Axodendritic sorting and pathological missorting of Tau are isoform-specific and determined by axon initial segment architecture

Journal of Biological Chemistry

Volumn 292, Issue 29, 2017, Pages 12192-12207

  Zempel, Hans ^a,b,c,d   Dennissen, Frank J A ^a,b   Kumar, Yatender ^a,c,e   Luedtke, Julia ^a,b   Biernat, Jacek ^a,b   Mandelkow, Eva Maria ^a,b,c   Mandelkow, Eckhard ^a,b,c  

^a GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^b CENTER OF ADVANCED EUROPEAN STUDIES AND RESEARCH CAESAR   (Germany)

^c MAX PLANCK INSTITUTE FOR NEUROLOGICAL RESEARCH   (Germany)

^d UNIVERSITY OF BONN   (Germany)

^e NETAJI SUBHAS INSTITUTE OF TECHNOLOGY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

DIFFUSION BARRIERS; ENZYMES; NEURODEGENERATIVE DISEASES;

ALZHEIMER DISEASE; DENDRITE GROWTH; GLYCOGEN SYNTHASE KINASE-3; LIVE-CELL IMAGING; MICROTUBULE ASSOCIATED PROTEIN; MICROTUBULE DYNAMICS; MISLOCALIZATION; SUPER RESOLUTION;

GLYCOPROTEINS;

AMYLOID BETA PROTEIN; ANKYRIN; ANKYRIN G; COFILIN; F ACTIN; GLYCOGEN SYNTHASE KINASE 3BETA; ISOPROTEIN; TAU PROTEIN; UNCLASSIFIED DRUG; HYBRID PROTEIN; MAPT PROTEIN, HUMAN; MAPT PROTEIN, MOUSE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; AXON; AXON INITIAL SEGMENT; CELL GROWTH; CELL SELECTION; CONTROLLED STUDY; DENDRITE; EMBRYO; FOREBRAIN; MICROTUBULE; MOLECULAR DYNAMICS; NERVE ELONGATION; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; WILD TYPE; ALZHEIMER DISEASE; AMINO ACID REPEAT; ANIMAL; ANTAGONISTS AND INHIBITORS; BRAIN CORTEX; C57BL MOUSE; CELL CULTURE; CHEMISTRY; CYTOLOGY; DIFFUSION; GENE DELETION; GENE EXPRESSION REGULATION; GENETICS; HUMAN; KNOCKOUT MOUSE; MAMMALIAN EMBRYO; METABOLISM; NERVE CELL; PATHOLOGY; PROTEIN DOMAIN; PROTEIN TRANSPORT; RNA INTERFERENCE; WISTAR RAT;

ALZHEIMER DISEASE; ANIMALS; AXON INITIAL SEGMENT; CELLS, CULTURED; CEREBRAL CORTEX; DENDRITES; DIFFUSION; EMBRYO, MAMMALIAN; GENE DELETION; HUMANS; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROTUBULES; MUTAGENESIS, INSERTIONAL; NEURONS; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN ISOFORMS; PROTEIN TRANSPORT; RATS, WISTAR; RECOMBINANT FUSION PROTEINS; REPETITIVE SEQUENCES, AMINO ACID; RNA INTERFERENCE; TAU PROTEINS;

EID: 85025167025     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M117.784702     Document Type: Article

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