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Volumn 42, Issue 2, 2018, Pages 114-128

Do sedation and analgesia contribute to long-term cognitive dysfunction in critical care survivors?;¿Contribuye la sedación y la analgesia a la disfunción cognitiva en supervivientes de una enfermedad crítica?

Author keywords

Cognition; Critical care; Intensive care unit sedation; Intensive care unit survivors; Mechanical ventilation

Indexed keywords

BENZODIAZEPINE DERIVATIVE; DEXMEDETOMIDINE; HALOPERIDOL; NARCOTIC ANALGESIC AGENT; PROPOFOL; REMIFENTANIL; SEDATIVE AGENT; ANALGESIC AGENT; HYPNOTIC SEDATIVE AGENT;

EID: 85026916201     PISSN: 02105691     EISSN: 15786749     Source Type: Journal    
DOI: 10.1016/j.medin.2017.06.010     Document Type: Short Survey
Times cited : (21)

References (80)
  • 1
    • 84883590421 scopus 로고    scopus 로고
    • Benzodiazepine versus nonbenzodiazepine-based sedation for mechanically ventilated, critically ill adults: a systematic review and meta-analysis of randomized trials
    • Fraser, G.L., Devlin, J.W., Worby, C.P., Alhazzani, W., Barr, J., Dasta, J.F., et al. Benzodiazepine versus nonbenzodiazepine-based sedation for mechanically ventilated, critically ill adults: a systematic review and meta-analysis of randomized trials. Crit Care Med 41 (2013), S30–S38.
    • (2013) Crit Care Med , vol.41 , pp. S30-S38
    • Fraser, G.L.1    Devlin, J.W.2    Worby, C.P.3    Alhazzani, W.4    Barr, J.5    Dasta, J.F.6
  • 2
  • 3
    • 84990845600 scopus 로고    scopus 로고
    • Lung–brain cross talk in the critically ill
    • Blanch, L., Quintel, M., Lung–brain cross talk in the critically ill. Intensive Care Med 43 (2017), 557–559.
    • (2017) Intensive Care Med , vol.43 , pp. 557-559
    • Blanch, L.1    Quintel, M.2
  • 5
    • 84963788070 scopus 로고    scopus 로고
    • The evolving approach to brain dysfunction in critically ill patients
    • Ely, E.W., Pandharipande, P.P., The evolving approach to brain dysfunction in critically ill patients. JAMA 315 (2016), 1455–1456.
    • (2016) JAMA , vol.315 , pp. 1455-1456
    • Ely, E.W.1    Pandharipande, P.P.2
  • 6
    • 1842867052 scopus 로고    scopus 로고
    • Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit
    • Ely, E.W., Shintani, A., Truman, B., Speroff, T., Gordon, S.M., Harrell, F.E. Jr., et al. Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit. JAMA 291 (2004), 1753–1762.
    • (2004) JAMA , vol.291 , pp. 1753-1762
    • Ely, E.W.1    Shintani, A.2    Truman, B.3    Speroff, T.4    Gordon, S.M.5    Harrell, F.E.6
  • 7
    • 78650305502 scopus 로고    scopus 로고
    • Delirium duration and mortality in lightly sedated, mechanically ventilated intensive care patients
    • Shehabi, Y., Riker, R.R., Bokesch, P.M., Wisemandle, W., Shintani, A., Ely, E.W., Delirium duration and mortality in lightly sedated, mechanically ventilated intensive care patients. Crit Care Med 38 (2010), 2311–2318.
    • (2010) Crit Care Med , vol.38 , pp. 2311-2318
    • Shehabi, Y.1    Riker, R.R.2    Bokesch, P.M.3    Wisemandle, W.4    Shintani, A.5    Ely, E.W.6
  • 8
    • 84936864182 scopus 로고    scopus 로고
    • Outcome of delirium in critically ill patients: systematic review and meta-analysis
    • Salluh, J.I., Wang, H., Schneider, E.B., Nagaraja, N., Yenokyan, G., Damluji, A., et al. Outcome of delirium in critically ill patients: systematic review and meta-analysis. BMJ, 350, 2015, h2538, 10.1136/bmj.h2538.
    • (2015) BMJ , vol.350 , pp. h2538
    • Salluh, J.I.1    Wang, H.2    Schneider, E.B.3    Nagaraja, N.4    Yenokyan, G.5    Damluji, A.6
  • 11
    • 84872087535 scopus 로고    scopus 로고
    • Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the intensive care unit
    • Barr, J., Fraser, G.L., Puntillo, K., Ely, E.W., Gelinas, C., Dasta, J.F., et al. Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the intensive care unit. Crit Care Med 41 (2013), 263–306.
    • (2013) Crit Care Med , vol.41 , pp. 263-306
    • Barr, J.1    Fraser, G.L.2    Puntillo, K.3    Ely, E.W.4    Gelinas, C.5    Dasta, J.F.6
  • 12
    • 67649974294 scopus 로고    scopus 로고
    • Prevalence and risk factors for development of delirium in surgical and trauma intensive care unit patients
    • Pandharipande, P., Cotton, B.A., Shintani, A., Thompson, J., Pun, B.T., Morris, J.A., et al. Prevalence and risk factors for development of delirium in surgical and trauma intensive care unit patients. J Trauma 65 (2008), 34–41.
    • (2008) J Trauma , vol.65 , pp. 34-41
    • Pandharipande, P.1    Cotton, B.A.2    Shintani, A.3    Thompson, J.4    Pun, B.T.5    Morris, J.A.6
  • 13
    • 33644851831 scopus 로고    scopus 로고
    • Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients
    • Pandharipande, P., Shintani, A., Peterson, J., Pun, B.T., Wilkinson, G.R., Dittus, R.S., et al. Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients. Anesthesiology 104 (2006), 21–26.
    • (2006) Anesthesiology , vol.104 , pp. 21-26
    • Pandharipande, P.1    Shintani, A.2    Peterson, J.3    Pun, B.T.4    Wilkinson, G.R.5    Dittus, R.S.6
  • 14
    • 84957851370 scopus 로고    scopus 로고
    • Impact of sedation on cognitive function in mechanically ventilated patients
    • Porhomayon, J., El-Solh, A.A., Adlparvar, G., Jaoude, P., Nader, N.D., Impact of sedation on cognitive function in mechanically ventilated patients. Lung 194 (2016), 43–52.
    • (2016) Lung , vol.194 , pp. 43-52
    • Porhomayon, J.1    El-Solh, A.A.2    Adlparvar, G.3    Jaoude, P.4    Nader, N.D.5
  • 15
    • 84905906664 scopus 로고    scopus 로고
    • Sedation and analgesia in mechanical ventilation
    • Strom, T., Toft, P., Sedation and analgesia in mechanical ventilation. Semin Respir Crit Care Med 35 (2014), 441–450.
    • (2014) Semin Respir Crit Care Med , vol.35 , pp. 441-450
    • Strom, T.1    Toft, P.2
  • 16
    • 0034682246 scopus 로고    scopus 로고
    • Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation
    • Kress, J.P., Pohlman, A.S., O'Connor, M.F., Hall, J.B., Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation. N Engl J Med 342 (2000), 1471–1477.
    • (2000) N Engl J Med , vol.342 , pp. 1471-1477
    • Kress, J.P.1    Pohlman, A.S.2    O'Connor, M.F.3    Hall, J.B.4
  • 17
    • 0346732063 scopus 로고    scopus 로고
    • The long-term psychological effects of daily sedative interruption on critically ill patients
    • Kress, J.P., Gehlbach, B., Lacy, M., Pliskin, N., Pohlman, A.S., Hall, J.B., The long-term psychological effects of daily sedative interruption on critically ill patients. Am J Respir Crit Care Med 168 (2003), 1457–1461.
    • (2003) Am J Respir Crit Care Med , vol.168 , pp. 1457-1461
    • Kress, J.P.1    Gehlbach, B.2    Lacy, M.3    Pliskin, N.4    Pohlman, A.S.5    Hall, J.B.6
  • 18
    • 84860195333 scopus 로고    scopus 로고
    • [Daily interruption of sedation: always a quality indicator?]
    • Muñoz-Martinez, T., [Daily interruption of sedation: always a quality indicator?]. Med Intensiva 36 (2012), 288–293.
    • (2012) Med Intensiva , vol.36 , pp. 288-293
    • Muñoz-Martinez, T.1
  • 19
    • 38049017332 scopus 로고    scopus 로고
    • Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial
    • Girard, T.D., Kress, J.P., Fuchs, B.D., Thomason, J.W., Schweickert, W.D., Pun, B.T., et al. Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial. Lancet 371 (2008), 126–134.
    • (2008) Lancet , vol.371 , pp. 126-134
    • Girard, T.D.1    Kress, J.P.2    Fuchs, B.D.3    Thomason, J.W.4    Schweickert, W.D.5    Pun, B.T.6
  • 20
    • 78649792372 scopus 로고    scopus 로고
    • The effect of nursing-implemented sedation on the duration of mechanical ventilation in the ICU
    • Yiliaz, C., Kelebek Girgin, N., Ozdemir, N., Kutlay, O., The effect of nursing-implemented sedation on the duration of mechanical ventilation in the ICU. Ulus Travma Acil Cerrahi Derg 16 (2010), 521–526.
    • (2010) Ulus Travma Acil Cerrahi Derg , vol.16 , pp. 521-526
    • Yiliaz, C.1    Kelebek Girgin, N.2    Ozdemir, N.3    Kutlay, O.4
  • 21
    • 63849310048 scopus 로고    scopus 로고
    • Daily interruption of sedative infusions in an adult medical-surgical intensive care unit: randomized controlled trial
    • Anifantaki, S., Prinianakis, G., Vitsaksaki, E., Katsouli, V., Mari, S., Symianakis, A., et al. Daily interruption of sedative infusions in an adult medical-surgical intensive care unit: randomized controlled trial. J Adv Nurs 65 (2009), 1054–1060.
    • (2009) J Adv Nurs , vol.65 , pp. 1054-1060
    • Anifantaki, S.1    Prinianakis, G.2    Vitsaksaki, E.3    Katsouli, V.4    Mari, S.5    Symianakis, A.6
  • 22
    • 84869193649 scopus 로고    scopus 로고
    • Daily sedation interruption in mechanically ventilated critically ill patients cared for with a sedation protocol: a randomized controlled trial
    • Mehta, S., Burry, L., Cook, D., Fergusson, D., Steinberg, M., Granton, J., et al. Daily sedation interruption in mechanically ventilated critically ill patients cared for with a sedation protocol: a randomized controlled trial. JAMA 308 (2012), 1985–1992.
    • (2012) JAMA , vol.308 , pp. 1985-1992
    • Mehta, S.1    Burry, L.2    Cook, D.3    Fergusson, D.4    Steinberg, M.5    Granton, J.6
  • 23
    • 84919382689 scopus 로고    scopus 로고
    • Daily sedative interruption versus intermittent sedation in mechanically ventilated critically ill patients: a randomized trial
    • Nassar Junior, A.P., Park, M., Daily sedative interruption versus intermittent sedation in mechanically ventilated critically ill patients: a randomized trial. Ann Intensive Care, 4, 2014, 10.1186/2110-5820-4-14.
    • (2014) Ann Intensive Care , vol.4
    • Nassar Junior, A.P.1    Park, M.2
  • 24
    • 84867587446 scopus 로고    scopus 로고
    • Early intensive care sedation predicts long-term mortality in ventilated critically ill patients
    • Shehabi, Y., Bellomo, R., Reade, M.C., Bailey, M., Bass, F., Howe, B., et al. Early intensive care sedation predicts long-term mortality in ventilated critically ill patients. Am J Respir Crit Care Med 186 (2012), 724–731.
    • (2012) Am J Respir Crit Care Med , vol.186 , pp. 724-731
    • Shehabi, Y.1    Bellomo, R.2    Reade, M.C.3    Bailey, M.4    Bass, F.5    Howe, B.6
  • 25
    • 84885020740 scopus 로고    scopus 로고
    • Sedation depth and long-term mortality in mechanically ventilated critically ill adults: a prospective longitudinal multicentre cohort study
    • Shehabi, Y., Chan, L., Kadiman, S., Alias, A., Ismail, W.N., Tan, M.A., et al. Sedation depth and long-term mortality in mechanically ventilated critically ill adults: a prospective longitudinal multicentre cohort study. Intensive Care Med 39 (2013), 910–918.
    • (2013) Intensive Care Med , vol.39 , pp. 910-918
    • Shehabi, Y.1    Chan, L.2    Kadiman, S.3    Alias, A.4    Ismail, W.N.5    Tan, M.A.6
  • 26
    • 84880943753 scopus 로고    scopus 로고
    • Early goal-directed sedation versus standard sedation in mechanically ventilated critically ill patients: a pilot study
    • Shehabi, Y., Bellomo, R., Reade, M.C., Bailey, M., Bass, F., Howe, B., et al. Early goal-directed sedation versus standard sedation in mechanically ventilated critically ill patients: a pilot study. Crit Care Med 41 (2013), 1983–1991.
    • (2013) Crit Care Med , vol.41 , pp. 1983-1991
    • Shehabi, Y.1    Bellomo, R.2    Reade, M.C.3    Bailey, M.4    Bass, F.5    Howe, B.6
  • 27
    • 75749106589 scopus 로고    scopus 로고
    • A protocol of no sedation for critically ill patients receiving mechanical ventilation: a randomised trial
    • Strom, T., Martinussen, T., Toft, P., A protocol of no sedation for critically ill patients receiving mechanical ventilation: a randomised trial. Lancet 375 (2010), 475–480.
    • (2010) Lancet , vol.375 , pp. 475-480
    • Strom, T.1    Martinussen, T.2    Toft, P.3
  • 28
    • 84898609372 scopus 로고    scopus 로고
    • Sedation and delirium in intensive care
    • Reade, M.C., Finfer, S., Sedation and delirium in intensive care. N Engl J Med, 370, 2014, 1567, 10.1056/NEJMc1402402.
    • (2014) N Engl J Med , vol.370 , pp. 1567
    • Reade, M.C.1    Finfer, S.2
  • 29
    • 67649210721 scopus 로고    scopus 로고
    • Delirium in elderly adults: diagnosis, prevention and treatment
    • Fong, T.G., Tulebaev, S.R., Inouye, S.K., Delirium in elderly adults: diagnosis, prevention and treatment. Nat Rev Neurol 5 (2009), 210–220.
    • (2009) Nat Rev Neurol , vol.5 , pp. 210-220
    • Fong, T.G.1    Tulebaev, S.R.2    Inouye, S.K.3
  • 31
    • 34548052715 scopus 로고    scopus 로고
    • Characteristics associated with delirium in older patients in a medical intensive care unit
    • Pisani, M.A., Murphy, T.E., Van Ness, P.H., Araujo, K.L., Inouye, S.K., Characteristics associated with delirium in older patients in a medical intensive care unit. Arch Intern Med 167 (2007), 1629–1634.
    • (2007) Arch Intern Med , vol.167 , pp. 1629-1634
    • Pisani, M.A.1    Murphy, T.E.2    Van Ness, P.H.3    Araujo, K.L.4    Inouye, S.K.5
  • 32
  • 33
    • 84857589102 scopus 로고    scopus 로고
    • Development and validation of PRE-DELIRIC (PREdiction of DELIRium in ICu patients) delirium prediction model for intensive care patients: observational multicentre study
    • van den Boogaard, M., Pickkers, P., Slooter, A.J., Kuiper, M.A., Spronk, P.E., van der Voort, P.H., et al. Development and validation of PRE-DELIRIC (PREdiction of DELIRium in ICu patients) delirium prediction model for intensive care patients: observational multicentre study. BMJ, 344, 2012, e420.
    • (2012) BMJ , vol.344 , pp. e420
    • van den Boogaard, M.1    Pickkers, P.2    Slooter, A.J.3    Kuiper, M.A.4    Spronk, P.E.5    van der Voort, P.H.6
  • 35
    • 78650351883 scopus 로고    scopus 로고
    • A screening, prevention, and restoration model for saving the injured brain in intensive care unit survivors
    • Vasilevskis, E.E., Pandharipande, P.P., Girard, T.D., Ely, E.W., A screening, prevention, and restoration model for saving the injured brain in intensive care unit survivors. Crit Care Med 38 (2010), S91–S683.
    • (2010) Crit Care Med , vol.38 , pp. S91-S683
    • Vasilevskis, E.E.1    Pandharipande, P.P.2    Girard, T.D.3    Ely, E.W.4
  • 36
    • 84925683050 scopus 로고    scopus 로고
    • A systematic review of risk factors for delirium in the ICU
    • Zaal, I.J., Devlin, J.W., Peelen, L.M., Slooter, A.J.C., A systematic review of risk factors for delirium in the ICU. Crit Care Med 43 (2015), 40–47.
    • (2015) Crit Care Med , vol.43 , pp. 40-47
    • Zaal, I.J.1    Devlin, J.W.2    Peelen, L.M.3    Slooter, A.J.C.4
  • 37
    • 84914166312 scopus 로고    scopus 로고
    • Burst suppression on processed electroencephalography as a predictor of postcoma delirium in mechanically ventilated ICU patients
    • Andresen, J.M., Girard, T.D., Pandharipande, P.P., Davidson, M.A., Ely, E.W., Watson, P.L., Burst suppression on processed electroencephalography as a predictor of postcoma delirium in mechanically ventilated ICU patients. Crit Care Med 42 (2014), 2244–2251.
    • (2014) Crit Care Med , vol.42 , pp. 2244-2251
    • Andresen, J.M.1    Girard, T.D.2    Pandharipande, P.P.3    Davidson, M.A.4    Ely, E.W.5    Watson, P.L.6
  • 40
    • 54449093594 scopus 로고    scopus 로고
    • The use of propofol for medium and long-term sedation in critically ill adult patients: a meta-analysis
    • Ho, K.M., Ng, J.Y., The use of propofol for medium and long-term sedation in critically ill adult patients: a meta-analysis. Intensive Care Med 34 (2008), 1969–1979.
    • (2008) Intensive Care Med , vol.34 , pp. 1969-1979
    • Ho, K.M.1    Ng, J.Y.2
  • 41
    • 84858657050 scopus 로고    scopus 로고
    • Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials
    • Jakob, S.M., Ruokonen, E., Grounds, R.M., Sarapohja, T., Garratt, C., Pocock, S.J., et al. Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials. JAMA 307 (2012), 1151–1160.
    • (2012) JAMA , vol.307 , pp. 1151-1160
    • Jakob, S.M.1    Ruokonen, E.2    Grounds, R.M.3    Sarapohja, T.4    Garratt, C.5    Pocock, S.J.6
  • 42
    • 37149040245 scopus 로고    scopus 로고
    • Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial
    • Pandharipande, P.P., Pun, B.T., Herr, D.L., Maze, M., Girard, T.D., Miller, R.R., et al. Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial. JAMA 298 (2007), 2644–2653.
    • (2007) JAMA , vol.298 , pp. 2644-2653
    • Pandharipande, P.P.1    Pun, B.T.2    Herr, D.L.3    Maze, M.4    Girard, T.D.5    Miller, R.R.6
  • 43
    • 59649127447 scopus 로고    scopus 로고
    • Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trial
    • Riker, R.R., Shehabi, Y., Bokesch, P.M., Ceraso, D., Wisemandle, W., Koura, F., et al. Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trial. JAMA 301 (2009), 489–499.
    • (2009) JAMA , vol.301 , pp. 489-499
    • Riker, R.R.1    Shehabi, Y.2    Bokesch, P.M.3    Ceraso, D.4    Wisemandle, W.5    Koura, F.6
  • 45
    • 84929492432 scopus 로고    scopus 로고
    • Neurocognitive dysfunction risk alleviation with the use of dexmedetomidine in perioperative conditions or as ICU sedation: a meta-analysis
    • ® (Baltimore), 94, 2015, 10.1097/MD.0000000000000597.
    • (2015) ® (Baltimore) , vol.94
    • Li, B.1    Wang, H.2    Wu, H.3    Gao, C.4
  • 46
    • 84963799128 scopus 로고    scopus 로고
    • Effect of dexmedetomidine added to standard care on ventilator-free time in patients with agitated delirium: a randomized clinical trial
    • Reade, M.C., Eastwood, G.M., Bellomo, R., Bailey, M., Bersten, A., Cheung, B., et al. Effect of dexmedetomidine added to standard care on ventilator-free time in patients with agitated delirium: a randomized clinical trial. JAMA 315 (2016), 1460–1468.
    • (2016) JAMA , vol.315 , pp. 1460-1468
    • Reade, M.C.1    Eastwood, G.M.2    Bellomo, R.3    Bailey, M.4    Bersten, A.5    Cheung, B.6
  • 47
    • 84959258761 scopus 로고    scopus 로고
    • Dexmedetomidine for the treatment of hyperactive delirium refractory to haloperidol in nonintubated ICU patients: a nonrandomized controlled trial
    • Carrasco, G., Baeza, N., Cabre, L., Portillo, E., Gimeno, G., Manzanedo, D., et al. Dexmedetomidine for the treatment of hyperactive delirium refractory to haloperidol in nonintubated ICU patients: a nonrandomized controlled trial. Crit Care Med 44 (2016), 1295–1306.
    • (2016) Crit Care Med , vol.44 , pp. 1295-1306
    • Carrasco, G.1    Baeza, N.2    Cabre, L.3    Portillo, E.4    Gimeno, G.5    Manzanedo, D.6
  • 50
    • 84971505042 scopus 로고    scopus 로고
    • Non-sedation versus sedation with a daily wake-up trial in critically ill patients receiving mechanical ventilation – effects on long-term cognitive function: Study protocol for a randomized controlled trial, a substudy of the NONSEDA trial
    • Nedergaard, H.K., Jensen, H.I., Stylsvig, M., Lauridsen, J.T., Toft, P., Non-sedation versus sedation with a daily wake-up trial in critically ill patients receiving mechanical ventilation – effects on long-term cognitive function: Study protocol for a randomized controlled trial, a substudy of the NONSEDA trial. Trials, 17, 2016, 269.
    • (2016) Trials , vol.17 , pp. 269
    • Nedergaard, H.K.1    Jensen, H.I.2    Stylsvig, M.3    Lauridsen, J.T.4    Toft, P.5
  • 51
    • 0344406139 scopus 로고    scopus 로고
    • Six-month neuropsychological outcome of medical intensive care unit patients
    • Jackson, J.C., Hart, R.P., Gordon, S.M., Shintani, A., Truman, B., May, L., et al. Six-month neuropsychological outcome of medical intensive care unit patients. Crit Care Med 31 (2003), 1226–1234.
    • (2003) Crit Care Med , vol.31 , pp. 1226-1234
    • Jackson, J.C.1    Hart, R.P.2    Gordon, S.M.3    Shintani, A.4    Truman, B.5    May, L.6
  • 53
    • 69349098164 scopus 로고    scopus 로고
    • Randomized trial of light versus deep sedation on mental health after critical illness
    • Treggiari, M.M., Romand, J.A., Yanez, N.D., Deem, S.A., Goldberg, J., Hudson, L., et al. Randomized trial of light versus deep sedation on mental health after critical illness. Crit Care Med 37 (2009), 2527–2534.
    • (2009) Crit Care Med , vol.37 , pp. 2527-2534
    • Treggiari, M.M.1    Romand, J.A.2    Yanez, N.D.3    Deem, S.A.4    Goldberg, J.5    Hudson, L.6
  • 54
    • 84856579294 scopus 로고    scopus 로고
    • Pharmacological and nonpharmacological management of delirium in critically ill patients
    • Hipp, D.M., Ely, E.W., Pharmacological and nonpharmacological management of delirium in critically ill patients. Neurotherapeutics 9 (2012), 158–175.
    • (2012) Neurotherapeutics , vol.9 , pp. 158-175
    • Hipp, D.M.1    Ely, E.W.2
  • 55
    • 84918802038 scopus 로고    scopus 로고
    • Dexmedetomidine controls systemic cytokine levels through the cholinergic anti-inflammatory pathway
    • Xiang, H., Hu, B., Li, Z., Li, J., Dexmedetomidine controls systemic cytokine levels through the cholinergic anti-inflammatory pathway. Inflammation 37 (2014), 1763–1770.
    • (2014) Inflammation , vol.37 , pp. 1763-1770
    • Xiang, H.1    Hu, B.2    Li, Z.3    Li, J.4
  • 56
    • 0033652991 scopus 로고    scopus 로고
    • Central cholinergic depletion induced by 192 IgG-saporin alleviates the sedative effects of propofol in rats
    • Pain, L., Jeltsch, H., Lehmann, O., Lazarus, C., Laalou, F.Z., Cassel, J.C., Central cholinergic depletion induced by 192 IgG-saporin alleviates the sedative effects of propofol in rats. Br J Anaesth 85 (2000), 869–873.
    • (2000) Br J Anaesth , vol.85 , pp. 869-873
    • Pain, L.1    Jeltsch, H.2    Lehmann, O.3    Lazarus, C.4    Laalou, F.Z.5    Cassel, J.C.6
  • 57
    • 0032509818 scopus 로고    scopus 로고
    • Upregulation of NMDA receptor subunit proteins in the cerebral cortex during diazepam withdrawal
    • Tsuda, M., Chiba, Y., Suzuki, T., Misawa, M., Upregulation of NMDA receptor subunit proteins in the cerebral cortex during diazepam withdrawal. Eur J Pharmacol 341 (1998), 1–2.
    • (1998) Eur J Pharmacol , vol.341 , pp. 1-2
    • Tsuda, M.1    Chiba, Y.2    Suzuki, T.3    Misawa, M.4
  • 58
    • 11144340901 scopus 로고    scopus 로고
    • Psychotogenic drugs and delirium pathogenesis: the central role of the thalamus
    • Gaudreau, J.D., Gagnon, P., Psychotogenic drugs and delirium pathogenesis: the central role of the thalamus. Med Hypotheses 64 (2005), 471–475.
    • (2005) Med Hypotheses , vol.64 , pp. 471-475
    • Gaudreau, J.D.1    Gagnon, P.2
  • 59
    • 3042570072 scopus 로고    scopus 로고
    • Abolished circadian rhythm of melatonin secretion in sedated and artificially ventilated intensive care patients
    • Olofsson, K., Alling, C., Lundberg, D., Malmros, C., Abolished circadian rhythm of melatonin secretion in sedated and artificially ventilated intensive care patients. Acta Anaesthesiol Scand 48 (2004), 679–684.
    • (2004) Acta Anaesthesiol Scand , vol.48 , pp. 679-684
    • Olofsson, K.1    Alling, C.2    Lundberg, D.3    Malmros, C.4
  • 60
    • 79951725860 scopus 로고    scopus 로고
    • Contribution of sedative-hypnotic agents to delirium via modulation of the sleep pathway
    • Sanders, R.D., Maze, M., Contribution of sedative-hypnotic agents to delirium via modulation of the sleep pathway. Can J Anaesth 58 (2011), 149–156.
    • (2011) Can J Anaesth , vol.58 , pp. 149-156
    • Sanders, R.D.1    Maze, M.2
  • 61
    • 27244437939 scopus 로고    scopus 로고
    • Drugs of anesthesia acting on central cholinergic system may cause post-operative cognitive dysfunction and delirium
    • Pratico, C., Quattrone, D., Lucanto, T., Amato, A., Penna, O., Roscitano, C., et al. Drugs of anesthesia acting on central cholinergic system may cause post-operative cognitive dysfunction and delirium. Med Hypotheses 65 (2005), 972–982.
    • (2005) Med Hypotheses , vol.65 , pp. 972-982
    • Pratico, C.1    Quattrone, D.2    Lucanto, T.3    Amato, A.4    Penna, O.5    Roscitano, C.6
  • 62
    • 24344434745 scopus 로고    scopus 로고
    • Potential mechanisms and markers of critical illness-associated cognitive dysfunction
    • Milbrandt, E.B., Angus, D.C., Potential mechanisms and markers of critical illness-associated cognitive dysfunction. Curr Opin Crit Care 11 (2005), 355–359.
    • (2005) Curr Opin Crit Care , vol.11 , pp. 355-359
    • Milbrandt, E.B.1    Angus, D.C.2
  • 65
    • 84863481438 scopus 로고    scopus 로고
    • Short- and long-term changes in extracellular glutamate and acetylcholine concentrations in the rat hippocampus following hypoxia
    • Lopez-Perez, S.J., Morales-Villagran, A., Ventura-Valenzuela, J., Medina-Ceja, L., Short- and long-term changes in extracellular glutamate and acetylcholine concentrations in the rat hippocampus following hypoxia. Neurochem Int 61 (2012), 258–265.
    • (2012) Neurochem Int , vol.61 , pp. 258-265
    • Lopez-Perez, S.J.1    Morales-Villagran, A.2    Ventura-Valenzuela, J.3    Medina-Ceja, L.4
  • 66
  • 70
    • 79955795863 scopus 로고    scopus 로고
    • Injurious mechanical ventilation affects neuronal activation in ventilated rats
    • Quilez, M.E., Fuster, G., Villar, J., Flores, C., Marti-Sistac, O., Blanch, L., et al. Injurious mechanical ventilation affects neuronal activation in ventilated rats. Crit Care, 15, 2011, R124, 10.1186/cc10230.
    • (2011) Crit Care , vol.15 , pp. R124
    • Quilez, M.E.1    Fuster, G.2    Villar, J.3    Flores, C.4    Marti-Sistac, O.5    Blanch, L.6
  • 71
    • 84947868562 scopus 로고    scopus 로고
    • Moderate peep after tracheal lipopolysaccharide instillation prevents inflammation and modifies the pattern of brain neuronal activation
    • Quilez, M.E., Rodriguez-Gonzalez, R., Turon, M., Fernandez-Gonzalo, S., Villar, J., Kacmarek, R.M., et al. Moderate peep after tracheal lipopolysaccharide instillation prevents inflammation and modifies the pattern of brain neuronal activation. Shock 44 (2015), 601–608.
    • (2015) Shock , vol.44 , pp. 601-608
    • Quilez, M.E.1    Rodriguez-Gonzalez, R.2    Turon, M.3    Fernandez-Gonzalo, S.4    Villar, J.5    Kacmarek, R.M.6
  • 72
    • 0034091146 scopus 로고    scopus 로고
    • Mechanotransduction, ventilator-induced lung injury and multiple organ dysfunction syndrome
    • dos Santos, C.C., Slutsky, A.S., Mechanotransduction, ventilator-induced lung injury and multiple organ dysfunction syndrome. Intensive Care Med 26 (2000), 638–642.
    • (2000) Intensive Care Med , vol.26 , pp. 638-642
    • dos Santos, C.C.1    Slutsky, A.S.2
  • 73
    • 40749097280 scopus 로고    scopus 로고
    • Bench-to-bedside review: brain–lung interaction in the critically ill – a pending issue revisited
    • Gonzalvo, R., Marti-Sistac, O., Blanch, L., Lopez-Aguilar, J., Bench-to-bedside review: brain–lung interaction in the critically ill – a pending issue revisited. Crit Care, 11, 2007, 216.
    • (2007) Crit Care , vol.11 , pp. 216
    • Gonzalvo, R.1    Marti-Sistac, O.2    Blanch, L.3    Lopez-Aguilar, J.4
  • 74
    • 84928886706 scopus 로고    scopus 로고
    • Prolonged mechanical ventilation-induced neuroinflammation affects postoperative memory dysfunction in surgical mice
    • Chen, C., Zhang, Z., Chen, T., Peng, M., Xu, X., Wang, Y., Prolonged mechanical ventilation-induced neuroinflammation affects postoperative memory dysfunction in surgical mice. Crit Care, 19, 2015, 159.
    • (2015) Crit Care , vol.19 , pp. 159
    • Chen, C.1    Zhang, Z.2    Chen, T.3    Peng, M.4    Xu, X.5    Wang, Y.6
  • 78
    • 61449194104 scopus 로고    scopus 로고
    • Observational study of patient-ventilator asynchrony and relationship to sedation level
    • de Wit, M., Pedram, S., Best, A.M., Epstein, S.K., Observational study of patient-ventilator asynchrony and relationship to sedation level. J Crit Care 24 (2009), 74–80.
    • (2009) J Crit Care , vol.24 , pp. 74-80
    • de Wit, M.1    Pedram, S.2    Best, A.M.3    Epstein, S.K.4


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