Drugs of anesthesia acting on central cholinergic system may cause post-operative cognitive dysfunction and delirium

Medical Hypotheses

Volumn 65, Issue 5, 2005, Pages 972-982

  Pratico C ^a   Quattrone, D ^a   Lucanto, T ^a   Amato, A ^a   Penna, O ^a   Roscitano, C ^a   Fodale, V ^a  

^a UNIVERSITY OF MESSINA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; ANESTHETIC AGENT; ANTIBIOTIC AGENT; ANTIEPILEPSIRINE; ANTIHISTAMINIC AGENT; ANTIPARKINSON AGENT; BARBITURIC ACID DERIVATIVE; CARDIAC AGENT; CHOLINERGIC RECEPTOR BLOCKING AGENT; EDROPHONIUM; ELECTROLYTE; HALOTHANE; HYPNOTIC AGENT; ION CHANNEL; ISOFLURANE; MORPHINE; MUSCARINIC RECEPTOR BLOCKING AGENT; MUSCLE RELAXANT AGENT; NARCOTIC ANALGESIC AGENT; NEOSTIGMINE; NEUROLEPTIC AGENT; NEUROTRANSMITTER; NONSTEROID ANTIINFLAMMATORY AGENT; OPIATE; PROPOFOL; PYRIDOSTIGMINE; SEDATIVE AGENT; SEROTONIN UPTAKE INHIBITOR; TRICYCLIC ANTIDEPRESSANT AGENT; UNINDEXED DRUG; MUSCARINIC RECEPTOR;

ALCOHOL ABUSE; ALZHEIMER DISEASE; BEHAVIOR; BRAIN BLOOD FLOW; BRAIN FUNCTION; BRAIN INFARCTION; CAROTID ARTERY BRUIT; CHOLINERGIC SYSTEM; CLINICAL FEATURE; COGNITIVE DEFECT; DELIRIUM; DIABETES MELLITUS; DISEASE ASSOCIATION; FUNCTIONAL STATUS; GENERAL ANESTHESIA; HEART ATRIUM FIBRILLATION; HOSPITALIZATION; HUMAN; HYPERCHOLESTEROLEMIA; HYPERTENSION; HYPOTENSION; HYPOXIA; ISCHEMIC HEART DISEASE; MALNUTRITION; MEMORY; MENTAL HEALTH; METABOLISM; MOOD; MORBIDITY; MORTALITY; MOTOR PERFORMANCE; NERVE CELL MEMBRANE; NEUROTRANSMITTER RELEASE; PARKINSON DISEASE; PATHOGENICITY; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; REVIEW; RISK FACTOR; SIGNAL TRANSDUCTION; SURGICAL TECHNIQUE; ARTICLE; BIOLOGICAL MODEL; BRAIN; CHEMICALLY INDUCED DISORDER; COMORBIDITY; DRUG EFFECT; EPIDEMIOLOGY; METHODOLOGY; PREVALENCE; RISK ASSESSMENT;

ANESTHETICS, GENERAL; BRAIN; CAUSALITY; CHOLINERGIC ANTAGONISTS; COGNITION DISORDERS; COMORBIDITY; DELIRIUM; HUMANS; MODELS, NEUROLOGICAL; POSTOPERATIVE COMPLICATIONS; PREVALENCE; RECEPTORS, MUSCARINIC; RISK ASSESSMENT; RISK FACTORS;

EID: 27244437939     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2005.05.037     Document Type: Article

References (85)

1. P.M. Lauven, J. Nadstawek, and S. Albrecht The safe use of anesthetics and muscle relaxants in older surgical patients Drugs Aging 3 1993 502 509
2. B. Fredman, O. Sheffer, and E. Zohar Fast-track eligibility of geriatric patients undergoing short urologic surgery procedures Anesth Analg 94 2002 560 564
3. J.T. Moller, P. Cluitmans, and L.S. Rasmussen Long-term postoperative cognitive dysfunction in the elderly ISPOCD1 study: ISPOCD investigators. International study of post-operative cognitive dysfunction Lancet 351 1998 857 861
4. The Tenth Revision of the International Classification of Diseases and Related Health Problems (ICD-10; World Health Organization, 1992).
5. M.G. Cole, J. McCusker, and F. Bellavance Systematic detection and multidisciplinary care of delirium in older medical inpatients: a randomized trial CMAJ 167 2002 753 759
6. S.M. Lin, C.Y. Liu, and C.H. Wang The impact of delirium on the survival of mechanically ventilated patients Crit Care Med 32 2004 2254 2259
7. E.R. Marcantonio, L. Goldman, and C.M. Mangione A clinical prediction rule for delirium after elective noncardiac surgery JAMA 271 1994 134 139
8. E.P. Lynch, M.A. Lazor, and J.E. Gellis The impact of postoperative pain on the development of postoperative delirium Anesth Analg 86 1998 781 785
9. A.Y. Bekker, and E.J. Weeks Cognitive function after anaesthesia in the elderly Best Pract Res Clin Anaesthesiol 17 2003 259 272
10. G.M. McKhann, M.A. Grega, and L.M. Borowicz Jr. Encephalopathy and stroke after coronary artery bypass grafting: incidence, consequences, and prediction Arch Neurol 59 2002 1422 1428
11. D. Litaker, J. Locala, and K. Franco Preoperative risk factors for postoperative delirium Gen Hosp Psychiatry 23 2001 84 89
12. S. Saeki, N. Watanabe, and R. Iida A study of post-operative delirium in elderly patients Masui 47 1998 290 299
13. H. Hashimoto, and M. Yamashiro Postoperative delirium and abnormal behaviour related with preoperative quality of life in elderly patients Nippon Ronen Igakkai Zasshi 31 1994 633 638
14. E.R. Marcantonio, L. Goldman, and E.J. Orav The association of intraoperative factors with the development of postoperative delirium Am J Med 105 1998 380 384
15. Parikh, and F. Chung Postoperative delirium in the elderly Anesth Analg 80 1995 1223 1232
16. H. Bohner, F. Schneider, and A. Stierstorfer Delirium after vascular surgery interventions. Intermediate-term results of a prospective study Chirurg 71 2000 215 221
17. U. Linstedt, O. Meyer, and A. Berkau Does intraoperative hyperventilation improve neurological functions of older patients after general anaesthesia? Anaesthesist 51 2002 457 462
18. H.K. Kamel, M.A. Iqbal, and R. Mogallapu Time to ambulation after hip fracture surgery: relation to hospitalization outcomes J Gerontol A Biol Sci Med Sci 58 2003 1042 1045
19. M.J. Schuurmans, S.A. Duursma, and L.M. Shortridge-Baggett Elderly patients with a hip fracture: the risk for delirium Appl Nurs Res 16 2003 75 84
20. B. Yildizeli, M.O. Ozyurtkan, and H.F. Batirel Factors associated with postoperative delirium after thoracic surgery Ann Thorac Surg 79 2005 1004 1009
21. M. Lundstrom, A. Edlund, and G. Bucht Dementia after delirium in patients with femoral neck fractures J Am Geriatr Soc 51 Jul 2003 1002 1006
22. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. (DSM-IV), Washington, (DC): American Psychiatric Association; 1994.
23. L. Caeiro, J.M. Ferro, R. Albuquerque, and M.L. Figueira Delirium in the first days of acute stroke J Neurol 251 2004 171 178
24. V. Vatsavayi, S. Malhotra, and K. Franco Agitated delirium with posterior cerebral artery infarction J Emerg Med 24 2003 263 266
25. L. Caeiro, C. Menger, and J.M. Ferro Delirium in acute subarachnoid haemorrhage Cerebrovasc Dis 19 2004 31 38
26. I.W. Tremont-Lukats, G. Bobustuc, and G.K. Lagos Brain metastasis from prostate carcinoma: the M.D. Anderson Cancer Center experience Cancer 98 2003 363 368
27. J. Syrjanen Central nervous system complications in patients with bacteremia Scand J Infect Dis 21 3 1989 285 296
28. G. Zuccala, A. Cocchi, and G. Gambassi Postsurgical complications in older patients. The role of pharmacological intervention Drugs Aging 5 1994 419 430
29. T.W. Heinrich, and G. Grahm Hypothyroidism presenting as psychosis. Myxedema madness revisited Prim Care Companion J Clin Psychiatry 5 2003 260 266
30. P.J. Velasco, M. Manshadi, K. Breen, and S. Lippmann Psychiatric aspects of parathyroid disease Psychosomatics 40 1999 486 490
31. B. Robertsson, K. Blennow, and G. Brane Hyperactivity in the hypothalamic-pituitary-adrenal axis in demented patients with delirium Int Clin Psychopharmacol 16 2001 39 47
32. J. Bucerius, J.F. Gummert, and M.A. Borger Predictors of delirium after cardiac surgery delirium: effect of beating-heart (off-pump) surgery J Thorac Cardiovasc Surg 127 2004 57 64
33. A.I. Granberg Axell, C.W. Malmros, I.L. Bergbom, and D.B. Lundberg Intensive care unit syndrome/delirium is associated with anemia, drug therapy and duration of ventilation treatment Acta Anaesthesiol Scand 46 2002 726 731
34. M. Kashiwagi, T. Tanabe, M. Shichiri, and H. Tamai Differential diagnosis in children having delirium associated with high fever No To Hattatsu 35 2003 310 315
35. A. Alciati, A. Fusi, and A. D'Arminio Monforte New-onset delusions and hallucinations in patients infected with HIV J Psychiatry Neurosci 26 2001 229 234
36. F.S. Santos, I.T. Velasco, and R. Fraguas Jr. Risk factors for delirium in the elderly after coronary artery bypass graft surgery Int Psychogeriatr 16 2004 175 193
37. Wound, Ostomy, and Continence Nurses Society. Identifying and treating reversible causes of urinary incontinence Ostomy Wound Manage 2003;49:28-33.
38. J.M. Bostwick The many faces of confusion. Timing and collateral history often hold the key to diagnosis Postgrad Med 108 2000 60 72
39. K. Olofsson, C. Alling, D. Lundberg, and C. Malmros Abolished circadian rhythm of melatonin secretion in sedated and artificially ventilated intensive care patients Acta Anaesthesiol Scand 48 2004 679 684
40. W.H. Waale, E. Bruijns, and P.J. Dautzenberg Delirium due to urinary retention: confusing for both the patient and the doctor Tijdschr Gerontol Geriatr 32 2001 100 103
41. J.H. Flaherty, S.H. Tariq, and S. Raghavan A model for managing delirious older inpatients J Am Geriatr Soc 51 2003 1031 1035
42. D.J. Culley, M. Baxter, R. Yukhananov, and G. Crosby The memory effects of general anesthesia persist for weeks in young and aged rats Anesth Analg 96 2003 1004 1009
43. N.P. Franks, and W.R. Lieb Molecular and cellular mechanisms of general anaesthesia Nature 367 1994 607 614
44. K.R. Magnusson, C. Scanga, A.E. Wagner, and C. Dunlop Changes in anesthetic sensitivity and glutamate receptors in the aging canine brain J Gerontol A Biol Sci Med Sci 55 2000 B448 B454
45. D.K. Ingram, P. Garofalo, and E.L. Spangler Reduced density of NMDA receptors and increased sensitivity to dizocilpine induced learning impairment in aged rats Brain Res 580 1992 273 280
46. R.E. Mrak, S.T. Griffin, and D.I. Graham Aging-associated changes in human brain J Neuropathol Exp Neurol 56 1997 1269 1275
47. R.C. van der Mast Pathophysiology of delirium J Geriatr Psychiatry Neurol 11 1998 138 145
48. J.M. Flacker, and L.A. Lipsitz Neural mechanisms of delirium: current hypotheses and evolving concepts J Gerontol A Biol Sci Med Sci 54 1999 B275
49. R. Strong Neurochemical changes in the aging human brain: implications for behavioral impairment and neurodegenerative disease Geriatrics 53 Suppl 1 1998 S9 S12
50. P. Eikelenboom, and W.J. Hoogendijk Do delirium and Alzheimer's dementia share specific pathogenetic mechanisms? Dement Geriatr Cogn Disord 10 1999 319 324
51. S. Hayley, Z. Merali, and H. Anisman Stress and cytokine-elicited neuroendocrine and neurotransmitter sensitization: implications for depressive illness Stress 6 2003 19 32
52. E. Perry, M. Walker, J. Grace, and R. Perry Acetylcholine in mind: a neurotransmitter correlate of consciousness? Trends Neurosci 22 1999 273 280
53. E.K. Perry, and R.H. Perry Acetylcholine and hallucinations. disease-related compared to drug-induced alterations in human consciousness Brain Cogn 28 1995 240 258
54. E. O'Hare, D.T. Weldon, and K. Bettin Serum anticholinergic activity and behavior following atropine sulfate administration in the rat Pharmacol Biochem Behav 56 1997 151 154
55. C.A. Ross, C.E. Peyser, I. Shapiro, and M.F. Folstein CNS arousal systems: possible role in delirium Int Psychogeriatr 3 1991 353 371
56. L.E. Tune, and S. Egeli Acetylcholine and delirium Dement Geriatr Cogn Disord 10 1999 342
57. V. Fodale, and L.B. Santamaria The inhibition of central nicotinic nAch receptors is the possible cause of prolonged cognitive impairment after anesthesia Anesth Analg 97 2003 1207
58. V. Fodale, and L.B. Santamaria Drugs of anesthesia, central nicotinic receptors and post-operative cognitive dysfunction Acta Anaesthesiol Scand 47 2003 1180
59. J.S. Felsch, T.G. Cachero, and E.G. Peralta Activation of protein tyrosine kinase PYK2 by the m1 muscarinic acetylcholine receptor Proc Natl Acad Sci USA 95 1998 5051 5056
60. M. Mangelus, A. Kroyter, R. Galron, and M. Sokolovsky Reactive oxygen species regulate signaling pathways induced by M1 muscarinic receptors in PC12M1 cells J Neurochem 76 2001 1701 1711
61. 3 muscarinic receptors induces phosphorylation of the Cdc42 effector activated Cdc42Hs-associated Kinase-1 via a fyn tyrosine kinase signaling pathway J Biol Chem 276 2001 5622 5628
62. P.G. Wylie, R.A. Challiss, and J.L. Blank Regulation of extracellular-signal regulated kinase and c-Jun N-terminal kinase by G-protein-linked muscarinic acetylcholine receptors Biochem J 338 1999 619 628
63. H. von der Kammer, C. Demiralay, and B. Andresen Regulation of gene expression by muscarinic acetylcholine receptors Biochem Soc Symp 67 2001 131 140
64. L. Tune, S. Carr, E. Hoag, and T. Cooper Anticholinergic effects of drugs commonly prescribed in the elderly: potential means for assessing risk for delirium Am J Psychiatry 149 1992 1393 1394
65. G. Roldan, E. Bolanos-Badillo, and H. Gonzalez-Sanchez Selective M1 muscarinic receptor antagonists disrupt memory consolidation of inhibitory avoidance in rats Neurosci Lett 230 1997 93 96
66. C. Mussi, R. Ferrari, S. Ascari, and G. Salvioli Importance of serum anticholinergic activity in the assessment of elderly patients with delirium J Geriatr Psychiatry Neurol 12 1999 82 86
67. B.A. Boucher, W.O. Witt, and T.S. Foster The postoperative adverse effects of inhalational anesthetics Heart Lung 15 1986 63 69
68. M.L. Ancelin, G. De Roquefeuil, and K. Ritchie Anesthesia and postoperative cognitive dysfunction in the elderly: a review of clinical and epidemiological observations Rev Epidemiol Sante Publique 48 2000 459 472
69. T. Shichino, M. Murakawa, and T. Adachi Effects of inhalation anaesthetics on the release of acetylcholine in the rat cerebral cortex in vivo Br J Anaesth 80 1998 365 370
70. G.W. Nietgen, C.W. Honemann, and C.K. Chan Volatile anaesthetics have differential effects on recombinant m1 and m3 muscarinic acetylcholine receptor function Br J Anaesth 81 1998 569 577
71. O. Murasaki, M. Kaibara, and Y. Nagase Site of action of the general anesthetic propofol in muscarinic M1 receptor-mediated signal transduction J Pharmacol Exp Ther 307 2003 995 1000
72. A. Nordberg, and G. Wahlstrom Cholinergic mechanisms in physical dependence on barbiturates, ethanol and benzodiazepines J Neural Transm Gen Sect 88 1992 199 221
73. K. Abe, K. Taguchi, and M. Kato Characterization of muscarinic receptor subtypes in the rostral ventrolateral medulla and effects on morphine-induced antinociception in rats Eur J Pharmacol 465 2003 237 249
74. J.J. Buccafusco Inhibition of the morphine withdrawal syndrome by a novel muscarinic antagonist (4-DAMP) Life Sci 48 1991 749 756
75. T. Yamanoue, J.M. Brum, and F.G. Estafanous Fentanyl attenuates porcine coronary arterial contraction through M3-muscarinic antagonism Anesth Analg 76 1993 382 390
76. O. Shibata, A. Tsuda, and T. Makita Contractile and phosphatidylinositol responses of rat trachea to anticholinesterase drugs Can J Anaesth 45 1998 1190 1195
77. M.H. Yoon, J.I. Choi, and S.W. Jeong Antinociception of intrathecal cholinesterase inhibitors and cholinergic receptors in rats Acta Anaesthesiol Scand 47 2003 1079 1084
78. E. Jooste, F. Klafter, C.A. Hirshman, and C.W. Emala A mechanism for rapacuronium-induced bronchospasm: M2 muscarinic receptor antagonism Anesthesiology 98 2003 906 911
79. V.Y. Hou, C.A. Hirshman, and C.W. Emala Neuromuscular relaxants as antagonists for M2 and M3 muscarinic receptors Anesthesiology 88 1998 744 750
80. A.L. Melnikov, K.Y. Malakhov, K.G. Helgesen, and D.A. Lathrop Cardiac effects of non-depolarizing neuromuscular blocking agents pancuronium, vecuronium, and rocuronium in isolated rat atria Gen Pharmacol 33 1999 313 317
81. L.E. Tune Serum anticholinergic activity levels and delirium in the elderly Semin Clin Neuropsychiatry 5 2000 149 153
82. J.S. Richardson, P.S. Miller, and J.S. Lemay Mental dysfunction and the blockade of muscarinic receptors in the brains of the normal elderly Prog Neuropsychopharmacol Biol Psychiatry 9 1985 651 654
83. M.G. Vannucchi, and G. Pepeu Muscarinic receptor modulation of acetylcholine release from rat cerebral cortex and hippocampus Neurosci Lett 190 1995 53 56
84. M.G. Vannucchi, C. Scali, and S.R. Kopf Muscarinic antagonists differentially affect in vivo acetylcholine release and memory performances of young and aged rats Neuroscience 79 1997 837 846
85. E. Freye, and J.V. Levy Use of opioids in the elderly - pharmacokinetic and pharmacodynamic considerations Anasthesiol Intensivmed Notfallmed Schmerzther 39 2004 527 537