PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection

Nature Immunology

Volumn 16, Issue 12, 2015, Pages 1215-1227

  Zhang, Yong ^a   Mao, Dailing ^a   Roswit, William T ^a   Jin, Xiaohua ^a   Patel, Anand C ^a   Patel, Dhara A ^a   Agapov, Eugene ^a   Wang, Zhepeng ^a   Tidwell, Rose M ^a   Atkinson, Jeffrey J ^a   Huang, Guangming ^a   McCarthy, Ronald ^a   Yu, Jinsheng ^a   Yun, Nadezhda E ^b   Paessler, Slobodan ^b   Lawson, T Glen ^c   Omattage, Natalie S ^a   Brett, Tom J ^a   Holtzman, Michael J ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^c BATES COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ACTIN; BETA INTERFERON; DTX3L PROTEIN; HEMOGLOBIN BETA CHAIN; HISTONE H2BJ; INTERFERON REGULATORY FACTOR 1; MESSENGER RNA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 9; STAT1 PROTEIN; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; 3C PROTEASES; CYSTEINE PROTEINASE; DTX3L PROTEIN, MOUSE; GAMMA INTERFERON; HISTONE; PARP9 PROTEIN, MOUSE; PROTEIN BINDING; RNA DIRECTED DNA POLYMERASE; TRANSCRIPTOME; UBIQUITIN PROTEIN LIGASE; VIRAL PROTEIN;

AMINO TERMINAL SEQUENCE; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTION; DNA REPAIR; GENE EXPRESSION; HISTONE MODIFICATION; HISTONE UBIQUITINATION; HUMAN; HUMAN CELL; IN VIVO STUDY; INFECTION CONTROL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; RING FINGER MOTIF; SIGNAL TRANSDUCTION; VENEZUELAN EQUINE ENCEPHALITIS VIRUS; VIRUS LOAD; ANIMAL; C57BL MOUSE; CELL LINE; CELL NUCLEUS; CONFOCAL MICROSCOPY; DRUG EFFECTS; ENCEPHALOMYOCARDITIS VIRUS; GENETICS; HEK293 CELL LINE; HOST PATHOGEN INTERACTION; IMMUNOBLOTTING; METABOLISM; MUTATION; PHYSIOLOGY; RNA INTERFERENCE; TRANSGENIC MOUSE;

ANIMALS; CELL LINE; CELL NUCLEUS; CYSTEINE ENDOPEPTIDASES; ENCEPHALOMYOCARDITIS VIRUS; HEK293 CELLS; HISTONES; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNOBLOTTING; INTERFERON-BETA; INTERFERON-GAMMA; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROSCOPY, CONFOCAL; MUTATION; POLY(ADP-RIBOSE) POLYMERASES; PROTEIN BINDING; RNA INTERFERENCE; RNA-DIRECTED DNA POLYMERASE; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; TRANSCRIPTOME; UBIQUITIN-PROTEIN LIGASES; VIRAL PROTEINS;

EID: 84947866665     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.3279     Document Type: Article

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