Hyperphosphorylated tau causes reduced hippocampal CA1 excitability by relocating the axon initial segment

Acta Neuropathologica

Volumn 133, Issue 5, 2017, Pages 717-730

  Hatch, Robert John ^a   Wei, Yan ^a,b   Xia, Di ^a   Götz, Jürgen ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b INSTITUTE OF BIOPHYSICS   (China)

Author keywords

Action potential; Axon initial segment; CA1; Hippocampus; Neurodegeneration; Tau

Indexed keywords

TAU PROTEIN; TAU PROTEIN P301L; UNCLASSIFIED DRUG; MAPT PROTEIN, MOUSE;

ACTION POTENTIAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AXON INITIAL SEGMENT; BRAIN SLICE; CONTROLLED STUDY; DEPOLARIZATION; ELECTROPHYSIOLOGICAL PROCEDURES; FEMALE; FIRING RATE; GENETIC TRANSFECTION; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL NEURONAL CULTURE; IMAGE ANALYSIS; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; INTERNEURON; MALE; MICROTUBULE; MOLECULAR PATHOLOGY; MOUSE; MUTAGENESIS; NERVE DEGENERATION; NERVE EXCITABILITY; NONHUMAN; PRIMARY CULTURE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; PROTEIN STRUCTURE; PYRAMIDAL NERVE CELL; WHOLE CELL PATCH CLAMP; ANIMAL; DISEASE MODEL; HIPPOCAMPUS; LONG TERM POTENTIATION; MEMORY DISORDER; METABOLISM; NERVE CELL; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; TAUOPATHY; TRANSGENIC MOUSE;

ANIMALS; AXON INITIAL SEGMENT; DISEASE MODELS, ANIMAL; HIPPOCAMPUS; LONG-TERM POTENTIATION; MEMORY DISORDERS; MICE; MICE, TRANSGENIC; NEURONS; PHOSPHORYLATION; TAU PROTEINS; TAUOPATHIES;

EID: 85009466282     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/s00401-017-1674-1     Document Type: Article

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