Interferon-γ Represses M2 Gene Expression in Human Macrophages by Disassembling Enhancers Bound by the Transcription Factor MAF

Immunity

Volumn 47, Issue 2, 2017, Pages 235-250.e4

  Kang, Kyuho ^a,b   Park, Sung Ho ^b   Chen, Janice ^b   Qiao, Yu ^b   Giannopoulou, Eugenia ^b,c   Berg, Karen ^d   Hanidu, Adedayo ^d   Li, Jun ^d   Nabozny, Gerald ^d   Kang, Keunsoo ^e   Park Min, Kyung Hyun ^b   Ivashkiv, Lionel B ^a,b  

^a Weill Cornell Medical Center   (United States)

^b HOSPITAL FOR SPECIAL SURGERY   (United States)

^c NEW YORK CITY COLLEGE OF TECHNOLOGY   (United States)

^d BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

^e Dankook University   (South Korea)

Author keywords

chromatin; enhancer; epigenomics; gene expression; interferon gamma; IRF; Macrophage; MAF; rheumatoid arthritis; transcription

Indexed keywords

CYTOKINE; GAMMA INTERFERON; HISTONE; MAF PROTEIN, HUMAN; PROTEIN BINDING; TRANSCRIPTION FACTOR C MAF; TRANSCRIPTOME;

CELL CULTURE; CELL DIFFERENTIATION; CELL LINEAGE; CHROMATIN ASSEMBLY AND DISASSEMBLY; ENHANCER REGION; GENE EXPRESSION REGULATION; GENETICS; HUMAN; IMMUNOLOGY; MACROPHAGE; METABOLISM; RHEUMATOID ARTHRITIS;

ARTHRITIS, RHEUMATOID; CELL DIFFERENTIATION; CELL LINEAGE; CELLS, CULTURED; CHROMATIN ASSEMBLY AND DISASSEMBLY; CYTOKINES; ENHANCER ELEMENTS, GENETIC; GENE EXPRESSION REGULATION; HISTONES; HUMANS; INTERFERON-GAMMA; MACROPHAGES; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-MAF; TRANSCRIPTOME;

EID: 85027374953     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2017.07.017     Document Type: Article

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