Human Genome-Wide RNAi Screen Identifies an Essential Role for Inositol Pyrophosphates in Type-I Interferon Response

PLoS Pathogens

Volumn 10, Issue 2, 2014, Pages

  Pulloor, Niyas Kudukkil ^a   Nair, Sajith ^a   Kostic, Aleksandar D ^b   Bist, Pradeep ^a   Weaver, Jeremy D ^c   Riley, Andrew M ^d   Tyagi, Richa ^e   Uchil, Pradeep D ^f   York, John D ^g   Snyder, Solomon H ^e   García Sastre, Adolfo ^h   Potter, Barry V L ^d   Lin, Rongtuan ⁱ   Shears, Stephen B ^c   Xavier, Ramnik J ^b   Krishnan, Manoj N ^a  

^a DUKE NUS MEDICAL SCHOOL   (Singapore)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^d University of Bath   (United Kingdom)

^e JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h MOUNT SINAI SCHOOL OF MEDICINE   (United States)

ⁱ MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; DIPHOSPHOINOSITOL PENTAKISPHOSPHATE KINASE; DIPHOSPHOINOSITOL PENTAKISPHOSPHATE KINASE 2; INOSITOL; INOSITOL PYROPHOSPHATE; INTERFERON; INTERFERON REGULATORY FACTOR 3; PATTERN RECOGNITION RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; BIOINFORMATICS; CELL MIGRATION; CONTROLLED STUDY; DIMERIZATION; FLUORESCENCE MICROSCOPY; GENE EXPRESSION; GENE ONTOLOGY; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN GENOME; INFLUENZA VIRUS A; INNATE IMMUNITY; NUCLEOTIDE SEQUENCE; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; REAL TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SENDAI VIRUS; VIRUS INFECTION; VIRUS LOAD; WESTERN BLOTTING;

GENE EXPRESSION REGULATION; HUMANS; IMMUNITY, INNATE; INTERFERON REGULATORY FACTOR-3; INTERFERON TYPE I; PHOSPHORIC MONOESTER HYDROLASES; RECEPTORS, RETINOIC ACID; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 84897675720     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1003981     Document Type: Article

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