Dexmedetomidine Controls Systemic Cytokine Levels through the Cholinergic Anti-inflammatory Pathway

Inflammation

Volumn 37, Issue 5, 2014, Pages 1763-1770

  Xiang, Hui ^a   Hu, Bo ^a   Li, Zhifeng ^a   Li, Jianguo ^a  

^a ZHONGNAN HOSPITAL OF WUHAN UNIVERSITY   (China)

Author keywords

cytokine; dexmedetomidine; endotoxemia; the cholinergic anti inflammatory pathway; vagus nerve

Indexed keywords

ALPHA BUNGAROTOXIN; BUNGAROTOXIN RECEPTOR; DEXMEDETOMIDINE; ENDOTOXIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; SODIUM CHLORIDE; TUMOR NECROSIS FACTOR ALPHA; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; ANTIINFLAMMATORY AGENT; AUTACOID; CYTOKINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CHOLINERGIC ACTIVITY; CLINICAL ASSESSMENT; CLINICAL PROTOCOL; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOKINE RESPONSE; DRUG MECHANISM; ELECTRIC ACTIVITY; ENZYME INHIBITION; EXPERIMENTAL ENDOTOXEMIA; INFORMATION PROCESSING; MALE; MOUSE; NONHUMAN; SHAM PROCEDURE; SIGNAL TRANSDUCTION; SUFFOCATION; SURVIVAL RATE; VAGOTOMY; VAGUS NERVE; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; DRUG EFFECTS; ENDOTOXEMIA; INFLAMMATION; METABOLISM; PHYSIOLOGY;

ANIMALIA; MURINAE; MUS;

ADRENERGIC ALPHA-2 RECEPTOR AGONISTS; ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR; ANIMALS; ANTI-INFLAMMATORY AGENTS; CYTOKINES; DEXMEDETOMIDINE; ENDOTOXEMIA; INFLAMMATION; INFLAMMATION MEDIATORS; MALE; MICE; MICE, INBRED BALB C; SIGNAL TRANSDUCTION;

EID: 84918802038     PISSN: 03603997     EISSN: 15732576     Source Type: Journal    
DOI: 10.1007/s10753-014-9906-1     Document Type: Article

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