Supramaximal cholecystokinin displaces Munc18c from the pancreatic acinar basal surface, redirecting apical exocytosis to the basal membrane

Journal of Clinical Investigation

Volumn 108, Issue 11, 2001, Pages 1597-1611

  Gaisano, H Y ^a   Lutz, M P ^a   Leser, J ^a   Sheu, L ^a   Lynch, G ^a   Tang, L ^a   Tamori, Y ^a   Trimble, W S ^a   Salapatek, A M F ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLECYSTOKININ; FLUORESCENT DYE; PROTEIN DERIVATIVE; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; PROTEIN MUNC18C; UNCLASSIFIED DRUG;

ACINAR CELL; ACUTE PANCREATITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASEMENT MEMBRANE; CELL STIMULATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME ACTIVATION; EXOCYTOSIS; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN SECRETION; RAT;

ANIMALS; CELL MEMBRANE; CHOLECYSTOKININ; EXOCYTOSIS; MEMBRANE PROTEINS; MUNC18 PROTEINS; NERVE TISSUE PROTEINS; PANCREAS; PANCREATITIS; PROTEIN KINASE C; PROTEINS; RATS; SNARE PROTEINS; TETRADECANOYLPHORBOL ACETATE; VESICULAR TRANSPORT PROTEINS;

EID: 0035206785     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI200109110     Document Type: Article

References (61)

1. Intracellular aspects of the process of protein synthesis
2. Secretory pathways in animal cells: With emphasis on pancreatic acinar cells
3. Stimulus-secretion coupling in pancreatic acinar cells
4. Exocytosis occurs at the lateral plasma membrane of the pancreatic acinar cell during supramaximal secretagogue stimulation
5. Acute interstitial pancreatitis in the rat induced by excessive doses of a pancreatic secretagogue
6. The cell biology of experimental pancreatitis
7. Human acute pancreatitis: Its pathogenesis in the light of immunocytochemical and ultrastructural findings in acinar cells
8. Novel tool for the study of CCK-stimulated pancreatic enzyme secretion
9. Complex role of protein kinase C in mediating the supramaximal inhibition pancreatic secretion observed with cholecystokinin
10. Suppression of Ca2+ oscillations induced by cholecystokinin (CCK) and its analog OPE in rat pancreatic acinar cells by low-level protein kinase C activation without transition of the CCK receptor from a high- to low-affinity state
11. 3-dependent in single rat pancreatic acinar cells
12. The synaptic vesicle cycle: A cascade of protein-protein interactions
13. SNAREpins: Minimal machinery for membrane fusion
14. Specificity and regulation of a synaptic vesicle docking complex
15. A hypothesis: SNARE-ing the mechanisms of regulated exocytosis and pathologic membrane fusions in the pancreatic acinar cell
16. Phosphorylation of Munc18/nSec1by protein kinase C
17. Regulation of Munc18/syntaxin 1A interaction by cyclin-dependent kinase 5 (Cdk5) in nerve endings
18. Tetanus toxin-light chain cleaves a vesicle-associated membrane protein (VAMP) isoform 2 in rat pancreatic zymogen granules and inhibits enzyme secretion
19. The VAMP family in pancreatic and parotid acinar cells
20. SNAP 23 is located in the basolateral plasma membrane of rat pancreatic acinar cells
21. Distinct locations of the syntaxin family of proteins in rat pancreatic acinar cells
22. Identification of a novel syntaxin and VAMP binding protein, SNAP 23, expressed in non-neuronal tissues
23. Molecular identification of two novel Munc18 isoforms expressed in non-neuronal tissues
24. Characterization of Munc18c and syntaxin 4 in 3T3-L1 adipocytes
25. Inhibition of the binding of SNAP 23 to syn-4 by Munc 18c
26. Inhibition of insulin-induced GLUT4 translocation by Munc18c through interaction with syntaxin 4 in 3T3-L1 adipocytes
27. Regulation of dense core release from neuroendocrine cells revealed by imaging of single exocytic events
28. Differential regulation of granule-to-granule and granule-to-plasma membrane fusion during secretion from rat pituitary lactotrophs. Regulation of dense core release from neuroendocrine cells revealed by imaging single exocytic events
29. Optical measurement of stimulus-evoked membrane dynamics in single pancreatic acinar cells
30. Dissociation and reassembly of adherens junctions during experimental acute pancreatitis
31. Disassembly of rat pancreatic acinar cell cytoskeleton during supramaximal secretagogue stimulation
32. The subapical actin cytoskeleton regulates secretion and membrane retrieval in pancreatic acinar cells
33. Phasic release of newly synthesized secretory proteins in the unstimulated rat exocrine pancreas
34. Redistribution of a Rab3-like GTP-binding protein from secretory granules to the Golgi complex in pancreatic acinar cells during regulated exocytosis
35. Vesicle dynamics during regulated secretion in a novel pancreatic acinar in vitro model
36. Alteration of membrane fusion as a cause of acute pancreatitis in the rat
37. Experimental acute pancreatitis: Studies of the early events that lead to cell injury
38. Acute pancreatitis
39. CCK-regulated exocytosis in rat pancreatic acinar cells is inhibited by a C-terminus truncated mutant of SNAP-23
40. Identification of SNAREs involved in regulated exocytosis in the pancreatic acinar cell
41. Relocation of the t-SNARE SNAP-23 from lamellipodia-like cell surface projections regulates compound exocytosis in mast cells
42. Syntaxin 4, VAMP-2, and/or VAMP-3 are functional t- and v-SNAREs for insulin-stimulated GLUT4 translocation in adipocytes
43. Regulation of insulin stimulated GLUT4 translocation by Munc18c in 3T3L1 adipocytes
44. Role of SNAP23 in insulin induced translocation of GLUT4 in 3T3-L1 adipocytes
45. Membrane fusion and exocytosis
46. Actin coating of secretory granules during regulated exocytosis correlates with release of rab3D
47. Overexpression of Rab3D enhances regulated amylase secretion from pancreatic acini of transgenic mice
48. Platelets contain SNARE proteins and a Sec1p homologue that interacts with syntaxin 4 and is phosphorylated after thrombin activation: Implications for platelet secretion
49. Surface dynamics in living acinar cells imaged by atomic force microscopy: Identification of plasma membrane structures involved in exocytosis
50. Sequential-replenishment mechanism of exocytosis in pancreatic acini
51. Sec6/8 complex is recruited to cell-cell contacts and specifies transport vesicle delivery to the basal-lateral membrane in epithelial cells
52. A conformational switch in syntaxin during exocytosis: Role of Munc 18
53. Rop, a Drosophila homolog of yeast Sec1 and vertebrate n-Sec1/Munc18 proteins, is a negative regulator of neurotransmitter release in vivo
54. Mutations in the Drosophila Rop gene suggest a function in general secretion and synaptic transmission
55. Control of fusion pore dynamics during exocytosis by Munc18
56. Actin filament disassembly is a sufficient final trigger for exocytosis in nonexcitable cells
57. Calcium can disrupt the SNARE protein complex on sea urchin egg secretory vesicles without irreversibly blocking fusion
58. Progressive disruption of acinar cell calcium signaling is an early feature of cerulein-induced pancreatitis in mice
59. Interstitial protease activation is the central event in progression to necrotizing pancreatitis
60. Interstitial trypsinogen release and its relevance to the transformation of mild into necrotizing pancreatitis in rats
61. Seven novel mammalian SNARE proteins localize to distinct membrane compartments