EX4 stabilizes and activates Nrf2 via PKCδ, contributing to the prevention of oxidative stress-induced pancreatic beta cell damage

Toxicology and Applied Pharmacology

Volumn 315, Issue , 2017, Pages 60-69

  Kim, Mi Hwi ^a   Kim, Eung Hwi ^a   Jung, Hye Seung ^b   Yang, Dongki ^a   Park, Eun Young ^c   Jun, Hee Sook ^a,d  

^a Gachon University College of Medicine   (South Korea)

^b Seoul National University College of Medicine   (South Korea)

^c Mokpo National University   (South Korea)

^d Gachon University Gil Hospital   (South Korea)

Author keywords

Beta cell; Exendin 4; INS 1 cell; Nrf2; Oxidative stress; Type 2 diabetes

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; EXENDIN 4; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; HEME OXYGENASE 1; HYDROGEN PEROXIDE; INSULIN; MESSENGER RNA; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PALMITIC ACID; PROTEIN KINASE C DELTA; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NRF2; ANTIOXIDANT; NFE2L2 PROTEIN, RAT; PEPTIDE; VENOM;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; CATALYSIS; CELL DAMAGE; CELL LEVEL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; FLOW CYTOMETRY; GENE; GENE EXPRESSION; INS 1 CELL LINE; INSULIN RELEASE; INSULINOMA CELL LINE; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PROTEIN SUBUNIT; RAT; SIGNAL TRANSDUCTION; ANIMAL; DRUG EFFECTS; METABOLISM; PANCREAS ISLET; TUMOR CELL LINE;

ANIMALS; ANTIOXIDANTS; CELL LINE, TUMOR; ENZYME ACTIVATION; ISLETS OF LANGERHANS; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PEPTIDES; PROTEIN KINASE C-DELTA; RATS; VENOMS;

EID: 85004147176     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2016.12.005     Document Type: Article

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