Senescence-associated secretory phenotype in a mouse model of bleomycin-induced lung injury

Experimental and Toxicologic Pathology

Volumn 65, Issue 7-8, 2013, Pages 1053-1062

  Aoshiba, Kazutetsu ^a   Tsuji, Takao ^a   Kameyama, Shinkichi ^b   Itoh, Masayuki ^a   Semba, Seitaro ^a   Yamaguchi, Kazuhiro ^c   Nakamura, Hiroyuki ^a  

^a TOKYO MEDICAL UNIVERSITY   (Japan)

^b TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^c TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

Bleomycin; Cell senescence; DNA damage; Double strand DNA breaks; Inflammation; Lung injury; Matrix metalloproteinase; NF B; Senescence associated secretory phenotype

Indexed keywords

ATM PROTEIN; ATR PROTEIN; BETA4 INTEGRIN; BLEOMYCIN; CYCLIN DEPENDENT KINASE INHIBITOR 1; GELATINASE A; GELATINASE B; HISTONE H2AX; I KAPPA B ALPHA; I KAPPA B BETA; INTERLEUKIN 6; KI 67 ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE P38; TUMOR NECROSIS FACTOR ALPHA; UVOMORULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; DOUBLE STRANDED DNA BREAK; LUNG ALVEOLUS EPITHELIUM; LUNG DISEASE; LUNG FIBROSIS; MALE; MOUSE; MOUSE MODEL; NONHUMAN; PHENOTYPIC VARIATION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SENESCENCE;

MURINAE; MUS;

BLEOMYCIN; CELL SENESCENCE; DNA DAMAGE; DOUBLE-STRAND DNA BREAKS; INFLAMMATION; LUNG INJURY; MATRIX METALLOPROTEINASE; NFΚB; SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; BLEOMYCIN; CELL AGING; DISEASE MODELS, ANIMAL; DNA DAMAGE; IMMUNOHISTOCHEMISTRY; LUNG INJURY; MALE; MICE; MICE, INBRED C57BL; PHENOTYPE;

EID: 84885833230     PISSN: 09402993     EISSN: 16181433     Source Type: Journal    
DOI: 10.1016/j.etp.2013.04.001     Document Type: Article

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