Methyltransferase SETD2-Mediated Methylation of STAT1 Is Critical for Interferon Antiviral Activity

Cell

Volumn 170, Issue 3, 2017, Pages 492-506.e14

  Chen, Kun ^a,b   Liu, Juan ^b   Liu, Shuxun ^b   Xia, Meng ^c   Zhang, Xiaomin ^b   Han, Dan ^a   Jiang, Yingming ^b   Wang, Chunmei ^c   Cao, Xuetao ^a,b,c  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

^c INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

Author keywords

antiviral immunity; interferon; lysine methylation; methyltransferase SETD2; STAT1

Indexed keywords

ALPHA INTERFERON; METHYLTRANSFERASE; SET DOMAIN CONTAINING PROTEIN 2; STAT1 PROTEIN; UNCLASSIFIED DRUG; HISTONE; HISTONE LYSINE METHYLTRANSFERASE; SET2 PROTEIN, HUMAN; STAT1 PROTEIN, HUMAN;

ANIMAL CELL; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; ENZYME MECHANISM; EPIGENETICS; HUMAN; HUMAN CELL; HUMAN TISSUE; LIMIT OF QUANTITATION; LIVER CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN METHYLATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; ANIMAL; CELL LINE; CHRONIC HEPATITIS B; GENETIC EPIGENESIS; GENETIC TRANSCRIPTION; GENETICS; HEPATITIS B VIRUS; IMMUNOLOGY; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN DOMAIN; TUMOR CELL LINE; VIROLOGY; VIRUS REPLICATION;

ANIMALS; CELL LINE; CELL LINE, TUMOR; EPIGENESIS, GENETIC; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HEPATOCYTES; HISTONE-LYSINE N-METHYLTRANSFERASE; HISTONES; HUMANS; INTERFERON-ALPHA; MICE; PHOSPHORYLATION; PROTEIN DOMAINS; RNA INTERFERENCE; STAT1 TRANSCRIPTION FACTOR; TRANSCRIPTION, GENETIC; VIRUS REPLICATION;

EID: 85026428458     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2017.06.042     Document Type: Article

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