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Volumn 41, Issue 9 SUPPL.1, 2013, Pages

Benzodiazepine versus nonbenzodiazepine-based sedation for mechanically ventilated, critically ill adults: A systematic review and meta-analysis of randomized trials

Author keywords

critical illness; delirium; dexmedetomidine; length of stay; lorazepam; mechanical ventilation; metaanalysis; midazolam; mortality; propofol; systematic review

Indexed keywords

BENZODIAZEPINE; DEXMEDETOMIDINE; LORAZEPAM; MIDAZOLAM; PROPOFOL; SEDATIVE AGENT;

EID: 84883590421     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e3182a16898     Document Type: Review
Times cited : (231)

References (40)
  • 1
    • 84872087535 scopus 로고    scopus 로고
    • Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the intensive care unit
    • American College of Critical Care Medicine
    • Barr J, Fraser GL, Puntillo K, et al; American College of Critical Care Medicine: Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the intensive care unit. Crit Care Med 2013; 41:263-306
    • (2013) Crit Care Med , vol.41 , pp. 263-306
    • Barr, J.1    Fraser, G.L.2    Puntillo, K.3
  • 2
    • 33646571863 scopus 로고    scopus 로고
    • A randomized trial of intermittent lorazepam versus propofol with daily interruption in mechanically ventilated patients
    • Carson SS, Kress JP, Rodgers JE, et al: A randomized trial of intermittent lorazepam versus propofol with daily interruption in mechanically ventilated patients. Crit Care Med 2006; 34:1326-1332
    • (2006) Crit Care Med , vol.34 , pp. 1326-1332
    • Carson, S.S.1    Kress, J.P.2    Rodgers, J.E.3
  • 3
    • 0031457178 scopus 로고    scopus 로고
    • Midazolam versus propofol for long-term sedation in the ICU: A randomized prospective comparison
    • Weinbroum AA, Halpern P, Rudick V, et al: Midazolam versus propofol for long-term sedation in the ICU: A randomized prospective comparison. Intensive Care Med 1997; 23:1258-1263
    • (1997) Intensive Care Med , vol.23 , pp. 1258-1263
    • Weinbroum, A.A.1    Halpern, P.2    Rudick, V.3
  • 4
    • 37149040245 scopus 로고    scopus 로고
    • Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: The MENDS randomized controlled trial
    • Pandharipande PP, Pun BT, Herr DL, et al: Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: The MENDS randomized controlled trial. JAMA 2007; 298:2644-2653
    • (2007) JAMA , vol.298 , pp. 2644-2653
    • Pandharipande, P.P.1    Pun, B.T.2    Herr, D.L.3
  • 5
    • 59649127447 scopus 로고    scopus 로고
    • Dexmedetomidine vs midazolam for sedation of critically ill patients: A randomized trial
    • SEDCOM (Safety and Efficacy of Dexmedetomidine Compared With Midazolam) Study Group
    • Riker RR, Shehabi Y, Bokesch PM, et al; SEDCOM (Safety and Efficacy of Dexmedetomidine Compared With Midazolam) Study Group: Dexmedetomidine vs midazolam for sedation of critically ill patients: A randomized trial. JAMA 2009; 301:489-499
    • (2009) JAMA , vol.301 , pp. 489-499
    • Riker, R.R.1    Shehabi, Y.2    Bokesch, P.M.3
  • 6
    • 59849087047 scopus 로고    scopus 로고
    • Dexmedetomidine versus propofol/midazolam for long-term sedation during mechanical ventilation
    • Dexmedetomidine for Continuous Sedation Investigators
    • Ruokonen E, Parviainen I, Jakob SM, et al; "Dexmedetomidine for Continuous Sedation" Investigators: Dexmedetomidine versus propofol/midazolam for long-term sedation during mechanical ventilation. Intensive Care Med 2009; 35:282-290
    • (2009) Intensive Care Med , vol.35 , pp. 282-290
    • Ruokonen, E.1    Parviainen, I.2    Jakob, S.M.3
  • 7
    • 67650921091 scopus 로고    scopus 로고
    • Dexmedetomidine and the reduction of postoperative delirium after cardiac surgery
    • Maldonado JR, Wysong A, van der Starre PJ, et al: Dexmedetomidine and the reduction of postoperative delirium after cardiac surgery. Psychosomatics 2009; 50:206-217
    • (2009) Psychosomatics , vol.50 , pp. 206-217
    • Maldonado, J.R.1    Wysong, A.2    Van Der Starre, P.J.3
  • 8
    • 36849065665 scopus 로고    scopus 로고
    • Propofol associated with a shorter duration of mechanical ventilation than scheduled intermittent lorazepam: A database analysis using Project IMPACT
    • Fong JJ, Kanji S, Dasta JF, et al: Propofol associated with a shorter duration of mechanical ventilation than scheduled intermittent lorazepam: A database analysis using Project IMPACT. Ann Pharmacother 2007; 41:1986-1991
    • (2007) Ann Pharmacother , vol.41 , pp. 1986-1991
    • Fong, J.J.1    Kanji, S.2    Dasta, J.F.3
  • 9
    • 70449524649 scopus 로고    scopus 로고
    • Comparison between dexmedetomidine and midazolam for sedation of eclampsia patients in the intensive care unit
    • Esmaoglu A, Ulgey A, Akin A, et al: Comparison between dexmedetomidine and midazolam for sedation of eclampsia patients in the intensive care unit. J Crit Care 2009; 24:551-555
    • (2009) J Crit Care , vol.24 , pp. 551-555
    • Esmaoglu, A.1    Ulgey, A.2    Akin, A.3
  • 10
    • 0036138914 scopus 로고    scopus 로고
    • Economic evaluation of propofol for sedation of patients admitted to intensive care units
    • Propofol Study Group
    • Anis AH, Wang XH, Leon H, et al; Propofol Study Group: Economic evaluation of propofol for sedation of patients admitted to intensive care units. Anesthesiology 2002; 96:196-201
    • (2002) Anesthesiology , vol.96 , pp. 196-201
    • Anis, A.H.1    Wang, X.H.2    Leon, H.3
  • 11
    • 0034912516 scopus 로고    scopus 로고
    • Propofol vs midazolam for ICU sedation: A Canadian multicenter randomized trial
    • Study Investigators
    • Hall RI, Sandham D, Cardinal P, et al; Study Investigators: Propofol vs midazolam for ICU sedation: A Canadian multicenter randomized trial. Chest 2001; 119:1151-1159
    • (2001) Chest , vol.119 , pp. 1151-1159
    • Hall, R.I.1    Sandham, D.2    Cardinal, P.3
  • 12
    • 43749099013 scopus 로고    scopus 로고
    • Comparison of the effect of protocol-directed sedation with propofol vs midazolam by nurses in intensive care: Efficacy, haemodynamic stability and patient satisfaction
    • Huey-Ling L, Chun-Che S, Jen-Jen T, et al: Comparison of the effect of protocol-directed sedation with propofol vs. midazolam by nurses in intensive care: Efficacy, haemodynamic stability and patient satisfaction. J Clin Nurs 2008; 17:1510-1517
    • (2008) J Clin Nurs , vol.17 , pp. 1510-1517
    • Huey-Ling, L.1    Chun-Che, S.2    Jen-Jen, T.3
  • 13
    • 1842378015 scopus 로고    scopus 로고
    • Propofol or midazolam for sedation and early extubation following cardiac surgery
    • Searle NR, Côté S, Taillefer J, et al: Propofol or midazolam for sedation and early extubation following cardiac surgery. Can J Anaesth 1997; 44:629-635
    • (1997) Can J Anaesth , vol.44 , pp. 629-635
    • Searle, N.R.1    Côté, S.2    Taillefer, J.3
  • 14
    • 77953076612 scopus 로고    scopus 로고
    • Effect of dexmedetomidine versus lorazepam on outcome in patients with sepsis: An a priori-designed analysis of the MENDS randomized controlled trial
    • MENDS investigators
    • Pandharipande PP, Sanders RD, Girard TD, et al; MENDS investigators: Effect of dexmedetomidine versus lorazepam on outcome in patients with sepsis: An a priori-designed analysis of the MENDS randomized controlled trial. Crit Care 2010; 14:R38
    • (2010) Crit Care , vol.14
    • Pandharipande, P.P.1    Sanders, R.D.2    Girard, T.D.3
  • 15
    • 84855571044 scopus 로고    scopus 로고
    • Critical care in pregnancy
    • Plaat F, Naik M: Critical care in pregnancy. Crit Care 2011; 15:1014
    • (2011) Crit Care , vol.15 , pp. 1014
    • Plaat, F.1    Naik, M.2
  • 16
    • 84859001212 scopus 로고    scopus 로고
    • The Cochrane Collaboration's tool for assessing risk of bias in randomised trials
    • Cochrane Bias Methods Group; Cochrane Statistical Methods Group
    • Higgins JP, Altman DG, Gøtzsche PC, et al; Cochrane Bias Methods Group; Cochrane Statistical Methods Group: The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. BMJ 2011; 343:d5928
    • (2011) BMJ , vol.343
    • Higgins, J.P.1    Altman, D.G.2    Gøtzsche, P.C.3
  • 17
    • 20044382229 scopus 로고    scopus 로고
    • Systems for grading the quality of evidence and the strength of recommendations I: Critical appraisal of existing approaches
    • The GRADE Working Group
    • Atkins D, Eccles M, Flottorp S, et al; The GRADE Working Group: Systems for grading the quality of evidence and the strength of recommendations I: Critical appraisal of existing approaches. BMC Health Serv Res 2004; 4:38
    • (2004) BMC Health Serv Res , vol.4 , pp. 38
    • Atkins, D.1    Eccles, M.2    Flottorp, S.3
  • 19
    • 0035141882 scopus 로고    scopus 로고
    • The immunomodulatory effects of prolonged intravenous infusion of propofol versus midazolam in critically ill surgical patients
    • Helmy SA, Al-Attiyah RJ: The immunomodulatory effects of prolonged intravenous infusion of propofol versus midazolam in critically ill surgical patients. Anaesthesia 2001; 56:4-8
    • (2001) Anaesthesia , vol.56 , pp. 4-8
    • Helmy, S.A.1    Al-Attiyah, R.J.2
  • 20
    • 34547809433 scopus 로고    scopus 로고
    • Effect of midazolam versus propofol sedation on markers of neurological injury and outcome after isolated severe head injury: A pilot study
    • Ghori KA, Harmon DC, Elashaal A, et al: Effect of midazolam versus propofol sedation on markers of neurological injury and outcome after isolated severe head injury: A pilot study. Crit Care Resusc 2007; 9:166-171
    • (2007) Crit Care Resusc , vol.9 , pp. 166-171
    • Ghori, K.A.1    Harmon, D.C.2    Elashaal, A.3
  • 21
    • 0032734454 scopus 로고    scopus 로고
    • Continuous infusions of lorazepam, midazolam, and propofol for sedation of the critically ill surgery trauma patient: A prospective, randomized comparison
    • McCollam JS, O'Neil MG, Norcross ED, et al: Continuous infusions of lorazepam, midazolam, and propofol for sedation of the critically ill surgery trauma patient: A prospective, randomized comparison. Crit Care Med 1999; 27:2454-2458
    • (1999) Crit Care Med , vol.27 , pp. 2454-2458
    • McCollam, J.S.1    O'Neil, M.G.2    Norcross, E.D.3
  • 22
    • 8944221183 scopus 로고    scopus 로고
    • Comparative study of propofol versus midazolam in the sedation of critically ill patients: Results of a prospective, randomized, multicenter trial
    • Chamorro C, de Latorre FJ, Montero A, et al: Comparative study of propofol versus midazolam in the sedation of critically ill patients: Results of a prospective, randomized, multicenter trial. Crit Care Med 1996; 24:932-939
    • (1996) Crit Care Med , vol.24 , pp. 932-939
    • Chamorro, C.1    De Latorre, F.J.2    Montero, A.3
  • 23
    • 33745627747 scopus 로고    scopus 로고
    • Postoperative sedation after major surgery with midazolam or propofol in the ICU: Effects on amnesia and anxiety
    • Hsiao PC, Tang YY, Liaw WJ, et al: Postoperative sedation after major surgery with midazolam or propofol in the ICU: Effects on amnesia and anxiety. Acta Anaesthesiol Taiwan 2006; 44:93-99
    • (2006) Acta Anaesthesiol Taiwan , vol.44 , pp. 93-99
    • Hsiao, P.C.1    Tang, Y.Y.2    Liaw, W.J.3
  • 24
    • 41549106656 scopus 로고    scopus 로고
    • The addition of haloperidol, propofol, or midazolam to sufentanil for intravenous sedation in the intensive care unit using bispectral index
    • Tukenmez B, Memis D, Pamukcu Z: The addition of haloperidol, propofol, or midazolam to sufentanil for intravenous sedation in the intensive care unit using bispectral index. J Opioid Manag 2008; 4:34-40
    • (2008) J Opioid Manag , vol.4 , pp. 34-40
    • Tukenmez, B.1    Memis, D.2    Pamukcu, Z.3
  • 25
    • 0029848594 scopus 로고    scopus 로고
    • Overnight sedation with midazolam or propofol in the ICU: Effects on sleep quality, anxiety and depression
    • Treggiari-Venzi M, Borgeat A, Fuchs-Buder T, et al: Overnight sedation with midazolam or propofol in the ICU: Effects on sleep quality, anxiety and depression. Intensive Care Med 1996; 22:1186-1190
    • (1996) Intensive Care Med , vol.22 , pp. 1186-1190
    • Treggiari-Venzi, M.1    Borgeat, A.2    Fuchs-Buder, T.3
  • 26
    • 0030012049 scopus 로고    scopus 로고
    • Sedation of critically ill patients during mechanical ventilation. A comparison of propofol and midazolam
    • Kress JP, O'Connor MF, Pohlman AS, et al: Sedation of critically ill patients during mechanical ventilation. A comparison of propofol and midazolam. Am J Respir Crit Care Med 1996; 153: 1012-1018
    • (1996) Am J Respir Crit Care Med , vol.153 , pp. 1012-1018
    • Kress, J.P.1    O'Connor, M.F.2    Pohlman, A.S.3
  • 27
    • 84858657050 scopus 로고    scopus 로고
    • Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: Two randomized controlled trials
    • Dexmedetomidine for Long-Term Sedation Investigators
    • Jakob SM, Ruokonen E, Grounds RM, et al; Dexmedetomidine for Long-Term Sedation Investigators: Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: Two randomized controlled trials. JAMA 2012; 307:1151-1160
    • (2012) JAMA , vol.307 , pp. 1151-1160
    • Jakob, S.M.1    Ruokonen, E.2    Grounds, R.M.3
  • 28
    • 0022256529 scopus 로고
    • APACHE II: A severity of disease classification system
    • Knaus WA, Draper EA, Wagner DP, et al: APACHE II: A severity of disease classification system. Crit Care Med 1985; 13: 818-829
    • (1985) Crit Care Med , vol.13 , pp. 818-829
    • Knaus, W.A.1    Draper, E.A.2    Wagner, D.P.3
  • 29
    • 84875603425 scopus 로고    scopus 로고
    • Data Resource Profile: Adult cardiac surgery database of the Netherlands Association for Cardio-Thoracic Surgery
    • Siregar S, Groenwold RH, Versteegh MI, et al: Data Resource Profile: Adult cardiac surgery database of the Netherlands Association for Cardio-Thoracic Surgery. Int J Epidemiol 2013; 42:142-149
    • (2013) Int J Epidemiol , vol.42 , pp. 142-149
    • Siregar, S.1    Groenwold, R.H.2    Versteegh, M.I.3
  • 30
    • 0142031128 scopus 로고    scopus 로고
    • ICU sedation after coronary artery bypass graft surgery: Dexmedetomidine-based versus propofolbased sedation regimens
    • Herr DL, Sum-Ping ST, England M: ICU sedation after coronary artery bypass graft surgery: Dexmedetomidine-based versus propofolbased sedation regimens. J Cardiothorac Vasc Anesth 2003; 17: 576-584
    • (2003) J Cardiothorac Vasc Anesth , vol.17 , pp. 576-584
    • Herr, D.L.1    Sum-Ping, S.T.2    England, M.3
  • 31
    • 80053966407 scopus 로고    scopus 로고
    • Current perceptions and practices surrounding the recognition and treatment of delirium in the intensive care unit: A survey of 250 critical care pharmacists from eight states
    • Devlin JW, Bhat S, Roberts RJ, et al: Current perceptions and practices surrounding the recognition and treatment of delirium in the intensive care unit: A survey of 250 critical care pharmacists from eight states. Ann Pharmacother 2011; 45:1217-1229
    • (2011) Ann Pharmacother , vol.45 , pp. 1217-1229
    • Devlin, J.W.1    Bhat, S.2    Roberts, R.J.3
  • 32
    • 33644851831 scopus 로고    scopus 로고
    • Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients
    • Pandharipande P, Shintani A, Peterson J, et al: Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients. Anesthesiology 2006; 104:21-26
    • (2006) Anesthesiology , vol.104 , pp. 21-26
    • Pandharipande, P.1    Shintani, A.2    Peterson, J.3
  • 33
    • 67649974294 scopus 로고    scopus 로고
    • Prevalence and risk factors for development of delirium in surgical and trauma intensive care unit patients
    • Pandharipande P, Cotton BA, Shintani A, et al: Prevalence and risk factors for development of delirium in surgical and trauma intensive care unit patients. J Trauma 2008; 65:34-41
    • (2008) J Trauma , vol.65 , pp. 34-41
    • Pandharipande, P.1    Cotton, B.A.2    Shintani, A.3
  • 34
    • 84875790477 scopus 로고    scopus 로고
    • Factors predisposing to coma and delirium: Fentanyl and midazolam exposure; CYP3A5, ABCB1, and ABCG2 genetic polymorphisms; And inflammatory factors
    • Skrobik Y, Leger C, Cossette M, et al: Factors predisposing to coma and delirium: Fentanyl and midazolam exposure; CYP3A5, ABCB1, and ABCG2 genetic polymorphisms; and inflammatory factors. Crit Care Med 2013; 41:999-1008
    • (2013) Crit Care Med , vol.41 , pp. 999-1008
    • Skrobik, Y.1    Leger, C.2    Cossette, M.3
  • 36
    • 84868240683 scopus 로고    scopus 로고
    • The problem of definitions in measuring and managing ICU cognitive function
    • Reade MC, Aitken LM: The problem of definitions in measuring and managing ICU cognitive function. Crit Care Resusc 2012; 14:236-243
    • (2012) Crit Care Resusc , vol.14 , pp. 236-243
    • Reade, M.C.1    Aitken, L.M.2
  • 37
  • 38
    • 81055150471 scopus 로고    scopus 로고
    • Pharmacology of commonly used analgesics and sedatives in the ICU: Benzodiazepines, propofol, and opioids
    • Devlin JW, Roberts RJ: Pharmacology of commonly used analgesics and sedatives in the ICU: Benzodiazepines, propofol, and opioids. Anesthesiol Clin 2011; 29:567-585
    • (2011) Anesthesiol Clin , vol.29 , pp. 567-585
    • Devlin, J.W.1    Roberts, R.J.2
  • 39
    • 0029075289 scopus 로고
    • Prolonged sedation due to accumulation of conjugated metabolites of midazolam
    • Bauer TM, Ritz R, Haberthür C, et al: Prolonged sedation due to accumulation of conjugated metabolites of midazolam. Lancet 1995; 346:145-147
    • (1995) Lancet , vol.346 , pp. 145-147
    • Bauer, T.M.1    Ritz, R.2    Haberthür, C.3
  • 40
    • 77955109235 scopus 로고    scopus 로고
    • Practice misalignments in randomized controlled trials: Identification, impact, and potential solutions
    • Deans KJ, Minneci PC, Danner RL, et al: Practice misalignments in randomized controlled trials: Identification, impact, and potential solutions. Anesth Analg 2010; 111:444-450
    • (2010) Anesth Analg , vol.111 , pp. 444-450
    • Deans, K.J.1    Minneci, P.C.2    Danner, R.L.3


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