메뉴 건너뛰기




Volumn 430, Issue 2, 2017, Pages 266-274

Reprogramming to developmental plasticity in cancer stem cells

Author keywords

Cancer; Development; EMT; Plasticity; Reprogramming; Stem

Indexed keywords

ADULTHOOD; CANCER STEM CELL; CANCER THERAPY; CELL LINEAGE; CELL METABOLISM; CELL PLASTICITY; EPITHELIAL MESENCHYMAL TRANSITION; HUMAN; NONHUMAN; NUCLEAR REPROGRAMMING; PHENOTYPIC PLASTICITY; PRIORITY JOURNAL; REPRODUCTION; REVIEW; TISSUE REGENERATION; CYTOLOGY; FORECASTING; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETICS; METABOLISM; METASTASIS; MUTATION; NEOPLASM; PATHOLOGY; PHENOTYPE;

EID: 85026646437     PISSN: 00121606     EISSN: 1095564X     Source Type: Journal    
DOI: 10.1016/j.ydbio.2017.07.025     Document Type: Review
Times cited : (37)

References (114)
  • 1
    • 5444256238 scopus 로고    scopus 로고
    • Self-renewal and solid tumor stem cells
    • Al-Hajj, M., Clarke, M.F., Self-renewal and solid tumor stem cells. Oncogene 23 (2004), 7274–7282.
    • (2004) Oncogene , vol.23 , pp. 7274-7282
    • Al-Hajj, M.1    Clarke, M.F.2
  • 3
    • 84958899570 scopus 로고    scopus 로고
    • Conversion to stem-cell state in response to microenvironmental cues is regulated by balance between epithelial and mesenchymal features in lung cancer cells
    • Andriani, F., Bertolini, G., Facchinetti, F., Baldoli, E., Moro, M., Casalini, P., Caserini, R., Milione, M., Leone, G., Pelosi, G., et al. Conversion to stem-cell state in response to microenvironmental cues is regulated by balance between epithelial and mesenchymal features in lung cancer cells. Mol. Oncol. 10 (2016), 253–271.
    • (2016) Mol. Oncol. , vol.10 , pp. 253-271
    • Andriani, F.1    Bertolini, G.2    Facchinetti, F.3    Baldoli, E.4    Moro, M.5    Casalini, P.6    Caserini, R.7    Milione, M.8    Leone, G.9    Pelosi, G.10
  • 5
    • 84884969557 scopus 로고    scopus 로고
    • Triple negative breast cancer initiating cell subsets differ in functional and molecular characteristics and in γ-secretase inhibitor drug responses
    • Azzam, D.J., Zhao, D., Sun, J., Minn, A.J., Ranganathan, P., Drews-Elger, K., Han, X., Picon-Ruiz, M., Gilbert, C.A., Wander, S.A., et al. Triple negative breast cancer initiating cell subsets differ in functional and molecular characteristics and in γ-secretase inhibitor drug responses. EMBO Mol. Med. 5 (2013), 1502–1522.
    • (2013) EMBO Mol. Med. , vol.5 , pp. 1502-1522
    • Azzam, D.J.1    Zhao, D.2    Sun, J.3    Minn, A.J.4    Ranganathan, P.5    Drews-Elger, K.6    Han, X.7    Picon-Ruiz, M.8    Gilbert, C.A.9    Wander, S.A.10
  • 10
    • 84954271052 scopus 로고    scopus 로고
    • Phenotypic plasticity determines cancer stem cell therapeutic resistance in oral squamous cell carcinoma
    • Biddle, A., Gammon, L., Liang, X., Costea, D.E., Mackenzie, I.C., Phenotypic plasticity determines cancer stem cell therapeutic resistance in oral squamous cell carcinoma. EBioMedicine 4 (2016), 138–145.
    • (2016) EBioMedicine , vol.4 , pp. 138-145
    • Biddle, A.1    Gammon, L.2    Liang, X.3    Costea, D.E.4    Mackenzie, I.C.5
  • 11
    • 79960936439 scopus 로고    scopus 로고
    • Cancer stem cells in squamous cell carcinoma switch between two distinct phenotypes that are preferentially migratory or proliferative
    • Biddle, A., Liang, X., Gammon, L., Fazil, B., Harper, L.J., Emich, H., Costea, D.E., Mackenzie, I.C., Cancer stem cells in squamous cell carcinoma switch between two distinct phenotypes that are preferentially migratory or proliferative. Cancer Res. 71 (2011), 5317–5326.
    • (2011) Cancer Res. , vol.71 , pp. 5317-5326
    • Biddle, A.1    Liang, X.2    Gammon, L.3    Fazil, B.4    Harper, L.J.5    Emich, H.6    Costea, D.E.7    Mackenzie, I.C.8
  • 13
    • 25444495269 scopus 로고    scopus 로고
    • Opinion: migrating cancer stem cells - an integrated concept of malignant tumour progression
    • Brabletz, T., Jung, A., Spaderna, S., Hlubek, F., Kirchner, T., Opinion: migrating cancer stem cells - an integrated concept of malignant tumour progression. Nat. Rev. Cancer 5 (2005), 744–749.
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 744-749
    • Brabletz, T.1    Jung, A.2    Spaderna, S.3    Hlubek, F.4    Kirchner, T.5
  • 16
    • 84884365015 scopus 로고    scopus 로고
    • The causes and consequences of genetic heterogeneity in cancer evolution
    • Burrell, R.A., McGranahan, N., Bartek, J., Swanton, C., The causes and consequences of genetic heterogeneity in cancer evolution. Nature 501 (2013), 338–345.
    • (2013) Nature , vol.501 , pp. 338-345
    • Burrell, R.A.1    McGranahan, N.2    Bartek, J.3    Swanton, C.4
  • 17
    • 85009400089 scopus 로고    scopus 로고
    • A quiescent Bcl11b high stem cell population is required for maintenance of the mammary gland
    • (e245)
    • Cai, S., Kalisky, T., Sahoo, D., Dalerba, P., Feng, W., Lin, Y., Qian, D., Kong, A., Yu, J., Wang, F., et al. A quiescent Bcl11b high stem cell population is required for maintenance of the mammary gland. Cell Stem Cell 20 (2017), 247–260 (e245).
    • (2017) Cell Stem Cell , vol.20 , pp. 247-260
    • Cai, S.1    Kalisky, T.2    Sahoo, D.3    Dalerba, P.4    Feng, W.5    Lin, Y.6    Qian, D.7    Kong, A.8    Yu, J.9    Wang, F.10
  • 18
    • 84875165863 scopus 로고    scopus 로고
    • Epigenetic programming and reprogramming during development
    • Cantone, I., Fisher, A.G., Epigenetic programming and reprogramming during development. Nat. Struct. Mol. Biol. 20 (2013), 282–289.
    • (2013) Nat. Struct. Mol. Biol. , vol.20 , pp. 282-289
    • Cantone, I.1    Fisher, A.G.2
  • 21
    • 84894581126 scopus 로고    scopus 로고
    • Collective invasion in breast cancer requires a conserved basal epithelial program
    • Cheung, K.J., Gabrielson, E., Werb, Z., Ewald, A.J., Collective invasion in breast cancer requires a conserved basal epithelial program. Cell 155 (2013), 1639–1651.
    • (2013) Cell , vol.155 , pp. 1639-1651
    • Cheung, K.J.1    Gabrielson, E.2    Werb, Z.3    Ewald, A.J.4
  • 25
    • 77954901231 scopus 로고    scopus 로고
    • Single-marker identification of head and neck squamous cell carcinoma cancer stem cells with aldehyde dehydrogenase
    • Clay, M.R., Tabor, M., Owen, J.H., Carey, T.E., Bradford, C.R., Wolf, G.T., Wicha, M.S., Prince, M.E., Single-marker identification of head and neck squamous cell carcinoma cancer stem cells with aldehyde dehydrogenase. Head Neck 32 (2010), 1195–1201.
    • (2010) Head Neck , vol.32 , pp. 1195-1201
    • Clay, M.R.1    Tabor, M.2    Owen, J.H.3    Carey, T.E.4    Bradford, C.R.5    Wolf, G.T.6    Wicha, M.S.7    Prince, M.E.8
  • 26
    • 34047096557 scopus 로고    scopus 로고
    • Cancer stem cells: models and concepts
    • Dalerba, P., Cho, R.W., Clarke, M.F., Cancer stem cells: models and concepts. Annu. Rev. Med. 58 (2007), 267–284.
    • (2007) Annu. Rev. Med. , vol.58 , pp. 267-284
    • Dalerba, P.1    Cho, R.W.2    Clarke, M.F.3
  • 27
    • 79953325707 scopus 로고    scopus 로고
    • Functional cooperation between Snail1 and twist in the regulation of ZEB1 expression during epithelial to mesenchymal transition
    • Dave, N., Guaita-Esteruelas, S., Gutarra, S., Frias, À., Beltran, M., Peiró S., de Herreros, A.G., Functional cooperation between Snail1 and twist in the regulation of ZEB1 expression during epithelial to mesenchymal transition. J. Biol. Chem. 286 (2011), 12024–12032.
    • (2011) J. Biol. Chem. , vol.286 , pp. 12024-12032
    • Dave, N.1    Guaita-Esteruelas, S.2    Gutarra, S.3    Frias, À.4    Beltran, M.5    Peiró, S.6    de Herreros, A.G.7
  • 29
    • 84901853867 scopus 로고    scopus 로고
    • Cancer epigenetics: tumor heterogeneity, plasticity of stem-like states, and drug resistance
    • Easwaran, H., Tsai, H.C., Baylin, S.B., Cancer epigenetics: tumor heterogeneity, plasticity of stem-like states, and drug resistance. Mol. Cell 54 (2014), 716–727.
    • (2014) Mol. Cell , vol.54 , pp. 716-727
    • Easwaran, H.1    Tsai, H.C.2    Baylin, S.B.3
  • 30
    • 77954641944 scopus 로고    scopus 로고
    • Radiation-induced cell death mechanisms
    • Eriksson, D., Stigbrand, T., Radiation-induced cell death mechanisms. Tumour Biol. 31 (2010), 363–372.
    • (2010) Tumour Biol. , vol.31 , pp. 363-372
    • Eriksson, D.1    Stigbrand, T.2
  • 32
    • 84948429460 scopus 로고    scopus 로고
    • Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance
    • Fischer, K.R., Durrans, A., Lee, S., Sheng, J., Li, F., Wong, S.T., Choi, H., El Rayes, T., Ryu, S., Troeger, J., et al. Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance. Nature 527 (2015), 472–476.
    • (2015) Nature , vol.527 , pp. 472-476
    • Fischer, K.R.1    Durrans, A.2    Lee, S.3    Sheng, J.4    Li, F.5    Wong, S.T.6    Choi, H.7    El Rayes, T.8    Ryu, S.9    Troeger, J.10
  • 33
    • 84875211731 scopus 로고    scopus 로고
    • Cancer heterogeneity: implications for targeted therapeutics
    • Fisher, R., Pusztai, L., Swanton, C., Cancer heterogeneity: implications for targeted therapeutics. Br. J. Cancer 108 (2013), 479–485.
    • (2013) Br. J. Cancer , vol.108 , pp. 479-485
    • Fisher, R.1    Pusztai, L.2    Swanton, C.3
  • 34
    • 84876971340 scopus 로고    scopus 로고
    • Sub-sets of cancer stem cells differ intrinsically in their patterns of oxygen metabolism
    • Gammon, L., Biddle, A., Heywood, H.K., Johannessen, A.C., Mackenzie, I.C., Sub-sets of cancer stem cells differ intrinsically in their patterns of oxygen metabolism. PLoS One, 8, 2013, e62493.
    • (2013) PLoS One , vol.8 , pp. e62493
    • Gammon, L.1    Biddle, A.2    Heywood, H.K.3    Johannessen, A.C.4    Mackenzie, I.C.5
  • 35
    • 70449526719 scopus 로고    scopus 로고
    • Localized and reversible TGFbeta signalling switches breast cancer cells from cohesive to single cell motility
    • Giampieri, S., Manning, C., Hooper, S., Jones, L., Hill, C.S., Sahai, E., Localized and reversible TGFbeta signalling switches breast cancer cells from cohesive to single cell motility. Nat. Cell Biol. 11 (2009), 1287–1296.
    • (2009) Nat. Cell Biol. , vol.11 , pp. 1287-1296
    • Giampieri, S.1    Manning, C.2    Hooper, S.3    Jones, L.4    Hill, C.S.5    Sahai, E.6
  • 37
    • 84923103818 scopus 로고    scopus 로고
    • Temporally sequenced anticancer drugs overcome adaptive resistance by targeting a vulnerable chemotherapy-induced phenotypic transition
    • Goldman, A., Majumder, B., Dhawan, A., Ravi, S., Goldman, D., Kohandel, M., Majumder, P.K., Sengupta, S., Temporally sequenced anticancer drugs overcome adaptive resistance by targeting a vulnerable chemotherapy-induced phenotypic transition. Nat. Commun., 6, 2015, 6139.
    • (2015) Nat. Commun. , vol.6 , pp. 6139
    • Goldman, A.1    Majumder, B.2    Dhawan, A.3    Ravi, S.4    Goldman, D.5    Kohandel, M.6    Majumder, P.K.7    Sengupta, S.8
  • 38
    • 84938773709 scopus 로고    scopus 로고
    • Evolutionary determinants of cancer
    • Greaves, M., Evolutionary determinants of cancer. Cancer Discov. 5 (2015), 806–820.
    • (2015) Cancer Discov. , vol.5 , pp. 806-820
    • Greaves, M.1
  • 39
    • 84928539298 scopus 로고    scopus 로고
    • Evolution of vertebrates as viewed from the crest
    • Green, S.A., Simoes-Costa, M., Bronner, M.E., Evolution of vertebrates as viewed from the crest. Nature 520 (2015), 474–482.
    • (2015) Nature , vol.520 , pp. 474-482
    • Green, S.A.1    Simoes-Costa, M.2    Bronner, M.E.3
  • 41
    • 68749099671 scopus 로고    scopus 로고
    • Identification of selective inhibitors of cancer stem cells by high-throughput screening
    • Gupta, P.B., Onder, T.T., Jiang, G., Tao, K., Kuperwasser, C., Weinberg, R.A., Lander, E.S., Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell 138 (2009), 645–659.
    • (2009) Cell , vol.138 , pp. 645-659
    • Gupta, P.B.1    Onder, T.T.2    Jiang, G.3    Tao, K.4    Kuperwasser, C.5    Weinberg, R.A.6    Lander, E.S.7
  • 42
  • 43
    • 20744439516 scopus 로고    scopus 로고
    • The mesenchymal cell, its role in the embryo, and the remarkable signaling mechanisms that create it
    • Hay, E.D., The mesenchymal cell, its role in the embryo, and the remarkable signaling mechanisms that create it. Dev. Dyn. 233 (2005), 706–720.
    • (2005) Dev. Dyn. , vol.233 , pp. 706-720
    • Hay, E.D.1
  • 44
    • 0021242388 scopus 로고
    • Tumor heterogeneity
    • Heppner, G.H., Tumor heterogeneity. Cancer Res. 44 (1984), 2259–2265.
    • (1984) Cancer Res. , vol.44 , pp. 2259-2265
    • Heppner, G.H.1
  • 45
    • 34548455927 scopus 로고    scopus 로고
    • Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer
    • Hermann, P.C., Huber, S.L., Herrler, T., Aicher, A., Ellwart, J.W., Guba, M., Bruns, C.J., Heeschen, C., Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. Cell Stem Cell 1 (2007), 313–323.
    • (2007) Cell Stem Cell , vol.1 , pp. 313-323
    • Hermann, P.C.1    Huber, S.L.2    Herrler, T.3    Aicher, A.4    Ellwart, J.W.5    Guba, M.6    Bruns, C.J.7    Heeschen, C.8
  • 46
    • 84889570568 scopus 로고    scopus 로고
    • An EMT spectrum defines an anoikis-resistant and spheroidogenic intermediate mesenchymal state that is sensitive to e-cadherin restoration by a src-kinase inhibitor, saracatinib (AZD0530)
    • Huang, R.Y., Wong, M.K., Tan, T.Z., Kuay, K.T., Ng, A.H., Chung, V.Y., Chu, Y.S., Matsumura, N., Lai, H.C., Lee, Y.F., et al. An EMT spectrum defines an anoikis-resistant and spheroidogenic intermediate mesenchymal state that is sensitive to e-cadherin restoration by a src-kinase inhibitor, saracatinib (AZD0530). Cell Death Dis., 4, 2013, e915.
    • (2013) Cell Death Dis. , vol.4 , pp. e915
    • Huang, R.Y.1    Wong, M.K.2    Tan, T.Z.3    Kuay, K.T.4    Ng, A.H.5    Chung, V.Y.6    Chu, Y.S.7    Matsumura, N.8    Lai, H.C.9    Lee, Y.F.10
  • 49
    • 84937412521 scopus 로고    scopus 로고
    • Molecular profiling of tumour budding implicates TGFβ-mediated epithelial-mesenchymal transition as a therapeutic target in oral squamous cell carcinoma
    • Jensen, D.H., Dabelsteen, E., Specht, L., Fiehn, A.M., Therkildsen, M.H., Jønson, L., Vikesaa, J., Nielsen, F.C., von Buchwald, C., Molecular profiling of tumour budding implicates TGFβ-mediated epithelial-mesenchymal transition as a therapeutic target in oral squamous cell carcinoma. J. Pathol. 236 (2015), 505–516.
    • (2015) J. Pathol. , vol.236 , pp. 505-516
    • Jensen, D.H.1    Dabelsteen, E.2    Specht, L.3    Fiehn, A.M.4    Therkildsen, M.H.5    Jønson, L.6    Vikesaa, J.7    Nielsen, F.C.8    von Buchwald, C.9
  • 51
    • 85048811708 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions during neural crest and somite development
    • Kalcheim, C., Epithelial-mesenchymal transitions during neural crest and somite development. J. Clin. Med., 2015, 5.
    • (2015) J. Clin. Med. , pp. 5
    • Kalcheim, C.1
  • 52
    • 78649328949 scopus 로고    scopus 로고
    • Global profiling of histone and DNA methylation reveals epigenetic-based regulation of gene expression during epithelial to mesenchymal transition in prostate cells
    • Ke, X.S., Qu, Y., Cheng, Y., Li, W.C., Rotter, V., Øyan, A.M., Kalland, K.H., Global profiling of histone and DNA methylation reveals epigenetic-based regulation of gene expression during epithelial to mesenchymal transition in prostate cells. BMC Genom., 11, 2010, 669.
    • (2010) BMC Genom. , vol.11 , pp. 669
    • Ke, X.S.1    Qu, Y.2    Cheng, Y.3    Li, W.C.4    Rotter, V.5    Øyan, A.M.6    Kalland, K.H.7
  • 53
    • 34547100275 scopus 로고    scopus 로고
    • The resurgence of platinum-based cancer chemotherapy
    • Kelland, L., The resurgence of platinum-based cancer chemotherapy. Nat. Rev. Cancer 7 (2007), 573–584.
    • (2007) Nat. Rev. Cancer , vol.7 , pp. 573-584
    • Kelland, L.1
  • 55
    • 84896125494 scopus 로고    scopus 로고
    • Evolution of the cancer stem cell model
    • Kreso, A., Dick, J.E., Evolution of the cancer stem cell model. Cell Stem Cell 14 (2014), 275–291.
    • (2014) Cell Stem Cell , vol.14 , pp. 275-291
    • Kreso, A.1    Dick, J.E.2
  • 59
    • 85025681648 scopus 로고    scopus 로고
    • Cancer stem cells: cellular plasticity, niche, and its clinical relevance
    • Lee, G., Hall, R.R., Ahmed, A.U., Cancer stem cells: cellular plasticity, niche, and its clinical relevance. J. Stem Cell Res. Ther., 2016, 6.
    • (2016) J. Stem Cell Res. Ther. , pp. 6
    • Lee, G.1    Hall, R.R.2    Ahmed, A.U.3
  • 60
    • 84978062327 scopus 로고    scopus 로고
    • Enhanced anti-tumor activity and cytotoxic effect on cancer stem cell population of metformin-butyrate compared with metformin HCl in breast cancer
    • Lee, K.M., Lee, M., Lee, J., Kim, S.W., Moon, H.G., Noh, D.Y., Han, W., Enhanced anti-tumor activity and cytotoxic effect on cancer stem cell population of metformin-butyrate compared with metformin HCl in breast cancer. Oncotarget 7 (2016), 38500–38512.
    • (2016) Oncotarget , vol.7 , pp. 38500-38512
    • Lee, K.M.1    Lee, M.2    Lee, J.3    Kim, S.W.4    Moon, H.G.5    Noh, D.Y.6    Han, W.7
  • 61
    • 84896294641 scopus 로고    scopus 로고
    • Mathematical model of adult stem cell regeneration with cross-talk between genetic and epigenetic regulation
    • Lei, J., Levin, S.A., Nie, Q., Mathematical model of adult stem cell regeneration with cross-talk between genetic and epigenetic regulation. Proc. Natl. Acad. Sci. USA 111 (2014), E880–E887.
    • (2014) Proc. Natl. Acad. Sci. USA , vol.111 , pp. E880-E887
    • Lei, J.1    Levin, S.A.2    Nie, Q.3
  • 62
    • 84866341656 scopus 로고    scopus 로고
    • A comparison of epithelial-to-mesenchymal transition and re-epithelialization
    • Leopold, P.L., Vincent, J., Wang, H., A comparison of epithelial-to-mesenchymal transition and re-epithelialization. Semin. Cancer Biol. 22 (2012), 471–483.
    • (2012) Semin. Cancer Biol. , vol.22 , pp. 471-483
    • Leopold, P.L.1    Vincent, J.2    Wang, H.3
  • 63
    • 33646428091 scopus 로고    scopus 로고
    • Normal stem cells and cancer stem cells: the niche matters
    • Li, L., Neaves, W.B., Normal stem cells and cancer stem cells: the niche matters. Cancer Res. 66 (2006), 4553–4557.
    • (2006) Cancer Res. , vol.66 , pp. 4553-4557
    • Li, L.1    Neaves, W.B.2
  • 65
    • 84865839326 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions: insights from development
    • Lim, J., Thiery, J.P., Epithelial-mesenchymal transitions: insights from development. Development 139 (2012), 3471–3486.
    • (2012) Development , vol.139 , pp. 3471-3486
    • Lim, J.1    Thiery, J.P.2
  • 66
    • 84961942167 scopus 로고    scopus 로고
    • Chemotherapy targeting cancer stem cells
    • Liu, H., Lv, L., Yang, K., Chemotherapy targeting cancer stem cells. Am. J. Cancer Res. 5 (2015), 880–893.
    • (2015) Am. J. Cancer Res. , vol.5 , pp. 880-893
    • Liu, H.1    Lv, L.2    Yang, K.3
  • 68
    • 25444482608 scopus 로고    scopus 로고
    • Retention of intrinsic stem cell hierarchies in carcinoma-derived cell lines
    • Locke, M., Heywood, M., Fawell, S., Mackenzie, I.C., Retention of intrinsic stem cell hierarchies in carcinoma-derived cell lines. Cancer Res. 65 (2005), 8944–8950.
    • (2005) Cancer Res. , vol.65 , pp. 8944-8950
    • Locke, M.1    Heywood, M.2    Fawell, S.3    Mackenzie, I.C.4
  • 69
    • 80052012674 scopus 로고    scopus 로고
    • Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells
    • Lu, D., Choi, M.Y., Yu, J., Castro, J.E., Kipps, T.J., Carson, D.A., Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells. Proc. Natl. Acad. Sci. USA 108 (2011), 13253–13257.
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 13253-13257
    • Lu, D.1    Choi, M.Y.2    Yu, J.3    Castro, J.E.4    Kipps, T.J.5    Carson, D.A.6
  • 70
    • 84964674918 scopus 로고    scopus 로고
    • Mipsagargin, a novel thapsigargin-based PSMA-activated prodrug: results of a first-in-man phase I clinical trial in patients with refractory, advanced or metastatic solid tumours
    • Mahalingam, D., Wilding, G., Denmeade, S., Sarantopoulas, J., Cosgrove, D., Cetnar, J., Azad, N., Bruce, J., Kurman, M., Allgood, V.E., Carducci, M., Mipsagargin, a novel thapsigargin-based PSMA-activated prodrug: results of a first-in-man phase I clinical trial in patients with refractory, advanced or metastatic solid tumours. Br. J. Cancer 114 (2016), 986–994.
    • (2016) Br. J. Cancer , vol.114 , pp. 986-994
    • Mahalingam, D.1    Wilding, G.2    Denmeade, S.3    Sarantopoulas, J.4    Cosgrove, D.5    Cetnar, J.6    Azad, N.7    Bruce, J.8    Kurman, M.9    Allgood, V.E.10    Carducci, M.11
  • 73
    • 79961023271 scopus 로고    scopus 로고
    • Genome-scale epigenetic reprogramming during epithelial-to-mesenchymal transition
    • McDonald, O.G., Wu, H., Timp, W., Doi, A., Feinberg, A.P., Genome-scale epigenetic reprogramming during epithelial-to-mesenchymal transition. Nat. Struct. Mol. Biol. 18 (2011), 867–874.
    • (2011) Nat. Struct. Mol. Biol. , vol.18 , pp. 867-874
    • McDonald, O.G.1    Wu, H.2    Timp, W.3    Doi, A.4    Feinberg, A.P.5
  • 74
    • 84876489727 scopus 로고    scopus 로고
    • Cancer stem cells: the challenges ahead
    • Medema, J.P., Cancer stem cells: the challenges ahead. Nat. Cell Biol. 15 (2013), 338–344.
    • (2013) Nat. Cell Biol. , vol.15 , pp. 338-344
    • Medema, J.P.1
  • 75
    • 84898892512 scopus 로고    scopus 로고
    • DNA methylation dynamics during epigenetic reprogramming in the germline and preimplantation embryos
    • Messerschmidt, D.M., Knowles, B.B., Solter, D., DNA methylation dynamics during epigenetic reprogramming in the germline and preimplantation embryos. Genes Dev. 28 (2014), 812–828.
    • (2014) Genes Dev. , vol.28 , pp. 812-828
    • Messerschmidt, D.M.1    Knowles, B.B.2    Solter, D.3
  • 77
    • 0033525587 scopus 로고    scopus 로고
    • Prospective identification, isolation by flow cytometry, and in vivo self-renewal of multipotent mammalian neural crest stem cells
    • Morrison, S.J., White, P.M., Zock, C., Anderson, D.J., Prospective identification, isolation by flow cytometry, and in vivo self-renewal of multipotent mammalian neural crest stem cells. Cell 96 (1999), 737–749.
    • (1999) Cell , vol.96 , pp. 737-749
    • Morrison, S.J.1    White, P.M.2    Zock, C.3    Anderson, D.J.4
  • 78
    • 0014739590 scopus 로고
    • Nature of dividing nuclei in skeletal muscle of growing rats
    • Moss, F.P., Leblond, C.P., Nature of dividing nuclei in skeletal muscle of growing rats. J. Cell Biol. 44 (1970), 459–462.
    • (1970) J. Cell Biol. , vol.44 , pp. 459-462
    • Moss, F.P.1    Leblond, C.P.2
  • 81
    • 84908154922 scopus 로고    scopus 로고
    • The EMT universe: space between cancer cell dissemination and metastasis initiation
    • Ombrato, L., Malanchi, I., The EMT universe: space between cancer cell dissemination and metastasis initiation. Crit. Rev. Oncog. 19 (2014), 349–361.
    • (2014) Crit. Rev. Oncog. , vol.19 , pp. 349-361
    • Ombrato, L.1    Malanchi, I.2
  • 82
    • 84923329516 scopus 로고    scopus 로고
    • TGF-β promotes heterogeneity and drug resistance in squamous cell carcinoma
    • Oshimori, N., Oristian, D., Fuchs, E., TGF-β promotes heterogeneity and drug resistance in squamous cell carcinoma. Cell 160 (2015), 963–976.
    • (2015) Cell , vol.160 , pp. 963-976
    • Oshimori, N.1    Oristian, D.2    Fuchs, E.3
  • 83
    • 33645026803 scopus 로고    scopus 로고
    • Highly purified CD44+ prostate cancer cells from xenograft human tumors are enriched in tumorigenic and metastatic progenitor cells
    • Patrawala, L., Calhoun, T., Schneider-Broussard, R., Li, H., Bhatia, B., Tang, S., Reilly, J.G., Chandra, D., Zhou, J., Claypool, K., et al. Highly purified CD44+ prostate cancer cells from xenograft human tumors are enriched in tumorigenic and metastatic progenitor cells. Oncogene 25 (2006), 1696–1708.
    • (2006) Oncogene , vol.25 , pp. 1696-1708
    • Patrawala, L.1    Calhoun, T.2    Schneider-Broussard, R.3    Li, H.4    Bhatia, B.5    Tang, S.6    Reilly, J.G.7    Chandra, D.8    Zhou, J.9    Claypool, K.10
  • 84
    • 0035418579 scopus 로고    scopus 로고
    • Therapeutic implications of enhanced G(0)/G(1) checkpoint control induced by coculture of prostate cancer cells with osteoblasts
    • Pinski, J., Parikh, A., Bova, G.S., Isaacs, J.T., Therapeutic implications of enhanced G(0)/G(1) checkpoint control induced by coculture of prostate cancer cells with osteoblasts. Cancer Res. 61 (2001), 6372–6376.
    • (2001) Cancer Res. , vol.61 , pp. 6372-6376
    • Pinski, J.1    Parikh, A.2    Bova, G.S.3    Isaacs, J.T.4
  • 86
    • 0029690056 scopus 로고    scopus 로고
    • CD24, a glycosylphosphatidylinositol-anchored molecules is transiently expressed during the development of human central nervous system and is a marker of human neural cell lineage tumors
    • Poncet, C., Frances, V., Gristina, R., Scheiner, C., Pellissier, J.F., Figarella-Branger, D., CD24, a glycosylphosphatidylinositol-anchored molecules is transiently expressed during the development of human central nervous system and is a marker of human neural cell lineage tumors. Acta Neuropathol. 91 (1996), 400–408.
    • (1996) Acta Neuropathol. , vol.91 , pp. 400-408
    • Poncet, C.1    Frances, V.2    Gristina, R.3    Scheiner, C.4    Pellissier, J.F.5    Figarella-Branger, D.6
  • 88
    • 84894267586 scopus 로고    scopus 로고
    • In situ identification of bipotent stem cells in the mammary gland
    • Rios, A.C., Fu, N.Y., Lindeman, G.J., Visvader, J.E., In situ identification of bipotent stem cells in the mammary gland. Nature 506 (2014), 322–327.
    • (2014) Nature , vol.506 , pp. 322-327
    • Rios, A.C.1    Fu, N.Y.2    Lindeman, G.J.3    Visvader, J.E.4
  • 90
    • 84942319012 scopus 로고    scopus 로고
    • Concise review: quiescence in adult stem cells: biological significance and relevance to tissue regeneration
    • Rumman, M., Dhawan, J., Kassem, M., Concise review: quiescence in adult stem cells: biological significance and relevance to tissue regeneration. Stem Cells 33 (2015), 2903–2912.
    • (2015) Stem Cells , vol.33 , pp. 2903-2912
    • Rumman, M.1    Dhawan, J.2    Kassem, M.3
  • 92
    • 80052431169 scopus 로고    scopus 로고
    • In vitro generation of human cells with cancer stem cell properties
    • Scaffidi, P., Misteli, T., In vitro generation of human cells with cancer stem cell properties. Nat. Cell Biol. 13 (2011), 1051–1061.
    • (2011) Nat. Cell Biol. , vol.13 , pp. 1051-1061
    • Scaffidi, P.1    Misteli, T.2
  • 96
    • 84906935783 scopus 로고    scopus 로고
    • Regulation of microRNA function in somatic stem cell proliferation and differentiation
    • Shenoy, A., Blelloch, R.H., Regulation of microRNA function in somatic stem cell proliferation and differentiation. Nat. Rev. Mol. Cell Biol. 15 (2014), 565–576.
    • (2014) Nat. Rev. Mol. Cell Biol. , vol.15 , pp. 565-576
    • Shenoy, A.1    Blelloch, R.H.2
  • 98
    • 58449087260 scopus 로고    scopus 로고
    • Detection and analysis of mammary gland stem cells
    • Stingl, J., Detection and analysis of mammary gland stem cells. J. Pathol. 217 (2009), 229–241.
    • (2009) J. Pathol. , vol.217 , pp. 229-241
    • Stingl, J.1
  • 99
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi, K., Yamanaka, S., Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126 (2006), 663–676.
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 100
    • 84887456252 scopus 로고    scopus 로고
    • The epigenetics of epithelial-mesenchymal plasticity in cancer
    • Tam, W.L., Weinberg, R.A., The epigenetics of epithelial-mesenchymal plasticity in cancer. Nat. Med. 19 (2013), 1438–1449.
    • (2013) Nat. Med. , vol.19 , pp. 1438-1449
    • Tam, W.L.1    Weinberg, R.A.2
  • 102
    • 0036595629 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in tumour progression
    • Thiery, J.P., Epithelial-mesenchymal transitions in tumour progression. Nat. Rev. Cancer 2 (2002), 442–454.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 442-454
    • Thiery, J.P.1
  • 103
    • 33244463813 scopus 로고    scopus 로고
    • Complex networks orchestrate epithelial-mesenchymal transitions
    • Thiery, J.P., Sleeman, J.P., Complex networks orchestrate epithelial-mesenchymal transitions. Nat. Rev. Mol. Cell Biol. 7 (2006), 131–142.
    • (2006) Nat. Rev. Mol. Cell Biol. , vol.7 , pp. 131-142
    • Thiery, J.P.1    Sleeman, J.P.2
  • 104
    • 84870845421 scopus 로고    scopus 로고
    • Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis
    • Tsai, J.H., Donaher, J.L., Murphy, D.A., Chau, S., Yang, J., Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis. Cancer Cell 22 (2012), 725–736.
    • (2012) Cancer Cell , vol.22 , pp. 725-736
    • Tsai, J.H.1    Donaher, J.L.2    Murphy, D.A.3    Chau, S.4    Yang, J.5
  • 106
    • 84942984691 scopus 로고    scopus 로고
    • Phenotypic plasticity and epithelial-to-mesenchymal transition in the behaviour and therapeutic response of oral squamous cell carcinoma
    • Vig, N., Mackenzie, I.C., Biddle, A., Phenotypic plasticity and epithelial-to-mesenchymal transition in the behaviour and therapeutic response of oral squamous cell carcinoma. J. Oral. Pathol. Med. 44 (2015), 649–655.
    • (2015) J. Oral. Pathol. Med. , vol.44 , pp. 649-655
    • Vig, N.1    Mackenzie, I.C.2    Biddle, A.3
  • 107
    • 84901758365 scopus 로고    scopus 로고
    • Mammary stem cells and the differentiation hierarchy: current status and perspectives
    • Visvader, J.E., Stingl, J., Mammary stem cells and the differentiation hierarchy: current status and perspectives. Genes Dev. 28 (2014), 1143–1158.
    • (2014) Genes Dev. , vol.28 , pp. 1143-1158
    • Visvader, J.E.1    Stingl, J.2
  • 108
    • 0004078878 scopus 로고
    • The Strategy of the Genes. A Discussion with Some Aspects of Theoretical Biologys
    • George Allen&Unwin, Ltd. London
    • Waddington, C.H., The Strategy of the Genes. A Discussion with Some Aspects of Theoretical Biologys. 1957, George Allen&Unwin, Ltd., London.
    • (1957)
    • Waddington, C.H.1
  • 111
    • 59449090107 scopus 로고    scopus 로고
    • TGF-beta-induced epithelial to mesenchymal transition
    • Xu, J., Lamouille, S., Derynck, R., TGF-beta-induced epithelial to mesenchymal transition. Cell Res. 19 (2009), 156–172.
    • (2009) Cell Res. , vol.19 , pp. 156-172
    • Xu, J.1    Lamouille, S.2    Derynck, R.3
  • 114
    • 84948407218 scopus 로고    scopus 로고
    • Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer
    • Zheng, X., Carstens, J.L., Kim, J., Scheible, M., Kaye, J., Sugimoto, H., Wu, C.C., LeBleu, V.S., Kalluri, R., Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer. Nature 527 (2015), 525–530.
    • (2015) Nature , vol.527 , pp. 525-530
    • Zheng, X.1    Carstens, J.L.2    Kim, J.3    Scheible, M.4    Kaye, J.5    Sugimoto, H.6    Wu, C.C.7    LeBleu, V.S.8    Kalluri, R.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.