Activation of protein kinase Cα inhibits growth of pancreatic cancer cells via p21(cip)-mediated G1 arrest

Journal of Cell Science

Volumn 113, Issue 17, 2000, Pages 3025-3035

  Detjen, K M ^a   Brembeck, F H ^a   Welzel, M ^a   Kaiser, A ^a   Haller, H ^a   Wiedenmann, B ^a   Rosewicz, S ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Cell cycle; Cyclin dependent kinase; P21(cip); Pancreatic cancer cell; Protein kinase C

Indexed keywords

CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE INHIBITOR; DNA; ISOENZYME; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; PROTEIN P21; RECOMBINANT ENZYME; RUBIDIUM;

ARTICLE; CANCER CELL; CANCER INHIBITION; CELL CYCLE G1 PHASE; CELL MEMBRANE; CELL NUCLEUS; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DNA SYNTHESIS INHIBITION; DOWN REGULATION; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME LOCALIZATION; HUMAN; HUMAN CELL; INTRACELLULAR TRANSPORT; MICROINJECTION; MITOSIS INHIBITION; PANCREAS CANCER; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN INDUCTION; REGULATORY MECHANISM;

APOPTOSIS; BIOLOGICAL TRANSPORT; CELL CYCLE; CELL DIVISION; CELL NUCLEUS; CYCLIN-DEPENDENT KINASES; CYCLINS; DNA REPLICATION; HUMAN; ISOENZYMES; PANCREATIC NEOPLASMS; PHOSPHORYLATION; PROTEIN KINASE C; PROTEIN-SERINE-THREONINE KINASES; RECOMBINANT PROTEINS; RETINOBLASTOMA PROTEIN; SUPPORT, NON-U.S. GOV'T; TETRADECANOYLPHORBOL ACETATE; TUMOR CELLS, CULTURED;

EID: 0033828604     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Protein kinase C alpha modulates growth and differentiation in Caco-2 cells
2. A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells
3. Role of cdc25-C phosphatase in the immediate G2 delay induced by the exogenous factors epidermal growth factor and phorbolester
4. Defects in p21WAF1/CIP1, Rb, and c-myc signaling in phorbol ester-resistant cancer cells
5. Expression of four protein kinase C isoforms in rat fibroblasts. Distinct subcellular distribution and regulation by calcium and phorbol esters
6. Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation
7. 1/S transition by 12-O-tetradecanoylphorbol-13-acetate (TPA) by modulation of CDK2 activity
8. Phorbol esters induce death in MCF-7 breast cancer cells with altered expression of protein kinase C isoforms. Role for p53-independent induction of gadd-45 in initiating death
9. Directed antisense therapy confirms the role of protein kinase C-alpha in the tumorigenicity of pancreatic cancer
10. Differentiation of pancreatic ductal carcinoma cells associated with selective expression of protein kinase C isoforms
11. Protein kinase C isozyme-mediated cell cycle arrest involves induction of p21(waf1/cip1) and p27(kip1) and hypophosphorylation of the retinoblastoma protein in intestinal epithelial cells
12. A mutant of the WEHI-231 B lymphocyte line that is resistant to phorbol esters is still sensitive to antigen receptor-mediated growth inhibition
13. 1/S cell cycle progression in human diploid fibroblasts
14. 2 delay and down-regulation of cdc25 expression
15. Protein kinase C activation and protooncogene expression in differentiation/retrodifferentiation of human U-937 leukemia cells
16. The potential for isoenzyme-selective modulation of protein kinase C
17. 1 pathways
18. Protein kinase C isoenzymes: Divergence in signal transduction?
19. Induction of differentiation in human promyelocytic HL-60 leukemia cells activates p21, WAF1/CIP1, expression in the absence of p53
20. A sensitive method for detection of calmodulin-dependent protein kinase II activity insodium dodecyl sulfate-polyacrylamide gel
21. Intracellular targeting of protein kinase C isoenzymes: Functional implications
22. 2 phase induced by phorbol ester and diacylglycerol in vascular endothelial cells
23. Linking protein kinase C to cell-cycle control
24. Linking protein kinase C to the cell cycle: Ectopic expression of PKC eta in NIH3T3 cells alters the expression of cyclins and Cdk inhibitors and induces adipogenesis
25. Phorbol ester induces apoptosis in HL-60 promyelocytic leukemia cells but not in HL-60 PET mutant
26. Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
27. D-type cyclin-dependent kinase activity in mammalian cells
28. Differential expression of protein kinase C isozymes and erythroleukemia cell differentiation
29. The extended protein kinase C superfamily
30. Frequent codeletion of p16/MTS1 and p15/MTS2 and genetic alterations in p16/MTS1 in pancreatic tumors
31. Differential growth regulation by all-trans retinoic acid is determined by protein kinase C alpha in human pancreatic carcinoma cells
32. Antiproliferative effects of interferon alpha on human pancreatic carcinoma cell lines are associated with differential regulation of protein kinase C isoenzymes
33. Phorbol ester inhibits the phosphorylation of the retinoblastoma protein without suppressing cyclin D-associated kinase in vascular smooth muscle cells
34. Activation of protein kinase C isozymes is associated with post-mitotic events in intestinal epithelial cells in situ
35. Decreased PKC-alpha expression increases cellular proliferation, decreases differentiation, and enhances the transformed phenotype of CaCo-2 cells
36. Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas
37. Cyclin E-CDK2 is a regulator of p27Kip1
38. Cancer cell cycles
39. 1,25-Dihydroxyvitamin D3 translocates protein kinase C beta to nucleus and enhances plasma membrane association of protein kinase C alpha in renal epithelial cells
40. The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C
41. Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor
42. Regulation of p21WAF1/CIP1 expression by p53-independent pathways
43. The cyclin-dependent kinase inhibitor p21cip1 mediates the growth inhibitory effect of phorbol esters in human venous endothelial cells
44. Retinoblastoma protein-dependent growth signal conflict and caspase activity are required for protein kinase C-signaled apoptosis of prostate epithelial cells
45. Protein kinase C-mediated bidirectional regulation of DNA synthesis RB protein phosphorylation, and cyclin-dependent kinases in human vascular endothelial cells
46. E2F1, B-myb and selective members of cyclin/cdk subunits are targets for protein kinase C-mediated bimodal growth regulation in vascular endothelial cells