Long-term cognitive and psychological outcomes in the awakening and breathing controlled trial

American Journal of Respiratory and Critical Care Medicine

Volumn 182, Issue 2, 2010, Pages 183-191

  Jackson, James C ^a,b   Girard, Timothy D ^a,c   Gordon, Sharon M ^a,c   Thompson, Jennifer L ^a   Shintani, Ayumi K ^a   Thomason, Jason W W ^d   Pun, Brenda T ^a   Canonico, Angelo E ^e   Dunn, Janet G ^e   Bernard, Gordon R ^a   Dittus, Robert S ^a,c   Wesley Ely, E ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Clinical Research Center of Excellence   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d Salem Chest Specialists   (United States)

^e SAINT THOMAS HOSPITAL   (United States)

Author keywords

Cognitive impairment; Depression; PTSD; Sedation

Indexed keywords

ADULT; ARTICLE; ARTIFICIAL VENTILATION; BREATHING EXERCISE; CLINICAL PROTOCOL; CLINICAL TRIAL; COGNITION; COGNITIVE DEFECT; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CRITICALLY ILL PATIENT; DAILY LIFE ACTIVITY; DEPRESSION; FEMALE; FOLLOW UP; FUNCTIONAL ASSESSMENT; HUMAN; INTENSIVE CARE; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NEUROPSYCHOLOGICAL TEST; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; PSYCHOLOGICAL ASPECT; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; RISK REDUCTION; SCORING SYSTEM; SEDATION; SINGLE BLIND PROCEDURE; SURVIVAL; TREATMENT OUTCOME; WAKEFULNESS; AGED; CONSCIOUS SEDATION; HOSPITAL DISCHARGE; INTENSIVE CARE UNIT; METHODOLOGY; MIDDLE AGED;

AGED; CLINICAL PROTOCOLS; COGNITION DISORDERS; CONSCIOUS SEDATION; CRITICAL CARE; DEPRESSION; FEMALE; FOLLOW-UP STUDIES; HUMANS; INTENSIVE CARE UNITS; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; PATIENT DISCHARGE; QUALITY OF LIFE; RESPIRATION, ARTIFICIAL; STRESS DISORDERS, POST-TRAUMATIC; VENTILATOR WEANING;

EID: 77956629839     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.200903-0442OC     Document Type: Article

References (71)

1. Arroliga AC, Thompson BT, Ancukiewicz M, Gonzales JP, Guntupalli KK, Park PK, Wiedemann HP, Anzueto A. Use of sedatives, opioids, and neuromuscular blocking agents in patients with acute lung injury and acute respiratory distress syndrome. Crit Care Med 2008;36:1083-1088.
2. Weinert CR, Calvin AD. Epidemiology of sedation and sedation adequacy for mechanically ventilated patients in a medical and surgical intensive care unit. Crit Care Med 2007;35:393-401.
3. Payen JF, Chanques G, Mantz J, Hercule C, Auriant I, Leguillou JL, Binhas M, Genty C, Rolland C, Bosson JL. Current practices in sedation and analgesia for mechanically ventilated critically ill patients: a prospective multicenter patient-based study. Anesthesiology 2007;106:687-695.
4. Heffner JE. A wake-up call in the intensive care unit. N Engl J Med 2000;342:1520-1522.
5. Brochard L. Sedation in the intensive-care unit: good and bad? Lancet 2008;371:95-97.
6. Brook AD, Ahrens TS, Schaiff R, Prentice D, Sherman G, Shannon W, Kollef MH. Effect of a nursing-implemented sedation protocol on the duration of mechanical ventilation. Crit Care Med 1999;27:2609-2615.
7. Kress JP, Pohlman AS, O'Connor MF, Hall JB. Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation. N Engl J Med 2000;342:1471-1477.
8. Girard TD, Kress JP, Fuchs BD, Thomason JW, Schweickert WD, Pun BT, Taichman DB, Dunn JG, Pohlman AS, Kinniry PA, et al. Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial. Lancet 2008;371:126-134.
9. Jones C, Griffiths RD, Humphris G, Skirrow PM. Memory, delusions, and the development of acute posttraumatic stress disorder-related symptoms after intensive care. Crit Care Med 2001;29:573-580.
10. Girard TD, Shintani AK, Jackson JC, Gordon SM, Pun BT, Henderson MS, Dittus RS, Bernard GR, Ely EW. Risk factors for posttraumatic stress disorder symptoms following critical illness requiring mechanical ventilation: a prospective cohort study. Crit Care 2007;11:R28.
11. Kress JP, Gehlbach B, Lacy M, Pliskin N, Pohlman AS, Hall JB. The long-term psychological effects of daily sedative interruption on critically ill patients. Am J Respir Crit Care Med 2003;168:1457-1461.
12. Herridge MS, Batt J, Hopkins RO. The pathophysiology of long-term neuromuscular and cognitive outcomes following critical illness. Crit Care Clin 2008;24:179-199.
13. Hopkins RO, Jackson JC. Long-term neurocognitive function after critical illness. Chest 2006;130:869-878.
14. Girard TD. Wake up and breathe flowchart. (Accessed June 14, 2010.) Available from: http://www.icudelirium.org/docs/WakeUpAndBreathe.pdf
15. Sessler CN, Gosnell MS, Grap MJ, Brophy GM, O'Neal PV, Keane KA, Tesoro EP, Elswick RK. The Richmond Agitation-Sedation Scale: validity and reliability in adult intensive care unit patients. Am J Respir Crit Care Med 2002;166:1338-1344.
16. Jorm AF. A short form of the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE): development and cross-validation. Psychol Med 1994;24:145-153.
17. Jorm AF, Jacomb PA. The Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE): socio-demographic correlates, reliability, validity and some norms. Psychol Med 1989;19:1015-1022.
18. Jorm AF, Scott R, Cullen JS, MacKinnon AJ. Performance of the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) as a screening test for dementia. Psychol Med 1991;21:785-790.
19. Jorm AF. The Informant Questionnaire on cognitive decline in the elderly (IQCODE): a review. Int Psychogeriatr 2004;16:275-293.
20. Ely EW, Inouye SK, Bernard GR, Gordon S, Francis J, May L, Truman B, Speroff T, Gautam S, Margolin R, et al. Delirium in mechanically ventilated patients: validity and reliability of the confusion assessment method for the intensive care unit (CAM-ICU). JAMA 2001;286:2703-2710. (Pubitemid 33135077)
21. Ely EW, Margolin R, Francis J, May L, Truman B, Dittus R, Speroff T, Gautam S, Bernard GR, Inouye SK. Evaluation of delirium in critically ill patients: validation of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU). Crit Care Med 2001;29:1370-1379. (Pubitemid 32641799)
22. Hilsabeck RC, Perry W, Hassanein TI. Neuropsychological impairment in patients with chronic hepatitis C. Hepatology 2002;35:440-446.
23. Vardy J, Wong K, Yi QL, Park A, Maruff P, Wagner L, Tannock IF. Assessing cognitive function in cancer patients. Support Care Cancer 2006;14:1111-1118.
24. Mathiesen HK, Jonsson A, Tscherning T, Hanson LG, Andresen J, Blinkenberg M, Paulson OB, Sorensen PS. Correlation of global N-acetyl aspartate with cognitive impairment in multiple sclerosis. Arch Neurol 2006;63:533-536.
25. Scarmeas N, Albert SM, Manly JJ, Stern Y. Education and rates of cognitive decline in incident Alzheimer's disease. J Neurol Neurosurg Psychiatry 2006;77:308-316.
26. Samra SK, Giordani B, Caveney AF, Clarke WR, Scott PA, Anderson S, Thompson BG, Todd MM. Recovery of cognitive function after surgery for aneurysmal subarachnoid hemorrhage. Stroke 2007;38:1864-1872.
27. Helzner EP, Luchsinger JA, Scarmeas N, Cosentino S, Brickman AM, Glymour MM, Stern Y. Contribution of vascular risk factors to the progression in Alzheimer disease. Arch Neurol 2009;66:343-348.
28. Rasmussen LS, Larsen K, Houx P, Skovgaard LT, Hanning CD, Moller JT. The assessment of postoperative cognitive function. Acta Anaesthesiol Scand 2001;45:275-289.
29. Mollica CM, Maruff P, Vance A. Development of a statistical approach to classifying treatment response in individual children with ADHD. Hum Psychopharmacol 2004;19:445-456.
30. Social Security Death Index. Available at: http://ssdi.rootsweb.com
31. Ihaka R, Gentleman RR. a language for data analysis and graphics. J Comput Graph Statist 1996;5:299-314.
32. Treggiari MM, Romand JA, Yanez ND, Deem SA, Goldberg J, Hudson L, Heidegger CP, Weiss NS. Randomized trial of light versus deep sedation on mental health after critical illness. Crit Care Med 2009;37:2527-2534.
33. Jackson JC, Hart RP, Gordon SM, Hopkins RO, Girard TD, Ely EW. Post-traumatic stress disorder and post-traumatic stress symptoms following critical illness in medical intensive care unit patients: assessing the magnitude of the problem. Crit Care 2007;11:R27.
34. Davydow DS, Gifford JM, Desai SV, Bienvenu OJ, Needham DM. Depression in general intensive care unit survivors: a systematic review. Intensive Care Med 2009;35:796-809.
35. Hopkins RO, Weaver LK, Pope D, Orme JF, Bigler ED, Larson-Lohr V. Neuropsychological sequelae and impaired health status in survivors of severe acute respiratory distress syndrome. Am J Respir Crit Care Med 1999;160:50-56.
36. Marquis KA, Curtis JR, Caldwell ES, Davidson TA, Davis JM, Sanchez P, Rosenbaum G, Hudson LD, Steinberg KP. Neuropsychological sequelae in survivors of ARDS compared with critically ill control patients [abstract]. Am J Respir Crit Care Med 2000;161:A383.
37. Rothenhausler HB, Ehrentraut S, Stoll C, Schelling G, Kapfhammer HP. The relationship between cognitive performance and employment and health status in long-term survivors of the acute respiratory distress syndrome: results of an exploratory study. Gen Hosp Psychiatry 2001;23:90-96.
38. Al-Saidi F, McAndrews MP, Cheung AM, Tansey CM, Matté-Martyn A, Diaz-Granados N, Herridge MS. Neuropsychological sequelae in ARDS survivors [abstract]. Am J Respir Crit Care Med 2003;167:A737.
39. Jackson JC, Hart RP, Gordon SM, Shintani A, Truman B, May L, Ely EW. Six-month neuropsychological outcome of medical intensive care unit patients. Crit Care Med 2003;31:1226-1234.
40. Hopkins RO, Weaver LK, Chan KJ, Orme JF Jr. Quality of life, emotional, and cognitive function following acute respiratory distress syndrome. J Int Neuropsychol Soc 2004;10:1005-1017.
41. Suchyta MR, Hopkins RO, White J, Jephson A, Morris AH. The incidence of cognitive dysfunction after ARDS [abstract]. Am J Respir Crit Care Med 2004;169:A18.
42. Hopkins RO, Weaver LK, Collingridge D, Parkinson RB, Chan KJ, Orme JF Jr. Two-year cognitive, emotional, and quality-of-life outcomes in acute respiratory distress syndrome. Am J Respir Crit Care Med 2005;171:340-347.
43. Hopkins RO, Jackson JC, Wallace C. Neurocognitive impairments in ICU patients with prolonged mechanical ventilation [abstract]. J Int Neuropsychol Soc 2005;11:60.
44. Sukantarat KT, Burgess PW, Williamson RC, Brett SJ. Prolonged cognitive dysfunction in survivors of critical illness. Anaesthesia 2005;60:847-853.
45. Christie JD, Biester RC, Taichman DB, Shull WH Jr, Hansen-Flaschen J, Shea JA, Hopkins RO. Formation and validation of a telephone battery to assess cognitive function in acute respiratory distress syndrome survivors. J Crit Care 2006;21:125-132.
46. Jones C, Griffiths RD, Slater T, Benjamin KS, Wilson S. Significant cognitive dysfunction in non-delirious patients identified during and persisting following critical illness. Intensive Care Med 2006;32:923-926.
47. Jackson JC, Obremskey W, Bauer R, Greevy R, Cotton BA, Anderson V, Song Y, Ely EW. Long-term cognitive, emotional, and functional outcomes in trauma intensive care unit survivors without intracranial hemorrhage. J Trauma 2007;62:80-88.
48. Newman MF, Kirchner JL, Phillips-Bute B, Gaver V, Grocott H, Jones RH, Mark DB, Reves JG, Blumenthal JA. Longitudinal assessment of neurocognitive function after coronary-artery bypass surgery. N Engl J Med 2001;344:395-402.
49. Newman MF, Croughwell ND, Blumenthal JA, White WD, Lewis JB, Smith LR, Frasco P, Towner EA, Schell RM, Hurwitz BJ. Effect of aging on cerebral autoregulation during cardiopulmonary bypass. Association with postoperative cognitive dysfunction. Circulation 1994;90:II243-II249.
50. Hammon JW Jr, Stump DA, Kon ND, Cordell AR, Hudspeth AS, Oaks TE, Brooker RF, Rogers AT, Hilbawi R, Coker LH, et al. Risk factors and solutions for the development of neurobehavioral changes after coronary artery bypass grafting. Ann Thorac Surg 1997;63:1613-1618.
51. Testa JA, Malec JF, Moessner AM, Brown AW. Outcome after traumatic brain injury: effects of aging on recovery. Arch Phys Med Rehabil 2005;86:1815-1823.
52. Marquez de la Plata CD, Hart T, Hammond FM, Frol AB, Hudak A, Harper CR, O'Neil-Pirozzi TM, Whyte J, Carlile M. az-Arrastia R. Impact of age on long-term recovery from traumatic brain injury. Arch Phys Med Rehabil 2008;89:896-903.
53. Murkin JM, Newman SP, Stump DA, Blumenthal JA. Statement of consensus on assessment of neurobehavioral outcomes after cardiac surgery. Ann Thorac Surg 1995;59:1289-1295.
54. Jackson JC, Gordon SM, Ely EW, Burger C, Hopkins RO. Research issues in the evaluation of cognitive impairment in intensive care unit survivors. Intensive Care Med 2004;30:2009-2016.
55. American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 3rd ed. Washington, DC: American Psychiatric Association; 1980.
56. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 4th ed. Text revision. Washington, DC: American Psychiatric Association; 2000.
57. Wechsler D. Wechsler Adult Intelligence Scale, 3rd ed. San Antonio: The Psychological Corporation; 1997.
58. Teng EL, Chui HC. The Modified Mini-Mental State (3MS) examination. J Clin Psychiatry 1987;48:314-318.
59. Crum RM, Anthony JC, Bassett SS, Folstein MF. Population-based norms for the Mini-Mental State Examination by age and educational level. JAMA 1993;269:2386-2391.
60. Rey A. L'examen psychologique dans les cas d'encephalopathie traumatique. Arch Psychol 1941;28:286-340.
61. Spreen O, Strauss E. A Compendium of neuropsychological tests: administration, norms, and commentary, 2nd ed. New York: Oxford University Press; 1998.
62. Rey A. L'examen clinique en psychologie. Paris: Presses Universitaites de France; 1964.
63. Reitan RM, Wolfson D. The Halstead Reitan neuropsychological test battery Tuscon, AZ: Neuropsychology Press; 1985.
64. Heaton RK, Grant I, Matthews CG. Comprehensive norms for an expanded Halstead-Reitan battery: demographic corrections, research findings, and clinical applications. Odessa, FL: Psychological Assessment Resources; 1991.
65. Spreen O, Benton AL. Neurosensory Center Comprehensive Examination for Aphasis (NCCEA) Victoria: University of Victoria Neuropsychological Laboratory; 1969.
66. Sherer M, Bergloff P, Boake C, High W Jr, Levin E. The Awareness Questionnaire: factor structure and internal consistency. Brain Inj 1998;12:63-68.
67. Beck AT. BDI-II depression inventory manual, 2nd ed. New York: Harcourt Brace; 1996.
68. Stoll C, Kapfhammer HP, Rothenhausler HB, Haller M, Briegel J, Schmidt M, Krauseneck T, Durst K, Schelling G. Sensitivity and specificity of a screening test to document traumatic experiences and to diagnose post-traumatic stress disorder in ARDS patients after intensive care treatment. Intensive Care Med 1999;25:697-704.
69. Pfeffer RI, Kurosaki TT, Harrah CH Jr, Chance JM, Filos S. Measurement of functional activities in older adults in the community. J Gerontol 1982;37:323-329.
70. Katz S, Ford AB, Moskowitz RW, Jackson BA, Jaffe MW. Studies of illness in the aged. The index of ADL: a standardized measure of biological and psychological function. JAMA 1963;185:914-919.
71. Ware JE. SF-36 physical and mental health summary scales: a user's manual, 5th ed. Boston: Health Assessment Lab, New England Medical Center; 1994.