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Volumn 5, Issue 4, 2009, Pages 210-220

Delirium in elderly adults: Diagnosis, prevention and treatment

Author keywords

[No Author keywords available]

Indexed keywords

DONEPEZIL; HALOPERIDOL; LORAZEPAM; OLANZAPINE; QUETIAPINE; RISPERIDONE;

EID: 67649210721     PISSN: 17594758     EISSN: 17594766     Source Type: Journal    
DOI: 10.1038/nrneurol.2009.24     Document Type: Review
Times cited : (680)

References (120)
  • 2
    • 52949116805 scopus 로고    scopus 로고
    • Understanding international differences in terminology for delirium and other types of acute brain dysfunction in critically ill patients
    • Morandi, A. et al. Understanding international differences in terminology for delirium and other types of acute brain dysfunction in critically ill patients. Intensive Care Med. 34, 1907-1915 (2008).
    • (2008) Intensive Care Med , vol.34 , pp. 1907-1915
    • Morandi, A.1
  • 3
    • 0032780701 scopus 로고    scopus 로고
    • Predisposing and precipitating factors for delirium in hospitalized older patients
    • Inouye, S. K. Predisposing and precipitating factors for delirium in hospitalized older patients. Dement. Geriatr. Cogn. Disord. 10 393-400 (1999).
    • (1999) Dement. Geriatr. Cogn. Disord , vol.10 , pp. 393-400
    • Inouye, S.K.1
  • 4
    • 0032447083 scopus 로고    scopus 로고
    • Delirium in hospitalized older patients: Recognition and risk factors
    • Inouye, S. K. Delirium in hospitalized older patients: Recognition and risk factors. J. Geriatr. Psychiatry Neurol. 11, 118-125 (1998).
    • (1998) J. Geriatr. Psychiatry Neurol , vol.11 , pp. 118-125
    • Inouye, S.K.1
  • 5
    • 33846413452 scopus 로고    scopus 로고
    • US Department of Health and Human Services, publication no. 03445, Centers for Medicare and Medicaid Services, Washington, DC
    • US Department of Health and Human Services. CMS statistics (publication no. 03445, Centers for Medicare and Medicaid Services, Washington, DC, 2004).
    • (2004) CMS statistics
  • 6
    • 0031727578 scopus 로고    scopus 로고
    • Delirium in hospitalized older patients
    • Inouye, S. K. Delirium in hospitalized older patients. Clin. Geriatr. Med. 14, 745-764 (1998).
    • (1998) Clin. Geriatr. Med , vol.14 , pp. 745-764
    • Inouye, S.K.1
  • 7
    • 33745403310 scopus 로고    scopus 로고
    • Occurrence and outcome of delirium in medical in-patients: A systematic literature review
    • Siddiqi, N., House, A. O. & Holmes, J. D. Occurrence and outcome of delirium in medical in-patients: A systematic literature review. Age Ageing 35, 350-364 (2006).
    • (2006) Age Ageing , vol.35 , pp. 350-364
    • Siddiqi, N.1    House, A.O.2    Holmes, J.D.3
  • 8
    • 33847792894 scopus 로고    scopus 로고
    • The incidence of delirium associated with orthopedic surgery: A meta-analytic review
    • Bruce, A. J., Ritchie, C. W., Blizard, R., Lai, R. & Raven, P. The incidence of delirium associated with orthopedic surgery: A meta-analytic review. Int. Psychogeriatr. 19, 197-214 (2007).
    • (2007) Int. Psychogeriatr , vol.19 , pp. 197-214
    • Bruce, A.J.1    Ritchie, C.W.2    Blizard, R.3    Lai, R.4    Raven, P.5
  • 9
    • 66149187082 scopus 로고    scopus 로고
    • Delirium in the critically ill patient
    • Girard, T. D. & Ely, E. W. Delirium in the critically ill patient. Handb. Clin. Neurol. 90, 39-56 (2008).
    • (2008) Handb. Clin. Neurol , vol.90 , pp. 39-56
    • Girard, T.D.1    Ely, E.W.2
  • 10
    • 33644988306 scopus 로고    scopus 로고
    • Delirium in older persons
    • Inouye, S. K. Delirium in older persons. N. Engl. J. Med. 354 1157-1165 (2006).
    • (2006) N. Engl. J. Med , vol.354 , pp. 1157-1165
    • Inouye, S.K.1
  • 11
    • 0347624024 scopus 로고    scopus 로고
    • Cognitive impairment in the intensive care unit
    • Pisani, M. A., McNicoll, L. & Inouye, S. K. Cognitive impairment in the intensive care unit. Clin. Chest Med. 24, 727-737 (2003).
    • (2003) Clin. Chest Med , vol.24 , pp. 727-737
    • Pisani, M.A.1    McNicoll, L.2    Inouye, S.K.3
  • 12
    • 33846464630 scopus 로고    scopus 로고
    • Cerebral perfusion changes in older delirious patients using 99mTc HMPAO SPECT
    • Fong, T. G. et al. Cerebral perfusion changes in older delirious patients using 99mTc HMPAO SPECT. J. Gerontol. A Biol. Sci. Med. Sci. 61, 1294-1299 (2006).
    • (2006) J. Gerontol. A Biol. Sci. Med. Sci , vol.61 , pp. 1294-1299
    • Fong, T.G.1
  • 15
    • 0032796101 scopus 로고    scopus 로고
    • Do delirium and Alzheimer's dementia share specific pathogenetic mechanisms?
    • Eikelenboom, P. & Hoogendijk, W. J. Do delirium and Alzheimer's dementia share specific pathogenetic mechanisms? Dement. Geriatr. Cogn. Disord. 10, 319-324 (1999).
    • (1999) Dement. Geriatr. Cogn. Disord , vol.10 , pp. 319-324
    • Eikelenboom, P.1    Hoogendijk, W.J.2
  • 16
    • 0034920302 scopus 로고    scopus 로고
    • Use of medications with anticholinergic effect predicts clinical severity of delirium symptoms in older medical inpatients
    • Han, L. et al. Use of medications with anticholinergic effect predicts clinical severity of delirium symptoms in older medical inpatients. Arch. Intern. Med. 161, 1099-1105 (2001).
    • (2001) Arch. Intern. Med , vol.161 , pp. 1099-1105
    • Han, L.1
  • 17
    • 0016765717 scopus 로고
    • Reversal of lorazepam delirium by physostigmine
    • Blitt, C. D. & Petty, W. C. Reversal of lorazepam delirium by physostigmine. Anesth. Analg. 54, 607-608 (1975).
    • (1975) Anesth. Analg , vol.54 , pp. 607-608
    • Blitt, C.D.1    Petty, W.C.2
  • 18
    • 0017645685 scopus 로고
    • Pheniramine aminosalicylate overdosage. Reversal of delirium and choreiform movements with tacrine treatment
    • Mendelson, G. Pheniramine aminosalicylate overdosage. Reversal of delirium and choreiform movements with tacrine treatment. Arch. Neurol. 34, 313 (1977).
    • (1977) Arch. Neurol , vol.34 , pp. 313
    • Mendelson, G.1
  • 20
    • 0031976089 scopus 로고    scopus 로고
    • The association of serum anticholinergic activity with delirium in elderly medical patients
    • Flacker, J. M. et al. The association of serum anticholinergic activity with delirium in elderly medical patients. Am. J. Geriatr. Psychiatry 6, 31-41 (1998).
    • (1998) Am. J. Geriatr. Psychiatry , vol.6 , pp. 31-41
    • Flacker, J.M.1
  • 21
    • 0029071961 scopus 로고
    • Serum anticholinergic activity in hospitalized older persons with delirium: A preliminary study
    • Mach, J. R. et al. Serum anticholinergic activity in hospitalized older persons with delirium: A preliminary study. J. Am. Geriatr. Soc. 43, 491-495 (1995).
    • (1995) J. Am. Geriatr. Soc , vol.43 , pp. 491-495
    • Mach, J.R.1
  • 22
    • 0032861077 scopus 로고    scopus 로고
    • Importance of serum anticholinergic activity in the assessment of elderly patients with delirium
    • Mussi, C., Ferrari, R., Ascari, S. & Salvioli, G. Importance of serum anticholinergic activity in the assessment of elderly patients with delirium. J. Geriatr. Psychiatry Neurol. 12, 82-86 (1999).
    • (1999) J. Geriatr. Psychiatry Neurol , vol.12 , pp. 82-86
    • Mussi, C.1    Ferrari, R.2    Ascari, S.3    Salvioli, G.4
  • 23
    • 0032935345 scopus 로고    scopus 로고
    • Serum anticholinergic activity changes with acute illness in elderly medical patients
    • Flacker, J. M. & Lipsitz, L. A. Serum anticholinergic activity changes with acute illness in elderly medical patients. J. Gerontol. A Biol. Sci. Med. Sci. 54, M12-M16 (1999).
    • (1999) J. Gerontol. A Biol. Sci. Med. Sci , vol.54
    • Flacker, J.M.1    Lipsitz, L.A.2
  • 24
    • 53749091555 scopus 로고    scopus 로고
    • Serum anticholinergic activity and cerebral cholinergic dysfunction: An EEG study in frail elderly with and without delirium
    • Thomas, C. et al. Serum anticholinergic activity and cerebral cholinergic dysfunction: An EEG study in frail elderly with and without delirium. BMC Neurosci. 9, 86 (2008).
    • (2008) BMC Neurosci , vol.9 , pp. 86
    • Thomas, C.1
  • 25
    • 0034167698 scopus 로고    scopus 로고
    • Is there a final common neural pathway in delirium? Focus on acetylcholine and dopamine
    • Trzepacz, P. T. Is there a final common neural pathway in delirium? Focus on acetylcholine and dopamine. Semin. Clin. Neuropsychiatry 5, 132-148 (2000).
    • (2000) Semin. Clin. Neuropsychiatry , vol.5 , pp. 132-148
    • Trzepacz, P.T.1
  • 26
    • 0030983603 scopus 로고    scopus 로고
    • Neuropsychiatric adverse effects of antiparkinsonian drugs. Characteristics, evaluation and treatment
    • Young, B. K., Camicioli, R. & Ganzini, L. Neuropsychiatric adverse effects of antiparkinsonian drugs. Characteristics, evaluation and treatment. Drugs Aging 10, 367-383 (1997).
    • (1997) Drugs Aging , vol.10 , pp. 367-383
    • Young, B.K.1    Camicioli, R.2    Ganzini, L.3
  • 27
    • 11144340901 scopus 로고    scopus 로고
    • Psychotogenic drugs and delirium pathogenesis: The central role of the thalamus
    • Gaudreau, J. D. & Gagnon, P. Psychotogenic drugs and delirium pathogenesis: The central role of the thalamus. Med. Hypotheses 64, 471-475 (2005).
    • (2005) Med. Hypotheses , vol.64 , pp. 471-475
    • Gaudreau, J.D.1    Gagnon, P.2
  • 28
    • 42449084575 scopus 로고    scopus 로고
    • Chemokines are associated with delirium after cardiac surgery
    • Rudolph, J. L. et al. Chemokines are associated with delirium after cardiac surgery. J. Gerontol. A Biol. Sci. Med. Sci. 63 184-189 (2008).
    • (2008) J. Gerontol. A Biol. Sci. Med. Sci , vol.63 , pp. 184-189
    • Rudolph, J.L.1
  • 29
    • 49149119577 scopus 로고    scopus 로고
    • Unravelling the pathophysiology of delirium: A focus on the role of aberrant stress responses
    • Maclullich, A. M., Ferguson, K. J., Miller, T., de rooij, S. E. & Cunningham, C. Unravelling the pathophysiology of delirium: A focus on the role of aberrant stress responses. J. Psychosom. Res. 65 229-238 (2008).
    • (2008) J. Psychosom. Res , vol.65 , pp. 229-238
    • Maclullich, A.M.1    Ferguson, K.J.2    Miller, T.3    de rooij, S.E.4    Cunningham, C.5
  • 30
    • 54249124166 scopus 로고    scopus 로고
    • Aging, microglial cell priming, and the discordant central inflammatory response to signals from the peripheral immune system
    • Dilger, R. N. & Johnson, R. W. Aging, microglial cell priming, and the discordant central inflammatory response to signals from the peripheral immune system. J. Leukoc. Biol. 84, 932-939 (2008).
    • (2008) J. Leukoc. Biol , vol.84 , pp. 932-939
    • Dilger, R.N.1    Johnson, R.W.2
  • 31
    • 33746724668 scopus 로고    scopus 로고
    • Effects of cytokines and infections on brain neurochemistry
    • Dunn, A. J. Effects of cytokines and infections on brain neurochemistry. Clin. Neurosci. Res. 6, 52-68 (2006).
    • (2006) Clin. Neurosci. Res , vol.6 , pp. 52-68
    • Dunn, A.J.1
  • 32
    • 0035996342 scopus 로고    scopus 로고
    • Immunological mechanisms and the spectrum of psychiatric syndromes in Alzheimer's disease
    • Eikelenboom, P., Hoogendijk, W. J., Jonker, C. & van Tilburg, W. Immunological mechanisms and the spectrum of psychiatric syndromes in Alzheimer's disease. J. Psychiatr. Res. 36, 269-280 (2002).
    • (2002) J. Psychiatr. Res , vol.36 , pp. 269-280
    • Eikelenboom, P.1    Hoogendijk, W.J.2    Jonker, C.3    van Tilburg, W.4
  • 34
    • 58349119112 scopus 로고    scopus 로고
    • Systemic inflammation induces acute behavioral and cognitive changes and accelerates neurodegenerative disease
    • Cunningham, C. et al. Systemic inflammation induces acute behavioral and cognitive changes and accelerates neurodegenerative disease. Biol. Psychiatry 65, 304-312 (2009).
    • (2009) Biol. Psychiatry , vol.65 , pp. 304-312
    • Cunningham, C.1
  • 35
    • 51249084777 scopus 로고    scopus 로고
    • Time-course of cytokines during delirium in elderly patients with hip fractures
    • van Munster, B. C. et al. Time-course of cytokines during delirium in elderly patients with hip fractures. J. Am. Geriatr. Soc. 56 1704-1709 (2008).
    • (2008) J. Am. Geriatr. Soc , vol.56 , pp. 1704-1709
    • van Munster, B.C.1
  • 37
    • 17244375167 scopus 로고    scopus 로고
    • Postoperative interleukin-6 and cortisol concentrations in elderly patients with postoperative confusion
    • Kudoh, A., Takase, H., Katagai, H. & Takazawa, T. Postoperative interleukin-6 and cortisol concentrations in elderly patients with postoperative confusion. Neuroimmunomodulation 12, 60-66 (2005).
    • (2005) Neuroimmunomodulation , vol.12 , pp. 60-66
    • Kudoh, A.1    Takase, H.2    Katagai, H.3    Takazawa, T.4
  • 38
    • 0022389485 scopus 로고
    • Beta-endorphin, cortisol and postoperative delirium: A preliminary report
    • Mcintosh, T. K. et al. Beta-endorphin, cortisol and postoperative delirium: A preliminary report. Psychoneuroendocrinology 10, 303-313 (1985).
    • (1985) Psychoneuroendocrinology , vol.10 , pp. 303-313
    • Mcintosh, T.K.1
  • 39
    • 0035173587 scopus 로고    scopus 로고
    • Hyperactivity in the hypothalamic-pituitary-adrenal axis in demented patients with delirium
    • Robertsson, B. et al. Hyperactivity in the hypothalamic-pituitary-adrenal axis in demented patients with delirium. Int. Clin. Psychopharmacol. 16, 39-47 (2001).
    • (2001) Int. Clin. Psychopharmacol , vol.16 , pp. 39-47
    • Robertsson, B.1
  • 40
    • 0027947589 scopus 로고
    • Delirium and the dexamethasone suppression test in the elderly
    • O'Keeffe, s. T. & Devlin, J. G. Delirium and the dexamethasone suppression test in the elderly. Neuropsychobiology 30, 153-156 (1994).
    • (1994) Neuropsychobiology , vol.30 , pp. 153-156
    • O'Keeffe, S.T.1    Devlin, J.G.2
  • 41
    • 0021229315 scopus 로고
    • Clinical use of the DST in a psychogeriatric population
    • McKeith, I. G. Clinical use of the DST in a psychogeriatric population. Br. J. Psychiatry 145, 389-393 (1984).
    • (1984) Br. J. Psychiatry , vol.145 , pp. 389-393
    • McKeith, I.G.1
  • 42
    • 49149129827 scopus 로고    scopus 로고
    • Neuroimaging studies of delirium: A systematic review
    • Soiza, R. L. et al. Neuroimaging studies of delirium: A systematic review. J. Psychosom. Res. 65, 239-248 (2008).
    • (2008) J. Psychosom. Res , vol.65 , pp. 239-248
    • Soiza, R.L.1
  • 44
    • 0029121097 scopus 로고
    • Delirium in critical care unit patients admitted through an emergency room
    • Kishi, Y., Iwasaki, Y., Takezawa, K., Kurosawa, H. & Endo, S. Delirium in critical care unit patients admitted through an emergency room. Gen. Hosp. Psychiatry 17, 371-379 (1995).
    • (1995) Gen. Hosp. Psychiatry , vol.17 , pp. 371-379
    • Kishi, Y.1    Iwasaki, Y.2    Takezawa, K.3    Kurosawa, H.4    Endo, S.5
  • 45
    • 0037367837 scopus 로고    scopus 로고
    • Oral amino acid load mimicking hemoglobin results in reduced regional cerebral perfusion and deterioration in memory tests in patients with cirrhosis of the liver
    • Jalan, R. et al. Oral amino acid load mimicking hemoglobin results in reduced regional cerebral perfusion and deterioration in memory tests in patients with cirrhosis of the liver. Metab. Brain Dis. 18 37-49 (2003).
    • (2003) Metab. Brain Dis , vol.18 , pp. 37-49
    • Jalan, R.1
  • 46
    • 0032697076 scopus 로고    scopus 로고
    • Regional cerebral blood flow during mechanical hyperventilation in patients with fulminant hepatic failure
    • Strauss, G. I. et al. Regional cerebral blood flow during mechanical hyperventilation in patients with fulminant hepatic failure. Hepatology 30, 1368-1373 (1999).
    • (1999) Hepatology , vol.30 , pp. 1368-1373
    • Strauss, G.I.1
  • 47
    • 0242656102 scopus 로고    scopus 로고
    • Value of regional cerebral blood flow in the evaluation of chronic liver disease and subclinical hepatic encephalopathy
    • Yazgan, Y. et al. Value of regional cerebral blood flow in the evaluation of chronic liver disease and subclinical hepatic encephalopathy. J. Gastroenterol. Hepatol. 18, 1162-1167 (2003).
    • (2003) J. Gastroenterol. Hepatol , vol.18 , pp. 1162-1167
    • Yazgan, Y.1
  • 48
    • 33846451414 scopus 로고    scopus 로고
    • The role of neuroimaging in elucidating delirium pathophysiology
    • Alsop, D. C. et al. The role of neuroimaging in elucidating delirium pathophysiology. J. Gerontol. A Biol. Sci. Med. Sci. 61, 1287-1293 (2006).
    • (2006) J. Gerontol. A Biol. Sci. Med. Sci , vol.61 , pp. 1287-1293
    • Alsop, D.C.1
  • 49
    • 0020599382 scopus 로고
    • Transient cognitive disorders (delirium, acute confusional states) in the elderly
    • Lipowski, Z. J. Transient cognitive disorders (delirium, acute confusional states) in the elderly. Am. J. Psychiatry 140, 1426-1436 (1983).
    • (1983) Am. J. Psychiatry , vol.140 , pp. 1426-1436
    • Lipowski, Z.J.1
  • 51
    • 51349133993 scopus 로고    scopus 로고
    • Diagnostic yield of cerebral imaging in patients with acute confusion
    • Hufschmidt, A. & Shabarin, V. Diagnostic yield of cerebral imaging in patients with acute confusion. Acta Neurol. Scand. 118, 245-250 (2008).
    • (2008) Acta Neurol. Scand , vol.118 , pp. 245-250
    • Hufschmidt, A.1    Shabarin, V.2
  • 52
    • 0025667229 scopus 로고
    • Clarifying confusion: The confusion assessment method. A new method for detection of delirium
    • Inouye, S. K. et al. Clarifying confusion: The confusion assessment method. A new method for detection of delirium. Ann. Intern. Med. 113, 941-948 (1990).
    • (1990) Ann. Intern. Med , vol.113 , pp. 941-948
    • Inouye, S.K.1
  • 53
    • 43249127769 scopus 로고    scopus 로고
    • The Confusion Assessment Method: A systematic review of current usage
    • Wei, L. A., Fearing, M. A., Sternberg, E. J. & Inouye, S. K. The Confusion Assessment Method: A systematic review of current usage. J. Am. Geriatr. Soc. 56, 823-830 (2008).
    • (2008) J. Am. Geriatr. Soc , vol.56 , pp. 823-830
    • Wei, L.A.1    Fearing, M.A.2    Sternberg, E.J.3    Inouye, S.K.4
  • 54
    • 0030955090 scopus 로고    scopus 로고
    • The Memorial Delirium Assessment Scale
    • Breitbart, W. et al. The Memorial Delirium Assessment Scale. J. Pain Symptom Manage. 13, 128-137 (1997).
    • (1997) J. Pain Symptom Manage , vol.13 , pp. 128-137
    • Breitbart, W.1
  • 55
    • 70350172979 scopus 로고    scopus 로고
    • The Hospital Elder Life Program HELP
    • The Hospital Elder Life Program (HELP) http://www.hospitalelderlifeprogram.org.
  • 56
    • 0033522146 scopus 로고    scopus 로고
    • A multicomponent intervention to prevent delirium in hospitalized older patients
    • Inouye, S. K. et al. A multicomponent intervention to prevent delirium in hospitalized older patients. N. Engl. J. Med. 340 669-676 (1999).
    • (1999) N. Engl. J. Med , vol.340 , pp. 669-676
    • Inouye, S.K.1
  • 58
    • 31144444672 scopus 로고    scopus 로고
    • Caplan, G. A., Coconis, J., Board, N., Sayers, A. & Woods, J. Does home treatment affect delirium? A randomised controlled trial of rehabilitation of elderly and care at home or usual treatment (The REACH-OUT trial). Age Ageing 35, 53-60 (2006).
    • Caplan, G. A., Coconis, J., Board, N., Sayers, A. & Woods, J. Does home treatment affect delirium? A randomised controlled trial of rehabilitation of elderly and care at home or usual treatment (The REACH-OUT trial). Age Ageing 35, 53-60 (2006).
  • 59
    • 0033386143 scopus 로고    scopus 로고
    • Prophylactic consecutive administration of haloperidol can reduce the occurrence of postoperative delirium in gastrointestinal surgery
    • Kaneko, T. et al. Prophylactic consecutive administration of haloperidol can reduce the occurrence of postoperative delirium in gastrointestinal surgery. Yonago Acta. Med. 42, 179-184 (1999).
    • (1999) Yonago Acta. Med , vol.42 , pp. 179-184
    • Kaneko, T.1
  • 60
    • 30944447824 scopus 로고    scopus 로고
    • Haloperidol prophylaxis for elderly hip-surgery patients at risk for delirium: A randomized placebo-controlled study
    • Kalisvaart, K. J. et al. Haloperidol prophylaxis for elderly hip-surgery patients at risk for delirium: A randomized placebo-controlled study. J. Am. Geriatr. Soc. 53, 1658-1666 (2005).
    • (2005) J. Am. Geriatr. Soc , vol.53 , pp. 1658-1666
    • Kalisvaart, K.J.1
  • 62
    • 34247629541 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled trial of donepezil hydrochloride (Aricept) for reducing the incidence of postoperative delirium after elective total hip replacement
    • Sampson, E. L. et al. A randomized, double-blind, placebo-controlled trial of donepezil hydrochloride (Aricept) for reducing the incidence of postoperative delirium after elective total hip replacement. Int. J. Geriatr. Psychiatry 22, 343-349 (2007).
    • (2007) Int. J. Geriatr. Psychiatry , vol.22 , pp. 343-349
    • Sampson, E.L.1
  • 64
    • 1542298870 scopus 로고    scopus 로고
    • Treatment of opioid-induced delirium with acetylcholinesterase inhibitors: A case report
    • Slatkin, N. & Rhiner, M. Treatment of opioid-induced delirium with acetylcholinesterase inhibitors: A case report. J. Pain Symptom Manage. 27, 268-273 (2004).
    • (2004) J. Pain Symptom Manage , vol.27 , pp. 268-273
    • Slatkin, N.1    Rhiner, M.2
  • 65
    • 0032433872 scopus 로고    scopus 로고
    • Donepezil improves symptoms of delirium in dementia: Implications for future research
    • Wengel, S. P., Roccaforte, W. H. & Burke, W. J. Donepezil improves symptoms of delirium in dementia: Implications for future research. J. Geriatr. Psychiatry Neurol. 11, 159-161 (1998).
    • (1998) J. Geriatr. Psychiatry Neurol , vol.11 , pp. 159-161
    • Wengel, S.P.1    Roccaforte, W.H.2    Burke, W.J.3
  • 66
    • 0041836176 scopus 로고    scopus 로고
    • Donepezil for postoperative delirium
    • Gleason, O. C. Donepezil for postoperative delirium. Psychosomatics 44, 437-438 (2003).
    • (2003) Psychosomatics , vol.44 , pp. 437-438
    • Gleason, O.C.1
  • 68
    • 33749848156 scopus 로고    scopus 로고
    • Pilot clinical trial of gabapentin to decrease postoperative delirium in older patients
    • Leung, J. M. et al. Pilot clinical trial of gabapentin to decrease postoperative delirium in older patients. Neurology 67, 1251-1253 (2006).
    • (2006) Neurology , vol.67 , pp. 1251-1253
    • Leung, J.M.1
  • 69
    • 0029019910 scopus 로고
    • Dexmedetomidine premedication attenuates ketamine-induced cardiostimulatory effects and postanesthetic delirium
    • Levanen, J., Makela, M. L. & Scheinin, H. Dexmedetomidine premedication attenuates ketamine-induced cardiostimulatory effects and postanesthetic delirium. Anesthesiology 82, 1117-1125 (1995).
    • (1995) Anesthesiology , vol.82 , pp. 1117-1125
    • Levanen, J.1    Makela, M.L.2    Scheinin, H.3
  • 70
    • 0016086035 scopus 로고
    • Effect of a reorientation technique on postcardiotomy delirium
    • Budd, S. & Brown, W. Effect of a reorientation technique on postcardiotomy delirium. Nurs. Res. 23, 341-348 (1974).
    • (1974) Nurs. Res , vol.23 , pp. 341-348
    • Budd, S.1    Brown, W.2
  • 71
    • 0028007623 scopus 로고
    • Systematic intervention for elderly inpatients with delirium: A randomized trial
    • Cole, M. et al. Systematic intervention for elderly inpatients with delirium: A randomized trial. Can. Med. Assoc. J. 151, 965-970 (1994).
    • (1994) Can. Med. Assoc. J , vol.151 , pp. 965-970
    • Cole, M.1
  • 72
    • 0014264930 scopus 로고
    • Prevention of psychosis following open-heart surgery
    • Lazarus, H. & Hagens, J. Prevention of psychosis following open-heart surgery. Am. J. Psychiatry 124, 1190-1195 (1968).
    • (1968) Am. J. Psychiatry , vol.124 , pp. 1190-1195
    • Lazarus, H.1    Hagens, J.2
  • 73
    • 0029977371 scopus 로고    scopus 로고
    • The use of environmental strategies and psychotropic medication in the management of delirium
    • Meagher, D., O'Hanlon, D., O'Mahony, E. & Casey, P. The use of environmental strategies and psychotropic medication in the management of delirium. Br. J. Psychiatry 168, 512-515 (1996).
    • (1996) Br. J. Psychiatry , vol.168 , pp. 512-515
    • Meagher, D.1    O'Hanlon, D.2    O'Mahony, E.3    Casey, P.4
  • 74
    • 0022308289 scopus 로고
    • Reducing acute confusional states in elderly patients with hip fractures
    • Williams, M., Campbell, E., Raynor, W., Mlynarczyk, S. & Ward, S. Reducing acute confusional states in elderly patients with hip fractures. Res. Nurs. Health 8, 329-337 (1985).
    • (1985) Res. Nurs. Health , vol.8 , pp. 329-337
    • Williams, M.1    Campbell, E.2    Raynor, W.3    Mlynarczyk, S.4    Ward, S.5
  • 76
    • 0031745587 scopus 로고    scopus 로고
    • A nonpharmacologic sleep protocol for hospitalized older patients
    • McDowell, J. A., Mion, L. C., Lydon, T. J. & Inouye, S. K. A nonpharmacologic sleep protocol for hospitalized older patients. J. Am. Geriatr. Soc. 46, 700-705 (1998).
    • (1998) J. Am. Geriatr. Soc , vol.46 , pp. 700-705
    • McDowell, J.A.1    Mion, L.C.2    Lydon, T.J.3    Inouye, S.K.4
  • 77
    • 0242285728 scopus 로고    scopus 로고
    • The role of adherence on the effectiveness of nonpharmacologic interventions: Evidence from the delirium prevention trial
    • Inouye, S. K., Bogardus, S. T., Jr, williams, C. S., Leo-summers, L. & Agostini, J. V. The role of adherence on the effectiveness of nonpharmacologic interventions: Evidence from the delirium prevention trial. Arch. Intern. Med. 163, 958-964 (2003).
    • (2003) Arch. Intern. Med , vol.163 , pp. 958-964
    • Inouye, S.K.1    Bogardus Jr, S.T.2    williams, C.S.3    Leo-summers, L.4    Agostini, J.V.5
  • 79
    • 33846865310 scopus 로고    scopus 로고
    • Antipsychotics in the treatment of delirium: A systematic review
    • Seitz, D. P., Gill, S. S. & van Zyl, L. T. Antipsychotics in the treatment of delirium: A systematic review. J. Clin. Psychiatry 68, 11-21 (2007).
    • (2007) J. Clin. Psychiatry , vol.68 , pp. 11-21
    • Seitz, D.P.1    Gill, S.S.2    van Zyl, L.T.3
  • 80
    • 0028082457 scopus 로고
    • Efficacy of neuroleptics for hypoactive delirium
    • Platt, M. M. et al. Efficacy of neuroleptics for hypoactive delirium. J. Neuropsychiatry Clin. Neurosci. 6, 66-67 (1994).
    • (1994) J. Neuropsychiatry Clin. Neurosci , vol.6 , pp. 66-67
    • Platt, M.M.1
  • 81
    • 9044244135 scopus 로고    scopus 로고
    • A double-blind trial of haloperidol, chlorpromazine, and lorazepam in the treatment of delirium in hospitalized AIDS patients
    • Breitbart, W. et al. A double-blind trial of haloperidol, chlorpromazine, and lorazepam in the treatment of delirium in hospitalized AIDS patients. Am. J. Psychiatry 153, 231-237 (1996).
    • (1996) Am. J. Psychiatry , vol.153 , pp. 231-237
    • Breitbart, W.1
  • 82
    • 33846056904 scopus 로고    scopus 로고
    • Olanzapine and haloperidol for senile delirium: A randomized controlled observation
    • Hu, H., Deng, W., Yang, H. & Liu, Y. Olanzapine and haloperidol for senile delirium: A randomized controlled observation. Chin. J. Clin. Rehab. 10, 188-190 (2006).
    • (2006) Chin. J. Clin. Rehab , vol.10 , pp. 188-190
    • Hu, H.1    Deng, W.2    Yang, H.3    Liu, Y.4
  • 83
    • 3042549215 scopus 로고    scopus 로고
    • A double-blind trial of risperidone and haloperidol for the treatment of delirium
    • Han, C. S. & Kim, Y. K. A double-blind trial of risperidone and haloperidol for the treatment of delirium. Psychosomatics 45 297-301 (2004).
    • (2004) Psychosomatics , vol.45 , pp. 297-301
    • Han, C.S.1    Kim, Y.K.2
  • 84
    • 17144364335 scopus 로고    scopus 로고
    • Antipsychotics and dopamine transporter gene polymorphisms in delirium patients
    • Kim, J. Y. et al. Antipsychotics and dopamine transporter gene polymorphisms in delirium patients. Psychiatry Clin. Neurosci. 59, 183-188 (2005).
    • (2005) Psychiatry Clin. Neurosci , vol.59 , pp. 183-188
    • Kim, J.Y.1
  • 87
    • 0036247735 scopus 로고    scopus 로고
    • Delirium severity and psychomotor types: Their relationship with outcomes after hip fracture repair
    • Marcantonio, E., Ta, T., Duthie, E. & Resnick, N. M. Delirium severity and psychomotor types: Their relationship with outcomes after hip fracture repair. J. Am. Geriatr. Soc. 50, 850-857 (2002).
    • (2002) J. Am. Geriatr. Soc , vol.50 , pp. 850-857
    • Marcantonio, E.1    Ta, T.2    Duthie, E.3    Resnick, N.M.4
  • 88
    • 0026506903 scopus 로고
    • Delirium. The occurrence and persistence of symptoms among elderly hospitalized patients
    • Levkoff, S. E. et al. Delirium. The occurrence and persistence of symptoms among elderly hospitalized patients. Arch. Intern. Med. 152, 334-340 (1992).
    • (1992) Arch. Intern. Med , vol.152 , pp. 334-340
    • Levkoff, S.E.1
  • 89
    • 0027295953 scopus 로고
    • Acute delirium and functional decline in the hospitalized elderly patient
    • Murray, A. M. et al. Acute delirium and functional decline in the hospitalized elderly patient. J. Gerontol. 48, M181-M186 (1993).
    • (1993) J. Gerontol , vol.48
    • Murray, A.M.1
  • 90
    • 0037977890 scopus 로고    scopus 로고
    • The prognostic significance of subsyndromal delirium in elderly medical inpatients
    • Cole, M., McCusker, J., Dendukuri, N. & Han, L. The prognostic significance of subsyndromal delirium in elderly medical inpatients. J. Am. Geriatr. Soc. 51, 754-760 (2003).
    • (2003) J. Am. Geriatr. Soc , vol.51 , pp. 754-760
    • Cole, M.1    McCusker, J.2    Dendukuri, N.3    Han, L.4
  • 91
    • 0028719251 scopus 로고
    • Delirium: A major diagnostic and therapeutic challenge for clinicians caring for the elderly
    • Levkoff, S. E. & Marcantonio, E. R. Delirium: A major diagnostic and therapeutic challenge for clinicians caring for the elderly. Compr. Ther. 20, 550-557 (1994).
    • (1994) Compr. Ther , vol.20 , pp. 550-557
    • Levkoff, S.E.1    Marcantonio, E.R.2
  • 92
    • 0034080165 scopus 로고    scopus 로고
    • Delirium is independently associated with poor functional recovery after hip fracture
    • Marcantonio, E. R., Flacker, J. M., Michaels, M. & Resnick, N. M. Delirium is independently associated with poor functional recovery after hip fracture. J. Am. Geriatr. Soc. 48, 618-624 (2000).
    • (2000) J. Am. Geriatr. Soc , vol.48 , pp. 618-624
    • Marcantonio, E.R.1    Flacker, J.M.2    Michaels, M.3    Resnick, N.M.4
  • 93
    • 0141650563 scopus 로고    scopus 로고
    • The course of delirium in older medical inpatients: A prospective study
    • McCusker, J., Cole, M., Dendukuri, N., Han, L. & Belzile, E. The course of delirium in older medical inpatients: A prospective study. J. Gen. Intern. Med. 18, 696-704 (2003).
    • (2003) J. Gen. Intern. Med , vol.18 , pp. 696-704
    • McCusker, J.1    Cole, M.2    Dendukuri, N.3    Han, L.4    Belzile, E.5
  • 94
    • 0027314741 scopus 로고
    • The occurrence and duration of symptoms in elderly patients with delirium
    • Rockwood, K. The occurrence and duration of symptoms in elderly patients with delirium. J. Gerontol. 48, M162-M166 (1993).
    • (1993) J. Gerontol , vol.48
    • Rockwood, K.1
  • 95
    • 0023764364 scopus 로고
    • The reversible dementias: Do they reverse?
    • Clarfield, A. M. The reversible dementias: Do they reverse? Ann. Intern. Med. 109, 476-486 (1988).
    • (1988) Ann. Intern. Med , vol.109 , pp. 476-486
    • Clarfield, A.M.1
  • 96
    • 34247151614 scopus 로고    scopus 로고
    • Impact of delirium on cognition, distress, and health-related quality of life after hematopoietic stem-cell transplantation
    • Fann, J. R., Alfano, C. M., Roth-Roemer, S., Katon, W. J. & Syrjala, K. L. Impact of delirium on cognition, distress, and health-related quality of life after hematopoietic stem-cell transplantation. J. Clin. Oncol. 25, 1223-1231 (2007).
    • (2007) J. Clin. Oncol , vol.25 , pp. 1223-1231
    • Fann, J.R.1    Alfano, C.M.2    Roth-Roemer, S.3    Katon, W.J.4    Syrjala, K.L.5
  • 97
    • 0035052799 scopus 로고    scopus 로고
    • Validating the diagnosis of delirium and evaluating its association with deterioration over a one-year period
    • Katz, I. R. et al. Validating the diagnosis of delirium and evaluating its association with deterioration over a one-year period. Am. J. Geriatr. Psychiatry 9, 148-159 (2001).
    • (2001) Am. J. Geriatr. Psychiatry , vol.9 , pp. 148-159
    • Katz, I.R.1
  • 98
    • 0034828343 scopus 로고    scopus 로고
    • Delirium in older medical inpatients and subsequent cognitive and functional status: A prospective study
    • McCusker, J., Cole, M., Dendukuri, N., Belzile, E. & Primeau, F. Delirium in older medical inpatients and subsequent cognitive and functional status: A prospective study. CMAJ 165, 575-583 (2001).
    • (2001) CMAJ , vol.165 , pp. 575-583
    • McCusker, J.1    Cole, M.2    Dendukuri, N.3    Belzile, E.4    Primeau, F.5
  • 99
    • 0033807096 scopus 로고    scopus 로고
    • Delirium episode as a sign of undetected dementia among community dwelling elderly subjects: A 2 year follow up study
    • Rahkonen, T., Luukkainen-Markkula, R., Paanila, S., Sivenius, J. & Sulkava, R. Delirium episode as a sign of undetected dementia among community dwelling elderly subjects: A 2 year follow up study. J. Neurol. Neurosurg. Psychiatry 69, 519-521 (2000).
    • (2000) J. Neurol. Neurosurg. Psychiatry , vol.69 , pp. 519-521
    • Rahkonen, T.1    Luukkainen-Markkula, R.2    Paanila, S.3    Sivenius, J.4    Sulkava, R.5
  • 100
    • 67649389937 scopus 로고    scopus 로고
    • Delirium accelerates cognitive decline in Alzheimer's disease
    • in press
    • Fong, T. G. et al. Delirium accelerates cognitive decline in Alzheimer's disease. Neurology, in press.
    • Neurology
    • Fong, T.G.1
  • 101
    • 0033219011 scopus 로고    scopus 로고
    • Delirium episodes during the course of clinically diagnosed Alzheimer's disease
    • Baker, F. M., Wiley, C., Kokmen, E., Chandra, V. & Schoenberg, B. S. Delirium episodes during the course of clinically diagnosed Alzheimer's disease. J. Natl Med. Assoc. 91, 625-630 (1999).
    • (1999) J. Natl Med. Assoc , vol.91 , pp. 625-630
    • Baker, F.M.1    Wiley, C.2    Kokmen, E.3    Chandra, V.4    Schoenberg, B.S.5
  • 102
    • 0033640976 scopus 로고    scopus 로고
    • Consequences of not recognizing delirium superimposed on dementia in hospitalized elderly individuals
    • Fick, D. & Foreman, M. Consequences of not recognizing delirium superimposed on dementia in hospitalized elderly individuals. J. Gerontol. Nurs. 26, 30-40 (2000).
    • (2000) J. Gerontol. Nurs , vol.26 , pp. 30-40
    • Fick, D.1    Foreman, M.2
  • 103
    • 0032721873 scopus 로고    scopus 로고
    • The risk of dementia and death after delirium
    • Rockwood, K. et al. The risk of dementia and death after delirium. Age Ageing 28, 551-556 (1999).
    • (1999) Age Ageing , vol.28 , pp. 551-556
    • Rockwood, K.1
  • 104
    • 0017805611 scopus 로고
    • Formulating priorities for quality assurance activity. Description of a method and its application
    • Williamson, J. W. Formulating priorities for quality assurance activity. Description of a method and its application. JAMA 239, 631-637 (1978).
    • (1978) JAMA , vol.239 , pp. 631-637
    • Williamson, J.W.1
  • 106
    • 17044446145 scopus 로고    scopus 로고
    • Selecting target conditions for quality of care improvement in vulnerable older adults
    • Sloss, E. M. et al. Selecting target conditions for quality of care improvement in vulnerable older adults. J. Am. Geriatr. Soc. 48, 363-369 (2000).
    • (2000) J. Am. Geriatr. Soc , vol.48 , pp. 363-369
    • Sloss, E.M.1
  • 107
    • 0033134711 scopus 로고    scopus 로고
    • Delirium: A symptom of how hospital care is failing older persons and a window to improve quality of hospital care
    • Inouye, S. K., Schlesinger, M. J. & Lydon, T. J. Delirium: A symptom of how hospital care is failing older persons and a window to improve quality of hospital care. Am. J. Med. 106, 565-573 (1999).
    • (1999) Am. J. Med , vol.106 , pp. 565-573
    • Inouye, S.K.1    Schlesinger, M.J.2    Lydon, T.J.3
  • 109
    • 28244501929 scopus 로고    scopus 로고
    • Costs and consequences of hip fracture occurrence in old age: An economic perspective
    • Haentjens, P., Lamraski, G. & Boonen, S. Costs and consequences of hip fracture occurrence in old age: An economic perspective. Disabil. Rehabil. 27, 1129-1141 (2005).
    • (2005) Disabil. Rehabil , vol.27 , pp. 1129-1141
    • Haentjens, P.1    Lamraski, G.2    Boonen, S.3
  • 110
    • 33750351974 scopus 로고    scopus 로고
    • The costs of fatal and non-fatal falls among older adults
    • Stevens, J. A., Corso, P. S., Finkelstein, E. A. & Miller, T. R. The costs of fatal and non-fatal falls among older adults. Inj. Prev. 12, 290-295 (2006).
    • (2006) Inj. Prev , vol.12 , pp. 290-295
    • Stevens, J.A.1    Corso, P.S.2    Finkelstein, E.A.3    Miller, T.R.4
  • 111
    • 0043244907 scopus 로고    scopus 로고
    • Economic costs of diabetes in the US in 2002
    • Hogan, P., Dall, T. & Nikolov, P. Economic costs of diabetes in the US in 2002. Diabetes Care 26, 917-932 (2003).
    • (2003) Diabetes Care , vol.26 , pp. 917-932
    • Hogan, P.1    Dall, T.2    Nikolov, P.3
  • 112
    • 33644849222 scopus 로고    scopus 로고
    • Heart disease and stroke statistics - 2006 update: A report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee
    • Thom, T. et al. Heart disease and stroke statistics - 2006 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 113, e85-e151 (2006).
    • (2006) Circulation , vol.113
    • Thom, T.1
  • 113
    • 0035814368 scopus 로고    scopus 로고
    • Delirium in mechanically ventilated patients: Validity and reliability of the confusion assessment method for the intensive care unit (CAM-ICU)
    • Ely, E. W. et al. Delirium in mechanically ventilated patients: validity and reliability of the confusion assessment method for the intensive care unit (CAM-ICU). JAMA 286, 2703-2710 (2001).
    • (2001) JAMA , vol.286 , pp. 2703-2710
    • Ely, E.W.1
  • 114
    • 0034948268 scopus 로고    scopus 로고
    • Evaluation of delirium in critically ill patients: Validation of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU)
    • Ely, E. W. et al. Evaluation of delirium in critically ill patients: Validation of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU). Crit. Care Med. 29, 1370-1379 (2001).
    • (2001) Crit. Care Med , vol.29 , pp. 1370-1379
    • Ely, E.W.1
  • 115
    • 0034984728 scopus 로고    scopus 로고
    • Validation of the Delirium Rating Scale-revised-98: Comparison with the delirium rating scale and the cognitive test for delirium
    • Trzepacz, P. T. et al. Validation of the Delirium Rating Scale-revised-98: Comparison with the delirium rating scale and the cognitive test for delirium. J. Neuropsychiatry Clin. Neurosci. 13, 229-242 (2001).
    • (2001) J. Neuropsychiatry Clin. Neurosci , vol.13 , pp. 229-242
    • Trzepacz, P.T.1
  • 116
    • 0026562407 scopus 로고
    • The delirium symptom interview: An interview for the detection of delirium symptoms in hospitalized patients
    • Albert, M. S. et al. The delirium symptom interview: An interview for the detection of delirium symptoms in hospitalized patients. J. Geriatr. Psychiatry Neurol. 5, 14-21 (1992).
    • (1992) J. Geriatr. Psychiatry Neurol , vol.5 , pp. 14-21
    • Albert, M.S.1
  • 117
    • 0030293351 scopus 로고    scopus 로고
    • The NEECHAM Confusion scale: Construction, validation, and clinical testing
    • Neelon, V. J., Champagne, M. T., Carlson, J. R. & Funk, S. G. The NEECHAM Confusion scale: Construction, validation, and clinical testing. Nurs. Res. 45, 324-330 (1996).
    • (1996) Nurs. Res , vol.45 , pp. 324-330
    • Neelon, V.J.1    Champagne, M.T.2    Carlson, J.R.3    Funk, S.G.4
  • 118
    • 0035023645 scopus 로고    scopus 로고
    • Intensive Care Delirium Screening Checklist: Evaluation of a new screening tool
    • Bergeron, N., Dubois, M. J., Dumont, M., Dial, S. & Skrobik, Y. Intensive Care Delirium Screening Checklist: Evaluation of a new screening tool. Intensive Care Med. 27, 859-864 (2001).
    • (2001) Intensive Care Med , vol.27 , pp. 859-864
    • Bergeron, N.1    Dubois, M.J.2    Dumont, M.3    Dial, S.4    Skrobik, Y.5
  • 120
    • 0029861331 scopus 로고    scopus 로고
    • Validation of a cognitive test for delirium in medical ICU patients
    • Hart, R. P. et al. Validation of a cognitive test for delirium in medical ICU patients. Psychosomatics 37, 533-546 (1996).
    • (1996) Psychosomatics , vol.37 , pp. 533-546
    • Hart, R.P.1


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