Effect of dexmedetomidine added to standard care on ventilator-free time in patients with agitated delirium a randomized clinical trial

JAMA - Journal of the American Medical Association

Volumn 315, Issue 14, 2016, Pages 1460-1468

  Reade, Michael C ^a   Eastwood, Glenn M ^b   Bellomo, Rinaldo ^b   Bailey, Michael ^c   Bersten, Andrew ^d   Cheung, Benjamin ^e   Davies, Andrew ^f   Delaney, Anthony ^g   Ghosh, Angaj ^h   Van Haren, Frank ⁱ   Harley, Nerina ^j   Knight, David ^k   McGuiness, Shay ^l   Mulder, John ^m   O'Donoghue, Steve ⁿ   Simpson, Nicholas ^o   Young, Paul ^p,q  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c MONASH UNIVERSITY   (Australia)

^d FLINDERS MEDICAL CENTRE   (Australia)

^e TOOWOOMBA HOSPITAL   (Australia)

^f PENINSULA HEALTH   (Australia)

^g ROYAL NORTH SHORE HOSPITAL   (Australia)

^h NORTHERN HOSPITAL   (Australia)

ⁱ CANBERRA HOSPITAL   (Australia)

^j ROYAL MELBOURNE HOSPITAL   (Australia)

^k CHRISTCHURCH HOSPITAL   (New Zealand)

^l AUCKLAND CITY HOSPITAL   (New Zealand)

^m WESTERN HOSPITAL   (Australia)

ⁿ ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

^o GEELONG HOSPITAL   (Australia)

^p WELLINGTON HOSPITAL   (New Zealand)

^q MEDICAL RESEARCH INSTITUTE OF NEW ZEALAND   (New Zealand)

more..

Author keywords

[No Author keywords available]

Indexed keywords

DEXMEDETOMIDINE; FENTANYL; HALOPERIDOL; MIDAZOLAM; MORPHINE; OLANZAPINE; PLACEBO; PROPOFOL; QUETIAPINE; RISPERIDONE; HYPNOTIC SEDATIVE AGENT;

ADULT; AGE DISTRIBUTION; AGED; AGITATION; ARTICLE; AUSTRALIA; BRADYCARDIA; COHORT ANALYSIS; CONTROLLED STUDY; DELIRIUM; DEMENTIA; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG DOSE TITRATION; DRUG EFFICACY; EXTUBATION; FEMALE; HEART VENTRICLE TACHYCARDIA; HUMAN; HYPOTENSION; INFORMED CONSENT; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MOTIVATION; MULTICENTER STUDY; NEW ZEALAND; NURSING STAFF; OPEN STUDY; PARALLEL DESIGN; PATIENT CARE; PRESCRIPTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RESTLESSNESS; RISK BENEFIT ANALYSIS; SEX RATIO; TRAUMATIC BRAIN INJURY; TREATMENT OUTCOME; VENTILATOR; ARTIFICIAL VENTILATION; CLINICAL TRIAL; COMPLICATION; CONTRAINDICATIONS; PROPORTIONAL HAZARDS MODEL; PSYCHOMOTOR AGITATION; STATISTICS AND NUMERICAL DATA; TIME FACTOR; VENTILATOR WEANING;

AGED; AUSTRALIA; DELIRIUM; DEXMEDETOMIDINE; DOUBLE-BLIND METHOD; FEMALE; HUMANS; HYPNOTICS AND SEDATIVES; MALE; MIDDLE AGED; NEW ZEALAND; PROPORTIONAL HAZARDS MODELS; PSYCHOMOTOR AGITATION; RESPIRATION, ARTIFICIAL; TIME FACTORS; TREATMENT OUTCOME; VENTILATOR WEANING;

EID: 84963799128     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.2016.2707     Document Type: Article

References (25)

1. Bergeron N, Dubois MJ, Dumont M, et al. Intensive Care Delirium Screening Checklist. Intensive Care Med. 2001;27(5):859-864.
2. Ely EW, Girard TD, Shintani AK, et al. Apolipoprotein E4 polymorphism as a genetic predisposition to delirium in critically ill patients. Crit Care Med. 2007;35(1):112-117.
3. Ely EW, Shintani A, Truman B, et al. Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit. JAMA. 2004;291(14):1753-1762.
4. Pandharipande PP, Girard TD, Jackson JC, et al. Long-term cognitive impairment after critical illness. N Engl J Med. 2013;369(14):1306-1316.
5. Van Den Boogaard M, Schoonhoven L, Evers AW, et al. Delirium in critically ill patients. Crit Care Med. 2012;40(1):112-118.
6. Dubois MJ, Bergeron N, Dumont M, et al. Delirium in an intensive care unit. Intensive Care Med. 2001;27(8):1297-1304.
7. Hoy SM, Keating GM. Dexmedetomidine. Drugs. 2011;71(11):1481-1501.
8. Ely EW, Inouye SK, Bernard GR, et al. Delirium in mechanically ventilated patients. JAMA. 2001;286(21):2703-2710.
9. Devlin JW, Boleski G, Mlynarek M, et al. Motor Activity Assessment Scale. Crit Care Med. 1999;27(7):1271-1275.
10. Therapeutic Goods Administration. Dexmedetomidine Hydrochloride (Precedex) Product Information. 6.0 ed. Canberra, Australia: Therapeutic Goods Administration; 2014.
11. Sessler CN, Gosnell MS, Grap MJ, et al. The Richmond Agitation-Sedation Scale. Am J Respir Crit Care Med. 2002;166(10):1338-1344.
12. Reade MC, O'Sullivan K, Bates S, et al. Dexmedetomidine vs haloperidol in delirious, agitated, intubated patients. Crit Care. 2009;13(3):R75.
13. Lehmann EL, D'Abrera HJM. Nonparametrics: Statistical Methods Based on Ranks. New York, NY: Springer; 2006.
14. Hart GK. The ANZICS CORE. Crit Care Resusc. 2008;10(2):83-88.
15. Pandharipande PP, Pun BT, Herr DL, et al. Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients. JAMA. 2007;298(22):2644-2653.
16. Riker RR, Shehabi Y, Bokesch PM, et al. Dexmedetomidine vs midazolam for sedation of critically ill patients. JAMA. 2009;301(5):489-499.
17. Jakob SM, Ruokonen E, Grounds RM, et al. Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation. JAMA. 2012;307(11):1151-1160.
18. Barr J, Fraser GL, Puntillo K, et al. Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the intensive care unit. Crit Care Med. 2013;41(1):263-306.
19. Mo Y, Zimmermann AE. Role of dexmedetomidine for the prevention and treatment of delirium in intensive care unit patients. Ann Pharmacother. 2013;47(6):869-876.
20. Yapici N, Coruh T, Kehlibar T, et al. Dexmedetomidine in cardiac surgery patients who fail extubation and present with a delirium state. Heart Surg Forum. 2011;14(2):E93-E98.
21. Riker RR, Picard JT, Fraser GL. Prospective evaluation of the Sedation-Agitation Scale for adult critically ill patients. Crit Care Med. 1999;27(7):1325-1329.
22. Devlin JW, Roberts RJ, Fong JJ, et al. Efficacy and safety of quetiapine in critically ill patients with delirium. Crit Care Med. 2010;38(2):419-427.
23. Reade MC, Aitken LM. The problem of definitions in measuring and managing ICU cognitive function. Crit Care Resusc. 2012;14(3):236-243.
24. Haenggi M, Blum S, Brechbuehl R, et al. Effect of sedation level on the prevalence of delirium when assessed with CAM-ICU and ICDSC. Intensive Care Med. 2013;39(12):2171-2179.
25. Patel SB, Poston JT, Pohlman A, et al. Rapidly reversible, sedation-related delirium versus persistent delirium in the intensive care unit. Am J Respir Crit Care Med. 2014;189(6):658-665.