Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis ex vivo

European Respiratory Journal

Volumn 50, Issue 2, 2017, Pages

  Lehmann, Mareike ^a   Korfei, Martina ^b   Mutze, Kathrin ^a   Klee, Stephan ^a   Skronska Wasek, Wioletta ^a   Alsafadi, Hani N ^a   Ota, Chiharu ^a   Costa, Rita ^a   Schiller, Herbert B ^a   Lindner, Michael ^c   Wagner, Darcy E ^a   Günther, Andreas ^b,d,e   Königshoff, Melanie ^a,f  

^a UNIVERSITY OF MUNICH   (Germany)

^b JUSTUS LIEBIG UNIVERSITY GIESSEN   (Germany)

^c Asklepios Clinic Munich Gauting   (Germany)

^d Agaplesion Lung Clinic Waldhof Elgershausen   (Germany)

^e European IPF Network   (Germany)

^f UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; DASATINIB; PROTEIN P16; PROTEIN P21; QUERCETIN; RESPIRATORY TRACT AGENT; SENOLYTIC DRUG; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLIN DEPENDENT KINASE INHIBITOR 2A;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL AGING; CELL FUNCTION; CELL POPULATION; COHORT ANALYSIS; CONTROLLED STUDY; DRUG TARGETING; ENZYME ACTIVITY; EX VIVO STUDY; EXPERIMENTAL DISEASE; EXTRACELLULAR MATRIX; FIBROSING ALVEOLITIS; GENE EXPRESSION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; LUNG ALVEOLUS EPITHELIUM CELL; LUNG PARENCHYMA; MOUSE; NONHUMAN; P16 GENE; P21 GENE; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; SENESCENCE ASSOCIATED SECRETORY PHENOTYPE; TISSUE CULTURE; TYPE 2 EPITHELIAL CELL; ANIMAL; DRUG EFFECT; GENETICS; LUNG; METABOLISM; PATHOLOGY;

ALVEOLAR EPITHELIAL CELLS; ANIMALS; BIOMARKERS; CELLULAR SENESCENCE; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYCLIN-DEPENDENT KINASE INHIBITOR P21; HUMANS; IDIOPATHIC PULMONARY FIBROSIS; LUNG; MICE;

EID: 85027886209     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/13993003.02367-2016     Document Type: Article

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