Daily sedation interruption in mechanically ventilated critically ill patients cared for with a sedation protocol: A randomized controlled trial

JAMA

Volumn 308, Issue 19, 2012, Pages 1985-1992

  Mehta, Sangeeta ^a   Burry, Lisa ^b   Cook, Deborah ^c,d   Fergusson, Dean ^e   Steinberg, Marilyn ^a   Granton, John ^b   Herridge, Margaret ^f   Ferguson, Niall ^a   Devlin, John ^g   Tanios, Maged ^h   Dodek, Peter ⁱ   Fowler, Robert ^j,k   Burns, Karen ^k,l,m   Jacka, Michael ⁿ   Olafson, Kendiss ^o   Skrobik, Yoanna ^p   Hébert, Paul ^q   Sabri, Elham ^e   Meade, Maureen ^c,r  

^a MOUNT SINAI HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c MCMASTER UNIVERSITY   (Canada)

^d MCMASTER UNIVERSITY   (Canada)

^e OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^f UNIVERSITY HEALTH NETWORK   (Canada)

^g NORTHEASTERN UNIVERSITY   (United States)

^h LONG BEACH MEMORIAL MEDICAL CENTER   (United States)

ⁱ UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^j SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^k UNIVERSITY OF TORONTO   (Canada)

^l UNIVERSITY OF TORONTO   (Canada)

^m ST MICHAEL'S HOSPITAL   (Canada)

ⁿ UNIVERSITY OF ALBERTA HOSPITAL   (Canada)

^o UNIVERSITY OF MANITOBA   (Canada)

^p MAISONNEUVE ROSEMONT HOSPITAL   (Canada)

^q UNIVERSITY OF OTTAWA   (Canada)

^r HAMILTON HEALTH SCIENCES   (Canada)

more..

Author keywords

[No Author keywords available]

Indexed keywords

BENZODIAZEPINE DERIVATIVE; DEXMEDETOMIDINE; FENTANYL; HYDROMORPHONE; KETAMINE; LORAZEPAM; MIDAZOLAM; MORPHINE; OPIATE; PROPOFOL;

ADULT; ANESTHESIA LEVEL; ARTICLE; ARTIFICIAL VENTILATION; CANADA; CLINICAL PROTOCOL; CONTROLLED STUDY; CRITICALLY ILL PATIENT; DAILY SEDATION INTERRUPTION; DELIRIUM; DRUG INTERMITTENT THERAPY; ENDOTRACHEAL TUBE; EXTUBATION; HUMAN; INTENSIVE CARE UNIT; LENGTH OF STAY; MAJOR CLINICAL STUDY; MEDICAL PRACTICE; MULTICENTER STUDY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTOCOLIZED SEDATION; RANDOMIZED CONTROLLED TRIAL; TERTIARY HEALTH CARE; UNITED STATES; VISUAL ANALOG SCALE; WORKLOAD;

EID: 84869193649     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.2012.13872     Document Type: Article

References (26)

1. Arroliga AC, Thompson BT, Ancukiewicz M, et al; Acute Respiratory Distress Syndrome Network. Use of sedatives, opioids, and neuromuscular blocking agents in patients with acute lung injury and acute respiratory distress syndrome. Crit Care Med. 2008;36(4):1083-1088.
2. Kollef MH, Levy NT, Ahrens TS, Schaiff R, Prentice D, Sherman G. The use of continuous iv sedation is associated with prolongation of mechanical ventilation. Chest. 1998;114(2):541-548.
3. Ouimet S, Kavanagh BP, Gottfried SB, Skrobik Y. Incidence, risk factors and consequences of ICU delirium. Intensive Care Med. 2007;33(1):66-73.
4. Brook AD, Ahrens TS, Schaiff R, et al. Effect of a nursing-implemented sedation protocol on the duration of mechanical ventilation. Crit Care Med. 1999;27(12):2609-2615.
5. Kress JP, Pohlman AS, O'Connor MF, Hall JB. Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation. N Engl J Med. 2000;342(20):1471-1477.
6. Jacobi J, Fraser GL, Coursin DB, et al; Task Force of the American College of Critical Care Medicine (ACCM) of the Society of Critical Care Medicine (SCCM), American Society of Health-System Pharmacists (ASHP), American College of Chest Physicians. Clinical practice guidelines for the sustained use of sedatives and analgesics in the critically ill adult. Crit Care Med. 2002;30(1):119-141.
7. Bucknall TK, Manias E, Presneill JJ. A randomized trial of protocol-directed sedation management for mechanical ventilation in an Australian intensive care unit. Crit Care Med. 2008;36(5):1444-1450.
8. de Wit M, Gennings C, Jenvey WI, Epstein SK. Randomized trial comparing daily interruption of sedation and nursing-implemented sedation algorithm in medical intensive care unit patients. Crit Care. 2008;12(3):R70.
9. Anifantaki S, Prinianakis G, Vitsaksaki E, et al. Daily interruption of sedative infusions in an adult medical-surgical intensive care unit: randomized controlled trial. J Adv Nurs. 2009;65(5):1054-1060.
10. Yiliaz C, Kelebek Girgin N, Ozdemir N, Kutlay O. The effect of nursing-implemented sedation on the duration of mechanical ventilation in the ICU. Ulus Travma Acil Cerrahi Derg. 2010;16(6):521-526.
11. Mehta S, Burry L, Fischer S, et al; Canadian Critical Care Trials Group. Canadian survey of the use of sedatives, analgesics, and neuromuscular blocking agents in critically ill patients. Crit Care Med. 2006;34(2):374-380.
12. Patel RP, Gambrell M, Speroff T, et al. Delirium and sedation in the intensive care unit: survey of behaviors and attitudes of 1384 healthcare professionals. Crit Care Med. 2009;37(3):825-832.
13. Tanios MA, de Wit M, Epstein SK, Devlin JW. Perceived barriers to the use of sedation protocols and daily sedation interruption: amultidisciplinary survey. J Crit Care. 2009;24(1):66-73.
14. Roberts RJ, de Wit M, Epstein SK, Didomenico D, Devlin JW. Predictors for daily interruption of sedation therapy by nurses: a prospective, multicenter study. J Crit Care. 2010;25(4):660.e1-7.
15. Augustes R, Ho KM. Meta-analysis of randomised controlled trials on daily sedation interruption for critically ill adult patients. Anaesth Intensive Care. 2011;39(3):401-409.
16. Mehta S, Burry L, Martinez-Motta JC, et al; Canadian Critical Care Trials Group. A randomized trial of daily awakening in critically ill patients managed with a sedation protocol: a pilot trial. Crit Care Med. 2008;36(7):2092-2099.
17. Riker RR, Picard JT, Fraser GL. Prospective evaluation of the Sedation-Agitation Scale for adult critically ill patients. Crit Care Med. 1999;27(7):1325-1329.
18. Sessler CN, Gosnell MS, Grap MJ, et al. The Richmond Agitation-Sedation Scale: validity and reliability in adult intensive care unit patients. Am J Respir Crit Care Med. 2002;166(10):1338-1344.
19. Bergeron N, Dubois M-J, Dumont M, Dial S, Skrobik Y. Intensive Care Delirium Screening Checklist: evaluation of a new screening tool. Intensive Care Med. 2001;27(5):859-864.
20. Patanwala AE, Duby J, Waters D, Erstad BL. Opioid conversions in acute care. Ann Pharmacother. 2007;41(2):255-266.
21. Girard TD, Kress JP, Fuchs BD, et al. Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial. Lancet. 2008;371(9607):126-134.
22. Weisbrodt L, McKinley S, Marshall AP, Cole L, Seppelt IM, Delaney A. Daily interruption of sedation in patients receiving mechanical ventilation. Am J Crit Care. 2011;20(4):e90-e98.
23. Ruokonen E, Parviainen I, Jakob SM, et al; Dexmedetomidine for Continuous Sedation Investigators. Dexmedetomidine versus propofol/midazolam for long-term sedation during mechanical ventilation. Intensive Care Med. 2009;35(2):282-290.
24. Burry L, Perreault M, Williamson D, et al. A prospective evaluation of sedative, analgesic, antipsychotic and paralytic practices in Canadian mechanically ventilated adults [abstract]. Proc Am Thorac Soc. 2009;179:A5492.
25. O'Connor M, Bucknall T, Manias E. Sedation management in Australian and New Zealand intensive care units: doctors' and nurses' practices and opinions. Am J Crit Care. 2010;19(3):285-295.
26. Burry L, Steinberg M, Kim S, et al; SLEAP Investigators and Canadian Critical Care Trials Group. Clinicians' perspectives on the use of a sedation protocol or daily sedative interruption in mechanically ventilated patients enrolled in a multicenter sedation trial [abstract]. Intensive Care Med. 2011;37:S83.