic signaling in human pancreatic carcinoma cell line PANC-1. Cancer Res. 63:10 (2003), 2379–2387.
-
(2003)
Cancer Res.
, vol.63
, Issue.10
, pp. 2379-2387
-
-
Guha, S.1
Lunn, J.A.2
Santiskulvong, C.3
Rozengurt, E.4
-
81
-
-
33746577861
-
Possible role of duration of PKC-induced ERK activation in the effects of agonists and phorbol esters on DNA synthesis in Panc-1 cells
-
Racz, G.Z., Szucs, A., Szlavik, V., Vag, J., Burghardt, B., Elliott, A.C., Varga, G., Possible role of duration of PKC-induced ERK activation in the effects of agonists and phorbol esters on DNA synthesis in Panc-1 cells. J. Cell. Biochem. 98:6 (2006), 1667–1680.
-
(2006)
J. Cell. Biochem.
, vol.98
, Issue.6
, pp. 1667-1680
-
-
Racz, G.Z.1
Szucs, A.2
Szlavik, V.3
Vag, J.4
Burghardt, B.5
Elliott, A.C.6
Varga, G.7
-
82
-
-
84920414826
-
Dying tumor cells stimulate proliferation of living tumor cells via caspase-dependent protein kinase Cdelta activation in pancreatic ductal adenocarcinoma
-
Cheng, J., Tian, L., Ma, J., Gong, Y., Zhang, Z., Chen, Z., Xu, B., Xiong, H., Li, C., Huang, Q., Dying tumor cells stimulate proliferation of living tumor cells via caspase-dependent protein kinase Cdelta activation in pancreatic ductal adenocarcinoma. Mol. Oncol. 9:1 (2015), 105–114.
-
(2015)
Mol. Oncol.
, vol.9
, Issue.1
, pp. 105-114
-
-
Cheng, J.1
Tian, L.2
Ma, J.3
Gong, Y.4
Zhang, Z.5
Chen, Z.6
Xu, B.7
Xiong, H.8
Li, C.9
Huang, Q.10
-
83
-
-
84883178112
-
Protein kinase C zeta regulates human pancreatic cancer cell transformed growth and invasion through a STAT3-dependent mechanism
-
Butler, A.M., Scotti Buzhardt, M.L., Li, S., Smith, K.E., Fields, A.P., Murray, N.R., Protein kinase C zeta regulates human pancreatic cancer cell transformed growth and invasion through a STAT3-dependent mechanism. PLoS One, 8(8), 2013, e72061.
-
(2013)
PLoS One
, vol.8
, Issue.8
-
-
Butler, A.M.1
Scotti Buzhardt, M.L.2
Li, S.3
Smith, K.E.4
Fields, A.P.5
Murray, N.R.6
-
84
-
-
79953756112
-
Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer
-
Lesina, M., Kurkowski, M.U., Ludes, K., Rose-John, S., Treiber, M., Kloppel, G., Yoshimura, A., Reindl, W., Sipos, B., Akira, S., Schmid, R.M., Algul, H., Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer. Cancer Cell 19:4 (2011), 456–469.
-
(2011)
Cancer Cell
, vol.19
, Issue.4
, pp. 456-469
-
-
Lesina, M.1
Kurkowski, M.U.2
Ludes, K.3
Rose-John, S.4
Treiber, M.5
Kloppel, G.6
Yoshimura, A.7
Reindl, W.8
Sipos, B.9
Akira, S.10
Schmid, R.M.11
Algul, H.12
-
85
-
-
84884701740
-
aPKClambda/iota is a beneficial prognostic marker for pancreatic neoplasms
-
Kato, S., Akimoto, K., Nagashima, Y., Ishiguro, H., Kubota, K., Kobayashi, N., Hosono, K., Watanabe, S., Sekino, Y., Sato, T., Sasaki, K., Nakaigawa, N., Kubota, Y., Inayama, Y., Endo, I., Ohno, S., Maeda, S., Nakajima, A., aPKClambda/iota is a beneficial prognostic marker for pancreatic neoplasms. Pancreatology 13:4 (2013), 360–368.
-
(2013)
Pancreatology
, vol.13
, Issue.4
, pp. 360-368
-
-
Kato, S.1
Akimoto, K.2
Nagashima, Y.3
Ishiguro, H.4
Kubota, K.5
Kobayashi, N.6
Hosono, K.7
Watanabe, S.8
Sekino, Y.9
Sato, T.10
Sasaki, K.11
Nakaigawa, N.12
Kubota, Y.13
Inayama, Y.14
Endo, I.15
Ohno, S.16
Maeda, S.17
Nakajima, A.18
-
86
-
-
0027212503
-
Nonpromoting 12-deoxyphorbol 13-esters inhibit phorbol 12-myristate 13-acetate induced tumor promotion in CD-1 mouse skin
-
Szallasi, Z., Krsmanovic, L., Blumberg, P.M., Nonpromoting 12-deoxyphorbol 13-esters inhibit phorbol 12-myristate 13-acetate induced tumor promotion in CD-1 mouse skin. Cancer Res. 53:11 (1993), 2507–2512.
-
(1993)
Cancer Res.
, vol.53
, Issue.11
, pp. 2507-2512
-
-
Szallasi, Z.1
Krsmanovic, L.2
Blumberg, P.M.3
-
87
-
-
77955191504
-
PKCalpha-induced drug resistance in pancreatic cancer cells is associated with transforming growth factor-beta1
-
Chen, Y., Yu, G., Yu, D., Zhu, M., PKCalpha-induced drug resistance in pancreatic cancer cells is associated with transforming growth factor-beta1. J. Exp. Clin. Cancer Res., 29, 2010, 104.
-
(2010)
J. Exp. Clin. Cancer Res.
, vol.29
, pp. 104
-
-
Chen, Y.1
Yu, G.2
Yu, D.3
Zhu, M.4
-
88
-
-
84878997835
-
Protein kinase Calpha inhibitor protects against downregulation of claudin-1 during epithelial-mesenchymal transition of pancreatic cancer
-
Kyuno, D., Kojima, T., Yamaguchi, H., Ito, T., Kimura, Y., Imamura, M., Takasawa, A., Murata, M., Tanaka, S., Hirata, K., Sawada, N., Protein kinase Calpha inhibitor protects against downregulation of claudin-1 during epithelial-mesenchymal transition of pancreatic cancer. Carcinogenesis 34:6 (2013), 1232–1243.
-
(2013)
Carcinogenesis
, vol.34
, Issue.6
, pp. 1232-1243
-
-
Kyuno, D.1
Kojima, T.2
Yamaguchi, H.3
Ito, T.4
Kimura, Y.5
Imamura, M.6
Takasawa, A.7
Murata, M.8
Tanaka, S.9
Hirata, K.10
Sawada, N.11
-
89
-
-
42049109067
-
TGF-beta mediates PTEN suppression and cell motility through calcium-dependent PKC-alpha activation in pancreatic cancer cells
-
Chow, J.Y., Dong, H., Quach, K.T., Van Nguyen, P.N., Chen, K., Carethers, J.M., TGF-beta mediates PTEN suppression and cell motility through calcium-dependent PKC-alpha activation in pancreatic cancer cells. Am. J. Physiol. Gastrointest. Liver Physiol. 294:4 (2008), G899–905.
-
(2008)
Am. J. Physiol. Gastrointest. Liver Physiol.
, vol.294
, Issue.4
, pp. G899-905
-
-
Chow, J.Y.1
Dong, H.2
Quach, K.T.3
Van Nguyen, P.N.4
Chen, K.5
Carethers, J.M.6
-
90
-
-
0033199874
-
Protein kinase C lies on the signaling pathway for vascular endothelial growth factor-mediated tumor development and angiogenesis
-
Yoshiji, H., Kuriyama, S., Ways, D.K., Yoshii, J., Miyamoto, Y., Kawata, M., Ikenaka, Y., Tsujinoue, H., Nakatani, T., Shibuya, M., Fukui, H., Protein kinase C lies on the signaling pathway for vascular endothelial growth factor-mediated tumor development and angiogenesis. Cancer Res. 59:17 (1999), 4413–4418.
-
(1999)
Cancer Res.
, vol.59
, Issue.17
, pp. 4413-4418
-
-
Yoshiji, H.1
Kuriyama, S.2
Ways, D.K.3
Yoshii, J.4
Miyamoto, Y.5
Kawata, M.6
Ikenaka, Y.7
Tsujinoue, H.8
Nakatani, T.9
Shibuya, M.10
Fukui, H.11
-
91
-
-
36749090072
-
Inhibition of protein kinase Cbeta by enzastaurin enhances radiation cytotoxicity in pancreatic cancer
-
Spalding, A.C., Watson, R., Davis, M.E., Kim, A.C., Lawrence, T.S., Ben-Josef, E., Inhibition of protein kinase Cbeta by enzastaurin enhances radiation cytotoxicity in pancreatic cancer. Clin. Cancer Res. 13:22 Pt 1 (2007), 6827–6833.
-
(2007)
Clin. Cancer Res.
, vol.13
, Issue.22
, pp. 6827-6833
-
-
Spalding, A.C.1
Watson, R.2
Davis, M.E.3
Kim, A.C.4
Lawrence, T.S.5
Ben-Josef, E.6
-
92
-
-
77951673958
-
GSK3beta and beta-catenin modulate radiation cytotoxicity in pancreatic cancer
-
Watson, R.L., Spalding, A.C., Zielske, S.P., Morgan, M., Kim, A.C., Bommer, G.T., Eldar-Finkelman, H., Giordano, T., Fearon, E.R., Hammer, G.D., Lawrence, T.S., Ben-Josef, E., GSK3beta and beta-catenin modulate radiation cytotoxicity in pancreatic cancer. Neoplasia 12:5 (2010), 357–365.
-
(2010)
Neoplasia
, vol.12
, Issue.5
, pp. 357-365
-
-
Watson, R.L.1
Spalding, A.C.2
Zielske, S.P.3
Morgan, M.4
Kim, A.C.5
Bommer, G.T.6
Eldar-Finkelman, H.7
Giordano, T.8
Fearon, E.R.9
Hammer, G.D.10
Lawrence, T.S.11
Ben-Josef, E.12
-
93
-
-
0026808555
-
Differential regulation of glycogen synthase kinase-3 beta by protein kinase C isotypes
-
Goode, N., Hughes, K., Woodgett, J.R., Parker, P.J., Differential regulation of glycogen synthase kinase-3 beta by protein kinase C isotypes. J. Biol. Chem. 267:24 (1992), 16878–16882.
-
(1992)
J. Biol. Chem.
, vol.267
, Issue.24
, pp. 16878-16882
-
-
Goode, N.1
Hughes, K.2
Woodgett, J.R.3
Parker, P.J.4
-
94
-
-
47649103741
-
The oral protein-kinase C beta inhibitor enzastaurin (LY317615) suppresses signalling through the AKT pathway, inhibits proliferation and induces apoptosis in multiple myeloma cell lines
-
Neri, A., Marmiroli, S., Tassone, P., Lombardi, L., Nobili, L., Verdelli, D., Civallero, M., Cosenza, M., Bertacchini, J., Federico, M., De Pol, A., Deliliers, G.L., Sacchi, S., The oral protein-kinase C beta inhibitor enzastaurin (LY317615) suppresses signalling through the AKT pathway, inhibits proliferation and induces apoptosis in multiple myeloma cell lines. Leuk. Lymphoma 49:7 (2008), 1374–1383.
-
(2008)
Leuk. Lymphoma
, vol.49
, Issue.7
, pp. 1374-1383
-
-
Neri, A.1
Marmiroli, S.2
Tassone, P.3
Lombardi, L.4
Nobili, L.5
Verdelli, D.6
Civallero, M.7
Cosenza, M.8
Bertacchini, J.9
Federico, M.10
De Pol, A.11
Deliliers, G.L.12
Sacchi, S.13
-
95
-
-
13344259987
-
Proteolytic activation of protein kinase C delta by an ICE-like protease in apoptotic cells
-
Emoto, Y., Manome, Y., Meinhardt, G., Kisaki, H., Kharbanda, S., Robertson, M., Ghayur, T., Wong, W.W., Kamen, R., Weichselbaum, R. et al., Proteolytic activation of protein kinase C delta by an ICE-like protease in apoptotic cells. EMBO J. 14:24 (1995), 6148–6156.
-
(1995)
EMBO J.
, vol.14
, Issue.24
, pp. 6148-6156
-
-
Emoto, Y.1
Manome, Y.2
Meinhardt, G.3
Kisaki, H.4
Kharbanda, S.5
Robertson, M.6
Ghayur, T.7
Wong, W.W.8
Kamen, R.9
Weichselbaum, R.10
-
96
-
-
0032727468
-
Proteolytic activation of protein kinase C delta and epsilon by caspase-3 in U937 cells during chemotherapeutic agent-induced apoptosis
-
Koriyama, H., Kouchi, Z., Umeda, T., Saido, T.C., Momoi, T., Ishiura, S., Suzuki, K., Proteolytic activation of protein kinase C delta and epsilon by caspase-3 in U937 cells during chemotherapeutic agent-induced apoptosis. Cell. Signal. 11:11 (1999), 831–838.
-
(1999)
Cell. Signal.
, vol.11
, Issue.11
, pp. 831-838
-
-
Koriyama, H.1
Kouchi, Z.2
Umeda, T.3
Saido, T.C.4
Momoi, T.5
Ishiura, S.6
Suzuki, K.7
-
97
-
-
84922211216
-
Cancer-associated protein kinase C mutations reveal kinase's role as tumor suppressor
-
Antal, C.E., Hudson, A.M., Kang, E., Zanca, C., Wirth, C., Stephenson, N.L., Trotter, E.W., Gallegos, L.L., Miller, C.J., Furnari, F.B., Hunter, T., Brognard, J., Newton, A.C., Cancer-associated protein kinase C mutations reveal kinase's role as tumor suppressor. Cell 160:3 (2015), 489–502.
-
(2015)
Cell
, vol.160
, Issue.3
, pp. 489-502
-
-
Antal, C.E.1
Hudson, A.M.2
Kang, E.3
Zanca, C.4
Wirth, C.5
Stephenson, N.L.6
Trotter, E.W.7
Gallegos, L.L.8
Miller, C.J.9
Furnari, F.B.10
Hunter, T.11
Brognard, J.12
Newton, A.C.13
-
98
-
-
84925669194
-
Targeting protein kinase C subtypes in pancreatic cancer
-
Storz, P., Targeting protein kinase C subtypes in pancreatic cancer. Expert. Rev. Anticancer. Ther. 15:4 (2015), 433–438.
-
(2015)
Expert. Rev. Anticancer. Ther.
, vol.15
, Issue.4
, pp. 433-438
-
-
Storz, P.1
-
99
-
-
0032721005
-
Pharmacology and clinical experience with bryostatin 1: a novel anticancer drug
-
Philip, P.A., Zonder, J.A., Pharmacology and clinical experience with bryostatin 1: a novel anticancer drug. Expert Opin. Investig. Drugs 8:12 (1999), 2189–2199.
-
(1999)
Expert Opin. Investig. Drugs
, vol.8
, Issue.12
, pp. 2189-2199
-
-
Philip, P.A.1
Zonder, J.A.2
-
100
-
-
42549158923
-
Protein kinase C: a target for therapy in pancreatic cancer
-
El-Rayes, B.F., Ali, S., Philip, P.A., Sarkar, F.H., Protein kinase C: a target for therapy in pancreatic cancer. Pancreas 36:4 (2008), 346–352.
-
(2008)
Pancreas
, vol.36
, Issue.4
, pp. 346-352
-
-
El-Rayes, B.F.1
Ali, S.2
Philip, P.A.3
Sarkar, F.H.4
-
101
-
-
77951078231
-
Phase II study of paclitaxel plus the protein kinase C inhibitor bryostatin-1 in advanced pancreatic carcinoma
-
Lam, A.P., Sparano, J.A., Vinciguerra, V., Ocean, A.J., Christos, P., Hochster, H., Camacho, F., Goel, S., Mani, S., Kaubisch, A., Phase II study of paclitaxel plus the protein kinase C inhibitor bryostatin-1 in advanced pancreatic carcinoma. Am. J. Clin. Oncol. 33:2 (2010), 121–124.
-
(2010)
Am. J. Clin. Oncol.
, vol.33
, Issue.2
, pp. 121-124
-
-
Lam, A.P.1
Sparano, J.A.2
Vinciguerra, V.3
Ocean, A.J.4
Christos, P.5
Hochster, H.6
Camacho, F.7
Goel, S.8
Mani, S.9
Kaubisch, A.10
-
102
-
-
0031827507
-
Directed antisense therapy confirms the role of protein kinase C-alpha in the tumorigenicity of pancreatic cancer
-
(discussion 223–4)
-
Denham, D.W., Franz, M.G., Denham, W., Zervos, E.E., Gower, W.R. Jr., Rosemurgy, A.S., Norman, J., Directed antisense therapy confirms the role of protein kinase C-alpha in the tumorigenicity of pancreatic cancer. Surgery 124:2 (1998), 218–223 (discussion 223–4).
-
(1998)
Surgery
, vol.124
, Issue.2
, pp. 218-223
-
-
Denham, D.W.1
Franz, M.G.2
Denham, W.3
Zervos, E.E.4
Gower, W.R.5
Rosemurgy, A.S.6
Norman, J.7
|